| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ribociclib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | 0.0979795 |
| PDE10A | phosphodiesterase 10A | 0.0737272 |
| TXNRD1 | thioredoxin reductase 1 | 0.0629737 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0583682 |
| EGFR | epidermal growth factor receptor | 0.0570929 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0538226 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0526768 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0525473 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0516687 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0504238 |
| ZNF292 | zinc finger protein 292 | 0.0490025 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0467032 |
| RBM39 | RNA binding motif protein 39 | 0.0466667 |
| PRKCA | protein kinase C, alpha | 0.0463799 |
| RTN4 | reticulon 4 | 0.0463778 |
| NCKAP5 | NCK-associated protein 5 | 0.0457086 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0453274 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0446673 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0436057 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0433057 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0431209 |
| RPS24 | ribosomal protein S24 | 0.0428804 |
| FN1 | fibronectin 1 | 0.0410578 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0405078 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.040466 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0403411 |
| AK1 | adenylate kinase 1 | 0.0401551 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0400761 |
| VCL | vinculin | 0.0398644 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.0391486 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0390634 |
| MED13 | mediator complex subunit 13 | 0.0387311 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.038235 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0381277 |
| HDLBP | high density lipoprotein binding protein | 0.0379618 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0377196 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0373377 |
| FOXJ3 | forkhead box J3 | 0.0372891 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0371857 |
| CD44 | CD44 molecule (Indian blood group) | 0.0368406 |
| PKP4 | plakophilin 4 | 0.0363025 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0362933 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0362638 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0357798 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0357403 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0354268 |
| NAV1 | neuron navigator 1 | 0.0352714 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0349737 |
| MKI67 | marker of proliferation Ki-67 | 0.0349377 |
| RPLP2 | ribosomal protein, large, P2 | 0.0348803 |
| SMYD3 | SET and MYND domain containing 3 | 0.0348752 |
| APP | amyloid beta (A4) precursor protein | 0.0343801 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.033597 |
| CANX | calnexin | 0.0334787 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.033335 |
| ATP13A3 | ATPase type 13A3 | 0.0331222 |
| MSI2 | musashi RNA-binding protein 2 | 0.0328929 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0328785 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0328442 |
| LAMA4 | laminin, alpha 4 | 0.0327473 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.032594 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0325445 |
| PATJ | PATJ crumbs cell polarity complex component | 0.03237 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0318631 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0318512 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0314828 |
| PTK2 | protein tyrosine kinase 2 | 0.0313233 |
| BBX | bobby sox homolog (Drosophila) | 0.0309104 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0307148 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0306644 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0301757 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0299275 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0297733 |
| NBAS | neuroblastoma amplified sequence | 0.0297362 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0289369 |
| H1-0 | H1.0 linker histone | 0.0288913 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0288226 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0285454 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0281429 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.02791 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.027851 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0278497 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0277626 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0276608 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0276371 |
| DENND4C | DENN/MADD domain containing 4C | 0.0276194 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0275525 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0275315 |
| RASA2 | RAS p21 protein activator 2 | 0.0274369 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.027415 |
| HPCAL1 | hippocalcin-like 1 | 0.0274018 |
| ARF1 | ADP-ribosylation factor 1 | 0.0272789 |
| BPTF | bromodomain PHD finger transcription factor | 0.0272006 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0271616 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0269885 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0269394 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.026907 |
| CDC73 | cell division cycle 73 | 0.026786 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0267745 |
| TUT4 | terminal uridylyl transferase 4 | 0.0265672 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.0951333 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0804309 |
| KRT17 | keratin 17, type I | -0.0799142 |
| B2M | beta-2-microglobulin | -0.077607 |
| NDRG1 | N-myc downstream regulated 1 | -0.0727028 |
| UBC | ubiquitin C | -0.0695245 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0688393 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0619241 |
| VIM | vimentin | -0.0617688 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0605821 |
| TMSB10 | thymosin beta 10 | -0.0583907 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.057525 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0546889 |
| RNF24 | ring finger protein 24 | -0.0536742 |
| MYO1E | myosin IE | -0.0518892 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0502837 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0498794 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0489137 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0488841 |
| CALR | calreticulin | -0.0469441 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0453022 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0448749 |
| MYO1D | myosin ID | -0.0441842 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0436205 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0434837 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0419915 |
| AHNAK | AHNAK nucleoprotein | -0.041754 |
| SETD5 | SET domain containing 5 | -0.0411171 |
| LAMB3 | laminin, beta 3 | -0.0399711 |
| CD109 | CD109 molecule | -0.0397853 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0395848 |
| LMO7 | LIM domain 7 | -0.0395117 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0394623 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0392611 |
| RCOR1 | REST corepressor 1 | -0.0389569 |
| YAP1 | Yes-associated protein 1 | -0.0388503 |
| LAMC2 | laminin, gamma 2 | -0.0387558 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0385373 |
| HBP1 | HMG-box transcription factor 1 | -0.0383469 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.0374258 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0372946 |
| RPS15 | ribosomal protein S15 | -0.0372124 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0371316 |
| POTEF | POTE ankyrin domain family, member F | -0.0369899 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0365169 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0365106 |
| IER3 | immediate early response 3 | -0.0360952 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0348237 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0346077 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0345593 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0344033 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0342851 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.0342583 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0337075 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.033268 |
| YEATS2 | YEATS domain containing 2 | -0.0330813 |
| SLK | STE20-like kinase | -0.0330673 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0329141 |
| FOXO3 | forkhead box O3 | -0.0328671 |
| GDF15 | growth differentiation factor 15 | -0.0325517 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0324384 |
| ATP11B | ATPase, class VI, type 11B | -0.032181 |
| PHIP | pleckstrin homology domain interacting protein | -0.0321415 |
| RPS3 | ribosomal protein S3 | -0.0320999 |
| ADM | adrenomedullin | -0.0315986 |
| ANXA4 | annexin A4 | -0.0314618 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0312792 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0311975 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0309709 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0308232 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0303149 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0302308 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.0302157 |
| USP53 | ubiquitin specific peptidase 53 | -0.0298554 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0297233 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0296419 |
| CCNI | cyclin I | -0.0294607 |
| ABLIM1 | actin binding LIM protein 1 | -0.0290579 |
| CA12 | carbonic anhydrase XII | -0.0289732 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0287946 |
| RNF145 | ring finger protein 145 | -0.0287753 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0287329 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.028157 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0281161 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0279035 |
| STX18 | syntaxin 18 | -0.0278827 |
| S100A10 | S100 calcium binding protein A10 | -0.0276244 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0273863 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0273702 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -0.0270674 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0268281 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.026826 |
| ENO1 | enolase 1, (alpha) | -0.0267867 |
| RPL21 | ribosomal protein L21 | -0.0267234 |
| FMN1 | formin 1 | -0.0266462 |
| FUS | FUS RNA binding protein | -0.0264191 |
| RHOA | ras homolog family member A | -0.026361 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0261868 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.026145 |
| CERS6 | ceramide synthase 6 | -0.0261183 |
