| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ribociclib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0951954 |
| PTMA | prothymosin, alpha | 0.0951098 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0877316 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0777227 |
| TPM3 | tropomyosin 3 | 0.0757347 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0687116 |
| RPL3 | ribosomal protein L3 | 0.0663221 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.059875 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0564839 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0520587 |
| ADAR | adenosine deaminase, RNA-specific | 0.0500075 |
| MKI67 | marker of proliferation Ki-67 | 0.0480861 |
| SMC4 | structural maintenance of chromosomes 4 | 0.047451 |
| SET | SET nuclear proto-oncogene | 0.0468829 |
| CPNE1 | copine I | 0.0460818 |
| PCBP2 | poly(rC) binding protein 2 | 0.0459659 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0458854 |
| XPO1 | exportin 1 | 0.0438446 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0421677 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.040862 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0396632 |
| HDGF | hepatoma-derived growth factor | 0.0392671 |
| TPM2 | tropomyosin 2 (beta) | 0.0390494 |
| KRT18 | keratin 18, type I | 0.0388011 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0380256 |
| VIM | vimentin | 0.0378701 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0375491 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0365778 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0355922 |
| BRD2 | bromodomain containing 2 | 0.0348549 |
| CENPF | centromere protein F, 350/400kDa | 0.0346475 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0333762 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0326812 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.032568 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0324939 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0313303 |
| LDHA | lactate dehydrogenase A | 0.0310411 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0305698 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0302153 |
| TPX2 | TPX2, microtubule-associated | 0.029402 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0293987 |
| RBM25 | RNA binding motif protein 25 | 0.0292947 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0289519 |
| PKM | pyruvate kinase, muscle | 0.0288056 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0283458 |
| MSH6 | mutS homolog 6 | 0.0281367 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0280031 |
| RTN4 | reticulon 4 | 0.0279947 |
| PNN | pinin, desmosome associated protein | 0.0279288 |
| RPS4X | ribosomal protein S4, X-linked | 0.0278532 |
| IPO7 | importin 7 | 0.0277998 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0272569 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0268344 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0264488 |
| RRM2 | ribonucleotide reductase M2 | 0.025833 |
| CANX | calnexin | 0.0255974 |
| WDR43 | WD repeat domain 43 | 0.0254057 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0253312 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0249715 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0248378 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0247194 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0246862 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0246185 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0246117 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0245579 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0242135 |
| YBX1 | Y box binding protein 1 | 0.0241079 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | 0.0240804 |
| TUBA1C | tubulin, alpha 1c | 0.0235129 |
| TUBA1B | tubulin, alpha 1b | 0.0234439 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | 0.0232749 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0231934 |
| PHF20 | PHD finger protein 20 | 0.0231895 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0228954 |
| LDHB | lactate dehydrogenase B | 0.0228323 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0226337 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0225072 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0224621 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0223946 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0223945 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0222414 |
| CEP250 | centrosomal protein 250kDa | 0.0221984 |
| PFN1 | profilin 1 | 0.0221541 |
| RAB10 | RAB10, member RAS oncogene family | 0.022064 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0220364 |
| PHIP | pleckstrin homology domain interacting protein | 0.0219917 |
| ACTN1 | actinin, alpha 1 | 0.0219872 |
| CEP192 | centrosomal protein 192kDa | 0.0219817 |
| CDC27 | cell division cycle 27 | 0.021744 |
| DIAPH3 | diaphanous-related formin 3 | 0.0217338 |
| ERBIN | erbb2 interacting protein | 0.0216757 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0216163 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0209162 |
| SETD5 | SET domain containing 5 | 0.0208947 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0206169 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0205999 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0203852 |
| DIAPH1 | diaphanous-related formin 1 | 0.0203141 |
| CTTN | cortactin | 0.0203065 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0202463 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0956271 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0683752 |
| TMSB10 | thymosin beta 10 | -0.0674458 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0639325 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0580229 |
| OSMR | oncostatin M receptor | -0.0570846 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0498972 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.046484 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0400931 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0386694 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0335013 |
| EGR1 | early growth response 1 | -0.033006 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0325517 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0313777 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0306705 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0304002 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0300171 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0296453 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0292631 |
| PDE10A | phosphodiesterase 10A | -0.0291828 |
| EGFR | epidermal growth factor receptor | -0.0289687 |
| ACTG1 | actin gamma 1 | -0.0285201 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0276885 |
| ATXN1 | ataxin 1 | -0.0262511 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0259025 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0252899 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0252349 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0236 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0226625 |
| IER3 | immediate early response 3 | -0.0225992 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0222167 |
| KLF6 | Kruppel-like factor 6 | -0.022057 |
| SMYD3 | SET and MYND domain containing 3 | -0.0212882 |
| DST | dystonin | -0.0211703 |
| PLSCR1 | phospholipid scramblase 1 | -0.0211448 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0210698 |
| PRKCE | protein kinase C, epsilon | -0.0205688 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0203311 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0199325 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0198823 |
| FMNL2 | formin-like 2 | -0.0198369 |
| ATG7 | autophagy related 7 | -0.0198348 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0195998 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.019217 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0188699 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0186977 |
| ANXA5 | annexin A5 | -0.0185835 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0180754 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0180288 |
| STC1 | stanniocalcin 1 | -0.0178352 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0178319 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0176899 |
| RPL38 | ribosomal protein L38 | -0.0176461 |
| HMGA2 | high mobility group AT-hook 2 | -0.0176136 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.017201 |
| ANXA2 | annexin A2 | -0.0168041 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0161707 |
| PYGL | phosphorylase, glycogen, liver | -0.0161393 |
| HLA-B | major histocompatibility complex, class I, B | -0.0160314 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0159512 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0157969 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0156151 |
| RACK1 | receptor for activated C kinase 1 | -0.0154964 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0154711 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.01547 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0153955 |
| TXNRD1 | thioredoxin reductase 1 | -0.0153707 |
| ATP11A | ATPase, class VI, type 11A | -0.0151706 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0151251 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0150291 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0149269 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0148889 |
| RYR3 | ryanodine receptor 3 | -0.0147908 |
| LOXL2 | lysyl oxidase-like 2 | -0.0147219 |
| ACAD11 | acyl-CoA dehydrogenase family, member 11 | -0.0144086 |
| YAP1 | Yes-associated protein 1 | -0.0144047 |
| BNC2 | basonuclin 2 | -0.014336 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0142974 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0142068 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0141406 |
| YBX3 | Y box binding protein 3 | -0.0140704 |
| IL6ST | interleukin 6 signal transducer | -0.0139578 |
| MACROD2 | MACRO domain containing 2 | -0.0138714 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0138134 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0137838 |
| DENND1A | DENN/MADD domain containing 1A | -0.0136699 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0136352 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0134741 |
| SVIL | supervillin | -0.0133701 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0133631 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0132315 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.013086 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0130091 |
| RPLP0 | ribosomal protein, large, P0 | -0.0128361 |
| H1-3 | H1.3 linker histone, cluster member | -0.0126702 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0126675 |
| WDR26 | WD repeat domain 26 | -0.0126514 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0126331 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0126112 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0126095 |
