| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ribociclib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ribociclib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.164034 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.156085 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.145343 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.121541 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.11143 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.080626 |
| OGA | O-GlcNAcase | 0.0772248 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0586564 |
| RPL26 | ribosomal protein L26 | 0.0560815 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0549734 |
| MT2A | metallothionein 2A | 0.0525921 |
| ZNF292 | zinc finger protein 292 | 0.0500421 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0487995 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0485005 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0480584 |
| RBM39 | RNA binding motif protein 39 | 0.0470986 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.047078 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.046546 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0463093 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0457199 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0438631 |
| NEK7 | NIMA-related kinase 7 | 0.0423731 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0422821 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0418714 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0407276 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0403502 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0395293 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0394694 |
| RPL12 | ribosomal protein L12 | 0.0393175 |
| CDC73 | cell division cycle 73 | 0.0388865 |
| RPS24 | ribosomal protein S24 | 0.0385477 |
| HELZ | helicase with zinc finger | 0.0379396 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0379188 |
| RHEB | Ras homolog enriched in brain | 0.0376872 |
| PTMA | prothymosin, alpha | 0.0373023 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0365959 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0364084 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0358174 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.035545 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0355097 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0353364 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0348838 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.034839 |
| RPS6 | ribosomal protein S6 | 0.0346925 |
| TXNRD1 | thioredoxin reductase 1 | 0.0346343 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0342005 |
| TPR | translocated promoter region, nuclear basket protein | 0.0339526 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0336758 |
| RLF | rearranged L-myc fusion | 0.0333426 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0332733 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.032688 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.032135 |
| RPLP1 | ribosomal protein, large, P1 | 0.0320768 |
| RBM25 | RNA binding motif protein 25 | 0.0320159 |
| RPL35A | ribosomal protein L35a | 0.0319905 |
| XPO1 | exportin 1 | 0.0315717 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0313743 |
| ZFR | zinc finger RNA binding protein | 0.0312155 |
| FBXO32 | F-box protein 32 | 0.0309865 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0308117 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0307319 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0303434 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0303329 |
| JMJD1C | jumonji domain containing 1C | 0.0302198 |
| GNAS | GNAS complex locus | 0.0301046 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0296322 |
| H1-0 | H1.0 linker histone | 0.0294637 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0293263 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0292871 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0292824 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.029218 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0291367 |
| OSMR | oncostatin M receptor | 0.0291251 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0290417 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0282133 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0280668 |
| TFG | TRK-fused gene | 0.0277921 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0276182 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.027454 |
| IER3 | immediate early response 3 | 0.0270904 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0270694 |
| RPL38 | ribosomal protein L38 | 0.0268548 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0267274 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0266383 |
| DENND5B | DENN/MADD domain containing 5B | 0.0265441 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0264024 |
| EREG | epiregulin | 0.0263589 |
| CLINT1 | clathrin interactor 1 | 0.0262197 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0261633 |
| COG5 | component of oligomeric golgi complex 5 | 0.0259293 |
| FNBP1 | formin binding protein 1 | 0.0259119 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0258709 |
| TMEM165 | transmembrane protein 165 | 0.0254669 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0254303 |
| WDR45B | WD repeat domain 45B | 0.0252382 |
| ANLN | anillin, actin binding protein | 0.0250566 |
| RAB1A | RAB1A, member RAS oncogene family | 0.025038 |
| USP3 | ubiquitin specific peptidase 3 | 0.0247421 |
| VIM | vimentin | 0.0243207 |
| B2M | beta-2-microglobulin | 0.0242878 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.2113 |
| FN1 | fibronectin 1 | -0.210075 |
| HMGA2 | high mobility group AT-hook 2 | -0.130522 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0918066 |
| ASPH | aspartate beta-hydroxylase | -0.0725155 |
| VEGFA | vascular endothelial growth factor A | -0.0720196 |
| POTEF | POTE ankyrin domain family, member F | -0.0715151 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0654533 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0623913 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0610001 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0609099 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0608217 |
| STC2 | stanniocalcin 2 | -0.0596266 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0555602 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0520949 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0500875 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0499375 |
| MCL1 | myeloid cell leukemia 1 | -0.0497043 |
| VCL | vinculin | -0.0482112 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0474013 |
| GLIS3 | GLIS family zinc finger 3 | -0.0468906 |
| PLIN2 | perilipin 2 | -0.0464445 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0452304 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0448859 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0448452 |
| FLNA | filamin A, alpha | -0.0446062 |
| RAI14 | retinoic acid induced 14 | -0.0431998 |
| CADM1 | cell adhesion molecule 1 | -0.0417017 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0392442 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0383787 |
| NDRG1 | N-myc downstream regulated 1 | -0.0381219 |
| GPC6 | glypican 6 | -0.0376696 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0369861 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0368363 |
| ENO1 | enolase 1, (alpha) | -0.0359385 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0357308 |
| EFNA5 | ephrin-A5 | -0.0356143 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0352028 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0340862 |
| GLUL | glutamate-ammonia ligase | -0.0338056 |
| EGR1 | early growth response 1 | -0.0335583 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0328334 |
| RPL3 | ribosomal protein L3 | -0.032301 |
| ACTG1 | actin gamma 1 | -0.0318367 |
| INTS6 | integrator complex subunit 6 | -0.0318248 |
| HDGF | hepatoma-derived growth factor | -0.0315334 |
| PRKCA | protein kinase C, alpha | -0.0305482 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0303645 |
| TMSB4X | thymosin beta 4, X-linked | -0.0293545 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0285759 |
| TENM4 | teneurin transmembrane protein 4 | -0.0284879 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0280377 |
| HMGA1 | high mobility group AT-hook 1 | -0.0274682 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0273491 |
| LOXL2 | lysyl oxidase-like 2 | -0.027283 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0271838 |
| AEBP2 | AE binding protein 2 | -0.0270929 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0270855 |
| GPATCH2L | G patch domain containing 2-like | -0.0270843 |
| LDHA | lactate dehydrogenase A | -0.026011 |
| SEPTIN9 | septin 9 | -0.0253404 |
| NAV1 | neuron navigator 1 | -0.0252584 |
| PKM | pyruvate kinase, muscle | -0.0251341 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0246749 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0246035 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.02453 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | -0.0243084 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0241802 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0240597 |
| MAP1B | microtubule-associated protein 1B | -0.0236333 |
| TPM3 | tropomyosin 3 | -0.0232851 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.022824 |
| MSN | moesin | -0.022665 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225446 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0225259 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0223534 |
| NXN | nucleoredoxin | -0.0222522 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0217119 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0214744 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0213423 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0210676 |
| LRRC23 | leucine rich repeat containing 23 | -0.0206086 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0205331 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.020487 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.020475 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0204088 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0201642 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0201365 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0201338 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.019982 |
| BRD2 | bromodomain containing 2 | -0.0196525 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0196462 |
| TPM4 | tropomyosin 4 | -0.0193476 |
| RASAL2 | RAS protein activator like 2 | -0.01934 |
| FOSL1 | FOS-like antigen 1 | -0.0192811 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0190896 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0187664 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0186506 |
| FAT1 | FAT atypical cadherin 1 | -0.0185062 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.018503 |
