Rifaximin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0760736
TF transferrin 0.0752697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0698191
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0662047
C3 complement component 3 0.056306
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.053805
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0517866
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0516891
AFDN afadin, adherens junction formation factor 0.0506046
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0503363
TNS1 tensin 1 0.047478
RPL7 ribosomal protein L7 0.042579
CAMTA1 calmodulin binding transcription activator 1 0.0415638
RBM39 RNA binding motif protein 39 0.0395483
RB1CC1 RB1-inducible coiled-coil 1 0.0366115
ELL2 elongation factor, RNA polymerase II, 2 0.0364427
DTNA dystrobrevin, alpha 0.0360335
DSCAM Down syndrome cell adhesion molecule 0.0356396
TOP1 topoisomerase (DNA) I 0.0352517
APLP2 amyloid beta (A4) precursor-like protein 2 0.0349728
INSIG2 insulin induced gene 2 0.034502
EPS8 epidermal growth factor receptor pathway substrate 8 0.0339235
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0336104
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0324673
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0324038
HELZ helicase with zinc finger 0.0318459
ZNF292 zinc finger protein 292 0.0314859
EIF4B eukaryotic translation initiation factor 4B 0.0310726
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0299171
MYO1B myosin IB 0.0298314
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0297669
NGLY1 N-glycanase 1 0.0296701
KTN1 kinectin 1 (kinesin receptor) 0.0294993
PTBP3 polypyrimidine tract binding protein 3 0.0289978
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0282231
GOLGA4 golgin A4 0.0281725
PCBP2 poly(rC) binding protein 2 0.0272898
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0270269
YTHDC1 YTH domain containing 1 0.0266804
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266564
SESTD1 SEC14 and spectrin domains 1 0.0266472
UBA6 ubiquitin-like modifier activating enzyme 6 0.0266246
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0265661
PCGF5 polycomb group ring finger 5 0.0263795
VEGFA vascular endothelial growth factor A 0.0260448
PICALM phosphatidylinositol binding clathrin assembly protein 0.0257037
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0256463
ZEB1 zinc finger E-box binding homeobox 1 0.0252198
GMDS GDP-mannose 4,6-dehydratase 0.0251524
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0243837
PTK2 protein tyrosine kinase 2 0.0241597
SNX9 sorting nexin 9 0.0241151
LCOR ligand dependent nuclear receptor corepressor 0.0240448
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0240257
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0240233
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0240212
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0234682
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0233184
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0232967
HOOK2 hook microtubule-tethering protein 2 0.023295
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0228171
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0226646
ATRN attractin 0.0226632
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0226302
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0225811
RBM25 RNA binding motif protein 25 0.0224647
ESYT2 extended synaptotagmin-like protein 2 0.0224211
NCKAP1 NCK-associated protein 1 0.0224197
COLEC11 collectin sub-family member 11 0.0222442
DIAPH1 diaphanous-related formin 1 0.0222079
KIF1B kinesin family member 1B 0.0218504
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0217947
KDM6A lysine (K)-specific demethylase 6A 0.0216964
NAMPT nicotinamide phosphoribosyltransferase 0.0214913
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0213233
CDC27 cell division cycle 27 0.0212429
PGK1 phosphoglycerate kinase 1 0.0211685
SMC5 structural maintenance of chromosomes 5 0.0211476
RPS18 ribosomal protein S18 0.0210859
ARF4 ADP-ribosylation factor 4 0.0210794
RICTOR RPTOR independent companion of MTOR, complex 2 0.0210023
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0209142
NPTN neuroplastin 0.0203345
NUP58 nucleoporin 58 0.0202431
ANXA5 annexin A5 0.0202428
FMNL2 formin-like 2 0.0202273
ARHGAP12 Rho GTPase activating protein 12 0.0202266
RREB1 ras responsive element binding protein 1 0.0202002
OLA1 Obg-like ATPase 1 0.0202
DDIT4 DNA-damage-inducible transcript 4 0.0201906
WAC WW domain containing adaptor with coiled-coil 0.0198835
CCNY cyclin Y 0.0197611
GSE1 Gse1 coiled-coil protein 0.0195458
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0195168
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0194905
TRA2A transformer 2 alpha homolog (Drosophila) 0.0194704
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0192584
SUCO SUN domain containing ossification factor 0.0192373
MAPK6 mitogen-activated protein kinase 6 0.0192067
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0191578

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.250055
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.144402
MT2A metallothionein 2A -0.138694
APOB apolipoprotein B -0.132861
IGFBP1 insulin-like growth factor binding protein 1 -0.107097
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1041
TPT1 tumor protein, translationally-controlled 1 -0.103248
EHBP1 EH domain binding protein 1 -0.0882661
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0866238
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0831585
FN1 fibronectin 1 -0.0814808
NKD1 naked cuticle homolog 1 (Drosophila) -0.0770307
TMSB10 thymosin beta 10 -0.0737219
APOA2 apolipoprotein A-II -0.0688466
GPC3 glypican 3 -0.0652417
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0628997
TM4SF1 transmembrane 4 L six family member 1 -0.060138
GPC6 glypican 6 -0.0578161
NPAS2 neuronal PAS domain protein 2 -0.049939
MAML2 mastermind-like 2 (Drosophila) -0.0492214
PTCHD4 patched domain containing 4 -0.0489852
RPL37A ribosomal protein L37a -0.0483745
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0458107
FTL ferritin, light polypeptide -0.0440123
SLC38A2 solute carrier family 38, member 2 -0.0426575
RPS19 ribosomal protein S19 -0.0424897
RPS6 ribosomal protein S6 -0.0409337
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0405846
FOXP1 forkhead box P1 -0.039111
OSMR oncostatin M receptor -0.0388815
LOC112694756 uncharaterized LOC112694756 -0.0385139
RPS24 ribosomal protein S24 -0.0379619
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.037676
ACTN4 actinin, alpha 4 -0.037341
FRMD5 FERM domain containing 5 -0.0366736
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0361762
GNAS GNAS complex locus -0.0358315
EGR1 early growth response 1 -0.035724
RPL34 ribosomal protein L34 -0.0330289
AKAP12 A kinase (PRKA) anchor protein 12 -0.0329855
RPL37 ribosomal protein L37 -0.0323417
ACTG1 actin gamma 1 -0.0321389
RPS8 ribosomal protein S8 -0.0319943
BCL2L1 BCL2-like 1 -0.0315548
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0313737
KIZ kizuna centrosomal protein -0.0306011
ZMYND8 zinc finger, MYND-type containing 8 -0.0300885
PEG3 paternally expressed 3 -0.0298808
RPL32 ribosomal protein L32 -0.0297564
RPL19 ribosomal protein L19 -0.0297045
RPL31 ribosomal protein L31 -0.0295045
KRT18 keratin 18, type I -0.0294954
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0294411
ZBTB20 zinc finger and BTB domain containing 20 -0.0293046
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0283687
MBNL3 muscleblind-like splicing regulator 3 -0.028224
ARL5A ADP-ribosylation factor-like 5A -0.0279126
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0278698
ITGAV integrin, alpha V -0.0278363
DLC1 DLC1 Rho GTPase activating protein -0.0277595
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0274627
IGF1R insulin-like growth factor 1 receptor -0.0274012
RPL23 ribosomal protein L23 -0.0272645
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0265824
RPS27A ribosomal protein S27a -0.0262954
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0261852
DNAH17 dynein, axonemal, heavy chain 17 -0.0259653
KRT23 keratin 23, type I -0.0257339
RPL4 ribosomal protein L4 -0.0252355
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0252193
PDGFB platelet-derived growth factor beta polypeptide -0.0248223
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0246249
BPTF bromodomain PHD finger transcription factor -0.0246144
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0242797
A2M alpha-2-macroglobulin -0.0242562
RPLP1 ribosomal protein, large, P1 -0.0242557
ZFHX3 zinc finger homeobox 3 -0.0242069
RPS29 ribosomal protein S29 -0.0239726
ASPH aspartate beta-hydroxylase -0.0238604
LMCD1 LIM and cysteine-rich domains 1 -0.0233101
HMGA2 high mobility group AT-hook 2 -0.0231542
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0227576
IER3 immediate early response 3 -0.0222167
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0221353
RPL35 ribosomal protein L35 -0.022013
PDLIM5 PDZ and LIM domain 5 -0.0219688
RNF213 ring finger protein 213 -0.0218594
FAM107B family with sequence similarity 107, member B -0.0218255
RPS14 ribosomal protein S14 -0.0216349
RPL38 ribosomal protein L38 -0.021415
RPS25 ribosomal protein S25 -0.0212344
TRIM26 tripartite motif containing 26 -0.020991
CDK6 cyclin-dependent kinase 6 -0.0209702
KLF6 Kruppel-like factor 6 -0.0208871
GCC2 GRIP and coiled-coil domain containing 2 -0.0208126
TPM1 tropomyosin 1 (alpha) -0.0207646
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.02076
RPS11 ribosomal protein S11 -0.0206655
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0204645
RPS27 ribosomal protein S27 -0.0204487