Rifaximin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.150223
ASPH aspartate beta-hydroxylase 0.144538
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.142779
TXNRD1 thioredoxin reductase 1 0.131791
TRIO trio Rho guanine nucleotide exchange factor 0.126581
EFNA5 ephrin-A5 0.120086
GDA guanine deaminase 0.110449
NEK7 NIMA-related kinase 7 0.0828717
COL5A2 collagen, type V, alpha 2 0.0793526
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0755353
CD109 CD109 molecule 0.074754
GRAMD1B GRAM domain containing 1B 0.071232
RTN4 reticulon 4 0.0701164
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0676921
MYOF myoferlin 0.0672399
NRCAM neuronal cell adhesion molecule 0.0643104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0631595
LIMCH1 LIM and calponin homology domains 1 0.0568494
ZEB2 zinc finger E-box binding homeobox 2 0.0552439
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0551697
OGA O-GlcNAcase 0.0538282
CXCL8 chemokine (C-X-C motif) ligand 8 0.0525819
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0525599
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0498074
CENPF centromere protein F, 350/400kDa 0.0491932
ELL2 elongation factor, RNA polymerase II, 2 0.0487836
PTGR1 prostaglandin reductase 1 0.0472284
RBM39 RNA binding motif protein 39 0.044815
PGK1 phosphoglycerate kinase 1 0.0435078
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0434516
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0427338
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0423313
SAMD4A sterile alpha motif domain containing 4A 0.0416168
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0415196
TNPO1 transportin 1 0.040827
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0405974
AGFG1 ArfGAP with FG repeats 1 0.0404502
PRRC2C proline-rich coiled-coil 2C 0.0404259
MKI67 marker of proliferation Ki-67 0.0398447
CTSC cathepsin C 0.0384964
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0371286
FNDC3B fibronectin type III domain containing 3B 0.0369314
SPAG9 sperm associated antigen 9 0.0368063
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0365743
EZR ezrin 0.036567
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0364068
BIRC6 baculoviral IAP repeat containing 6 0.0355939
CARD16 caspase recruitment domain family, member 16 0.0354112
TGFBR1 transforming growth factor, beta receptor 1 0.0350337
TFPI2 tissue factor pathway inhibitor 2 0.0346813
PALLD palladin, cytoskeletal associated protein 0.0338689
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0333878
COL8A1 collagen, type VIII, alpha 1 0.0333166
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0326419
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0324095
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0322458
ANKRD28 ankyrin repeat domain 28 0.03181
COL4A6 collagen, type IV, alpha 6 0.031763
USP3 ubiquitin specific peptidase 3 0.0314826
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.031476
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0313167
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0313118
AVL9 AVL9 homolog (S. cerevisiase) 0.0309816
BRWD3 bromodomain and WD repeat domain containing 3 0.030912
MATR3 matrin 3 0.0306743
ATP13A3 ATPase type 13A3 0.0305537
SMYD3 SET and MYND domain containing 3 0.0305214
WDR43 WD repeat domain 43 0.0304233
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0303393
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0302585
SFPQ splicing factor proline/glutamine-rich 0.030066
ITPRID2 ITPR interacting domain containing 2 0.0296575
NBAS neuroblastoma amplified sequence 0.0294653
MFF mitochondrial fission factor 0.0294327
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0288049
PLCB4 phospholipase C, beta 4 0.0287778
ARHGAP29 Rho GTPase activating protein 29 0.0286963
KMT2C lysine (K)-specific methyltransferase 2C 0.0286945
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0286789
ESYT2 extended synaptotagmin-like protein 2 0.0285213
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.028514
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0283433
TNIP1 TNFAIP3 interacting protein 1 0.0283397
PTEN phosphatase and tensin homolog 0.0282834
NUP58 nucleoporin 58 0.0282153
PTK2 protein tyrosine kinase 2 0.0281399
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0279823
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0277119
XPO1 exportin 1 0.0275411
FAM13A family with sequence similarity 13, member A 0.0273915
ADAM9 ADAM metallopeptidase domain 9 0.0268884
PCBP2 poly(rC) binding protein 2 0.0268836
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0267979
POU2F1 POU class 2 homeobox 1 0.0267813
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0267361
ENAH enabled homolog (Drosophila) 0.0266474
AKR1C1 aldo-keto reductase family 1, member C1 0.0266429
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0265792
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0265791
LAMB1 laminin, beta 1 0.0261959

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.255427
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.144719
PDE4D phosphodiesterase 4D, cAMP-specific -0.111035
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0950921
TPT1 tumor protein, translationally-controlled 1 -0.0868042
CDH13 cadherin 13 -0.0845726
TMSB10 thymosin beta 10 -0.0817704
VIM vimentin -0.0774884
RPL31 ribosomal protein L31 -0.0757714
AUTS2 autism susceptibility candidate 2 -0.0673105
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0671548
RPS6 ribosomal protein S6 -0.0661578
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0657596
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0643536
FTL ferritin, light polypeptide -0.0642324
RPS8 ribosomal protein S8 -0.0576104
ADGRD1 adhesion G protein-coupled receptor D1 -0.0575044
RPS23 ribosomal protein S23 -0.0573834
RPL35A ribosomal protein L35a -0.0570805
RPLP1 ribosomal protein, large, P1 -0.0551062
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0546758
RPL37A ribosomal protein L37a -0.0544461
PRKN parkin RBR E3 ubiquitin protein ligase -0.0544303
INTS6 integrator complex subunit 6 -0.0516889
MAML3 mastermind-like 3 (Drosophila) -0.0511069
RPS19 ribosomal protein S19 -0.0481105
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0475101
SMOC1 SPARC related modular calcium binding 1 -0.0469747
RPS12 ribosomal protein S12 -0.046516
RPS29 ribosomal protein S29 -0.0462721
VCL vinculin -0.0443681
RPL9 ribosomal protein L9 -0.0425231
RPL26 ribosomal protein L26 -0.0420249
RAD51B RAD51 paralog B -0.0420087
RPS3 ribosomal protein S3 -0.0418043
RPL7A ribosomal protein L7a -0.0417958
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0411483
RPL19 ribosomal protein L19 -0.0402767
PRELID2 PRELI domain containing 2 -0.0395539
RPS24 ribosomal protein S24 -0.0391977
RPL37 ribosomal protein L37 -0.0390487
GLRX glutaredoxin (thioltransferase) -0.0387663
SMAD2 SMAD family member 2 -0.0383616
RACK1 receptor for activated C kinase 1 -0.0382622
DST dystonin -0.0381884
MT2A metallothionein 2A -0.0376002
RPL12 ribosomal protein L12 -0.0373781
RPL23 ribosomal protein L23 -0.036695
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0363524
RPS13 ribosomal protein S13 -0.0360895
PTPRM protein tyrosine phosphatase, receptor type, M -0.0348791
HLA-B major histocompatibility complex, class I, B -0.0345891
RPS25 ribosomal protein S25 -0.0343037
RPS27 ribosomal protein S27 -0.0340956
PTMA prothymosin, alpha -0.0339655
CUX1 cut-like homeobox 1 -0.0339242
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0339031
MAP7 microtubule-associated protein 7 -0.0336733
RPL34 ribosomal protein L34 -0.0336049
RPL36 ribosomal protein L36 -0.031997
DENND1A DENN/MADD domain containing 1A -0.0319586
RPS27A ribosomal protein S27a -0.0318873
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.031672
GNAS GNAS complex locus -0.0315335
FN1 fibronectin 1 -0.0315154
NDRG1 N-myc downstream regulated 1 -0.0314069
RPS16 ribosomal protein S16 -0.0314042
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0310766
ACTG1 actin gamma 1 -0.0303104
RPL38 ribosomal protein L38 -0.0299639
LSAMP limbic system-associated membrane protein -0.0295605
XYLT1 xylosyltransferase I -0.0295126
RPS14 ribosomal protein S14 -0.0279877
SQSTM1 sequestosome 1 -0.0279104
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0279035
RPL36A ribosomal protein L36a -0.0274203
RPS17 ribosomal protein S17 -0.0273757
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0273398
RPLP2 ribosomal protein, large, P2 -0.0271438
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0270943
AEBP2 AE binding protein 2 -0.0267303
SOX6 SRY (sex determining region Y)-box 6 -0.0263783
PCDH15 protocadherin-related 15 -0.0262829
RPL13A ribosomal protein L13a -0.0261997
NCKAP5 NCK-associated protein 5 -0.0260212
HDAC4 histone deacetylase 4 -0.0256619
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0251505
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0247216
RPL27 ribosomal protein L27 -0.0246626
NBEAL1 neurobeachin-like 1 -0.0244262
RPL5 ribosomal protein L5 -0.0236156
RPS5 ribosomal protein S5 -0.0232635
RPS10 ribosomal protein S10 -0.023259
EXT1 exostosin glycosyltransferase 1 -0.0230676
S100A10 S100 calcium binding protein A10 -0.0229681
TTC28 tetratricopeptide repeat domain 28 -0.0228839
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0227749
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0227198
RPL28 ribosomal protein L28 -0.0227106
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226254