Ribociclib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.166405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.14659
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.103604
KRT8 keratin 8, type II 0.0912873
TPT1 tumor protein, translationally-controlled 1 0.0836505
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0828642
EREG epiregulin 0.06946
TMSB10 thymosin beta 10 0.0672512
B2M beta-2-microglobulin 0.0536473
RPS6 ribosomal protein S6 0.0524022
ACTG1 actin gamma 1 0.0491831
ANKRD11 ankyrin repeat domain 11 0.0455998
RPS8 ribosomal protein S8 0.045042
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0449225
GPHN gephyrin 0.0441922
RPS12 ribosomal protein S12 0.0401625
NCOR1 nuclear receptor corepressor 1 0.0396256
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0383392
CALR calreticulin 0.0381919
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0353063
GARS1 glycyl-tRNA synthetase 1 0.0348227
COG5 component of oligomeric golgi complex 5 0.0328552
RPL34 ribosomal protein L34 0.0320078
SETD5 SET domain containing 5 0.0316811
PRRC2C proline-rich coiled-coil 2C 0.0315528
RPL9 ribosomal protein L9 0.0310067
RPL36A ribosomal protein L36a 0.0304925
S100A6 S100 calcium binding protein A6 0.0303528
RPL37A ribosomal protein L37a 0.0302737
IARS1 isoleucyl-tRNA synthetase 1 0.0295704
RPLP2 ribosomal protein, large, P2 0.0295024
RPS25 ribosomal protein S25 0.0294249
RPL7A ribosomal protein L7a 0.0287474
RPS3 ribosomal protein S3 0.0287226
GOLGA4 golgin A4 0.02866
OGA O-GlcNAcase 0.0285321
RPLP1 ribosomal protein, large, P1 0.0282063
RPL5 ribosomal protein L5 0.0278947
JMJD1C jumonji domain containing 1C 0.0274017
CTNND1 catenin (cadherin-associated protein), delta 1 0.0273454
RPL36 ribosomal protein L36 0.0272927
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0272857
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0268865
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0267835
RAD21 RAD21 homolog (S. pombe) 0.0265454
ANKRD10 ankyrin repeat domain 10 0.0264633
PUM2 pumilio RNA-binding family member 2 0.0262715
GPBP1 GC-rich promoter binding protein 1 0.0261917
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0258606
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0258447
NPEPPS aminopeptidase puromycin sensitive 0.0254433
RPL23 ribosomal protein L23 0.0254355
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0252343
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0252159
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0248573
RPL32 ribosomal protein L32 0.0247046
PHIP pleckstrin homology domain interacting protein 0.0246826
CD47 CD47 molecule 0.0241193
RPS24 ribosomal protein S24 0.0239801
S100A10 S100 calcium binding protein A10 0.0237638
SENP6 SUMO1/sentrin specific peptidase 6 0.0235437
RPL35A ribosomal protein L35a 0.0234095
RBM25 RNA binding motif protein 25 0.0232748
UBA6 ubiquitin-like modifier activating enzyme 6 0.0232583
RPS2 ribosomal protein S2 0.0231868
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0231455
RPL21 ribosomal protein L21 0.0231175
UBE2H ubiquitin-conjugating enzyme E2H 0.0230856
NAP1L1 nucleosome assembly protein 1-like 1 0.0230323
RPS27A ribosomal protein S27a 0.0229953
NF1 neurofibromin 1 0.0229732
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0229731
MTDH metadherin 0.022972
RAB6A RAB6A, member RAS oncogene family 0.0228123
MAP4 microtubule-associated protein 4 0.0227291
PDE4D phosphodiesterase 4D, cAMP-specific 0.0227111
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0226896
NEMF nuclear export mediator factor 0.022556
UBE2B ubiquitin-conjugating enzyme E2B 0.0222432
RPL26 ribosomal protein L26 0.0220008
FHIT fragile histidine triad 0.0217522
SSR1 signal sequence receptor, alpha 0.0213643
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0210731
RPL31 ribosomal protein L31 0.0209594
TNPO1 transportin 1 0.0207451
RPS16 ribosomal protein S16 0.0205423
PA2G4 proliferation-associated 2G4, 38kDa 0.0204874
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0202967
RPS21 ribosomal protein S21 0.0201857
IER3 immediate early response 3 0.0201819
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.02014
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0201125
S100P S100 calcium binding protein P 0.0198989
TMED2 transmembrane emp24 domain trafficking protein 2 0.0198561
VMP1 vacuole membrane protein 1 0.0196473
ECT2 epithelial cell transforming 2 0.0195041
KMT2E lysine (K)-specific methyltransferase 2E 0.0194837
ZFC3H1 zinc finger, C3H1-type containing 0.019474
RSRC1 arginine/serine-rich coiled-coil 1 0.0194658
KTN1 kinectin 1 (kinesin receptor) 0.019447

decreased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A -0.152839
RPL3 ribosomal protein L3 -0.112622
FLNB filamin B, beta -0.0802592
FAT1 FAT atypical cadherin 1 -0.0729145
KRT18 keratin 18, type I -0.0604627
VEGFA vascular endothelial growth factor A -0.0567972
HDLBP high density lipoprotein binding protein -0.0523941
ITGA6 integrin, alpha 6 -0.0518685
NDRG1 N-myc downstream regulated 1 -0.0496493
LOC112694756 uncharaterized LOC112694756 -0.0459228
RPL13A ribosomal protein L13a -0.0450665
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0446975
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0439681
NALF1 NALCN channel auxiliary factor 1 -0.0418048
MYO1E myosin IE -0.0417749
MPRIP myosin phosphatase Rho interacting protein -0.0395628
ANTXR2 anthrax toxin receptor 2 -0.0388025
SRRM2 serine/arginine repetitive matrix 2 -0.0362838
MYH9 myosin, heavy chain 9, non-muscle -0.035557
AHNAK AHNAK nucleoprotein -0.0351501
LMO7 LIM domain 7 -0.0348836
CANX calnexin -0.0345667
ANXA11 annexin A11 -0.0326067
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0317736
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0307146
EEF2 eukaryotic translation elongation factor 2 -0.0305765
PLEC plectin -0.0302066
RPL18A ribosomal protein L18a -0.0294776
ANXA2 annexin A2 -0.0290518
EZR ezrin -0.0277939
CADPS Ca++-dependent secretion activator -0.0277518
FTH1 ferritin, heavy polypeptide 1 -0.0269882
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0267899
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0258893
HSPA8 heat shock 70kDa protein 8 -0.0254133
CEMIP cell migration inducing protein, hyaluronan binding -0.0253981
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0251932
NCOR2 nuclear receptor corepressor 2 -0.0235817
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0233245
FLNA filamin A, alpha -0.0231745
ATXN1 ataxin 1 -0.022982
EEF1G eukaryotic translation elongation factor 1 gamma -0.0228401
PRSS3 protease, serine, 3 -0.0220629
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0210325
PSD3 pleckstrin and Sec7 domain containing 3 -0.0207357
RPL4 ribosomal protein L4 -0.0204758
DDIT4 DNA-damage-inducible transcript 4 -0.0204716
EMP1 epithelial membrane protein 1 -0.0202856
MCL1 myeloid cell leukemia 1 -0.0200102
MUC17 mucin 17, cell surface associated -0.0198364
MYO18A myosin XVIIIA -0.0193705
TBC1D22A TBC1 domain family, member 22A -0.019337
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0191837
POF1B premature ovarian failure, 1B -0.019163
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.018314
RPL11 ribosomal protein L11 -0.0182502
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0181654
CLDN7 claudin 7 -0.0181617
LAMA4 laminin, alpha 4 -0.0177421
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0176183
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0175825
GREB1L growth regulation by estrogen in breast cancer-like -0.017561
YBX1 Y box binding protein 1 -0.017483
PTEN phosphatase and tensin homolog -0.0172561
TXNIP thioredoxin interacting protein -0.0171506
TRIB1 tribbles pseudokinase 1 -0.0169432
MANF mesencephalic astrocyte-derived neurotrophic factor -0.0168449
MYO1D myosin ID -0.0160524
KDM4C lysine (K)-specific demethylase 4C -0.0159807
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0158757
ESYT2 extended synaptotagmin-like protein 2 -0.0158275
TRAK1 trafficking protein, kinesin binding 1 -0.0157998
S100A14 S100 calcium binding protein A14 -0.0157835
GLS2 glutaminase 2 (liver, mitochondrial) -0.0157339
SHB Src homology 2 domain containing adaptor protein B -0.0155201
AGRN agrin -0.0153278
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0149423
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0145709
RPSA ribosomal protein SA -0.0145312
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -0.0144661
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0144513
MRPS6 mitochondrial ribosomal protein S6 -0.0144474
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0143916
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0140037
XPC xeroderma pigmentosum, complementation group C -0.0137548
UNC13B unc-13 homolog B (C. elegans) -0.0136134
RNF217 ring finger protein 217 -0.013559
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0135128
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0134836
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0134443
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0133713
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.0131934
PTPRK protein tyrosine phosphatase, receptor type, K -0.01307
MPZL3 myelin protein zero-like 3 -0.0130378
PLS1 plastin 1 -0.0129611
MACF1 microtubule-actin crosslinking factor 1 -0.0129356
INSIG2 insulin induced gene 2 -0.0129009
FAM114A1 family with sequence similarity 114, member A1 -0.0128048
EFNB2 ephrin-B2 -0.0127971
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0127372