| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A rifamycin that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei) (Chemical Entities of Biological Interest Ontology, CHEBI_28077) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135398735 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Rifampicin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EVA1C | eva-1 homolog C (C. elegans) | 1.81 |
| ALPK3 | alpha-kinase 3 | 1.64 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 1.26 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 1.19 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 0.94 |
| FXN | frataxin | 0.81 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.73 |
| KLC1 | kinesin light chain 1 | 0.69 |
| FAM117B | family with sequence similarity 117, member B | 0.61 |
| SATB1 | SATB homeobox 1 | 0.56 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.55 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.48 |
| SPHK2 | sphingosine kinase 2 | 0.48 |
| ZNF320 | zinc finger protein 320 | 0.46 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.45 |
| SASH1 | SAM and SH3 domain containing 1 | 0.45 |
| ZBTB46 | zinc finger and BTB domain containing 46 | 0.44 |
| TBRG4 | transforming growth factor beta regulator 4 | 0.41 |
| TPM4 | tropomyosin 4 | 0.41 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.41 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.41 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.41 |
| HES1 | hes family bHLH transcription factor 1 | 0.4 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.4 |
| PARPBP | PARP1 binding protein | 0.39 |
| TMEM106C | transmembrane protein 106C | 0.39 |
| HIST2H2BF | histone cluster 2, H2bf | 0.38 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.38 |
| CAPRIN2 | caprin family member 2 | 0.37 |
| MOCOS | molybdenum cofactor sulfurase | 0.37 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.37 |
| DCHS1 | dachsous cadherin-related 1 | 0.36 |
| SLC25A39 | solute carrier family 25, member 39 | 0.36 |
| RPL36AL | ribosomal protein L36a-like | 0.36 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.35 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.35 |
| FAM49B | family with sequence similarity 49, member B | 0.34 |
| SMO | smoothened, frizzled class receptor | 0.34 |
| ODC1 | ornithine decarboxylase 1 | 0.34 |
| CCDC85B | coiled-coil domain containing 85B | 0.34 |
| ZNF14 | zinc finger protein 14 | 0.33 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.33 |
| CERS4 | ceramide synthase 4 | 0.33 |
| COMMD6 | COMM domain containing 6 | 0.33 |
| ZNF160 | zinc finger protein 160 | 0.33 |
| NEMP2 | nuclear envelope integral membrane protein 2 | 0.33 |
| HSBP1 | heat shock factor binding protein 1 | 0.32 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | 0.32 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.31 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.31 |
| RCC2 | regulator of chromosome condensation 2 | 0.3 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | 0.3 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.3 |
| RND3 | Rho family GTPase 3 | 0.29 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 0.28 |
| FER1L5 | fer-1-like family member 5 | 0.28 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.28 |
| ZNF808 | zinc finger protein 808 | 0.28 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.28 |
| PITX2 | paired-like homeodomain 2 | 0.28 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.27 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.27 |
| LSM10 | LSM10, U7 small nuclear RNA associated | 0.27 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.27 |
| RPS10 | ribosomal protein S10 | 0.27 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.27 |
| EIF3CL | eukaryotic translation initiation factor 3, subunit C-like | 0.26 |
| GNB2 | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 0.26 |
| STX16 | syntaxin 16 | 0.26 |
| MIEF1 | mitochondrial elongation factor 1 | 0.26 |
| PEX26 | peroxisomal biogenesis factor 26 | 0.26 |
| ZNF525 | zinc finger protein 525 | 0.25 |
| NKAP | NFKB activating protein | 0.25 |
| SP110 | SP110 nuclear body protein | 0.25 |
| RPL19 | ribosomal protein L19 | 0.25 |
| COL6A6 | collagen, type VI, alpha 6 | 0.25 |
| XBP1 | X-box binding protein 1 | 0.25 |
| TCP1 | t-complex 1 | 0.25 |
| DBNL | drebrin-like | 0.25 |
| TDRD9 | tudor domain containing 9 | 0.24 |
| RPL10A | ribosomal protein L10a | 0.24 |
| PDGFC | platelet derived growth factor C | 0.23 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.23 |
| ACTN1 | actinin, alpha 1 | 0.23 |
| STOML1 | stomatin (EPB72)-like 1 | 0.23 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.23 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.23 |
| RPS20 | ribosomal protein S20 | 0.23 |
| STEAP3 | STEAP family member 3, metalloreductase | 0.23 |
| ULK1 | unc-51 like autophagy activating kinase 1 | 0.23 |
| RGN | regucalcin | 0.23 |
| MGA | MGA, MAX dimerization protein | 0.23 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.23 |
| ERMARD | ER membrane-associated RNA degradation | 0.22 |
| ATP13A2 | ATPase type 13A2 | 0.22 |
| S100A5 | S100 calcium binding protein A5 | 0.22 |
| SLC45A4 | solute carrier family 45, member 4 | 0.22 |
| CEP70 | centrosomal protein 70kDa | 0.22 |
| C2ORF42 | chromosome 2 open reading frame 42 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -1.56 |
| POF1B | premature ovarian failure, 1B | -1.39 |
| ALKBH5 | AlkB family member 5, RNA demethylase | -1.22 |
| PIP | prolactin-induced protein | -0.93 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.66 |
| NGFR | nerve growth factor receptor | -0.58 |
| FN1 | fibronectin 1 | -0.55 |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit | -0.55 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.55 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.52 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.52 |
| HBA1 | hemoglobin, alpha 1 | -0.52 |
| SPATA7 | spermatogenesis associated 7 | -0.5 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.5 |
| MED8 | mediator complex subunit 8 | -0.5 |
| SLC35A5 | solute carrier family 35, member A5 | -0.48 |
| ERICH5 | glutamate-rich 5 | -0.47 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.47 |
| TXNDC15 | thioredoxin domain containing 15 | -0.46 |
| LYST | lysosomal trafficking regulator | -0.42 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | -0.41 |
| ZYX | zyxin | -0.41 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | -0.4 |
| NCOA4 | nuclear receptor coactivator 4 | -0.4 |
| ECM1 | extracellular matrix protein 1 | -0.4 |
| KLF13 | Kruppel-like factor 13 | -0.39 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.38 |
| CES3 | carboxylesterase 3 | -0.38 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | -0.37 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.37 |
| TRAF5 | TNF receptor-associated factor 5 | -0.36 |
| MARCKSL1 | MARCKS-like 1 | -0.36 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.36 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.36 |
| FBRSL1 | fibrosin-like 1 | -0.36 |
| YAP1 | Yes-associated protein 1 | -0.35 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.35 |
| FKBPL | FK506 binding protein like | -0.35 |
| MTX3 | metaxin 3 | -0.34 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.34 |
| KHSRP | KH-type splicing regulatory protein | -0.34 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.34 |
| IFI30 | interferon, gamma-inducible protein 30 | -0.33 |
| SELENOK | selenoprotein K | -0.33 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.33 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.32 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -0.32 |
| F8A1 | coagulation factor VIII-associated 1 | -0.32 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.32 |
| KRT8 | keratin 8, type II | -0.32 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | -0.32 |
| ZNF282 | zinc finger protein 282 | -0.31 |
| TNNC2 | troponin C type 2 (fast) | -0.31 |
| STYX | serine/threonine/tyrosine interacting protein | -0.31 |
| KMT5B | lysine methyltransferase 5B | -0.31 |
| MYO18B | myosin XVIIIB | -0.31 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.31 |
| EPS15L1 | epidermal growth factor receptor pathway substrate 15-like 1 | -0.31 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.31 |
| GLMP | glycosylated lysosomal membrane protein | -0.31 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.31 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.31 |
| ZNF551 | zinc finger protein 551 | -0.31 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.3 |
| APOL2 | apolipoprotein L, 2 | -0.3 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.3 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | -0.3 |
| GGPS1 | geranylgeranyl diphosphate synthase 1 | -0.3 |
| DCP1B | decapping mRNA 1B | -0.3 |
| PDLIM3 | PDZ and LIM domain 3 | -0.3 |
| FANCC | Fanconi anemia, complementation group C | -0.3 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.3 |
| LETMD1 | LETM1 domain containing 1 | -0.29 |
| MAP2 | microtubule-associated protein 2 | -0.29 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.29 |
| MISP3 | MISP family member 3 | -0.29 |
| IRGQ | immunity-related GTPase family, Q | -0.29 |
| CPE | carboxypeptidase E | -0.29 |
| RABEP1 | rabaptin, RAB GTPase binding effector protein 1 | -0.29 |
| SIRT3 | sirtuin 3 | -0.29 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | -0.29 |
| UBE2F | ubiquitin-conjugating enzyme E2F (putative) | -0.29 |
| TSC22D4 | TSC22 domain family, member 4 | -0.29 |
| S100PBP | S100P binding protein | -0.29 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.29 |
| LMF1 | lipase maturation factor 1 | -0.28 |
| COPS4 | COP9 signalosome subunit 4 | -0.28 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.28 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.28 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.28 |
| SYNE4 | spectrin repeat containing, nuclear envelope family member 4 | -0.28 |
| CCDC158 | coiled-coil domain containing 158 | -0.28 |
| NDRG2 | NDRG family member 2 | -0.28 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.28 |
| ISOC2 | isochorismatase domain containing 2 | -0.28 |
| BAK1 | BCL2-antagonist/killer 1 | -0.28 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.28 |
| TMEM98 | transmembrane protein 98 | -0.28 |
