Rifaximin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.121173
AHNAK AHNAK nucleoprotein 0.0954181
MYH9 myosin, heavy chain 9, non-muscle 0.087509
TIMP3 TIMP metallopeptidase inhibitor 3 0.0761004
PGK1 phosphoglycerate kinase 1 0.0708261
TRIO trio Rho guanine nucleotide exchange factor 0.0555612
MEF2A myocyte enhancer factor 2A 0.055128
RAI14 retinoic acid induced 14 0.053532
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0495237
OGA O-GlcNAcase 0.0483583
CANX calnexin 0.0473623
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0468386
ZEB1 zinc finger E-box binding homeobox 1 0.0464241
STC1 stanniocalcin 1 0.0442655
LMO7 LIM domain 7 0.0439826
TMSB4X thymosin beta 4, X-linked 0.0424127
MACF1 microtubule-actin crosslinking factor 1 0.0384348
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0370449
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0368394
EXT1 exostosin glycosyltransferase 1 0.0364609
ASPH aspartate beta-hydroxylase 0.0358122
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0354467
C4BPB complement component 4 binding protein, beta 0.0352727
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0349411
ITGA6 integrin, alpha 6 0.0348984
ARHGAP21 Rho GTPase activating protein 21 0.0344605
RBM39 RNA binding motif protein 39 0.0333321
ANLN anillin, actin binding protein 0.0327474
ALCAM activated leukocyte cell adhesion molecule 0.0311837
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0311421
DOK5 docking protein 5 0.0311006
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0303718
DIDO1 death inducer-obliterator 1 0.030323
IQGAP1 IQ motif containing GTPase activating protein 1 0.030195
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029393
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0289063
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0284581
MSN moesin 0.028335
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0282648
IFI16 interferon, gamma-inducible protein 16 0.0281916
PTK2 protein tyrosine kinase 2 0.0280112
APLP2 amyloid beta (A4) precursor-like protein 2 0.0278183
KRT17 keratin 17, type I 0.0277816
DST dystonin 0.0277632
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0272412
MYO10 myosin X 0.0271551
STAG2 stromal antigen 2 0.0270602
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0270524
KDM6A lysine (K)-specific demethylase 6A 0.0269539
KLF5 Kruppel-like factor 5 (intestinal) 0.0268043
PDE4D phosphodiesterase 4D, cAMP-specific 0.0264149
SPAG9 sperm associated antigen 9 0.025937
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0259027
RPL7 ribosomal protein L7 0.0258956
RNF19B ring finger protein 19B 0.0256238
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0254194
ARRDC3 arrestin domain containing 3 0.0251077
FNIP1 folliculin interacting protein 1 0.0247237
RASA3 RAS p21 protein activator 3 0.024631
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0246178
PLEC plectin 0.0246104
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0244377
TNIP1 TNFAIP3 interacting protein 1 0.0241462
NAV2 neuron navigator 2 0.0236845
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0234481
SEPTIN9 septin 9 0.0233289
NRIP1 nuclear receptor interacting protein 1 0.0232799
AKAP13 A kinase (PRKA) anchor protein 13 0.0232339
ZMYM2 zinc finger, MYM-type 2 0.0232153
METTL15 methyltransferase like 15 0.0231045
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.023037
TMF1 TATA element modulatory factor 1 0.0227252
MTSS1 metastasis suppressor 1 0.0224686
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0223475
PDLIM5 PDZ and LIM domain 5 0.0222847
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0220494
MCL1 myeloid cell leukemia 1 0.0220076
KDM7A lysine (K)-specific demethylase 7A 0.0219236
CEP250 centrosomal protein 250kDa 0.0219001
PPME1 protein phosphatase methylesterase 1 0.021864
SDCBP syndecan binding protein (syntenin) 0.0218557
SNX9 sorting nexin 9 0.0217846
SLC45A4 solute carrier family 45, member 4 0.0217825
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.0217781
ITPRID2 ITPR interacting domain containing 2 0.0216601
CEMIP cell migration inducing protein, hyaluronan binding 0.021574
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0215404
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0215074
ARCN1 archain 1 0.0214909
MYOF myoferlin 0.021456
WAC WW domain containing adaptor with coiled-coil 0.0212302
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0209956
SUCO SUN domain containing ossification factor 0.0209608
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0209134
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0208158
PRRC2C proline-rich coiled-coil 2C 0.0208084
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0207999
FLNA filamin A, alpha 0.0207523
TPT1 tumor protein, translationally-controlled 1 0.020629
ESYT2 extended synaptotagmin-like protein 2 0.0205934

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177693
TMSB10 thymosin beta 10 -0.156271
NDRG1 N-myc downstream regulated 1 -0.142116
MT2A metallothionein 2A -0.107495
POTEF POTE ankyrin domain family, member F -0.105534
GNAS GNAS complex locus -0.0981277
HSPG2 heparan sulfate proteoglycan 2 -0.0892632
RPS6 ribosomal protein S6 -0.0865378
HLA-B major histocompatibility complex, class I, B -0.0754309
LOC112694756 uncharaterized LOC112694756 -0.0710999
IFITM3 interferon induced transmembrane protein 3 -0.0695271
CD44 CD44 molecule (Indian blood group) -0.0641147
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0627924
S100A10 S100 calcium binding protein A10 -0.0600142
RPS13 ribosomal protein S13 -0.059196
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0577891
RPL37 ribosomal protein L37 -0.0547428
RPLP2 ribosomal protein, large, P2 -0.0542696
S100A9 S100 calcium binding protein A9 -0.0538849
RPS21 ribosomal protein S21 -0.0530838
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0523953
RPS19 ribosomal protein S19 -0.0490312
IGF2 insulin-like growth factor 2 -0.0487973
B2M beta-2-microglobulin -0.0477821
FTL ferritin, light polypeptide -0.0468975
ACTN4 actinin, alpha 4 -0.0466307
RPS3 ribosomal protein S3 -0.0457886
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0456566
RPL36 ribosomal protein L36 -0.0439392
FSCN1 fascin actin-bundling protein 1 -0.0435571
S100A2 S100 calcium binding protein A2 -0.0418094
RPL28 ribosomal protein L28 -0.0415689
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.041014
RPL11 ribosomal protein L11 -0.0407152
IFITM1 interferon induced transmembrane protein 1 -0.0405023
CNRIP1 cannabinoid receptor interacting protein 1 -0.037537
OSMR oncostatin M receptor -0.0374848
RACK1 receptor for activated C kinase 1 -0.0368606
S100A6 S100 calcium binding protein A6 -0.0364895
S100A11 S100 calcium binding protein A11 -0.0357472
RPS29 ribosomal protein S29 -0.0354579
RPL5 ribosomal protein L5 -0.0353185
RPS2 ribosomal protein S2 -0.0350879
EGR1 early growth response 1 -0.0347803
RPLP1 ribosomal protein, large, P1 -0.0346065
LDHA lactate dehydrogenase A -0.0341919
PKM pyruvate kinase, muscle -0.0341003
CYB5R3 cytochrome b5 reductase 3 -0.0340622
IFI6 interferon, alpha-inducible protein 6 -0.0334725
CAV1 caveolin 1, caveolae protein, 22kDa -0.0334025
BSG basigin (Ok blood group) -0.0331173
RPL19 ribosomal protein L19 -0.0328243
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0327563
RPL8 ribosomal protein L8 -0.032117
IGFBP4 insulin-like growth factor binding protein 4 -0.0320404
FOSL1 FOS-like antigen 1 -0.0317242
PFN1 profilin 1 -0.0316291
PODXL podocalyxin-like -0.0314333
RPL35A ribosomal protein L35a -0.0311568
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.031024
RPS8 ribosomal protein S8 -0.030872
RPS27 ribosomal protein S27 -0.030426
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0297858
HLA-A major histocompatibility complex, class I, A -0.0297239
RPL34 ribosomal protein L34 -0.0296829
IFI27 interferon, alpha-inducible protein 27 -0.0287752
PCDH1 protocadherin 1 -0.0286056
LAMA5 laminin, alpha 5 -0.0285741
HM13 histocompatibility (minor) 13 -0.0281356
ARF1 ADP-ribosylation factor 1 -0.0280533
RPS23 ribosomal protein S23 -0.0280038
ISG15 ISG15 ubiquitin-like modifier -0.0279467
ENO2 enolase 2 (gamma, neuronal) -0.0278888
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0276462
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0275731
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275694
MT1X metallothionein 1X -0.0275624
LMNA lamin A/C -0.0274661
BHLHE40 basic helix-loop-helix family, member e40 -0.0269606
EIF1 eukaryotic translation initiation factor 1 -0.0269046
CST3 cystatin C -0.0268597
RPL23 ribosomal protein L23 -0.0267934
FOXO1 forkhead box O1 -0.0266943
FTH1 ferritin, heavy polypeptide 1 -0.0266642
MBNL1 muscleblind-like splicing regulator 1 -0.026664
RPL18 ribosomal protein L18 -0.0265448
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.026433
RPL35 ribosomal protein L35 -0.0263052
DSTN destrin (actin depolymerizing factor) -0.0252445
RPS14 ribosomal protein S14 -0.02516
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0251273
RPL31 ribosomal protein L31 -0.0249618
EGFR epidermal growth factor receptor -0.0248528
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0247968
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0247242
TAPBP TAP binding protein (tapasin) -0.0245883
ATP5F1E ATP synthase F1 subunit epsilon -0.024395
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0243558
GUK1 guanylate kinase 1 -0.0243468
HLA-E major histocompatibility complex, class I, E -0.0241986