| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6436173 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Rifaximin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABHD4 | abhydrolase domain containing 4 | 0.79 |
| RBM20 | RNA binding motif protein 20 | 0.71 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.59 |
| SPIN4 | spindlin family, member 4 | 0.57 |
| HYLS1 | hydrolethalus syndrome 1 | 0.54 |
| PACRGL | PARK2 co-regulated-like | 0.53 |
| ADCY9 | adenylate cyclase 9 | 0.49 |
| PLSCR3 | phospholipid scramblase 3 | 0.46 |
| CBLL1 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase | 0.46 |
| RNF13 | ring finger protein 13 | 0.44 |
| BORCS5 | BLOC-1 related complex subunit 5 | 0.43 |
| TFAP2E | transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | 0.42 |
| ARMC7 | armadillo repeat containing 7 | 0.4 |
| ZNF594 | zinc finger protein 594 | 0.39 |
| TRIM37 | tripartite motif containing 37 | 0.38 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | 0.38 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.38 |
| PLD6 | phospholipase D family, member 6 | 0.38 |
| STK17B | serine/threonine kinase 17b | 0.37 |
| RCAN1 | regulator of calcineurin 1 | 0.37 |
| YBX3 | Y box binding protein 3 | 0.36 |
| ZNF320 | zinc finger protein 320 | 0.35 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.35 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.35 |
| S100A2 | S100 calcium binding protein A2 | 0.34 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.33 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.33 |
| TATDN2 | TatD DNase domain containing 2 | 0.33 |
| KAT5 | K(lysine) acetyltransferase 5 | 0.33 |
| MYT1 | myelin transcription factor 1 | 0.33 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.33 |
| REV1 | REV1, polymerase (DNA directed) | 0.32 |
| ZNF362 | zinc finger protein 362 | 0.31 |
| TSPAN33 | tetraspanin 33 | 0.3 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.29 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.29 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.28 |
| COQ4 | coenzyme Q4 | 0.28 |
| PHF1 | PHD finger protein 1 | 0.28 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | 0.28 |
| ANKRD39 | ankyrin repeat domain 39 | 0.28 |
| RTEL1 | regulator of telomere elongation helicase 1 | 0.28 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.27 |
| DCLRE1C | DNA cross-link repair 1C | 0.27 |
| RNF26 | ring finger protein 26 | 0.27 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.27 |
| ADIPOR1 | adiponectin receptor 1 | 0.27 |
| ZFP37 | ZFP37 zinc finger protein | 0.27 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 0.27 |
| IP6K2 | inositol hexakisphosphate kinase 2 | 0.27 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.27 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.27 |
| TP73 | tumor protein p73 | 0.26 |
| MSX1 | msh homeobox 1 | 0.26 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.26 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.26 |
| COMMD8 | COMM domain containing 8 | 0.26 |
| NKAPD1 | NKAP domain containing 1 | 0.26 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.25 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.25 |
| PIH1D1 | PIH1 domain containing 1 | 0.25 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.25 |
| DESI2 | desumoylating isopeptidase 2 | 0.25 |
| KLF10 | Kruppel-like factor 10 | 0.25 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.25 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.25 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.25 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.25 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | 0.24 |
| USP48 | ubiquitin specific peptidase 48 | 0.24 |
| SNIP1 | Smad nuclear interacting protein 1 | 0.24 |
| TMEM9 | transmembrane protein 9 | 0.24 |
| SPTA1 | spectrin, alpha, erythrocytic 1 | 0.24 |
| RGS12 | regulator of G-protein signaling 12 | 0.24 |
| SYTL3 | synaptotagmin-like 3 | 0.24 |
| CCDC138 | coiled-coil domain containing 138 | 0.24 |
| CEP152 | centrosomal protein 152kDa | 0.24 |
| COMMD3 | COMM domain containing 3 | 0.23 |
| NABP1 | nucleic acid binding protein 1 | 0.23 |
| SNTA1 | syntrophin, alpha 1 | 0.23 |
| CCDC117 | coiled-coil domain containing 117 | 0.23 |
| ELOB | elongin B | 0.23 |
| C7 | complement component 7 | 0.23 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.23 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.23 |
| LINS1 | lines homolog 1 | 0.23 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.23 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.23 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.22 |
| SP100 | SP100 nuclear antigen | 0.22 |
| PPFIA3 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 | 0.22 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.22 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.22 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.22 |
| METTL6 | methyltransferase like 6 | 0.22 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.22 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.21 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.21 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMOD1 | leiomodin 1 (smooth muscle) | -1.36 |
| FGA | fibrinogen alpha chain | -1.06 |
| FN1 | fibronectin 1 | -1.0 |
| GGACT | gamma-glutamylamine cyclotransferase | -0.72 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | -0.69 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | -0.66 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.62 |
| ZNF689 | zinc finger protein 689 | -0.62 |
| GRAMD4 | GRAM domain containing 4 | -0.51 |
| ZNF267 | zinc finger protein 267 | -0.47 |
| WDR25 | WD repeat domain 25 | -0.46 |
| MT-ATP6 | ATP synthase F0 subunit 6 | -0.45 |
| ZNF714 | zinc finger protein 714 | -0.45 |
| ZNF532 | zinc finger protein 532 | -0.45 |
| DAP | death-associated protein | -0.43 |
| PNPO | pyridoxamine 5'-phosphate oxidase | -0.42 |
| CCDC110 | coiled-coil domain containing 110 | -0.42 |
| TCTN1 | tectonic family member 1 | -0.41 |
| RUNX3 | runt-related transcription factor 3 | -0.4 |
| TMEM59 | transmembrane protein 59 | -0.4 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.4 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.4 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.4 |
| ITGA1 | integrin, alpha 1 | -0.38 |
| NOL12 | nucleolar protein 12 | -0.38 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.38 |
| CMC1 | C-x(9)-C motif containing 1 | -0.37 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.37 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | -0.37 |
| RNFT2 | ring finger protein, transmembrane 2 | -0.36 |
| ATXN7L3B | ataxin 7-like 3B | -0.36 |
| CCDC32 | coiled-coil domain containing 32 | -0.36 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.36 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -0.36 |
| GJB3 | gap junction protein, beta 3, 31kDa | -0.36 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.35 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.35 |
| TANK | TRAF family member-associated NFKB activator | -0.35 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.35 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.35 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.35 |
| MRPS14 | mitochondrial ribosomal protein S14 | -0.35 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.34 |
| SUCO | SUN domain containing ossification factor | -0.34 |
| ZBTB41 | zinc finger and BTB domain containing 41 | -0.34 |
| RNF167 | ring finger protein 167 | -0.34 |
| ZNF623 | zinc finger protein 623 | -0.34 |
| HBA1 | hemoglobin, alpha 1 | -0.34 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.33 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.33 |
| TMEM102 | transmembrane protein 102 | -0.32 |
| FAM133A | family with sequence similarity 133, member A | -0.32 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.32 |
| ZNF672 | zinc finger protein 672 | -0.32 |
| TRNP1 | TMF1-regulated nuclear protein 1 | -0.32 |
| FRK | fyn-related Src family tyrosine kinase | -0.32 |
| NDUFA8 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa | -0.32 |
| PUS10 | pseudouridylate synthase 10 | -0.32 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | -0.32 |
| SLC35A5 | solute carrier family 35, member A5 | -0.31 |
| ZNF276 | zinc finger protein 276 | -0.31 |
| CCDC82 | coiled-coil domain containing 82 | -0.31 |
| AXL | AXL receptor tyrosine kinase | -0.31 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | -0.31 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -0.31 |
| ITGA7 | integrin, alpha 7 | -0.31 |
| MSH5 | mutS homolog 5 | -0.3 |
| VSIR | V-set immunoregulatory receptor | -0.3 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.3 |
| SMAP1 | small ArfGAP 1 | -0.3 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | -0.3 |
| CCDC158 | coiled-coil domain containing 158 | -0.3 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.3 |
| NCKAP1L | NCK-associated protein 1-like | -0.3 |
| DENND5A | DENN/MADD domain containing 5A | -0.3 |
| ZNF335 | zinc finger protein 335 | -0.3 |
| HDDC3 | HD domain containing 3 | -0.3 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.29 |
| JRK | Jrk homolog (mouse) | -0.29 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.29 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.29 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.29 |
| GCDH | glutaryl-CoA dehydrogenase | -0.29 |
| ZNF282 | zinc finger protein 282 | -0.29 |
| REPIN1 | replication initiator 1 | -0.29 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.28 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.28 |
| ABLIM2 | actin binding LIM protein family, member 2 | -0.28 |
| KSR1 | kinase suppressor of ras 1 | -0.28 |
| PEX26 | peroxisomal biogenesis factor 26 | -0.28 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.28 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.28 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | -0.28 |
| ZNF264 | zinc finger protein 264 | -0.28 |
| APOE | apolipoprotein E | -0.27 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.27 |
| CMTM6 | CKLF-like MARVEL transmembrane domain containing 6 | -0.27 |
| CKM | creatine kinase, muscle | -0.27 |
| ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | -0.27 |
