Ribociclib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.214343
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.131157
TIMP3 TIMP metallopeptidase inhibitor 3 0.113321
DPYD dihydropyrimidine dehydrogenase 0.0838513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0604737
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0600873
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0571572
FOXP1 forkhead box P1 0.0559973
TPT1 tumor protein, translationally-controlled 1 0.0552061
OSMR oncostatin M receptor 0.0485341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0484562
RIN2 Ras and Rab interactor 2 0.0465279
IGF2 insulin-like growth factor 2 0.0462252
SMYD3 SET and MYND domain containing 3 0.0455683
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0442697
RPS24 ribosomal protein S24 0.0409134
AOPEP aminopeptidase O (putative) 0.0394578
EFNA5 ephrin-A5 0.0384425
RABGAP1L RAB GTPase activating protein 1-like 0.0375349
AHNAK AHNAK nucleoprotein 0.0350891
HMGA2 high mobility group AT-hook 2 0.0349043
MECOM MDS1 and EVI1 complex locus 0.0347762
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0334548
PRELID2 PRELI domain containing 2 0.0327394
ANKRD10 ankyrin repeat domain 10 0.0320377
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0316299
SLC35F3 solute carrier family 35, member F3 0.0316274
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.030292
C4BPB complement component 4 binding protein, beta 0.0302455
PDE4D phosphodiesterase 4D, cAMP-specific 0.0302158
MTSS1 metastasis suppressor 1 0.0292355
CDK6 cyclin-dependent kinase 6 0.0283791
NEK7 NIMA-related kinase 7 0.0283665
BMAL2 basic helix-loop-helix ARNT like 2 0.0283648
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0280688
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0279212
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0269511
NBEAL1 neurobeachin-like 1 0.0263389
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0262092
NRG1 neuregulin 1 0.0261544
DOCK5 dedicator of cytokinesis 5 0.0260053
CNTNAP3 contactin associated protein-like 3 0.0259279
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0257461
MBD5 methyl-CpG binding domain protein 5 0.0255375
EXOC6B exocyst complex component 6B 0.0253175
PLAT plasminogen activator, tissue 0.024883
BCAR3 breast cancer anti-estrogen resistance 3 0.0248308
NRIP1 nuclear receptor interacting protein 1 0.0248068
FRMD5 FERM domain containing 5 0.024658
EHBP1 EH domain binding protein 1 0.0240919
PDGFB platelet-derived growth factor beta polypeptide 0.0239902
TM4SF1 transmembrane 4 L six family member 1 0.0238821
ASPH aspartate beta-hydroxylase 0.0236845
RPL26 ribosomal protein L26 0.0234676
NF1 neurofibromin 1 0.0230077
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.022624
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0220535
CAPN2 calpain 2, (m/II) large subunit 0.0220264
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0217766
RAD51B RAD51 paralog B 0.0214232
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0209534
KLF5 Kruppel-like factor 5 (intestinal) 0.0208183
PALLD palladin, cytoskeletal associated protein 0.0207191
ZMYND8 zinc finger, MYND-type containing 8 0.020616
SOX7 SRY (sex determining region Y)-box 7 0.0204368
NFIA nuclear factor I/A 0.0204096
THSD4 thrombospondin, type I, domain containing 4 0.0201829
OXR1 oxidation resistance 1 0.0201499
SLC45A4 solute carrier family 45, member 4 0.0201433
MTAP methylthioadenosine phosphorylase 0.0200455
TMSB4X thymosin beta 4, X-linked 0.0195636
DLG1 discs, large homolog 1 (Drosophila) 0.0194798
SBF2 SET binding factor 2 0.0193907
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0193832
FAF1 Fas (TNFRSF6) associated factor 1 0.019136
IER3 immediate early response 3 0.0188314
NRCAM neuronal cell adhesion molecule 0.0188102
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0186782
CDK13 cyclin-dependent kinase 13 0.0186327
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0186121
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0184883
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0184278
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0183622
USP34 ubiquitin specific peptidase 34 0.0182745
ANO1 anoctamin 1, calcium activated chloride channel 0.0182406
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0179968
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0178551
NIPBL Nipped-B homolog (Drosophila) 0.0177468
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.017742
TNS3 tensin 3 0.0177223
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0176969
IFI16 interferon, gamma-inducible protein 16 0.0176968
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0176631
ABI3BP ABI family, member 3 (NESH) binding protein 0.0176145
SLC38A2 solute carrier family 38, member 2 0.0172511
NDE1 nudE neurodevelopment protein 1 0.0172474
TBC1D5 TBC1 domain family, member 5 0.0171011
CAVIN1 caveolae associated protein 1 0.0170344
RPS21 ribosomal protein S21 0.0170133
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.016991

decreased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A -0.181295
NDRG1 N-myc downstream regulated 1 -0.167962
APLP2 amyloid beta (A4) precursor-like protein 2 -0.139067
MYH9 myosin, heavy chain 9, non-muscle -0.104104
MSN moesin -0.0959199
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0934413
RPL3 ribosomal protein L3 -0.0907325
CLU clusterin -0.0863335
ENO1 enolase 1, (alpha) -0.0850406
ANXA1 annexin A1 -0.0813712
KRT17 keratin 17, type I -0.077023
FLNA filamin A, alpha -0.0749125
PLEC plectin -0.0735133
TGM2 transglutaminase 2 -0.0729213
PLS3 plastin 3 -0.0699252
FLNB filamin B, beta -0.067117
CANX calnexin -0.0626897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0606982
LOC112694756 uncharaterized LOC112694756 -0.0598392
MCL1 myeloid cell leukemia 1 -0.056271
EZR ezrin -0.0543327
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0538993
TPM3 tropomyosin 3 -0.0518758
FTH1 ferritin, heavy polypeptide 1 -0.0504196
EEF2 eukaryotic translation elongation factor 2 -0.0479545
CPNE1 copine I -0.0467852
SQLE squalene epoxidase -0.0452971
YBX1 Y box binding protein 1 -0.0451823
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0449648
PCBP2 poly(rC) binding protein 2 -0.0445547
POTEF POTE ankyrin domain family, member F -0.043841
PKM pyruvate kinase, muscle -0.0437156
NCOR2 nuclear receptor corepressor 2 -0.0416748
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0397336
COPA coatomer protein complex, subunit alpha -0.0396728
MORF4L2 mortality factor 4 like 2 -0.0391063
GOLGA4 golgin A4 -0.0386964
TAGLN2 transgelin 2 -0.0386578
UBC ubiquitin C -0.0384788
DSTN destrin (actin depolymerizing factor) -0.0364769
ARRDC3 arrestin domain containing 3 -0.0363539
EFHD2 EF-hand domain family, member D2 -0.0355681
ANXA2 annexin A2 -0.0348515
KRT14 keratin 14, type I -0.0341003
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0335956
CALU calumenin -0.033102
HDGF hepatoma-derived growth factor -0.0329718
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0323761
EGR1 early growth response 1 -0.0318808
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0317237
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314045
VEGFA vascular endothelial growth factor A -0.0313316
SRRM2 serine/arginine repetitive matrix 2 -0.0308844
MBNL2 muscleblind-like splicing regulator 2 -0.0308564
ACBD3 acyl-CoA binding domain containing 3 -0.0307621
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0306566
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.029953
SET SET nuclear proto-oncogene -0.0296854
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0294005
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0292797
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290537
PDIA3 protein disulfide isomerase family A, member 3 -0.0283797
TNIP1 TNFAIP3 interacting protein 1 -0.0281527
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0279263
HDLBP high density lipoprotein binding protein -0.0277297
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0276045
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0274611
RBM39 RNA binding motif protein 39 -0.0272494
RND3 Rho family GTPase 3 -0.0272255
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0270169
PCDH1 protocadherin 1 -0.0269982
LMO7 LIM domain 7 -0.0265963
SRP54 signal recognition particle 54kDa -0.0264658
CD99 CD99 molecule -0.0258173
COPB1 coatomer protein complex, subunit beta 1 -0.025554
CSDE1 cold shock domain containing E1, RNA-binding -0.0254501
LAMA5 laminin, alpha 5 -0.0252097
CD44 CD44 molecule (Indian blood group) -0.0251813
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0250524
CYB5R3 cytochrome b5 reductase 3 -0.0249872
SUCO SUN domain containing ossification factor -0.0244202
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0243341
SQSTM1 sequestosome 1 -0.0243131
TFG TRK-fused gene -0.0243035
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0241383
RPL8 ribosomal protein L8 -0.0240862
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.0238721
SLK STE20-like kinase -0.0238406
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0237524
EEF1G eukaryotic translation elongation factor 1 gamma -0.0233258
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0231481
PDIA6 protein disulfide isomerase family A, member 6 -0.0231315
RIOK3 RIO kinase 3 -0.0230694
ESYT2 extended synaptotagmin-like protein 2 -0.0228043
PGK1 phosphoglycerate kinase 1 -0.0227822
WASF2 WAS protein family, member 2 -0.0226722
DIAPH1 diaphanous-related formin 1 -0.0224851
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0224588
CALR calreticulin -0.0224193
KDM6A lysine (K)-specific demethylase 6A -0.0224052