Rifaximin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rifaximin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.147604
VIM vimentin 0.117555
PDE4D phosphodiesterase 4D, cAMP-specific 0.0852463
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0770487
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0758986
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0570509
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.05059
YBX3 Y box binding protein 3 0.0502231
TAS2R14 taste receptor, type 2, member 14 0.0497645
RPL7 ribosomal protein L7 0.0496984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0493739
EIF4A2 eukaryotic translation initiation factor 4A2 0.0476937
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0470605
ZBTB20 zinc finger and BTB domain containing 20 0.0469609
PTMA prothymosin, alpha 0.0464128
TPR translocated promoter region, nuclear basket protein 0.044877
KIF5B kinesin family member 5B 0.0446358
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0431131
ATP11A ATPase, class VI, type 11A 0.0429066
SPATS2 spermatogenesis associated, serine-rich 2 0.0406066
CSNK1A1 casein kinase 1, alpha 1 0.0403894
MKI67 marker of proliferation Ki-67 0.0395909
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0385957
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0382376
EHBP1 EH domain binding protein 1 0.0367605
AREG amphiregulin 0.0361349
CEP192 centrosomal protein 192kDa 0.0339078
AHNAK AHNAK nucleoprotein 0.0336882
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0325602
OGA O-GlcNAcase 0.0324886
KDM3A lysine (K)-specific demethylase 3A 0.0324782
CXADR coxsackie virus and adenovirus receptor 0.0322945
EPHA6 EPH receptor A6 0.0317814
CELF2 CUGBP, Elav-like family member 2 0.0314005
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0309556
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0307845
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0304856
CHD1 chromodomain helicase DNA binding protein 1 0.0298526
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0296782
KTN1 kinectin 1 (kinesin receptor) 0.0295144
SERINC1 serine incorporator 1 0.0293689
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0292473
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0290974
ZNF292 zinc finger protein 292 0.0290663
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.028849
BCAS3 breast carcinoma amplified sequence 3 0.0286799
NOP58 NOP58 ribonucleoprotein 0.0280178
EDARADD EDAR-associated death domain 0.0272565
WWOX WW domain containing oxidoreductase 0.0271406
MED13L mediator complex subunit 13-like 0.0266255
TRA2B transformer 2 beta homolog (Drosophila) 0.02659
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0263543
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0261967
EIF4B eukaryotic translation initiation factor 4B 0.0261553
XPOT exportin, tRNA 0.0261508
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0261301
PUM2 pumilio RNA-binding family member 2 0.0259699
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.025735
USP1 ubiquitin specific peptidase 1 0.0255392
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0255252
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0247144
PGK1 phosphoglycerate kinase 1 0.0244768
KIAA1328 KIAA1328 0.024412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243791
CAMTA1 calmodulin binding transcription activator 1 0.0240307
FER fer (fps/fes related) tyrosine kinase 0.023986
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0238901
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0234703
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0234029
ANXA2 annexin A2 0.0232334
CAMKMT calmodulin-lysine N-methyltransferase 0.0230731
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0229818
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0226336
PA2G4 proliferation-associated 2G4, 38kDa 0.0225824
RBM39 RNA binding motif protein 39 0.0224254
GCG glucagon 0.0222736
POU2F1 POU class 2 homeobox 1 0.0218706
EXOC6B exocyst complex component 6B 0.0218641
SINHCAF SIN3-HDAC complex associated factor 0.0218334
RRM2 ribonucleotide reductase M2 0.0217409
EEF1G eukaryotic translation elongation factor 1 gamma 0.0217174
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0216899
CEP95 centrosomal protein 95kDa 0.0216519
USP53 ubiquitin specific peptidase 53 0.0216409
PRRC2C proline-rich coiled-coil 2C 0.0214748
RAD21 RAD21 homolog (S. pombe) 0.0213539
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0213358
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0213086
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.021217
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0210522
YEATS2 YEATS domain containing 2 0.021029
SMYD3 SET and MYND domain containing 3 0.0209233
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0209152
PNISR PNN-interacting serine/arginine-rich protein 0.0208365
XRN1 5'-3' exoribonuclease 1 0.0208108
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0207904
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0207449
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0205826
SEC31A SEC31 homolog A (S. cerevisiae) 0.020455
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0204534

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138203
TMSB10 thymosin beta 10 -0.117431
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0862972
POTEF POTE ankyrin domain family, member F -0.0697666
PFN1 profilin 1 -0.0588335
HMGA1 high mobility group AT-hook 1 -0.0577894
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0556192
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0527957
FTL ferritin, light polypeptide -0.0518282
EGR1 early growth response 1 -0.043368
CCN2 cellular communication network factor 2 -0.0368265
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0357474
PCDH7 protocadherin 7 -0.0349099
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0336023
RPS2 ribosomal protein S2 -0.0332247
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0332242
RPS6 ribosomal protein S6 -0.0328708
CCNL1 cyclin L1 -0.0324184
CLDN1 claudin 1 -0.0315322
SLC38A2 solute carrier family 38, member 2 -0.0313278
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0304777
ACTG1 actin gamma 1 -0.030463
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0304357
PDIA6 protein disulfide isomerase family A, member 6 -0.0303594
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0295863
HSPB1 heat shock 27kDa protein 1 -0.0288417
RASAL2 RAS protein activator like 2 -0.0283267
TUBA1B tubulin, alpha 1b -0.0278209
PTMS parathymosin -0.0273574
RPL37 ribosomal protein L37 -0.0272093
CLTC clathrin, heavy chain (Hc) -0.0268595
GNAS GNAS complex locus -0.0266077
JMJD1C jumonji domain containing 1C -0.0264339
NHSL1 NHS-like 1 -0.025785
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0254458
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0251944
EEF2 eukaryotic translation elongation factor 2 -0.0251409
RPS19 ribosomal protein S19 -0.0245653
NABP1 nucleic acid binding protein 1 -0.0241208
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0236857
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0229442
IPO7 importin 7 -0.0225207
KIF2A kinesin heavy chain member 2A -0.0222774
ARL15 ADP-ribosylation factor-like 15 -0.0222159
HMGA2 high mobility group AT-hook 2 -0.021961
C6ORF62 chromosome 6 open reading frame 62 -0.0219357
CNRIP1 cannabinoid receptor interacting protein 1 -0.0219284
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0209634
CREBBP CREB binding protein -0.0209203
TPI1 triosephosphate isomerase 1 -0.020855
ATP5F1B ATP synthase F1 subunit beta -0.0207396
RPS11 ribosomal protein S11 -0.0205241
NLGN1 neuroligin 1 -0.0205164
MYADM myeloid-associated differentiation marker -0.0204723
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.0204159
ENO1 enolase 1, (alpha) -0.0198223
CSMD3 CUB and Sushi multiple domains 3 -0.0197686
ZNF804A zinc finger protein 804A -0.0197179
TAPBP TAP binding protein (tapasin) -0.0191045
ANKRD17 ankyrin repeat domain 17 -0.018751
BMPR1B bone morphogenetic protein receptor, type IB -0.0183166
PDIA3 protein disulfide isomerase family A, member 3 -0.0180537
RTN3 reticulon 3 -0.0178951
S100A11 S100 calcium binding protein A11 -0.0177543
RPS14 ribosomal protein S14 -0.0171418
DLC1 DLC1 Rho GTPase activating protein -0.0170398
ZNF207 zinc finger protein 207 -0.0170362
PRKCE protein kinase C, epsilon -0.0165794
SRRM2 serine/arginine repetitive matrix 2 -0.0165466
ATN1 atrophin 1 -0.0164776
VMP1 vacuole membrane protein 1 -0.0161893
SHTN1 shootin 1 -0.0159562
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0159325
NCKAP1 NCK-associated protein 1 -0.015889
LMO7 LIM domain 7 -0.015603
PAPOLA poly(A) polymerase alpha -0.0155421
ENAH enabled homolog (Drosophila) -0.0155156
PFN2 profilin 2 -0.0154093
ACLY ATP citrate lyase -0.0153478
TNPO3 transportin 3 -0.0151488
RPS3 ribosomal protein S3 -0.0151477
FASN fatty acid synthase -0.0151163
CUX1 cut-like homeobox 1 -0.0149002
MRPL19 mitochondrial ribosomal protein L19 -0.0147473
MAP4 microtubule-associated protein 4 -0.0147354
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0147263
TRAF3 TNF receptor-associated factor 3 -0.0146244
GLG1 golgi glycoprotein 1 -0.0144697
IGF2 insulin-like growth factor 2 -0.0144455
SLC25A39 solute carrier family 25, member 39 -0.0143292
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0138951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0138886
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0138877
TCF12 transcription factor 12 -0.0137662
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0136214
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0135621
RNF13 ring finger protein 13 -0.0134974
LOC102724023 ES1 protein homolog, mitochondrial -0.0134751
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0134465
RPL34 ribosomal protein L34 -0.0134034