Ribociclib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ribociclib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ribociclib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.211882
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.143794
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.10809
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0796424
RTN4 reticulon 4 0.0781728
S100A6 S100 calcium binding protein A6 0.0650421
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.064175
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0608708
ZFAND3 zinc finger, AN1-type domain 3 0.0586444
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0570049
GARS1 glycyl-tRNA synthetase 1 0.054181
SLC38A2 solute carrier family 38, member 2 0.0529203
AHNAK AHNAK nucleoprotein 0.0518264
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.050632
JMJD1C jumonji domain containing 1C 0.0505465
COG5 component of oligomeric golgi complex 5 0.0477428
VCL vinculin 0.0471071
EGFR epidermal growth factor receptor 0.046321
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0457223
NCEH1 neutral cholesterol ester hydrolase 1 0.0439221
TJP1 tight junction protein 1 0.0387806
TPT1 tumor protein, translationally-controlled 1 0.0385118
NFE2L2 nuclear factor, erythroid 2-like 2 0.0382529
NAMPT nicotinamide phosphoribosyltransferase 0.0366821
DSCAM Down syndrome cell adhesion molecule 0.0353971
EML4 echinoderm microtubule associated protein like 4 0.0352535
IFI16 interferon, gamma-inducible protein 16 0.0348132
TXNRD1 thioredoxin reductase 1 0.0341333
PNISR PNN-interacting serine/arginine-rich protein 0.0340668
ZBTB20 zinc finger and BTB domain containing 20 0.033287
METTL15 methyltransferase like 15 0.0330844
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.032723
ATP9B ATPase, class II, type 9B 0.0325913
PUM2 pumilio RNA-binding family member 2 0.031677
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0306469
TBC1D5 TBC1 domain family, member 5 0.0305602
NCKAP1 NCK-associated protein 1 0.0305344
TM4SF1 transmembrane 4 L six family member 1 0.0304814
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0300921
BCAS3 breast carcinoma amplified sequence 3 0.029995
ZNF292 zinc finger protein 292 0.0294965
ARL15 ADP-ribosylation factor-like 15 0.0294745
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0294555
NBAS neuroblastoma amplified sequence 0.0281342
B2M beta-2-microglobulin 0.0278851
RAB27B RAB27B, member RAS oncogene family 0.0278598
VMP1 vacuole membrane protein 1 0.0266308
NF1 neurofibromin 1 0.0261338
PRELID2 PRELI domain containing 2 0.0261329
PYGB phosphorylase, glycogen; brain 0.0260837
IARS1 isoleucyl-tRNA synthetase 1 0.0259038
OLA1 Obg-like ATPase 1 0.0259006
ADNP activity-dependent neuroprotector homeobox 0.0258197
ACTG1 actin gamma 1 0.0257531
RPS29 ribosomal protein S29 0.0255647
MAPK8 mitogen-activated protein kinase 8 0.0251486
RPL12 ribosomal protein L12 0.0246582
ANKRD10 ankyrin repeat domain 10 0.0244262
NCOR1 nuclear receptor corepressor 1 0.0243453
RHOA ras homolog family member A 0.0237072
FBXO11 F-box protein 11 0.0233542
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0232389
TMEM39A transmembrane protein 39A 0.023235
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0232331
TNPO1 transportin 1 0.0231977
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0227321
ZFAND6 zinc finger, AN1-type domain 6 0.0227253
RPL26 ribosomal protein L26 0.0226855
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0222184
ABHD12 abhydrolase domain containing 12 0.0221119
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0220852
TMEM41B transmembrane protein 41B 0.0217491
OSMR oncostatin M receptor 0.0217359
S100A10 S100 calcium binding protein A10 0.021651
PDGFC platelet derived growth factor C 0.0216425
PHF3 PHD finger protein 3 0.0216422
DENND4A DENN/MADD domain containing 4A 0.0214411
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0213623
TLK1 tousled-like kinase 1 0.0212998
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0212851
PLPP3 phospholipid phosphatase 3 0.0212426
ZNF217 zinc finger protein 217 0.0212315
GOLT1B golgi transport 1B 0.0210661
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0208666
MACROD2 MACRO domain containing 2 0.0207793
ZMYND8 zinc finger, MYND-type containing 8 0.0206881
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.020586
BBS9 Bardet-Biedl syndrome 9 0.0205722
VGLL4 vestigial-like family member 4 0.0204231
RTN3 reticulon 3 0.0203458
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0201785
PTBP2 polypyrimidine tract binding protein 2 0.0201278
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0200693
RICTOR RPTOR independent companion of MTOR, complex 2 0.0199954
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0199494
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0197451
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0197301
RIGI RNA sensor RIG-I 0.019716
VWA8 von Willebrand factor A domain containing 8 0.0197102
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0197006

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.16807
RPL3 ribosomal protein L3 -0.118147
PDE4B phosphodiesterase 4B, cAMP-specific -0.094323
EEF2 eukaryotic translation elongation factor 2 -0.0892588
LDHA lactate dehydrogenase A -0.0806625
BMP10 bone morphogenetic protein 10 -0.0778135
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0775397
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0748493
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0693622
FOXP1 forkhead box P1 -0.0637762
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0597314
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0577894
ENO2 enolase 2 (gamma, neuronal) -0.0572256
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0567997
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0559454
MKI67 marker of proliferation Ki-67 -0.0511316
PCBP2 poly(rC) binding protein 2 -0.0446194
SOX6 SRY (sex determining region Y)-box 6 -0.0443004
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0442085
SRRM2 serine/arginine repetitive matrix 2 -0.0421245
HDGF hepatoma-derived growth factor -0.0410415
SET SET nuclear proto-oncogene -0.041016
LPP LIM domain containing preferred translocation partner in lipoma -0.0400861
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0396871
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0390995
NAV2 neuron navigator 2 -0.0384382
ENO1 enolase 1, (alpha) -0.0376806
CENPF centromere protein F, 350/400kDa -0.0376381
CAMKMT calmodulin-lysine N-methyltransferase -0.0368347
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0367898
EFNA5 ephrin-A5 -0.0362775
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0358673
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0352021
EBNA1BP2 EBNA1 binding protein 2 -0.0350819
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0342516
PTMA prothymosin, alpha -0.0339011
NEBL nebulette -0.0336492
EVI5 ecotropic viral integration site 5 -0.0329713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0327439
SMC3 structural maintenance of chromosomes 3 -0.0319408
PTPRG protein tyrosine phosphatase, receptor type, G -0.029908
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0299044
KIF5B kinesin family member 5B -0.0297431
SDK1 sidekick cell adhesion molecule 1 -0.0296196
HDLBP high density lipoprotein binding protein -0.0295987
CALR calreticulin -0.0293662
N4BP2L2 NEDD4 binding protein 2-like 2 -0.028895
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0287444
TPM4 tropomyosin 4 -0.0286591
MYOF myoferlin -0.0279121
PLXNA1 plexin A1 -0.027675
RPL13A ribosomal protein L13a -0.0275926
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0275119
APP amyloid beta (A4) precursor protein -0.027503
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0266555
HDAC9 histone deacetylase 9 -0.0266298
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.026584
SMC4 structural maintenance of chromosomes 4 -0.026416
NPAS2 neuronal PAS domain protein 2 -0.0260142
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0259287
UNC13A unc-13 homolog A (C. elegans) -0.0259227
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.0258961
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -0.0257142
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0255155
HSPA8 heat shock 70kDa protein 8 -0.0254242
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0247592
CTIF CBP80/20-dependent translation initiation factor -0.0245957
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0245725
CUX1 cut-like homeobox 1 -0.0243752
EIF3A eukaryotic translation initiation factor 3, subunit A -0.024253
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0241214
DIAPH3 diaphanous-related formin 3 -0.0237813
VEGFA vascular endothelial growth factor A -0.0236675
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0235053
DPYD dihydropyrimidine dehydrogenase -0.0228712
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0225606
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -0.022544
CAMTA1 calmodulin binding transcription activator 1 -0.0224801
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0221142
FAT1 FAT atypical cadherin 1 -0.022029
RPS4X ribosomal protein S4, X-linked -0.0218171
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0218097
CANX calnexin -0.0214978
TTC28 tetratricopeptide repeat domain 28 -0.0212452
GLI2 GLI family zinc finger 2 -0.0210919
TPX2 TPX2, microtubule-associated -0.0210889
DOCK1 dedicator of cytokinesis 1 -0.0207992
KPNB1 karyopherin (importin) beta 1 -0.0207638
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0205169
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0203711
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0201784
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0199176
RPL18A ribosomal protein L18a -0.0197226
TPI1 triosephosphate isomerase 1 -0.0195748
CSDE1 cold shock domain containing E1, RNA-binding -0.0195135
AMOTL2 angiomotin like 2 -0.0193443
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0192811
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0191791
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0190979
FAM13A family with sequence similarity 13, member A -0.0188397