Rifaximin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PHF3 PHD finger protein 3 0.0702584
ARHGAP26 Rho GTPase activating protein 26 0.0623644
BTBD9 BTB (POZ) domain containing 9 0.058655
GMDS GDP-mannose 4,6-dehydratase 0.0551647
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0546427
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0527888
RBM39 RNA binding motif protein 39 0.0457425
FNDC3B fibronectin type III domain containing 3B 0.0452949
CANX calnexin 0.0448201
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0446036
FNIP1 folliculin interacting protein 1 0.0426725
NPSR1 neuropeptide S receptor 1 0.0404665
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0403127
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0393302
EPSTI1 epithelial stromal interaction 1 (breast) 0.0390373
FAT1 FAT atypical cadherin 1 0.038842
RABGAP1L RAB GTPase activating protein 1-like 0.0384709
GOLGB1 golgin B1 0.0379358
STK39 serine threonine kinase 39 0.0373804
MSI2 musashi RNA-binding protein 2 0.0360748
AHI1 Abelson helper integration site 1 0.0340456
DSCAM Down syndrome cell adhesion molecule 0.0339538
LYZ lysozyme 0.0336151
MX1 MX dynamin-like GTPase 1 0.0335239
TRIO trio Rho guanine nucleotide exchange factor 0.0332094
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0328964
KIF16B kinesin family member 16B 0.0315712
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0311106
GRK3 G protein-coupled receptor kinase 3 0.0301525
GNPDA1 glucosamine-6-phosphate deaminase 1 0.030072
STS steroid sulfatase (microsomal), isozyme S 0.0293668
SQSTM1 sequestosome 1 0.0290715
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0289672
APP amyloid beta (A4) precursor protein 0.0287438
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0282887
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0280497
PRELID2 PRELI domain containing 2 0.0278329
SPATA13 spermatogenesis associated 13 0.0275095
MAML2 mastermind-like 2 (Drosophila) 0.0273279
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0267781
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0265586
PRKCA protein kinase C, alpha 0.0264302
KDM6A lysine (K)-specific demethylase 6A 0.0264189
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0261913
MBNL2 muscleblind-like splicing regulator 2 0.0259742
NF1 neurofibromin 1 0.0258914
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0258189
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0255694
ADAM10 ADAM metallopeptidase domain 10 0.0248143
CEMIP2 cell migration inducing hyaluronidase 2 0.0244278
PADI1 peptidyl arginine deiminase, type I 0.0241811
PLSCR1 phospholipid scramblase 1 0.024134
SRSF1 serine/arginine-rich splicing factor 1 0.0240617
SREBF2 sterol regulatory element binding transcription factor 2 0.0240124
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0237486
PTEN phosphatase and tensin homolog 0.0236028
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0234889
EXT1 exostosin glycosyltransferase 1 0.0233993
TAS2R14 taste receptor, type 2, member 14 0.0233813
ZBTB20 zinc finger and BTB domain containing 20 0.0228886
LNPEP leucyl/cystinyl aminopeptidase 0.0228466
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.022655
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0226513
SSH2 slingshot protein phosphatase 2 0.0222491
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0222391
TMEM39A transmembrane protein 39A 0.0220799
HDAC4 histone deacetylase 4 0.0217811
CCDC146 coiled-coil domain containing 146 0.0215895
RAD51B RAD51 paralog B 0.021414
SAMD4A sterile alpha motif domain containing 4A 0.0212513
FNDC3A fibronectin type III domain containing 3A 0.0211958
BCLAF1 BCL2-associated transcription factor 1 0.021145
ERBIN erbb2 interacting protein 0.0210991
ASPH aspartate beta-hydroxylase 0.0206947
MCTP2 multiple C2 domains, transmembrane 2 0.0204268
ZNF148 zinc finger protein 148 0.0203217
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0201695
ZNF638 zinc finger protein 638 0.0201689
ETV6 ets variant 6 0.0200262
GOLGA2 golgin A2 0.0198966
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0194697
SFPQ splicing factor proline/glutamine-rich 0.0193363
ARHGAP32 Rho GTPase activating protein 32 0.0191211
YEATS2 YEATS domain containing 2 0.0188027
EHBP1 EH domain binding protein 1 0.0187366
XRN1 5'-3' exoribonuclease 1 0.0186284
SERINC5 serine incorporator 5 0.0184718
ALPK1 alpha-kinase 1 0.0183214
POF1B premature ovarian failure, 1B 0.0182401
SP3 Sp3 transcription factor 0.0180602
FMN1 formin 1 0.0180011
RARS1 arginyl-tRNA synthetase 1 0.0178831
MYH9 myosin, heavy chain 9, non-muscle 0.0178405
PTPRJ protein tyrosine phosphatase, receptor type, J 0.017809
CATSPERB catsper channel auxiliary subunit beta 0.0177452
RIGI RNA sensor RIG-I 0.0177109
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0175512
ETNK1 ethanolamine kinase 1 0.0174433
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.017331
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0173045

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.24512
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.203321
TPT1 tumor protein, translationally-controlled 1 -0.142054
LCN2 lipocalin 2 -0.133819
HLA-B major histocompatibility complex, class I, B -0.116978
FTL ferritin, light polypeptide -0.105543
RPS6 ribosomal protein S6 -0.103206
EGR1 early growth response 1 -0.0961292
IFI6 interferon, alpha-inducible protein 6 -0.0915215
TMSB10 thymosin beta 10 -0.0793805
MT2A metallothionein 2A -0.0768963
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0749224
RPL35A ribosomal protein L35a -0.0739961
RPLP1 ribosomal protein, large, P1 -0.0720855
EIF1 eukaryotic translation initiation factor 1 -0.0694176
NDRG1 N-myc downstream regulated 1 -0.0693934
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.068079
C6ORF132 chromosome 6 open reading frame 132 -0.067209
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0658603
RPL23 ribosomal protein L23 -0.0599069
RPS19 ribosomal protein S19 -0.0597327
PTMA prothymosin, alpha -0.0544797
PKM pyruvate kinase, muscle -0.0541606
IFI27 interferon, alpha-inducible protein 27 -0.0533614
S100A10 S100 calcium binding protein A10 -0.0519662
GCLC glutamate-cysteine ligase, catalytic subunit -0.0514349
RPL19 ribosomal protein L19 -0.0498507
RPL34 ribosomal protein L34 -0.0493676
LOC102724023 ES1 protein homolog, mitochondrial -0.0490141
RPS8 ribosomal protein S8 -0.0469852
MYO1E myosin IE -0.0463176
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0453413
CLDN4 claudin 4 -0.0445461
LOC112694756 uncharaterized LOC112694756 -0.0441973
PERP PERP, TP53 apoptosis effector -0.0439269
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0435188
CST3 cystatin C -0.0417613
RPL37A ribosomal protein L37a -0.0412222
POTEF POTE ankyrin domain family, member F -0.0410096
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0409154
TXNIP thioredoxin interacting protein -0.0405522
HLA-C major histocompatibility complex, class I, C -0.0400323
CSTB cystatin B (stefin B) -0.0395408
RPLP2 ribosomal protein, large, P2 -0.0387526
RPS3 ribosomal protein S3 -0.0385476
RPL31 ribosomal protein L31 -0.0380214
RPL28 ribosomal protein L28 -0.0376036
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0373778
RPS27 ribosomal protein S27 -0.0370607
UBE2B ubiquitin-conjugating enzyme E2B -0.0370235
RPS29 ribosomal protein S29 -0.0356423
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0352873
IFITM3 interferon induced transmembrane protein 3 -0.0351771
ACTG1 actin gamma 1 -0.0348553
AREG amphiregulin -0.0347909
RPL12 ribosomal protein L12 -0.0347203
DSTN destrin (actin depolymerizing factor) -0.0342938
RPL36 ribosomal protein L36 -0.0338596
RPL11 ribosomal protein L11 -0.0334594
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0333918
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0325765
MT1X metallothionein 1X -0.03254
RPS23 ribosomal protein S23 -0.0323161
RPL37 ribosomal protein L37 -0.0322684
LMO7 LIM domain 7 -0.0320211
WSB1 WD repeat and SOCS box containing 1 -0.0318069
TPI1 triosephosphate isomerase 1 -0.0317992
ATF4 activating transcription factor 4 -0.0317348
RUNX1 runt-related transcription factor 1 -0.0314981
RPL7A ribosomal protein L7a -0.0314752
RPL18 ribosomal protein L18 -0.0313956
SLC38A1 solute carrier family 38, member 1 -0.0310957
RPL30 ribosomal protein L30 -0.0307601
PRRC2C proline-rich coiled-coil 2C -0.0298847
ENO1 enolase 1, (alpha) -0.0292084
GNAS GNAS complex locus -0.0291389
RPS13 ribosomal protein S13 -0.0288904
RHOBTB3 Rho-related BTB domain containing 3 -0.0288447
RPS25 ribosomal protein S25 -0.0284384
HLA-A major histocompatibility complex, class I, A -0.0283747
SERF2 small EDRK-rich factor 2 -0.02837
RACK1 receptor for activated C kinase 1 -0.0282899
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.028006
RPS24 ribosomal protein S24 -0.0279966
ENO2 enolase 2 (gamma, neuronal) -0.027934
RPL38 ribosomal protein L38 -0.0279249
KLF6 Kruppel-like factor 6 -0.0278665
RPS16 ribosomal protein S16 -0.0276548
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276526
NAMPT nicotinamide phosphoribosyltransferase -0.0273969
RPS4X ribosomal protein S4, X-linked -0.0273798
AKAP9 A kinase (PRKA) anchor protein 9 -0.0270453
POMP proteasome maturation protein -0.0267411
RPS28 ribosomal protein S28 -0.0267091
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0267004
S100A11 S100 calcium binding protein A11 -0.0258818
S100P S100 calcium binding protein P -0.0257929
RBM25 RNA binding motif protein 25 -0.0257505
RPL35 ribosomal protein L35 -0.0256811
VIM vimentin -0.0255088