Rifaximin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.147656
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.118618
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.116017
LSAMP limbic system-associated membrane protein 0.0913263
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0840686
FAM13A family with sequence similarity 13, member A 0.0699176
AKAP12 A kinase (PRKA) anchor protein 12 0.0685712
CENPF centromere protein F, 350/400kDa 0.0674914
SEPTIN9 septin 9 0.0627702
STC1 stanniocalcin 1 0.0618169
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0600642
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0588895
PSD3 pleckstrin and Sec7 domain containing 3 0.0560875
MSI2 musashi RNA-binding protein 2 0.0551599
PLAT plasminogen activator, tissue 0.0542513
PTPRD protein tyrosine phosphatase, receptor type, D 0.0539134
SOS1 son of sevenless homolog 1 (Drosophila) 0.0516198
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0468866
THSD4 thrombospondin, type I, domain containing 4 0.0454303
SMYD3 SET and MYND domain containing 3 0.0433169
CRH corticotropin releasing hormone 0.0428403
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.0405619
NDRG1 N-myc downstream regulated 1 0.040465
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0403876
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0403812
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0402018
NUP58 nucleoporin 58 0.0401874
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0394586
PGK1 phosphoglycerate kinase 1 0.0384394
ARHGAP9 Rho GTPase activating protein 9 0.0380991
ASPH aspartate beta-hydroxylase 0.0379058
LIMCH1 LIM and calponin homology domains 1 0.037681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.037513
UBA6 ubiquitin-like modifier activating enzyme 6 0.0359852
MACF1 microtubule-actin crosslinking factor 1 0.0357929
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.035714
CEP95 centrosomal protein 95kDa 0.0357085
LINGO2 leucine rich repeat and Ig domain containing 2 0.0350429
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.034935
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0343947
RAD51B RAD51 paralog B 0.0329306
NCOR2 nuclear receptor corepressor 2 0.0327966
NREP neuronal regeneration related protein 0.0324772
DACH2 dachshund family transcription factor 2 0.031632
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0312506
PDS5A PDS5 cohesin associated factor A 0.0312071
NALF1 NALCN channel auxiliary factor 1 0.0309579
COPA coatomer protein complex, subunit alpha 0.0303679
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0302091
AHNAK AHNAK nucleoprotein 0.0300793
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0300749
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0297708
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.0295665
ATXN1 ataxin 1 0.0293981
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0291043
KDM4C lysine (K)-specific demethylase 4C 0.0286292
NBAS neuroblastoma amplified sequence 0.0285576
ZNF638 zinc finger protein 638 0.0283537
KIF5B kinesin family member 5B 0.0280167
HELZ helicase with zinc finger 0.0279702
CPED1 cadherin-like and PC-esterase domain containing 1 0.0278406
LCORL ligand dependent nuclear receptor corepressor-like 0.0278388
NES nestin 0.0277566
ZNF148 zinc finger protein 148 0.0275269
RABGAP1L RAB GTPase activating protein 1-like 0.0270817
SON SON DNA binding protein 0.0269956
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0268551
CCNY cyclin Y 0.0266167
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0265033
NFIA nuclear factor I/A 0.0263575
SLITRK6 SLIT and NTRK-like family, member 6 0.0262468
MRTFA myocardin related transcription factor A 0.0261166
SSBP3 single stranded DNA binding protein 3 0.0260069
PEAK1 pseudopodium-enriched atypical kinase 1 0.0259013
RB1CC1 RB1-inducible coiled-coil 1 0.0257919
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0257899
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0256943
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0256135
ATXN10 ataxin 10 0.0252352
RBMX RNA binding motif protein, X-linked 0.0252199
CDK19 cyclin-dependent kinase 19 0.0252081
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0250876
MED13 mediator complex subunit 13 0.0250617
SLC35F3 solute carrier family 35, member F3 0.0250071
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.024994
MKI67 marker of proliferation Ki-67 0.0249937
MYO1B myosin IB 0.0245447
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0245405
ASCC3 activating signal cointegrator 1 complex subunit 3 0.024473
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0244585
RBM20 RNA binding motif protein 20 0.0244263
DCAF7 DDB1 and CUL4 associated factor 7 0.0242772
RIC1 RAB6A GEF complex partner 1 0.0242745
VCAN versican 0.0240207
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0239966
PRR11 proline rich 11 0.0239904
LONP2 lon peptidase 2, peroxisomal 0.0238274
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237912
AFDN afadin, adherens junction formation factor 0.0237501
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0237101

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17158
IGF2 insulin-like growth factor 2 -0.160174
SYT1 synaptotagmin I -0.0912003
FRMD4A FERM domain containing 4A -0.09038
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0769657
TPST1 tyrosylprotein sulfotransferase 1 -0.0681756
RPL19 ribosomal protein L19 -0.0626539
VCL vinculin -0.0600202
TMSB10 thymosin beta 10 -0.0592647
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0581609
PTMA prothymosin, alpha -0.056823
COL1A1 collagen, type I, alpha 1 -0.0544918
MBD5 methyl-CpG binding domain protein 5 -0.0536227
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0515395
NCOA7 nuclear receptor coactivator 7 -0.0495361
FTL ferritin, light polypeptide -0.0488725
ACTG1 actin gamma 1 -0.0480118
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0466822
RPL31 ribosomal protein L31 -0.0464265
RPLP1 ribosomal protein, large, P1 -0.0457661
RPL34 ribosomal protein L34 -0.0453963
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0443473
RPL23 ribosomal protein L23 -0.0430759
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0429061
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0424266
RPS19 ribosomal protein S19 -0.0419462
LMNA lamin A/C -0.0416005
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0415543
NRP1 neuropilin 1 -0.0412234
ANKRD17 ankyrin repeat domain 17 -0.0411328
RPS6 ribosomal protein S6 -0.0400933
EIF1 eukaryotic translation initiation factor 1 -0.0397975
CALD1 caldesmon 1 -0.0393341
EXT1 exostosin glycosyltransferase 1 -0.0371486
CEMIP cell migration inducing protein, hyaluronan binding -0.0368379
RPL35A ribosomal protein L35a -0.0366465
SIK2 salt-inducible kinase 2 -0.0363505
NCAM2 neural cell adhesion molecule 2 -0.0361478
RPS12 ribosomal protein S12 -0.0360932
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0359597
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.035555
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0353918
RPS24 ribosomal protein S24 -0.0349062
RPL36 ribosomal protein L36 -0.0348766
MAP1B microtubule-associated protein 1B -0.0342324
RPL38 ribosomal protein L38 -0.0341911
ACBD3 acyl-CoA binding domain containing 3 -0.034168
TRIO trio Rho guanine nucleotide exchange factor -0.0340882
MBNL2 muscleblind-like splicing regulator 2 -0.0339606
RNF213 ring finger protein 213 -0.0338995
RPL26 ribosomal protein L26 -0.0337032
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0332942
RAB2A RAB2A, member RAS oncogene family -0.0326867
SLC38A2 solute carrier family 38, member 2 -0.0317359
H1-0 H1.0 linker histone -0.0313181
ZFAND3 zinc finger, AN1-type domain 3 -0.0309827
NEK7 NIMA-related kinase 7 -0.030853
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0307315
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0301832
ARF1 ADP-ribosylation factor 1 -0.0301619
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0300873
RPLP0 ribosomal protein, large, P0 -0.0295113
RPS27A ribosomal protein S27a -0.0293431
FKBP10 FK506 binding protein 10, 65 kDa -0.0290772
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0285784
RPS14 ribosomal protein S14 -0.0285399
MYO9A myosin IXA -0.0281584
RPL27 ribosomal protein L27 -0.0280236
RIGI RNA sensor RIG-I -0.027806
RPS23 ribosomal protein S23 -0.0274695
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0269891
TLE4 transducin-like enhancer of split 4 -0.0268906
EIF5B eukaryotic translation initiation factor 5B -0.0267809
SP100 SP100 nuclear antigen -0.0266422
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0264995
SDCCAG8 serologically defined colon cancer antigen 8 -0.0263138
MTSS2 MTSS I-BAR domain containing 2 -0.025997
ARHGAP5 Rho GTPase activating protein 5 -0.0258937
GLCCI1 glucocorticoid induced 1 -0.0258461
LOC112694756 uncharaterized LOC112694756 -0.0257978
RPL32 ribosomal protein L32 -0.0257849
TPT1 tumor protein, translationally-controlled 1 -0.0255356
RPL8 ribosomal protein L8 -0.0254777
UBE2B ubiquitin-conjugating enzyme E2B -0.0253313
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0252252
OPTN optineurin -0.025216
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0248714
SYNPO2 synaptopodin 2 -0.0248531
TPM1 tropomyosin 1 (alpha) -0.0247897
PALLD palladin, cytoskeletal associated protein -0.0245734
RPL9 ribosomal protein L9 -0.0242439
ETV1 ets variant 1 -0.0239802
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0238385
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0237968
RPS25 ribosomal protein S25 -0.0237417
RBM25 RNA binding motif protein 25 -0.0236746
CELF1 CUGBP, Elav-like family member 1 -0.0236636
RAB10 RAB10, member RAS oncogene family -0.0234121
TNPO1 transportin 1 -0.0233784
TXNRD1 thioredoxin reductase 1 -0.0232669