| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rifaximin perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rifaximin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.173247 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.128988 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0878622 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0770612 |
| RAD51B | RAD51 paralog B | 0.0766868 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0750765 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0618869 |
| KRT18 | keratin 18, type I | 0.0565329 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.054824 |
| TPM3 | tropomyosin 3 | 0.0535674 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0526766 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0516842 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0500004 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0487054 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0485229 |
| TPM2 | tropomyosin 2 (beta) | 0.0477496 |
| VIM | vimentin | 0.0467839 |
| MCL1 | myeloid cell leukemia 1 | 0.046158 |
| PRELID2 | PRELI domain containing 2 | 0.0447418 |
| PHF20 | PHD finger protein 20 | 0.0444257 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0428168 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0411287 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0408725 |
| PYGL | phosphorylase, glycogen, liver | 0.0406732 |
| YBX1 | Y box binding protein 1 | 0.0405456 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0380635 |
| HDGF | hepatoma-derived growth factor | 0.0380472 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0376263 |
| ENO1 | enolase 1, (alpha) | 0.0360757 |
| PGK1 | phosphoglycerate kinase 1 | 0.0359809 |
| RYR3 | ryanodine receptor 3 | 0.0354924 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0349876 |
| XPO1 | exportin 1 | 0.0349522 |
| CANX | calnexin | 0.0348284 |
| RPL7 | ribosomal protein L7 | 0.034438 |
| CEP250 | centrosomal protein 250kDa | 0.0343999 |
| ATXN1 | ataxin 1 | 0.0341904 |
| PCBP2 | poly(rC) binding protein 2 | 0.0339298 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0333399 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0330592 |
| GOLGB1 | golgin B1 | 0.0325031 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0323954 |
| AEBP2 | AE binding protein 2 | 0.0319299 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0318023 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.031467 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0311473 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0310404 |
| LDHA | lactate dehydrogenase A | 0.0306209 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0304411 |
| AHNAK | AHNAK nucleoprotein | 0.0303065 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0302345 |
| CALR | calreticulin | 0.0300438 |
| PTMA | prothymosin, alpha | 0.0297681 |
| SFTPA2 | surfactant protein A2 | 0.0289647 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0286024 |
| WWOX | WW domain containing oxidoreductase | 0.0285907 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0282916 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0282236 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0271569 |
| MSH6 | mutS homolog 6 | 0.0264454 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0256543 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0256388 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0253203 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0251469 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0248578 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0246953 |
| NUP58 | nucleoporin 58 | 0.0246319 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0245234 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0244186 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0242602 |
| CEP192 | centrosomal protein 192kDa | 0.02416 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0241325 |
| HYOU1 | hypoxia up-regulated 1 | 0.0239908 |
| FAM168A | family with sequence similarity 168, member A | 0.0239516 |
| FAM13A | family with sequence similarity 13, member A | 0.0239364 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0238089 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0236868 |
| APTX | aprataxin | 0.0232625 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0230422 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0229474 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0226182 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0224806 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0224054 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0224012 |
| DST | dystonin | 0.022374 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0223648 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0223335 |
| CTTN | cortactin | 0.0222132 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0221489 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0220138 |
| COPA | coatomer protein complex, subunit alpha | 0.0218728 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0217892 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0217782 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.02147 |
| XPOT | exportin, tRNA | 0.0213775 |
| OGA | O-GlcNAcase | 0.021301 |
| PRKCE | protein kinase C, epsilon | 0.0209385 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0208076 |
| UBN2 | ubinuclein 2 | 0.0206091 |
| SET | SET nuclear proto-oncogene | 0.0205584 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.174311 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.139517 |
| EGR1 | early growth response 1 | -0.0803286 |
| OSMR | oncostatin M receptor | -0.075234 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0695254 |
| TMSB10 | thymosin beta 10 | -0.0651271 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0641347 |
| CDK17 | cyclin-dependent kinase 17 | -0.0562865 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0557152 |
| YBX3 | Y box binding protein 3 | -0.0525996 |
| SLC38A2 | solute carrier family 38, member 2 | -0.051897 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0499524 |
| NABP1 | nucleic acid binding protein 1 | -0.0497462 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.047917 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0465337 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0435156 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0427731 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0426138 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0418637 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0411748 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0408333 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0408288 |
| VCL | vinculin | -0.0403269 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0397195 |
| KLF6 | Kruppel-like factor 6 | -0.0392396 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0387574 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0375815 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0375109 |
| MT2A | metallothionein 2A | -0.0374882 |
| TPI1 | triosephosphate isomerase 1 | -0.0371015 |
| SPAG9 | sperm associated antigen 9 | -0.0369339 |
| LATS2 | large tumor suppressor kinase 2 | -0.0363664 |
| JMJD1C | jumonji domain containing 1C | -0.0358894 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0353352 |
| GNAS | GNAS complex locus | -0.0353141 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0352477 |
| ACTG1 | actin gamma 1 | -0.0349314 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0346231 |
| FTL | ferritin, light polypeptide | -0.0338207 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0335529 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0335005 |
| CCNL1 | cyclin L1 | -0.0325795 |
| CALD1 | caldesmon 1 | -0.0320314 |
| RIGI | RNA sensor RIG-I | -0.030932 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0301913 |
| RPS6 | ribosomal protein S6 | -0.0300039 |
| ATXN2 | ataxin 2 | -0.029764 |
| RHEB | Ras homolog enriched in brain | -0.0290936 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0290285 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0280807 |
| TMEM41B | transmembrane protein 41B | -0.0279458 |
| CD44 | CD44 molecule (Indian blood group) | -0.0276661 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0276167 |
| FHL2 | four and a half LIM domains 2 | -0.0274075 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0273673 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0271212 |
| RASAL2 | RAS protein activator like 2 | -0.0271146 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0271005 |
| VMP1 | vacuole membrane protein 1 | -0.0270128 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0269904 |
| ZFR | zinc finger RNA binding protein | -0.0269085 |
| DOCK3 | dedicator of cytokinesis 3 | -0.026866 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0266833 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0266691 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0265713 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263299 |
| CAVIN1 | caveolae associated protein 1 | -0.0258892 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0257501 |
| E2F3 | E2F transcription factor 3 | -0.0252497 |
| NF1 | neurofibromin 1 | -0.0250396 |
| PLSCR1 | phospholipid scramblase 1 | -0.024775 |
| ATP11A | ATPase, class VI, type 11A | -0.0246825 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0244419 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0244128 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0243393 |
| PFN1 | profilin 1 | -0.0241761 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0239545 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0238207 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0233208 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0233185 |
| RPLP1 | ribosomal protein, large, P1 | -0.0232895 |
| RPS15 | ribosomal protein S15 | -0.0231943 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.023145 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0231208 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0229523 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0227721 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0227495 |
| CLDN1 | claudin 1 | -0.0226459 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0226452 |
| USP15 | ubiquitin specific peptidase 15 | -0.0224011 |
| POTEF | POTE ankyrin domain family, member F | -0.022377 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0222823 |
| NCOA1 | nuclear receptor coactivator 1 | -0.0221574 |
| DHFR | dihydrofolate reductase | -0.0220737 |
| RPL35A | ribosomal protein L35a | -0.0220187 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0220061 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0218457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0218209 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -0.0217632 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0215979 |
