| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ribociclib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HELZ | helicase with zinc finger | 0.108649 |
| FAM13A | family with sequence similarity 13, member A | 0.104903 |
| NDRG1 | N-myc downstream regulated 1 | 0.0840784 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0800081 |
| VIM | vimentin | 0.0749991 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0648772 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0647174 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0643898 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0615204 |
| PTMA | prothymosin, alpha | 0.0595341 |
| IGF2 | insulin-like growth factor 2 | 0.0568918 |
| ZNF292 | zinc finger protein 292 | 0.056472 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.054759 |
| WDR45B | WD repeat domain 45B | 0.0511157 |
| PGK1 | phosphoglycerate kinase 1 | 0.050208 |
| RPL37A | ribosomal protein L37a | 0.0497619 |
| OGA | O-GlcNAcase | 0.0497224 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0496662 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0441907 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0441541 |
| FNBP1 | formin binding protein 1 | 0.0434298 |
| DTNA | dystrobrevin, alpha | 0.0407148 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0403568 |
| HMGB2 | high mobility group box 2 | 0.0402336 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0398134 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0381078 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0375244 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0374707 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.036912 |
| MEF2A | myocyte enhancer factor 2A | 0.0366538 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0365432 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.036049 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0359529 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0346329 |
| RTN4 | reticulon 4 | 0.0344111 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0339439 |
| CENPF | centromere protein F, 350/400kDa | 0.0339327 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0338883 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0334353 |
| MXI1 | MAX interactor 1, dimerization protein | 0.033011 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0324539 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0323524 |
| PKM | pyruvate kinase, muscle | 0.0321451 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0310726 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0310699 |
| CDC27 | cell division cycle 27 | 0.0310036 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0308965 |
| CDK19 | cyclin-dependent kinase 19 | 0.0305864 |
| MED13 | mediator complex subunit 13 | 0.0303629 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0302928 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0302877 |
| GOLGA4 | golgin A4 | 0.0300058 |
| ANXA2 | annexin A2 | 0.0300051 |
| TMSB10 | thymosin beta 10 | 0.0299142 |
| NUP58 | nucleoporin 58 | 0.029857 |
| RPL35A | ribosomal protein L35a | 0.0298548 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0295131 |
| PHIP | pleckstrin homology domain interacting protein | 0.0292162 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0290805 |
| TPR | translocated promoter region, nuclear basket protein | 0.0290674 |
| B2M | beta-2-microglobulin | 0.0282557 |
| ENAH | enabled homolog (Drosophila) | 0.0281743 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0280774 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0279793 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0278656 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0276336 |
| ECT2 | epithelial cell transforming 2 | 0.0276255 |
| ZNF207 | zinc finger protein 207 | 0.0272867 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0272034 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0270954 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0270751 |
| ASPH | aspartate beta-hydroxylase | 0.027032 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.027028 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0269414 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0267205 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0266509 |
| RIOK3 | RIO kinase 3 | 0.0264278 |
| SBF2 | SET binding factor 2 | 0.0262781 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0258172 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0252582 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0250951 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0249508 |
| CCNL1 | cyclin L1 | 0.0248765 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0245277 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0244379 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0244152 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0243791 |
| SUCO | SUN domain containing ossification factor | 0.0243434 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0242529 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0242068 |
| TLK2 | tousled-like kinase 2 | 0.0240098 |
| GSPT1 | G1 to S phase transition 1 | 0.0239935 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0239871 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0238963 |
| RPL34 | ribosomal protein L34 | 0.0238722 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0238018 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0237925 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0236773 |
| FTL | ferritin, light polypeptide | 0.0234873 |
| STX6 | syntaxin 6 | 0.0234427 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | -0.212606 |
| VCL | vinculin | -0.148524 |
| NRG1 | neuregulin 1 | -0.11221 |
| EXT1 | exostosin glycosyltransferase 1 | -0.104196 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0943777 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0880867 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0858914 |
| SYT1 | synaptotagmin I | -0.0831981 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.081263 |
| KLHL13 | kelch-like family member 13 | -0.0794206 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0733967 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0704617 |
| FRMD4A | FERM domain containing 4A | -0.0662615 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0641939 |
| TLE4 | transducin-like enhancer of split 4 | -0.0634629 |
| RNF213 | ring finger protein 213 | -0.0631709 |
| RIGI | RNA sensor RIG-I | -0.0628132 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0610175 |
| ZNF804A | zinc finger protein 804A | -0.0608317 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0601281 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0600374 |
| LSAMP | limbic system-associated membrane protein | -0.0562505 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0559771 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0551069 |
| SIK2 | salt-inducible kinase 2 | -0.0534334 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0522752 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0520478 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0516907 |
| GPC5 | glypican 5 | -0.0498946 |
| GLCCI1 | glucocorticoid induced 1 | -0.048076 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0471303 |
| FAM107B | family with sequence similarity 107, member B | -0.0467519 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0442863 |
| SP100 | SP100 nuclear antigen | -0.0425047 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0424073 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0418768 |
| TPM1 | tropomyosin 1 (alpha) | -0.0412871 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0403269 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0396507 |
| DNM3 | dynamin 3 | -0.0391172 |
| COL1A1 | collagen, type I, alpha 1 | -0.0386211 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0384551 |
| MEIS2 | Meis homeobox 2 | -0.0373553 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0369223 |
| PRKCA | protein kinase C, alpha | -0.0361312 |
| COL3A1 | collagen, type III, alpha 1 | -0.0357553 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0356713 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0356683 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.035547 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0349271 |
| PDE10A | phosphodiesterase 10A | -0.0346768 |
| EGR1 | early growth response 1 | -0.0346428 |
| RPL3 | ribosomal protein L3 | -0.0346183 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0344767 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.034118 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0333865 |
| NRP1 | neuropilin 1 | -0.0332758 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0328639 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0322491 |
| STK38L | serine/threonine kinase 38 like | -0.0317487 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.031665 |
| ATRNL1 | attractin-like 1 | -0.0311873 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0310595 |
| BPTF | bromodomain PHD finger transcription factor | -0.0309141 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0306785 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0305892 |
| SYNPO2 | synaptopodin 2 | -0.0299537 |
| VMP1 | vacuole membrane protein 1 | -0.0299496 |
| THBS1 | thrombospondin 1 | -0.029691 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0296157 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0293682 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0292346 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0291675 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0290723 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0290064 |
| IRS1 | insulin receptor substrate 1 | -0.0289942 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0288414 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0287967 |
| MX1 | MX dynamin-like GTPase 1 | -0.0281859 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0277254 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0276669 |
| MAP1B | microtubule-associated protein 1B | -0.0276468 |
| RPL4 | ribosomal protein L4 | -0.0272735 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.0272655 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0270778 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0270177 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0269648 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.026654 |
| SVIL | supervillin | -0.0265904 |
| PCBP3 | poly(rC) binding protein 3 | -0.026551 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.026463 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.026442 |
| VGF | VGF nerve growth factor inducible | -0.0264041 |
| AEBP2 | AE binding protein 2 | -0.0262504 |
| MYO1E | myosin IE | -0.0262023 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0259149 |
| CNTN4 | contactin 4 | -0.0259039 |
| AHI1 | Abelson helper integration site 1 | -0.0256681 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0254935 |
| DGKH | diacylglycerol kinase, eta | -0.0254379 |
