| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ribociclib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.253696 |
| FN1 | fibronectin 1 | 0.180496 |
| C3 | complement component 3 | 0.153148 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.130154 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0960413 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0941863 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0892839 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0802746 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0706639 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.067382 |
| RPL3 | ribosomal protein L3 | 0.0645663 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.057894 |
| TF | transferrin | 0.0574701 |
| SDC4 | syndecan 4 | 0.0556264 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0546705 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0535449 |
| A2M | alpha-2-macroglobulin | 0.0504015 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0487597 |
| FLNB | filamin B, beta | 0.0481227 |
| MRTFA | myocardin related transcription factor A | 0.0470944 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0451177 |
| RBM39 | RNA binding motif protein 39 | 0.0432271 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0424525 |
| TNS1 | tensin 1 | 0.0419812 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0397683 |
| VEGFA | vascular endothelial growth factor A | 0.0384561 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 0.037856 |
| CCNY | cyclin Y | 0.0378252 |
| RPS12 | ribosomal protein S12 | 0.036963 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0366414 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0364208 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0358961 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0353239 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0347643 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0335987 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0335935 |
| SMAD3 | SMAD family member 3 | 0.0331307 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0330922 |
| CFB | complement factor B | 0.0330708 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0329254 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0323549 |
| TBC1D22A | TBC1 domain family, member 22A | 0.032349 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.03199 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0319584 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0318996 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0318586 |
| FNDC3B | fibronectin type III domain containing 3B | 0.031442 |
| YAP1 | Yes-associated protein 1 | 0.0314187 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0314116 |
| EHBP1 | EH domain binding protein 1 | 0.0312743 |
| TRIM26 | tripartite motif containing 26 | 0.0312503 |
| MAPK1 | mitogen-activated protein kinase 1 | 0.0309841 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0308602 |
| BCL2L1 | BCL2-like 1 | 0.0306804 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0303696 |
| CANX | calnexin | 0.0295876 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0295087 |
| CPE | carboxypeptidase E | 0.0290884 |
| FAM107B | family with sequence similarity 107, member B | 0.0289335 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0287761 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0287729 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0285517 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0283102 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0282071 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.027839 |
| AHR | aryl hydrocarbon receptor | 0.0278312 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0277296 |
| FAT1 | FAT atypical cadherin 1 | 0.0276479 |
| MATN3 | matrilin 3 | 0.0276285 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0273088 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0271987 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0271406 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0271284 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0270957 |
| SDC2 | syndecan 2 | 0.0267248 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0263417 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0263246 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0262541 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0260098 |
| FBXO31 | F-box protein 31 | 0.0259321 |
| AFDN | afadin, adherens junction formation factor | 0.0249761 |
| JAG1 | jagged 1 | 0.0249192 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0248983 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0248433 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0246969 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0246544 |
| TNS3 | tensin 3 | 0.0246101 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.02448 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0241684 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0240054 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | 0.0239995 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0239398 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0238531 |
| VIL1 | villin 1 | 0.0237303 |
| MAP4 | microtubule-associated protein 4 | 0.0237237 |
| SYNJ2 | synaptojanin 2 | 0.0236765 |
| SKI | SKI proto-oncogene | 0.0234964 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0233141 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.023308 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0232208 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.167815 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.154215 |
| APOA2 | apolipoprotein A-II | -0.151307 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.137848 |
| ENO1 | enolase 1, (alpha) | -0.132057 |
| MT2A | metallothionein 2A | -0.116689 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.109525 |
| FTL | ferritin, light polypeptide | -0.101139 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.098242 |
| TMSB10 | thymosin beta 10 | -0.0852393 |
| HMGA1 | high mobility group AT-hook 1 | -0.0803182 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.077741 |
| RPS6 | ribosomal protein S6 | -0.077613 |
| RPL12 | ribosomal protein L12 | -0.0767901 |
| RPLP0 | ribosomal protein, large, P0 | -0.075399 |
| RPS19 | ribosomal protein S19 | -0.0738839 |
| RPL35A | ribosomal protein L35a | -0.0699378 |
| RPLP1 | ribosomal protein, large, P1 | -0.0696443 |
| RPS24 | ribosomal protein S24 | -0.0605205 |
| RPS8 | ribosomal protein S8 | -0.0597737 |
| H1-0 | H1.0 linker histone | -0.0589704 |
| NDRG1 | N-myc downstream regulated 1 | -0.0538184 |
| RPL32 | ribosomal protein L32 | -0.0512086 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0503516 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0501718 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0497434 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0487926 |
| RPLP2 | ribosomal protein, large, P2 | -0.0482166 |
| RPS29 | ribosomal protein S29 | -0.0452775 |
| RPS23 | ribosomal protein S23 | -0.0443961 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0436438 |
| RPL34 | ribosomal protein L34 | -0.0416881 |
| GDF15 | growth differentiation factor 15 | -0.0414995 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0406084 |
| RPL11 | ribosomal protein L11 | -0.0398109 |
| RPS27A | ribosomal protein S27a | -0.0386474 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.038208 |
| RPS14 | ribosomal protein S14 | -0.0377643 |
| RPS16 | ribosomal protein S16 | -0.037331 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0372731 |
| RPS21 | ribosomal protein S21 | -0.0365997 |
| VIM | vimentin | -0.0361482 |
| FMNL2 | formin-like 2 | -0.0359952 |
| RPL31 | ribosomal protein L31 | -0.0358125 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0356042 |
| S100A10 | S100 calcium binding protein A10 | -0.0352432 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0349731 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0342648 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0332871 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0330963 |
| PLIN2 | perilipin 2 | -0.0330771 |
| RPL23 | ribosomal protein L23 | -0.032284 |
| FRMD5 | FERM domain containing 5 | -0.0313596 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0312986 |
| APOC1 | apolipoprotein C-I | -0.0311776 |
| RPL19 | ribosomal protein L19 | -0.0306417 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0306066 |
| RPL27A | ribosomal protein L27a | -0.0292712 |
| RUNX1 | runt-related transcription factor 1 | -0.0292313 |
| MORF4L2 | mortality factor 4 like 2 | -0.0292006 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0290088 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0287831 |
| S100A9 | S100 calcium binding protein A9 | -0.0282215 |
| AHSG | alpha-2-HS-glycoprotein | -0.0281901 |
| RPS11 | ribosomal protein S11 | -0.0280005 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0278041 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0277044 |
| RPL5 | ribosomal protein L5 | -0.0274534 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0273482 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0271989 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0271254 |
| RPS27 | ribosomal protein S27 | -0.0269503 |
| RPL8 | ribosomal protein L8 | -0.0269081 |
| RPL36 | ribosomal protein L36 | -0.0265094 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0265031 |
| PTK2 | protein tyrosine kinase 2 | -0.0261773 |
| EGR1 | early growth response 1 | -0.0260808 |
| RPL18 | ribosomal protein L18 | -0.0257034 |
| ZNF292 | zinc finger protein 292 | -0.0256148 |
| WDR45B | WD repeat domain 45B | -0.0252998 |
| SEPTIN2 | septin 2 | -0.0252558 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0249023 |
| PERP | PERP, TP53 apoptosis effector | -0.0248293 |
| NFIA | nuclear factor I/A | -0.0248144 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0247998 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0246858 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0245864 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0240653 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0240631 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0240216 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0240035 |
| RPL36A | ribosomal protein L36a | -0.0239146 |
| SBF2 | SET binding factor 2 | -0.0238496 |
| RPL27 | ribosomal protein L27 | -0.0236637 |
| RDX | radixin | -0.0234945 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0230377 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0227203 |
| TMEM263 | transmembrane protein 263 | -0.0226772 |
| VCL | vinculin | -0.0225584 |
| KRT19 | keratin 19, type I | -0.0224967 |
