| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ribociclib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.167045 |
| FN1 | fibronectin 1 | 0.115443 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0791349 |
| BICC1 | BicC family RNA binding protein 1 | 0.0749714 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0673916 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0598317 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0580994 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0562668 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0534155 |
| MKI67 | marker of proliferation Ki-67 | 0.0476675 |
| KYNU | kynureninase | 0.0417517 |
| OGA | O-GlcNAcase | 0.0403712 |
| VCL | vinculin | 0.0392721 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0376246 |
| ATXN1 | ataxin 1 | 0.0354356 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0347668 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0346425 |
| ANLN | anillin, actin binding protein | 0.032629 |
| SMAD3 | SMAD family member 3 | 0.0323131 |
| RIGI | RNA sensor RIG-I | 0.0322838 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0321398 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.030807 |
| SMYD3 | SET and MYND domain containing 3 | 0.0297867 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0286884 |
| METTL15 | methyltransferase like 15 | 0.0286376 |
| TXNRD1 | thioredoxin reductase 1 | 0.0274927 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0266116 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0265733 |
| SBF2 | SET binding factor 2 | 0.0263612 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0259315 |
| BPTF | bromodomain PHD finger transcription factor | 0.0253353 |
| OSMR | oncostatin M receptor | 0.0253299 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0252126 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0251945 |
| CENPF | centromere protein F, 350/400kDa | 0.0249899 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0237323 |
| PALLD | palladin, cytoskeletal associated protein | 0.0232804 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0228796 |
| FRMD5 | FERM domain containing 5 | 0.0227551 |
| RNF213 | ring finger protein 213 | 0.0219869 |
| SDC4 | syndecan 4 | 0.021689 |
| HDAC8 | histone deacetylase 8 | 0.0216219 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.0215999 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0214817 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0210682 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0210624 |
| KIF4A | kinesin family member 4A | 0.0206113 |
| ATG10 | autophagy related 10 | 0.0205284 |
| CDCP1 | CUB domain containing protein 1 | 0.0204444 |
| EHBP1 | EH domain binding protein 1 | 0.0203341 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0203142 |
| THBS2 | thrombospondin 2 | 0.0202949 |
| PRELID2 | PRELI domain containing 2 | 0.0195292 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0193579 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0193449 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0193214 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0192329 |
| THOC2 | THO complex 2 | 0.0191844 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0190567 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0190438 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | 0.0189521 |
| KIF18A | kinesin family member 18A | 0.0189426 |
| MTAP | methylthioadenosine phosphorylase | 0.0189164 |
| FNIP1 | folliculin interacting protein 1 | 0.0188452 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0187247 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0187159 |
| CEP95 | centrosomal protein 95kDa | 0.0186822 |
| JAK2 | Janus kinase 2 | 0.0185887 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0184363 |
| FAM20C | family with sequence similarity 20, member C | 0.0183711 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0181939 |
| ATM | ATM serine/threonine kinase | 0.0181766 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0181613 |
| PRR11 | proline rich 11 | 0.0181202 |
| CLTC | clathrin, heavy chain (Hc) | 0.018105 |
| THBS1 | thrombospondin 1 | 0.0180791 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0180152 |
| DIAPH3 | diaphanous-related formin 3 | 0.0179036 |
| PLSCR1 | phospholipid scramblase 1 | 0.0177925 |
| PHF20 | PHD finger protein 20 | 0.0177792 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0177293 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0176159 |
| AHNAK | AHNAK nucleoprotein | 0.0175859 |
| PTK2 | protein tyrosine kinase 2 | 0.0175716 |
| XAF1 | XIAP associated factor 1 | 0.0173098 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0172892 |
| TPX2 | TPX2, microtubule-associated | 0.0172474 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.017228 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0171227 |
| RASA2 | RAS p21 protein activator 2 | 0.0170882 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0170737 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0170582 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0164685 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.016414 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0162694 |
| FAM3C | family with sequence similarity 3, member C | 0.0162508 |
| TRIM38 | tripartite motif containing 38 | 0.0162241 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0162012 |
| KIF11 | kinesin family member 11 | 0.016177 |
| KLF6 | Kruppel-like factor 6 | 0.0160222 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.237102 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.14345 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.129334 |
| FTL | ferritin, light polypeptide | -0.127821 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.108494 |
| LDHA | lactate dehydrogenase A | -0.103689 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.096118 |
| ADM | adrenomedullin | -0.0877531 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0827524 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0793494 |
| VEGFA | vascular endothelial growth factor A | -0.0773767 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0760704 |
| RPS6 | ribosomal protein S6 | -0.0724172 |
| HLA-A | major histocompatibility complex, class I, A | -0.0716776 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0652482 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.065149 |
| TMSB10 | thymosin beta 10 | -0.064835 |
| PLIN2 | perilipin 2 | -0.0635874 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0561266 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0535718 |
| CDH13 | cadherin 13 | -0.0535216 |
| NDRG1 | N-myc downstream regulated 1 | -0.0534192 |
| CANX | calnexin | -0.0529447 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0519739 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0515918 |
| IER3 | immediate early response 3 | -0.0513843 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0503486 |
| HLA-E | major histocompatibility complex, class I, E | -0.0491166 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0487976 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0485581 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0470309 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0467494 |
| ENO1 | enolase 1, (alpha) | -0.0463523 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0459029 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.045867 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.045657 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0453057 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0451929 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0450405 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0426321 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0424246 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0421797 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0409667 |
| MMP12 | matrix metallopeptidase 12 | -0.0406219 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0403852 |
| EGR1 | early growth response 1 | -0.0398839 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0395274 |
| SEPTIN9 | septin 9 | -0.0379137 |
| CADM1 | cell adhesion molecule 1 | -0.0374919 |
| FRMD4A | FERM domain containing 4A | -0.0372951 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0362856 |
| HMGA1 | high mobility group AT-hook 1 | -0.0361099 |
| PCBP2 | poly(rC) binding protein 2 | -0.0357623 |
| RPL11 | ribosomal protein L11 | -0.0344356 |
| CTSB | cathepsin B | -0.0342238 |
| EGFR | epidermal growth factor receptor | -0.0341721 |
| RND3 | Rho family GTPase 3 | -0.0341299 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0333974 |
| MSN | moesin | -0.0333432 |
| SFTPA2 | surfactant protein A2 | -0.0324431 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0319091 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0318381 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0309359 |
| FLNA | filamin A, alpha | -0.0307819 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0307422 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0305769 |
| FMNL2 | formin-like 2 | -0.0303649 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0303105 |
| CALR | calreticulin | -0.0301919 |
| RPL3 | ribosomal protein L3 | -0.0301561 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0300599 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0298774 |
| BRD2 | bromodomain containing 2 | -0.0298129 |
| LOX | lysyl oxidase | -0.0293664 |
| YBX1 | Y box binding protein 1 | -0.0291594 |
| C3 | complement component 3 | -0.0284956 |
| POTEF | POTE ankyrin domain family, member F | -0.0283607 |
| ERBIN | erbb2 interacting protein | -0.0283484 |
| CD44 | CD44 molecule (Indian blood group) | -0.0278489 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0274308 |
| SQSTM1 | sequestosome 1 | -0.0273138 |
| MORF4L2 | mortality factor 4 like 2 | -0.027219 |
| PGK1 | phosphoglycerate kinase 1 | -0.0271498 |
| RPS23 | ribosomal protein S23 | -0.0270942 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0270604 |
| RPS4X | ribosomal protein S4, X-linked | -0.0268909 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0264761 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0257258 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.0255558 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0253253 |
| EFNA5 | ephrin-A5 | -0.0252501 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.0249773 |
| JUN | jun proto-oncogene | -0.0248768 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0247457 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0246886 |
| TPM4 | tropomyosin 4 | -0.024598 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0245058 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0243295 |
| RAI14 | retinoic acid induced 14 | -0.0242748 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0242286 |
