| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ribociclib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.125384 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0992588 |
| CADM1 | cell adhesion molecule 1 | 0.0977251 |
| ATP13A3 | ATPase type 13A3 | 0.0947295 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0903684 |
| PTMA | prothymosin, alpha | 0.0801078 |
| VIM | vimentin | 0.0767651 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0755198 |
| SPAG9 | sperm associated antigen 9 | 0.0734109 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0713464 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0711617 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0656755 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0592158 |
| ZNF292 | zinc finger protein 292 | 0.0541989 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0482241 |
| USP3 | ubiquitin specific peptidase 3 | 0.0475712 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0468882 |
| QKI | QKI, KH domain containing, RNA binding | 0.0466469 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0463615 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0446405 |
| TFG | TRK-fused gene | 0.0429534 |
| MRTFA | myocardin related transcription factor A | 0.0428411 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.042091 |
| RASA2 | RAS p21 protein activator 2 | 0.0420229 |
| RLF | rearranged L-myc fusion | 0.0420057 |
| PTK2 | protein tyrosine kinase 2 | 0.0419359 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0401195 |
| SQLE | squalene epoxidase | 0.0378777 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0371158 |
| B2M | beta-2-microglobulin | 0.0365141 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0359139 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0353955 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0351353 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0345742 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344846 |
| RNF145 | ring finger protein 145 | 0.0339975 |
| RPS8 | ribosomal protein S8 | 0.0339419 |
| SEPTIN7 | septin 7 | 0.0337524 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0335716 |
| ARRDC3 | arrestin domain containing 3 | 0.0335437 |
| CALR | calreticulin | 0.0332967 |
| CLINT1 | clathrin interactor 1 | 0.0323386 |
| UBC | ubiquitin C | 0.0322284 |
| IER3 | immediate early response 3 | 0.0322233 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0321821 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0321206 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0321032 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0318871 |
| GOLGA4 | golgin A4 | 0.0316803 |
| RPS6 | ribosomal protein S6 | 0.0315777 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0315092 |
| OGA | O-GlcNAcase | 0.0314979 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0312005 |
| FOXJ3 | forkhead box J3 | 0.0307056 |
| PDE8A | phosphodiesterase 8A | 0.0305232 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0304224 |
| FMNL2 | formin-like 2 | 0.0296213 |
| MATR3 | matrin 3 | 0.0293763 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0291104 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0289046 |
| RYBP | RING1 and YY1 binding protein | 0.028819 |
| DSTN | destrin (actin depolymerizing factor) | 0.0283765 |
| COPA | coatomer protein complex, subunit alpha | 0.0282937 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0281046 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0281019 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0280102 |
| FN1 | fibronectin 1 | 0.0279857 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0279681 |
| RHEB | Ras homolog enriched in brain | 0.0279444 |
| TRAM1 | translocation associated membrane protein 1 | 0.0277021 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.027632 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0276082 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0275972 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0272772 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0272217 |
| SETD5 | SET domain containing 5 | 0.0271143 |
| DENND5A | DENN/MADD domain containing 5A | 0.0269909 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0268897 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0267051 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0266548 |
| FNDC3B | fibronectin type III domain containing 3B | 0.026634 |
| RPL5 | ribosomal protein L5 | 0.0264943 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0263444 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.026258 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0260713 |
| RNF24 | ring finger protein 24 | 0.0254755 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0249511 |
| RYK | receptor-like tyrosine kinase | 0.0248644 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0248601 |
| CCNL1 | cyclin L1 | 0.0248474 |
| HELZ | helicase with zinc finger | 0.0247116 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0244474 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0242209 |
| MTDH | metadherin | 0.0242164 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.023999 |
| ECT2 | epithelial cell transforming 2 | 0.0236225 |
| FNBP1L | formin binding protein 1-like | 0.0235801 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0235336 |
| MED13L | mediator complex subunit 13-like | 0.0235329 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0233026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0918724 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0891903 |
| CDH13 | cadherin 13 | -0.0890137 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0871643 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0818253 |
| EXT1 | exostosin glycosyltransferase 1 | -0.081668 |
| FBN1 | fibrillin 1 | -0.0594507 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0541698 |
| COL5A1 | collagen, type V, alpha 1 | -0.0518133 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0516693 |
| GLIS3 | GLIS family zinc finger 3 | -0.050442 |
| NAV1 | neuron navigator 1 | -0.0492824 |
| ASPH | aspartate beta-hydroxylase | -0.0475944 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0475877 |
| TMSB10 | thymosin beta 10 | -0.0455204 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0453783 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0392024 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0390839 |
| MT2A | metallothionein 2A | -0.0380452 |
| VCL | vinculin | -0.0351614 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0348664 |
| HMGA2 | high mobility group AT-hook 2 | -0.0340302 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0323041 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0319586 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0316952 |
| CD44 | CD44 molecule (Indian blood group) | -0.0312491 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0302497 |
| PRELID2 | PRELI domain containing 2 | -0.0301389 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0286803 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0284647 |
| OSMR | oncostatin M receptor | -0.0273279 |
| LOC112694756 | uncharaterized LOC112694756 | -0.027131 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0271251 |
| HDAC9 | histone deacetylase 9 | -0.0259489 |
| EGR1 | early growth response 1 | -0.0255122 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0249522 |
| ATXN1 | ataxin 1 | -0.0233143 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0227998 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0225844 |
| COL1A1 | collagen, type I, alpha 1 | -0.0224745 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0222658 |
| CNTN5 | contactin 5 | -0.0216266 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0216043 |
| SMYD3 | SET and MYND domain containing 3 | -0.0213218 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0211218 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0209551 |
| GOLGB1 | golgin B1 | -0.0209094 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0207943 |
| CPQ | carboxypeptidase Q | -0.0204064 |
| MYO1E | myosin IE | -0.0200846 |
| AHNAK | AHNAK nucleoprotein | -0.0199061 |
| CALD1 | caldesmon 1 | -0.0194866 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0192567 |
| FER | fer (fps/fes related) tyrosine kinase | -0.019192 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0189524 |
| PLEC | plectin | -0.0188185 |
| RRBP1 | ribosome binding protein 1 | -0.01878 |
| INHBA | inhibin, beta A | -0.0186492 |
| EPHB1 | EPH receptor B1 | -0.0186462 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0181278 |
| COL7A1 | collagen, type VII, alpha 1 | -0.018006 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0178661 |
| EGFR | epidermal growth factor receptor | -0.0177438 |
| SETBP1 | SET binding protein 1 | -0.0174667 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0173307 |
| EFNA5 | ephrin-A5 | -0.0169389 |
| FRMD4A | FERM domain containing 4A | -0.0169252 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0165771 |
| SDC2 | syndecan 2 | -0.0164799 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0161585 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0159288 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0158129 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0157984 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0157868 |
| LOXL2 | lysyl oxidase-like 2 | -0.0157348 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0156343 |
| NABP1 | nucleic acid binding protein 1 | -0.0154446 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0153735 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0152669 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0152658 |
| STC1 | stanniocalcin 1 | -0.015209 |
| INTS6 | integrator complex subunit 6 | -0.0151856 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0151707 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0147857 |
| RBPMS | RNA binding protein with multiple splicing | -0.0146909 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0146381 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0144723 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0144094 |
| HMCN1 | hemicentin 1 | -0.0143734 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0139052 |
| ZNF644 | zinc finger protein 644 | -0.0138717 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0138598 |
| FAM20C | family with sequence similarity 20, member C | -0.0136318 |
| BNC2 | basonuclin 2 | -0.0135734 |
| HAS2 | hyaluronan synthase 2 | -0.0133581 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0132931 |
| SULF1 | sulfatase 1 | -0.0131043 |
| NREP | neuronal regeneration related protein | -0.012985 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.012745 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0127191 |
