| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ribociclib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.151768 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.13965 |
| FAM13A | family with sequence similarity 13, member A | 0.12703 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.102593 |
| VIM | vimentin | 0.0980923 |
| PTMA | prothymosin, alpha | 0.0878292 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0846596 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0842071 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0787016 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0769303 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0692378 |
| NGLY1 | N-glycanase 1 | 0.0691506 |
| OGA | O-GlcNAcase | 0.0678503 |
| USP3 | ubiquitin specific peptidase 3 | 0.0672126 |
| WAC | WW domain containing adaptor with coiled-coil | 0.062388 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0602045 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0589716 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0574004 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0571395 |
| ATP13A3 | ATPase type 13A3 | 0.0562387 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0560961 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0542803 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0528583 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0528532 |
| RNF145 | ring finger protein 145 | 0.0515604 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0515107 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0506069 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0501586 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0500126 |
| WDR45B | WD repeat domain 45B | 0.0496629 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0472991 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0468218 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0460051 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.044544 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0444616 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0443711 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0431175 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0427709 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0426187 |
| CD109 | CD109 molecule | 0.0421237 |
| SPAG9 | sperm associated antigen 9 | 0.0419569 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0419493 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0418777 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0415682 |
| RIOK3 | RIO kinase 3 | 0.04117 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0408593 |
| HELZ | helicase with zinc finger | 0.0408377 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0408329 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0405826 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.040078 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0392631 |
| COG5 | component of oligomeric golgi complex 5 | 0.0392352 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.039155 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.038711 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0379349 |
| NUP58 | nucleoporin 58 | 0.0373922 |
| RPL35A | ribosomal protein L35a | 0.0366194 |
| CDC73 | cell division cycle 73 | 0.0362728 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0357938 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.035711 |
| CALR | calreticulin | 0.0356312 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0352829 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0352812 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0352583 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0344766 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.034053 |
| RPS8 | ribosomal protein S8 | 0.0340528 |
| RPL23 | ribosomal protein L23 | 0.0337717 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0337516 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0333885 |
| GNAS | GNAS complex locus | 0.0333767 |
| ZNF207 | zinc finger protein 207 | 0.0332072 |
| RPS24 | ribosomal protein S24 | 0.0331723 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0329661 |
| RPS12 | ribosomal protein S12 | 0.0329348 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0328349 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0326185 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0326138 |
| KLHL24 | kelch-like family member 24 | 0.032285 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0322042 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0320832 |
| RAB21 | RAB21, member RAS oncogene family | 0.0318259 |
| RPS25 | ribosomal protein S25 | 0.031649 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.031609 |
| SETD5 | SET domain containing 5 | 0.030864 |
| MEF2A | myocyte enhancer factor 2A | 0.0308496 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0308092 |
| RPLP1 | ribosomal protein, large, P1 | 0.0307563 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0305309 |
| COPA | coatomer protein complex, subunit alpha | 0.0301831 |
| RPL37A | ribosomal protein L37a | 0.0300097 |
| FN1 | fibronectin 1 | 0.0298464 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0297443 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0291495 |
| FAM162A | family with sequence similarity 162, member A | 0.0289597 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0288438 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.028809 |
| MATR3 | matrin 3 | 0.0288015 |
| IER3 | immediate early response 3 | 0.0285359 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0285277 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | -0.186236 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.151465 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.129303 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.098566 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0982411 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0881912 |
| EFNA5 | ephrin-A5 | -0.0833746 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0829244 |
| MT2A | metallothionein 2A | -0.0790804 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0738203 |
| SMAD3 | SMAD family member 3 | -0.0695085 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.068098 |
| TGM2 | transglutaminase 2 | -0.0659536 |
| RAD51B | RAD51 paralog B | -0.0654528 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0644978 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0642811 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0618981 |
| EGFR | epidermal growth factor receptor | -0.059979 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0585498 |
| DST | dystonin | -0.0581534 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0575417 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0569265 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0554443 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0524257 |
| GLCCI1 | glucocorticoid induced 1 | -0.0486255 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0476872 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.046896 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0468713 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0441095 |
| OSMR | oncostatin M receptor | -0.0433869 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0429268 |
| HDLBP | high density lipoprotein binding protein | -0.042062 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0419834 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0413285 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0413251 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0413008 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0411357 |
| ATXN1 | ataxin 1 | -0.0410743 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0409125 |
| NRG1 | neuregulin 1 | -0.039227 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0387999 |
| NPC1 | Niemann-Pick disease, type C1 | -0.038671 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0382939 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.037874 |
| MCL1 | myeloid cell leukemia 1 | -0.036741 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0367181 |
| USP34 | ubiquitin specific peptidase 34 | -0.0354335 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0351018 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0348899 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.034724 |
| KSR1 | kinase suppressor of ras 1 | -0.034667 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.034636 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0343668 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0341544 |
| ETV6 | ets variant 6 | -0.0340882 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0340347 |
| SEPTIN9 | septin 9 | -0.0338174 |
| ANKRD28 | ankyrin repeat domain 28 | -0.033772 |
| MSN | moesin | -0.0333828 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0331608 |
| NTN4 | netrin 4 | -0.0330468 |
| CDH13 | cadherin 13 | -0.0328933 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0328881 |
| FRMD4A | FERM domain containing 4A | -0.0328059 |
| LOX | lysyl oxidase | -0.0327055 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0323585 |
| EXOC4 | exocyst complex component 4 | -0.0320958 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0320235 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0319174 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0318993 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.03176 |
| RAB27B | RAB27B, member RAS oncogene family | -0.03158 |
| NRP1 | neuropilin 1 | -0.0312468 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0310618 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0308466 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0307935 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0306068 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0301592 |
| KYNU | kynureninase | -0.0301402 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.030022 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.029644 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0295289 |
| MTSS1 | metastasis suppressor 1 | -0.0292024 |
| ECE1 | endothelin converting enzyme 1 | -0.0290675 |
| STK38L | serine/threonine kinase 38 like | -0.0288356 |
| GOLGB1 | golgin B1 | -0.0287818 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0287655 |
| IL6ST | interleukin 6 signal transducer | -0.0286033 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0284592 |
| GPC6 | glypican 6 | -0.0280704 |
| DUSP5 | dual specificity phosphatase 5 | -0.0275132 |
| HDAC9 | histone deacetylase 9 | -0.0273047 |
| MYO10 | myosin X | -0.027254 |
| CANX | calnexin | -0.026956 |
| TNNC1 | troponin C type 1 (slow) | -0.0269019 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0266763 |
| GLIS3 | GLIS family zinc finger 3 | -0.0256857 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0254842 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0254666 |
| EGR1 | early growth response 1 | -0.025426 |
