Ribociclib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.213255
EFNA5 ephrin-A5 0.169397
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.134847
ASPH aspartate beta-hydroxylase 0.127316
PSD3 pleckstrin and Sec7 domain containing 3 0.111881
PDE10A phosphodiesterase 10A 0.109557
COL5A2 collagen, type V, alpha 2 0.102846
NRCAM neuronal cell adhesion molecule 0.099629
TXNRD1 thioredoxin reductase 1 0.0923545
GRAMD1B GRAM domain containing 1B 0.0916459
NEK7 NIMA-related kinase 7 0.0892076
COL4A5 collagen, type IV, alpha 5 0.0837682
GDA guanine deaminase 0.0809232
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0799148
TRIO trio Rho guanine nucleotide exchange factor 0.0796226
NAMPT nicotinamide phosphoribosyltransferase 0.0764805
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0674728
MYOF myoferlin 0.0669769
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0605758
COL8A1 collagen, type VIII, alpha 1 0.0602678
DST dystonin 0.0573603
MFF mitochondrial fission factor 0.0519588
NALF1 NALCN channel auxiliary factor 1 0.0516112
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0492467
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0488501
SMYD3 SET and MYND domain containing 3 0.0481174
COL4A6 collagen, type IV, alpha 6 0.0473309
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0470613
PTGR1 prostaglandin reductase 1 0.0467607
LIMCH1 LIM and calponin homology domains 1 0.045466
CTSC cathepsin C 0.045289
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0436783
FNDC3B fibronectin type III domain containing 3B 0.0435887
AGFG1 ArfGAP with FG repeats 1 0.0431745
ENAH enabled homolog (Drosophila) 0.0426274
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0418901
RTN4 reticulon 4 0.0418438
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0416551
CD109 CD109 molecule 0.0403144
TNPO1 transportin 1 0.0390315
PDLIM5 PDZ and LIM domain 5 0.0384453
PALLD palladin, cytoskeletal associated protein 0.0362521
DOCK4 dedicator of cytokinesis 4 0.0361791
PCBP3 poly(rC) binding protein 3 0.0359723
PTEN phosphatase and tensin homolog 0.0348813
OGA O-GlcNAcase 0.0348389
PBX1 pre-B-cell leukemia homeobox 1 0.0314927
RPL3 ribosomal protein L3 0.0304726
ANKRD28 ankyrin repeat domain 28 0.0292388
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0292188
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0292114
RBM39 RNA binding motif protein 39 0.0290675
NPAS2 neuronal PAS domain protein 2 0.0287306
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0286999
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0286723
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0283058
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0280569
BRWD3 bromodomain and WD repeat domain containing 3 0.0276587
SAMD4A sterile alpha motif domain containing 4A 0.0274015
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0270576
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0269344
ARHGAP29 Rho GTPase activating protein 29 0.0268309
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0267128
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0264047
RTN1 reticulon 1 0.0263932
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0260597
CENPF centromere protein F, 350/400kDa 0.0260257
PRKD3 protein kinase D3 0.025985
MAML3 mastermind-like 3 (Drosophila) 0.0257239
XPO1 exportin 1 0.0255107
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.025132
FLNB filamin B, beta 0.0249515
DPYD dihydropyrimidine dehydrogenase 0.0249418
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0249032
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0248039
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.024641
BIRC6 baculoviral IAP repeat containing 6 0.0245817
GPRIN3 GPRIN family member 3 0.0244985
ZNF292 zinc finger protein 292 0.0244591
ATXN1 ataxin 1 0.0243852
ESYT2 extended synaptotagmin-like protein 2 0.0243517
NF1 neurofibromin 1 0.0240445
AVL9 AVL9 homolog (S. cerevisiase) 0.0239158
NHSL1 NHS-like 1 0.023679
SLF1 SMC5-SMC6 complex localization factor 1 0.0236719
PYGL phosphorylase, glycogen, liver 0.0235127
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0233146
TGFBI transforming growth factor, beta-induced, 68kDa 0.0231435
PNISR PNN-interacting serine/arginine-rich protein 0.0230747
MKI67 marker of proliferation Ki-67 0.0230515
METTL15 methyltransferase like 15 0.0228018
USP34 ubiquitin specific peptidase 34 0.0227525
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0226935
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0225828
WDFY2 WD repeat and FYVE domain containing 2 0.0224821
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0223675
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0223217
BCAR3 breast cancer anti-estrogen resistance 3 0.0222739
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0220125
SPTBN1 spectrin, beta, non-erythrocytic 1 0.021996

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.270876
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.256536
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.251034
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.156644
VIM vimentin -0.120908
TPT1 tumor protein, translationally-controlled 1 -0.120517
TMSB10 thymosin beta 10 -0.103953
FTL ferritin, light polypeptide -0.0893467
FN1 fibronectin 1 -0.0821111
RPLP1 ribosomal protein, large, P1 -0.0791621
RPS6 ribosomal protein S6 -0.0726949
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.065721
RPS8 ribosomal protein S8 -0.0600666
RPL12 ribosomal protein L12 -0.059985
B2M beta-2-microglobulin -0.0542933
RPL31 ribosomal protein L31 -0.0535259
RPLP0 ribosomal protein, large, P0 -0.0511003
RACK1 receptor for activated C kinase 1 -0.0509464
FTH1 ferritin, heavy polypeptide 1 -0.0501015
EIF1 eukaryotic translation initiation factor 1 -0.0500516
EEF2 eukaryotic translation elongation factor 2 -0.0478276
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0477636
RPS19 ribosomal protein S19 -0.0476796
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0462585
RPS23 ribosomal protein S23 -0.0461415
STC1 stanniocalcin 1 -0.0437615
RPL35A ribosomal protein L35a -0.0432602
RPS12 ribosomal protein S12 -0.0427107
ENO1 enolase 1, (alpha) -0.0423781
RPS24 ribosomal protein S24 -0.0420646
RPL19 ribosomal protein L19 -0.0415755
BZW1 basic leucine zipper and W2 domains 1 -0.0409752
SQSTM1 sequestosome 1 -0.0398407
HLA-B major histocompatibility complex, class I, B -0.0396156
RPS14 ribosomal protein S14 -0.039298
UBC ubiquitin C -0.0387908
RPL37A ribosomal protein L37a -0.0386926
RPS27 ribosomal protein S27 -0.0384351
RPL7A ribosomal protein L7a -0.0384181
FNDC3A fibronectin type III domain containing 3A -0.038234
RPL34 ribosomal protein L34 -0.0381571
ACTG1 actin gamma 1 -0.037784
RPL26 ribosomal protein L26 -0.0356114
RPL36A ribosomal protein L36a -0.03516
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0347472
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0347317
RPS3 ribosomal protein S3 -0.0344095
RPS16 ribosomal protein S16 -0.0341776
EGR1 early growth response 1 -0.0340163
RPS2 ribosomal protein S2 -0.0332301
PTMA prothymosin, alpha -0.0330658
RPS27A ribosomal protein S27a -0.0324178
LOC112694756 uncharaterized LOC112694756 -0.0319397
SOX4 SRY (sex determining region Y)-box 4 -0.0309644
CALR calreticulin -0.0305127
INHBA inhibin, beta A -0.0304178
RPLP2 ribosomal protein, large, P2 -0.0302296
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0301926
HLA-A major histocompatibility complex, class I, A -0.0295901
S100A10 S100 calcium binding protein A10 -0.0295514
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0295425
VCL vinculin -0.0295171
RPS25 ribosomal protein S25 -0.0291461
RPL35 ribosomal protein L35 -0.0289958
NDRG1 N-myc downstream regulated 1 -0.0286268
ASTN2 astrotactin 2 -0.0281374
PDIA4 protein disulfide isomerase family A, member 4 -0.027943
IGFBP3 insulin-like growth factor binding protein 3 -0.0279399
RPL36 ribosomal protein L36 -0.027549
S100A6 S100 calcium binding protein A6 -0.0273174
CD44 CD44 molecule (Indian blood group) -0.0272358
RPL32 ribosomal protein L32 -0.0271204
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0267804
SMAD2 SMAD family member 2 -0.0265654
RPL37 ribosomal protein L37 -0.0265452
RPS5 ribosomal protein S5 -0.0262982
RPL38 ribosomal protein L38 -0.026132
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0260601
RPS29 ribosomal protein S29 -0.0260282
SMOC1 SPARC related modular calcium binding 1 -0.0258793
WARS1 tryptophanyl-tRNA synthetase 1 -0.0255384
RAB7A RAB7A, member RAS oncogene family -0.0253797
RPL11 ribosomal protein L11 -0.0251738
RPS13 ribosomal protein S13 -0.0251095
RPS17 ribosomal protein S17 -0.0248913
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0245993
LOC102724023 ES1 protein homolog, mitochondrial -0.0242125
RPL23 ribosomal protein L23 -0.0238303
PDIA3 protein disulfide isomerase family A, member 3 -0.023805
IL6 interleukin 6 -0.0232767
CDH13 cadherin 13 -0.0231446
TM4SF1 transmembrane 4 L six family member 1 -0.0229093
RHOB ras homolog family member B -0.022894
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0228035
RPL28 ribosomal protein L28 -0.0227458
OASL 2'-5'-oligoadenylate synthetase-like -0.0223201
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0221789
RPS28 ribosomal protein S28 -0.021402
RPS11 ribosomal protein S11 -0.0209631
RPL27A ribosomal protein L27a -0.0209506