Ribociclib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.169462
LDHA lactate dehydrogenase A 0.126741
RPS4Y1 ribosomal protein S4, Y-linked 1 0.112891
VIM vimentin 0.0844925
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0777299
FGB fibrinogen beta chain 0.0692625
RPL3 ribosomal protein L3 0.0676006
EEF2 eukaryotic translation elongation factor 2 0.0669073
APP amyloid beta (A4) precursor protein 0.0640697
CXCL8 chemokine (C-X-C motif) ligand 8 0.0622637
FTH1 ferritin, heavy polypeptide 1 0.0622015
SLC38A2 solute carrier family 38, member 2 0.0608963
UBASH3B ubiquitin associated and SH3 domain containing B 0.0532474
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0529848
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.052057
TPM4 tropomyosin 4 0.0515345
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0502342
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0480636
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0470975
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0466112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0463688
THBS1 thrombospondin 1 0.0462993
ERBIN erbb2 interacting protein 0.0437396
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0426534
PCBP2 poly(rC) binding protein 2 0.042289
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0422584
CALR calreticulin 0.0422071
MYL12B myosin, light chain 12B, regulatory 0.0415812
EEF1G eukaryotic translation elongation factor 1 gamma 0.0414509
ZNF207 zinc finger protein 207 0.0412692
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0410034
RPL13A ribosomal protein L13a 0.0409951
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0405002
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0402853
GNAS GNAS complex locus 0.040201
PTMA prothymosin, alpha 0.0394936
COTL1 coactosin-like F-actin binding protein 1 0.0387452
COPA coatomer protein complex, subunit alpha 0.037901
HDGF hepatoma-derived growth factor 0.0373627
BASP1 brain abundant, membrane attached signal protein 1 0.0364791
UGCG UDP-glucose ceramide glucosyltransferase 0.0355297
RPL23 ribosomal protein L23 0.0355002
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0348492
USP3 ubiquitin specific peptidase 3 0.0346985
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0342133
CANX calnexin 0.0341981
ECT2 epithelial cell transforming 2 0.0340014
AHNAK AHNAK nucleoprotein 0.0336769
TUBB tubulin, beta class I 0.0333185
ANXA2 annexin A2 0.0329342
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0322613
FLNA filamin A, alpha 0.0321122
FAM168A family with sequence similarity 168, member A 0.03143
WDR43 WD repeat domain 43 0.0312254
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0302972
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0299803
RPL18A ribosomal protein L18a 0.0298387
PKM pyruvate kinase, muscle 0.0296804
CSDE1 cold shock domain containing E1, RNA-binding 0.0296788
ARHGAP29 Rho GTPase activating protein 29 0.0296634
RPL11 ribosomal protein L11 0.0292145
PAWR PRKC, apoptosis, WT1, regulator 0.0285339
ANKRD11 ankyrin repeat domain 11 0.0284681
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.028421
TXNRD1 thioredoxin reductase 1 0.0283084
RPL4 ribosomal protein L4 0.0271199
CHN1 chimerin 1 0.0270932
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0264424
TMEM123 transmembrane protein 123 0.0259556
TPD52 tumor protein D52 0.0257597
RPS4X ribosomal protein S4, X-linked 0.0257434
ACTN1 actinin, alpha 1 0.0256123
LASP1 LIM and SH3 protein 1 0.0256045
CCNL1 cyclin L1 0.0254656
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0254267
ADGRG6 adhesion G protein-coupled receptor G6 0.025352
ARHGAP12 Rho GTPase activating protein 12 0.0251484
PTK2 protein tyrosine kinase 2 0.0251381
YME1L1 YME1-like 1 ATPase 0.025024
PUM1 pumilio RNA-binding family member 1 0.024942
PDIA6 protein disulfide isomerase family A, member 6 0.0247954
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0247097
ANKRD28 ankyrin repeat domain 28 0.0246532
NAP1L1 nucleosome assembly protein 1-like 1 0.0245709
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0240846
KPNB1 karyopherin (importin) beta 1 0.0240484
FNBP1L formin binding protein 1-like 0.0240458
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0240147
VDAC1 voltage-dependent anion channel 1 0.0238934
RHOA ras homolog family member A 0.0238838
BHLHE40 basic helix-loop-helix family, member e40 0.0238273
RRM2 ribonucleotide reductase M2 0.0236224
NPTN neuroplastin 0.0235216
SRGN serglycin 0.0235193
IST1 increased sodium tolerance 1 homolog (yeast) 0.0234062
HYOU1 hypoxia up-regulated 1 0.0230648
RACGAP1 Rac GTPase activating protein 1 0.0230367
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0229134
CELF1 CUGBP, Elav-like family member 1 0.0227044
KLF6 Kruppel-like factor 6 0.0226187

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.232126
MT2A metallothionein 2A -0.2041
PM20D1 peptidase M20 domain containing 1 -0.135673
AKAP12 A kinase (PRKA) anchor protein 12 -0.114788
RPS2 ribosomal protein S2 -0.102133
GRAMD1B GRAM domain containing 1B -0.0953774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0931315
TMSB10 thymosin beta 10 -0.0893086
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.073543
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0597232
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0581705
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0533871
STC1 stanniocalcin 1 -0.0492969
POTEF POTE ankyrin domain family, member F -0.0483028
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0473098
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0453581
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0451219
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0422854
USP34 ubiquitin specific peptidase 34 -0.0414635
FNDC3B fibronectin type III domain containing 3B -0.0399101
PYGL phosphorylase, glycogen, liver -0.0391761
TM4SF1 transmembrane 4 L six family member 1 -0.0390629
DOCK5 dedicator of cytokinesis 5 -0.0385835
PFDN2 prefoldin subunit 2 -0.0379011
IER3 immediate early response 3 -0.0373902
GOLGB1 golgin B1 -0.0370364
TFPI2 tissue factor pathway inhibitor 2 -0.0368853
CLTC clathrin, heavy chain (Hc) -0.0359593
HSPA8 heat shock 70kDa protein 8 -0.0355945
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0352499
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0348382
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0342288
C15ORF48 chromosome 15 open reading frame 48 -0.0341581
GOLT1B golgi transport 1B -0.0340826
KIF5B kinesin family member 5B -0.0337998
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0335772
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.033427
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0323887
RTN4 reticulon 4 -0.0318147
EIF1 eukaryotic translation initiation factor 1 -0.030922
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.030773
RPS6 ribosomal protein S6 -0.0297813
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0297396
NUMB numb homolog (Drosophila) -0.0295642
SAMD4A sterile alpha motif domain containing 4A -0.0294626
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0286547
KTN1 kinectin 1 (kinesin receptor) -0.0284111
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0283541
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0279836
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0279498
ATXN1 ataxin 1 -0.0278585
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0277654
BMP6 bone morphogenetic protein 6 -0.0274962
BRD2 bromodomain containing 2 -0.0271845
UBXN4 UBX domain protein 4 -0.0269643
GOLGA4 golgin A4 -0.0267711
WWOX WW domain containing oxidoreductase -0.0262951
CDCP1 CUB domain containing protein 1 -0.0255377
EGFR epidermal growth factor receptor -0.0252881
NIPBL Nipped-B homolog (Drosophila) -0.0251689
EHBP1 EH domain binding protein 1 -0.0248906
ZBTB20 zinc finger and BTB domain containing 20 -0.0244852
SRPK1 SRSF protein kinase 1 -0.0243012
NRIP1 nuclear receptor interacting protein 1 -0.0240378
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0238949
MTDH metadherin -0.023233
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0231759
EGR1 early growth response 1 -0.0230585
RPS18 ribosomal protein S18 -0.0230502
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0226022
SENP6 SUMO1/sentrin specific peptidase 6 -0.0225351
PDIA3 protein disulfide isomerase family A, member 3 -0.0224476
NBEAL1 neurobeachin-like 1 -0.0222183
CHD1 chromodomain helicase DNA binding protein 1 -0.0218679
ARID1B AT rich interactive domain 1B (SWI1-like) -0.021815
ATF4 activating transcription factor 4 -0.021728
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0211758
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0211597
IGFBP3 insulin-like growth factor binding protein 3 -0.0211492
CBFB core-binding factor, beta subunit -0.0211082
ITCH itchy E3 ubiquitin protein ligase -0.0210602
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0210456
RB1CC1 RB1-inducible coiled-coil 1 -0.0209305
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0208766
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0208261
NDRG1 N-myc downstream regulated 1 -0.0208102
KMT2C lysine (K)-specific methyltransferase 2C -0.0204712
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0204296
TERF2IP telomeric repeat binding factor 2, interacting protein -0.0203696
CCNY cyclin Y -0.0203116
LOC102724023 ES1 protein homolog, mitochondrial -0.0203084
RCOR1 REST corepressor 1 -0.0202462
PCNX1 pecanex 1 -0.0202395
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0201522
CREBBP CREB binding protein -0.019996
CCL5 chemokine (C-C motif) ligand 5 -0.0199105
RPL12 ribosomal protein L12 -0.0197473
PHIP pleckstrin homology domain interacting protein -0.0197461
RPLP1 ribosomal protein, large, P1 -0.0196992
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0196165