| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ribociclib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.23032 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.171585 |
| CADM2 | cell adhesion molecule 2 | 0.13454 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.120322 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.104414 |
| ZNF292 | zinc finger protein 292 | 0.0845891 |
| JMJD1C | jumonji domain containing 1C | 0.0801794 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0771334 |
| COL3A1 | collagen, type III, alpha 1 | 0.0714366 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0709134 |
| HDAC9 | histone deacetylase 9 | 0.0666434 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.064987 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0649002 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0638606 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0632611 |
| RBM20 | RNA binding motif protein 20 | 0.0592161 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.055682 |
| DST | dystonin | 0.0545484 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0533823 |
| NBAS | neuroblastoma amplified sequence | 0.0524237 |
| PDGFC | platelet derived growth factor C | 0.0502617 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0501907 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.050178 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0488613 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0486189 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0477354 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.04664 |
| ITGAV | integrin, alpha V | 0.044152 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0434274 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.043348 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0432911 |
| SYT1 | synaptotagmin I | 0.0432394 |
| NFIA | nuclear factor I/A | 0.0422061 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0419495 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0419009 |
| SMYD3 | SET and MYND domain containing 3 | 0.0415913 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.041206 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0410458 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0387474 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0386386 |
| ANK2 | ankyrin 2, neuronal | 0.0379951 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 0.0370291 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0369687 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0368705 |
| EMP1 | epithelial membrane protein 1 | 0.0363641 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0359944 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.035642 |
| ETV1 | ets variant 1 | 0.0353595 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0349656 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.034917 |
| MEF2C | myocyte enhancer factor 2C | 0.034654 |
| TMEM123 | transmembrane protein 123 | 0.0335701 |
| DENND4C | DENN/MADD domain containing 4C | 0.0332386 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0332301 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0328323 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0319905 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0319566 |
| GASK1B | golgi associated kinase 1B | 0.0311739 |
| ZNF217 | zinc finger protein 217 | 0.0310455 |
| RHEB | Ras homolog enriched in brain | 0.0309426 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0308315 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0308231 |
| FOXG1 | forkhead box G1 | 0.0302881 |
| RYBP | RING1 and YY1 binding protein | 0.0300816 |
| USP3 | ubiquitin specific peptidase 3 | 0.030046 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0298066 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0296973 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.0296042 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0293841 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.029358 |
| MACROD2 | MACRO domain containing 2 | 0.0290453 |
| TMEM64 | transmembrane protein 64 | 0.0288881 |
| RPL6 | ribosomal protein L6 | 0.0288401 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0287354 |
| NUMB | numb homolog (Drosophila) | 0.0287199 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.02871 |
| YAP1 | Yes-associated protein 1 | 0.0285446 |
| CCDC112 | coiled-coil domain containing 112 | 0.0275051 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0273293 |
| RPL26 | ribosomal protein L26 | 0.0270468 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0269635 |
| MB21D2 | Mab-21 domain containing 2 | 0.0265942 |
| PRKD1 | protein kinase D1 | 0.0265846 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0263881 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0262679 |
| XPO1 | exportin 1 | 0.0261507 |
| PRR16 | proline rich 16 | 0.0261438 |
| EAPP | E2F-associated phosphoprotein | 0.0260816 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0260254 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 0.0259887 |
| QKI | QKI, KH domain containing, RNA binding | 0.0259653 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0259571 |
| EPHA3 | EPH receptor A3 | 0.0259519 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.0257688 |
| DMD | dystrophin | 0.0257327 |
| MEIS2 | Meis homeobox 2 | 0.0256716 |
| NHSL1 | NHS-like 1 | 0.025387 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.025382 |
| RIOK3 | RIO kinase 3 | 0.0253608 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0253475 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.102463 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0887989 |
| POTEF | POTE ankyrin domain family, member F | -0.0742379 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0689008 |
| PEG10 | paternally expressed 10 | -0.0631883 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.063187 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0613047 |
| VIM | vimentin | -0.0610225 |
| PHIP | pleckstrin homology domain interacting protein | -0.0587021 |
| LDHA | lactate dehydrogenase A | -0.055279 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.05341 |
| UTRN | utrophin | -0.0512893 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0503023 |
| PFN1 | profilin 1 | -0.0496082 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0484087 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0463692 |
| WASF2 | WAS protein family, member 2 | -0.0457211 |
| CALR | calreticulin | -0.0453704 |
| RPS8 | ribosomal protein S8 | -0.0414723 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0410684 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0409376 |
| PRPF8 | pre-mRNA processing factor 8 | -0.040482 |
| SUGT1 | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | -0.039 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0381964 |
| COL5A2 | collagen, type V, alpha 2 | -0.0379503 |
| NRDC | nardilysin convertase | -0.0373362 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0342434 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0340809 |
| GPC4 | glypican 4 | -0.0336881 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0334863 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0334271 |
| RPS16 | ribosomal protein S16 | -0.0333443 |
| RCOR1 | REST corepressor 1 | -0.0323072 |
| RPL11 | ribosomal protein L11 | -0.032151 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0320011 |
| PCDH9 | protocadherin 9 | -0.0315775 |
| CENPF | centromere protein F, 350/400kDa | -0.0315301 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0311991 |
| RAD51B | RAD51 paralog B | -0.0310979 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0310131 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0310054 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0308909 |
| TPM3 | tropomyosin 3 | -0.0305221 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0297446 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0290416 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.028947 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0289251 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0288712 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0287688 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0287179 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0281369 |
| RANBP2 | RAN binding protein 2 | -0.0281098 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0280211 |
| SFTPA2 | surfactant protein A2 | -0.0279019 |
| RDX | radixin | -0.0278688 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0276848 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0275256 |
| SET | SET nuclear proto-oncogene | -0.027503 |
| GANAB | glucosidase, alpha; neutral AB | -0.0273873 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0271504 |
| RAI1 | retinoic acid induced 1 | -0.0270704 |
| MKI67 | marker of proliferation Ki-67 | -0.0266362 |
| FAT1 | FAT atypical cadherin 1 | -0.0266184 |
| B2M | beta-2-microglobulin | -0.0265166 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0265143 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.026431 |
| FBL | fibrillarin | -0.0263339 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0263264 |
| RHOA | ras homolog family member A | -0.0262547 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.026168 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0260583 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0251413 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0251211 |
| PAPOLA | poly(A) polymerase alpha | -0.0246239 |
| DEK | DEK proto-oncogene | -0.0245392 |
| NONO | non-POU domain containing, octamer-binding | -0.0245095 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0242895 |
| UBXN4 | UBX domain protein 4 | -0.0242365 |
| CSPP1 | centrosome and spindle pole associated protein 1 | -0.0240667 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0238779 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0238303 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | -0.0237994 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.023762 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 | -0.0237349 |
| TPM4 | tropomyosin 4 | -0.0236819 |
| HTATSF1 | HIV-1 Tat specific factor 1 | -0.0236206 |
| APP | amyloid beta (A4) precursor protein | -0.0236152 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0235041 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.023332 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.023176 |
| TMSB4X | thymosin beta 4, X-linked | -0.0231399 |
| RPN1 | ribophorin I | -0.0230606 |
| KLHL15 | kelch-like family member 15 | -0.0230002 |
| CDK6 | cyclin-dependent kinase 6 | -0.0229267 |
| GOLIM4 | golgi integral membrane protein 4 | -0.022865 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0228132 |
| RLF | rearranged L-myc fusion | -0.0227828 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0227053 |
| CLIC4 | chloride intracellular channel 4 | -0.0223103 |
| RBM27 | RNA binding motif protein 27 | -0.0222035 |
