Ribosome biogenesis in eukaryotes Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. (Kyoto Encyclopedia of Genes and Genomes, hsa03008)
External Link https://www.kegg.jp/entry/hsa03008
Similar Terms
Downloads & Tools

Genes

76 proteins participating in the Ribosome biogenesis in eukaryotes pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AFG2A AFG2 AAA ATPase homolog A
AK6 adenylate kinase 6
BMS1 BMS1 ribosome biogenesis factor
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2A3 casein kinase 2, alpha 3 polypeptide
CSNK2B casein kinase 2, beta polypeptide
DKC1 dyskeratosis congenita 1, dyskerin
DROSHA drosha, ribonuclease type III
EFL1 elongation factor like GTPase 1
EIF6 eukaryotic translation initiation factor 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FBL fibrillarin
FBLL1 fibrillarin-like 1
FCF1 FCF1 rRNA-processing protein
GAR1 GAR1 ribonucleoprotein
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GTPBP4 GTP binding protein 4
HEATR1 HEAT repeat containing 1
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
LSG1 large 60S subunit nuclear export GTPase 1
MDN1 MDN1, midasin homolog (yeast)
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
NAT10 N-acetyltransferase 10 (GCN5-related)
NHP2 NHP2 ribonucleoprotein
NLRP2B NLR family pyrin domain containing 2B
NMD3 NMD3 ribosome export adaptor
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOP10 NOP10 ribonucleoprotein
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NVL nuclear VCP-like
NXF1 nuclear RNA export factor 1
NXF2 nuclear RNA export factor 2
NXF2B nuclear RNA export factor 2B
NXF3 nuclear RNA export factor 3
NXT1 nuclear transport factor 2-like export factor 1
NXT2 nuclear transport factor 2-like export factor 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYDC1 PYD (pyrin domain) containing 1
RAN RAN, member RAS oncogene family
RBM28 RNA binding motif protein 28
RCL1 RNA terminal phosphate cyclase-like 1
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
REXO2 RNA exonuclease 2
REXO5 RNA exonuclease 5
RIOK1 RIO kinase 1
RIOK2 RIO kinase 2
RPP25 ribonuclease P/MRP 25kDa subunit
RPP25L ribonuclease P/MRP 25kDa subunit-like
RPP30 ribonuclease P/MRP 30kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RPP40 ribonuclease P/MRP 40kDa subunit
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
SBDS Shwachman-Bodian-Diamond syndrome
SNU13 small nuclear ribonucleoprotein 13
SPPL2A signal peptide peptidase like 2A
TBL3 transducin (beta)-like 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP4 UTP4 small subunit processome component
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR3 WD repeat domain 3
WDR36 WD repeat domain 36
WDR43 WD repeat domain 43
WDR75 WD repeat domain 75
XPO1 exportin 1
XRN1 5'-3' exoribonuclease 1
XRN2 5'-3' exoribonuclease 2