| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
190 genes differentially expressed following the Ribociclib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.216687 |
| ANKRD11 | ankyrin repeat domain 11 | 0.132785 |
| SBF2 | SET binding factor 2 | 0.116509 |
| CCND1 | cyclin D1 | 0.109437 |
| FTL | ferritin, light polypeptide | 0.105767 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.103894 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.102332 |
| NDRG1 | N-myc downstream regulated 1 | 0.100341 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0902167 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0893449 |
| MYOF | myoferlin | 0.0890383 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0880411 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0795548 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0791311 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0787505 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0730465 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0687643 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0652524 |
| PTK2 | protein tyrosine kinase 2 | 0.0650789 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0637985 |
| SEPTIN9 | septin 9 | 0.0627825 |
| DST | dystonin | 0.0627485 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0622554 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0620076 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0618551 |
| SQSTM1 | sequestosome 1 | 0.0617674 |
| FAM13A | family with sequence similarity 13, member A | 0.0603527 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0585151 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0579934 |
| FLNB | filamin B, beta | 0.0572029 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0570954 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0567605 |
| SRPK2 | SRSF protein kinase 2 | 0.0549466 |
| ASPH | aspartate beta-hydroxylase | 0.0548681 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0541985 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.051294 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.050333 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0503002 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0485907 |
| LDHA | lactate dehydrogenase A | 0.0471909 |
| OGA | O-GlcNAcase | 0.0463882 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0451087 |
| PCBP2 | poly(rC) binding protein 2 | 0.044675 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0445064 |
| INHBA | inhibin, beta A | 0.0425971 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0410507 |
| CANX | calnexin | 0.0391754 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0387608 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0369745 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0361068 |
| ATXN1 | ataxin 1 | 0.0349512 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0345214 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0341273 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0326707 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0307529 |
| APP | amyloid beta (A4) precursor protein | 0.0300402 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299088 |
| MAP4 | microtubule-associated protein 4 | 0.0281063 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0271854 |
| OSMR | oncostatin M receptor | 0.0258766 |
| PGK1 | phosphoglycerate kinase 1 | 0.0237917 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0229593 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0221945 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0207918 |
| CCNI | cyclin I | 0.0206826 |
| PDE10A | phosphodiesterase 10A | 0.0199473 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0194584 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0185049 |
| SPAG9 | sperm associated antigen 9 | 0.0181816 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0166544 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0154366 |
| GOLGA4 | golgin A4 | 0.0149892 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0148287 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0141109 |
| SLTM | SAFB-like, transcription modulator | 0.0123347 |
| CALR | calreticulin | 0.0122599 |
| RPL11 | ribosomal protein L11 | 0.0104219 |
| SETD5 | SET domain containing 5 | 0.0097998 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.009141 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.00886176 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.00721005 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.00719569 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.00693966 |
| RPL35A | ribosomal protein L35a | 0.00532825 |
| RAD51B | RAD51 paralog B | 0.00382629 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.00360278 |
| PTMA | prothymosin, alpha | 0.00307421 |
| ZNF292 | zinc finger protein 292 | 0.00294367 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.00159927 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 5.7952E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | -0.131956 |
| MT2A | metallothionein 2A | -0.130161 |
| TMSB10 | thymosin beta 10 | -0.122753 |
| IGF2 | insulin-like growth factor 2 | -0.119937 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.118719 |
| HMGA2 | high mobility group AT-hook 2 | -0.118672 |
| VIM | vimentin | -0.109501 |
| VCL | vinculin | -0.0997738 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0944643 |
| RPL34 | ribosomal protein L34 | -0.0936616 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0879268 |
| RPS19 | ribosomal protein S19 | -0.0874454 |
| RACK1 | receptor for activated C kinase 1 | -0.0868741 |
| RPS12 | ribosomal protein S12 | -0.0815116 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0793028 |
| SP100 | SP100 nuclear antigen | -0.0760936 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0753722 |
| RPS25 | ribosomal protein S25 | -0.0743064 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0741247 |
| PKM | pyruvate kinase, muscle | -0.0693169 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0681514 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0648423 |
| RTN4 | reticulon 4 | -0.0644325 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0638029 |
| RPL26 | ribosomal protein L26 | -0.0618536 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0615806 |
| RPLP2 | ribosomal protein, large, P2 | -0.0602896 |
| LAMB3 | laminin, beta 3 | -0.0594656 |
| COL5A1 | collagen, type V, alpha 1 | -0.0589278 |
| B2M | beta-2-microglobulin | -0.0580508 |
| RBM39 | RNA binding motif protein 39 | -0.0574932 |
| DIAPH2 | diaphanous-related formin 2 | -0.056199 |
| MYO1E | myosin IE | -0.0560498 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0551096 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0548546 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0540795 |
| SMYD3 | SET and MYND domain containing 3 | -0.0539117 |
| RPS24 | ribosomal protein S24 | -0.0507681 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0500155 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0497469 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0495198 |
| EGFR | epidermal growth factor receptor | -0.0485371 |
| PRKCA | protein kinase C, alpha | -0.0484735 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0465079 |
| CDH13 | cadherin 13 | -0.0463613 |
| RPLP1 | ribosomal protein, large, P1 | -0.0459267 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0444086 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.044132 |
| RPL12 | ribosomal protein L12 | -0.0434372 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.042879 |
| PARD3 | par-3 family cell polarity regulator | -0.0424768 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0413411 |
| KIF5B | kinesin family member 5B | -0.0409012 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0396973 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0392251 |
| RPL37A | ribosomal protein L37a | -0.0383187 |
| MCL1 | myeloid cell leukemia 1 | -0.0375057 |
| RPL19 | ribosomal protein L19 | -0.036722 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0365493 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0363831 |
| PUM2 | pumilio RNA-binding family member 2 | -0.032594 |
| RPS8 | ribosomal protein S8 | -0.0309878 |
| RUNX1 | runt-related transcription factor 1 | -0.0309731 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0300983 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0298704 |
| MORF4L2 | mortality factor 4 like 2 | -0.0269973 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0267205 |
| EFNA5 | ephrin-A5 | -0.0261526 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0246271 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0244237 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0237313 |
| USP34 | ubiquitin specific peptidase 34 | -0.0234049 |
| LMNA | lamin A/C | -0.0221923 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0216715 |
| RBM25 | RNA binding motif protein 25 | -0.0214403 |
| RPLP0 | ribosomal protein, large, P0 | -0.0211038 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0209316 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0200262 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0195232 |
| TXNIP | thioredoxin interacting protein | -0.0192285 |
| RPS27A | ribosomal protein S27a | -0.0187637 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0177094 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0168147 |
| ENO1 | enolase 1, (alpha) | -0.0133027 |
| RPS6 | ribosomal protein S6 | -0.0129322 |
| NAV2 | neuron navigator 2 | -0.011367 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0110771 |
| MED13 | mediator complex subunit 13 | -0.00996399 |
| WAC | WW domain containing adaptor with coiled-coil | -0.00976319 |
| STC1 | stanniocalcin 1 | -0.00918701 |
| RPL23 | ribosomal protein L23 | -0.00906016 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.00863836 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.00821333 |
| JMJD1C | jumonji domain containing 1C | -0.00801316 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0077966 |
| HDLBP | high density lipoprotein binding protein | -0.00749594 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.00737484 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.00664922 |
| TOP1 | topoisomerase (DNA) I | -0.00631485 |
| SIK3 | SIK family kinase 3 | -0.00464106 |
