Ribociclib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.178354
TRIO trio Rho guanine nucleotide exchange factor 0.143804
ASPH aspartate beta-hydroxylase 0.136479
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.118629
FNDC3B fibronectin type III domain containing 3B 0.116396
ALCAM activated leukocyte cell adhesion molecule 0.116357
NDRG1 N-myc downstream regulated 1 0.0989009
NAMPT nicotinamide phosphoribosyltransferase 0.0963875
KRT7 keratin 7, type II 0.0873484
ELL2 elongation factor, RNA polymerase II, 2 0.0836594
SLC38A1 solute carrier family 38, member 1 0.0833981
KMT2E lysine (K)-specific methyltransferase 2E 0.076522
GRB10 growth factor receptor-bound protein 10 0.0734573
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0713111
S100A6 S100 calcium binding protein A6 0.0710192
ACTG1 actin gamma 1 0.0693351
FN1 fibronectin 1 0.0683368
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0683227
TXNRD1 thioredoxin reductase 1 0.0628537
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0618386
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0617664
CAPN2 calpain 2, (m/II) large subunit 0.060349
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0587677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0572085
RNF145 ring finger protein 145 0.0560298
RPL9 ribosomal protein L9 0.0552691
MBNL1 muscleblind-like splicing regulator 1 0.0549359
SPAG9 sperm associated antigen 9 0.0548877
CLINT1 clathrin interactor 1 0.0544549
RPS12 ribosomal protein S12 0.0541009
UBA6 ubiquitin-like modifier activating enzyme 6 0.0536478
RPL5 ribosomal protein L5 0.0525947
TFG TRK-fused gene 0.0521912
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0508195
NAP1L1 nucleosome assembly protein 1-like 1 0.0506822
DSCAM Down syndrome cell adhesion molecule 0.0505704
BHLHE40 basic helix-loop-helix family, member e40 0.0504245
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0503659
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0503044
CDCP1 CUB domain containing protein 1 0.0500831
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0482712
RAD21 RAD21 homolog (S. pombe) 0.0482534
RUNX1 runt-related transcription factor 1 0.0480739
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0480682
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0480247
GOLGA4 golgin A4 0.0479829
CAB39 calcium binding protein 39 0.0479742
CCNL1 cyclin L1 0.0476524
ZNF292 zinc finger protein 292 0.0475206
TNPO1 transportin 1 0.0472636
RPL30 ribosomal protein L30 0.0467471
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0453523
SMC4 structural maintenance of chromosomes 4 0.0453077
SMAD3 SMAD family member 3 0.0450165
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.044656
CTNND1 catenin (cadherin-associated protein), delta 1 0.0445538
RACK1 receptor for activated C kinase 1 0.0444239
RPS3 ribosomal protein S3 0.044226
MARCHF6 membrane associated ring-CH-type finger 6 0.0441225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0440425
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0431271
GPBP1 GC-rich promoter binding protein 1 0.0426598
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0426351
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0418645
ERRFI1 ERBB receptor feedback inhibitor 1 0.0415019
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0412043
AREG amphiregulin 0.0405566
TOP1 topoisomerase (DNA) I 0.0403487
RBM39 RNA binding motif protein 39 0.0401141
STRN3 striatin, calmodulin binding protein 3 0.0398224
PAPOLA poly(A) polymerase alpha 0.0398198
RPL37A ribosomal protein L37a 0.0396611
NRIP1 nuclear receptor interacting protein 1 0.0390605
UGCG UDP-glucose ceramide glucosyltransferase 0.0390064
FLNB filamin B, beta 0.0389671
MGST1 microsomal glutathione S-transferase 1 0.0388415
KPNB1 karyopherin (importin) beta 1 0.0385305
KIAA1217 KIAA1217 0.0384194
SACK1A scaffolding CK1 anchoring protein A 0.0382928
ZNF207 zinc finger protein 207 0.03821
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0381936
SLMAP sarcolemma associated protein 0.0381864
ANXA5 annexin A5 0.0379867
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0378037
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0374919
COPA coatomer protein complex, subunit alpha 0.0372683
RPL34 ribosomal protein L34 0.037003
S100A10 S100 calcium binding protein A10 0.0364485
EREG epiregulin 0.0364055
RYK receptor-like tyrosine kinase 0.0360485
PTK2 protein tyrosine kinase 2 0.0357276
MATR3 matrin 3 0.0356189
KTN1 kinectin 1 (kinesin receptor) 0.0353565
GARS1 glycyl-tRNA synthetase 1 0.0353094
RTN4 reticulon 4 0.035222
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0350355
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0349158
SDC4 syndecan 4 0.0345071
FAM3C family with sequence similarity 3, member C 0.0345027
STK24 serine/threonine kinase 24 0.0343526

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.259806
TMSB10 thymosin beta 10 -0.107421
FTH1 ferritin, heavy polypeptide 1 -0.0784336
IGFBP3 insulin-like growth factor binding protein 3 -0.0643407
LDHA lactate dehydrogenase A -0.0584614
POTEF POTE ankyrin domain family, member F -0.0580847
H1-0 H1.0 linker histone -0.0543441
IFI27 interferon, alpha-inducible protein 27 -0.0506631
LPP LIM domain containing preferred translocation partner in lipoma -0.0440056
ENO2 enolase 2 (gamma, neuronal) -0.0401174
LOC112694756 uncharaterized LOC112694756 -0.0374304
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0373352
IFI16 interferon, gamma-inducible protein 16 -0.0372722
HDLBP high density lipoprotein binding protein -0.0363539
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0362861
IFITM3 interferon induced transmembrane protein 3 -0.0357081
HSPB1 heat shock 27kDa protein 1 -0.0349336
LIMCH1 LIM and calponin homology domains 1 -0.0342634
DSPP dentin sialophosphoprotein -0.033797
CSTB cystatin B (stefin B) -0.0337272
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0324306
AHNAK AHNAK nucleoprotein -0.0321965
IFI6 interferon, alpha-inducible protein 6 -0.0307993
WSB1 WD repeat and SOCS box containing 1 -0.0304749
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0299994
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0289247
RNF213 ring finger protein 213 -0.0281844
MSI2 musashi RNA-binding protein 2 -0.0275038
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0272779
BZW1 basic leucine zipper and W2 domains 1 -0.0269407
LY6E lymphocyte antigen 6 complex, locus E -0.0268408
RPL8 ribosomal protein L8 -0.0264679
PGBD5 piggyBac transposable element derived 5 -0.0244736
CANX calnexin -0.0243135
MACC1 metastasis associated in colon cancer 1 -0.0243103
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0234399
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0229539
MX2 MX dynamin-like GTPase 2 -0.02207
YBX1 Y box binding protein 1 -0.0217062
CTSB cathepsin B -0.0210552
MDK midkine (neurite growth-promoting factor 2) -0.0210048
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0208009
RPLP1 ribosomal protein, large, P1 -0.0206538
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0205506
TXNIP thioredoxin interacting protein -0.0202645
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0198262
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0194668
HLA-A major histocompatibility complex, class I, A -0.0192866
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0188767
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0188141
TPI1 triosephosphate isomerase 1 -0.0185389
LAP3 leucine aminopeptidase 3 -0.0184337
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0183807
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0182974
ANKRD17 ankyrin repeat domain 17 -0.0181408
ENO1 enolase 1, (alpha) -0.01799
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0179813
SP100 SP100 nuclear antigen -0.0178978
ETV6 ets variant 6 -0.017809
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0173966
NCOA2 nuclear receptor coactivator 2 -0.0173196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0173119
PDLIM5 PDZ and LIM domain 5 -0.0172464
GOLGB1 golgin B1 -0.0169762
PLIN2 perilipin 2 -0.0169735
MORF4L2 mortality factor 4 like 2 -0.0169212
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0168426
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0165482
MUC20 mucin 20, cell surface associated -0.0165459
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0163746
TMEM263 transmembrane protein 263 -0.016137
KLF10 Kruppel-like factor 10 -0.016095
ARF4 ADP-ribosylation factor 4 -0.0160679
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0159616
HSPA8 heat shock 70kDa protein 8 -0.015877
RPS14 ribosomal protein S14 -0.0158652
EMP1 epithelial membrane protein 1 -0.0157249
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0156208
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0151959
ATOSA atos homolog A -0.01514
ARHGAP20 Rho GTPase activating protein 20 -0.0150982
IFRD1 interferon-related developmental regulator 1 -0.015048
FBXO32 F-box protein 32 -0.0150427
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0149789
RRBP1 ribosome binding protein 1 -0.0148592
F3 coagulation factor III (thromboplastin, tissue factor) -0.0148093
GSTP1 glutathione S-transferase pi 1 -0.0145369
ZNF217 zinc finger protein 217 -0.014371
TNRC6B trinucleotide repeat containing 6B -0.0143258
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0142688
MX1 MX dynamin-like GTPase 1 -0.0142657
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha -0.0139703
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0138103
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 -0.0137828
HSPA1B heat shock 70kDa protein 1B -0.0137696
ZHX2 zinc fingers and homeoboxes 2 -0.0137313
CAPN7 calpain 7 -0.0137174
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.013671
DPP4 dipeptidyl-peptidase 4 -0.0134834
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0134344