Rifaximin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

96 genes differentially expressed following the Rifaximin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.208317
RPS6 ribosomal protein S6 0.205426
TRIO trio Rho guanine nucleotide exchange factor 0.201093
FTL ferritin, light polypeptide 0.187696
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.160714
VIM vimentin 0.134441
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.105045
MT2A metallothionein 2A 0.0982037
FNDC3B fibronectin type III domain containing 3B 0.0913161
TMSB10 thymosin beta 10 0.0875574
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0794897
B2M beta-2-microglobulin 0.0758041
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0728095
GOLGA4 golgin A4 0.070946
EFNA5 ephrin-A5 0.0665395
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0582171
OGA O-GlcNAcase 0.0544302
ASPH aspartate beta-hydroxylase 0.0521963
DSCAM Down syndrome cell adhesion molecule 0.0498326
PTMA prothymosin, alpha 0.0453837
TXNRD1 thioredoxin reductase 1 0.0395749
NDRG1 N-myc downstream regulated 1 0.035997
ELL2 elongation factor, RNA polymerase II, 2 0.033218
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0266558
RTN4 reticulon 4 0.0244931
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0216243
RPS8 ribosomal protein S8 0.0202806
RPLP1 ribosomal protein, large, P1 0.019849
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0155071
SLC38A2 solute carrier family 38, member 2 0.013469
RLF rearranged L-myc fusion 0.0130433
NAMPT nicotinamide phosphoribosyltransferase 0.00884399
APLP2 amyloid beta (A4) precursor-like protein 2 0.00869079
NAV2 neuron navigator 2 0.00648362
ERRFI1 ERBB receptor feedback inhibitor 1 0.00403691
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00392682
RPLP2 ribosomal protein, large, P2 0.00235126
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00146809
KYNU kynureninase 6.38962E-4

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.154635
NKD1 naked cuticle homolog 1 (Drosophila) -0.134224
UBC ubiquitin C -0.125577
MAML2 mastermind-like 2 (Drosophila) -0.117258
ZBTB20 zinc finger and BTB domain containing 20 -0.111335
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0940971
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0793515
FN1 fibronectin 1 -0.0703165
ACTN4 actinin, alpha 4 -0.0692309
RNF213 ring finger protein 213 -0.0656699
RIGI RNA sensor RIG-I -0.0638937
GPC6 glypican 6 -0.062747
SNX9 sorting nexin 9 -0.0622415
JMJD1C jumonji domain containing 1C -0.0612791
NUP58 nucleoporin 58 -0.0608456
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0602602
PARD3 par-3 family cell polarity regulator -0.0599654
LMO7 LIM domain 7 -0.0583334
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0567656
CEMIP cell migration inducing protein, hyaluronan binding -0.055456
TBC1D22A TBC1 domain family, member 22A -0.0505449
CCNI cyclin I -0.0480643
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0478586
PTK2 protein tyrosine kinase 2 -0.0449459
MACF1 microtubule-actin crosslinking factor 1 -0.0429077
RBM25 RNA binding motif protein 25 -0.0408611
COL5A2 collagen, type V, alpha 2 -0.0406685
RPS16 ribosomal protein S16 -0.0401863
LDHA lactate dehydrogenase A -0.038575
WAC WW domain containing adaptor with coiled-coil -0.0368845
RPL23 ribosomal protein L23 -0.0339463
ITGA6 integrin, alpha 6 -0.0338708
RUNX1 runt-related transcription factor 1 -0.0338014
CARD16 caspase recruitment domain family, member 16 -0.032873
RPS27A ribosomal protein S27a -0.0315318
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0300676
PKM pyruvate kinase, muscle -0.0286351
BIRC6 baculoviral IAP repeat containing 6 -0.0274041
TAS2R14 taste receptor, type 2, member 14 -0.0271155
NAP1L1 nucleosome assembly protein 1-like 1 -0.0261226
JARID2 jumonji, AT rich interactive domain 2 -0.0244938
COL6A3 collagen, type VI, alpha 3 -0.0234986
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0228805
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.022704
PRKCA protein kinase C, alpha -0.0226394
GRB10 growth factor receptor-bound protein 10 -0.0189463
ZNF292 zinc finger protein 292 -0.0176688
KMT2E lysine (K)-specific methyltransferase 2E -0.0161282
STAG2 stromal antigen 2 -0.0154313
ANXA2 annexin A2 -0.0142951
TFG TRK-fused gene -0.012225
DOCK4 dedicator of cytokinesis 4 -0.010626
PGK1 phosphoglycerate kinase 1 -0.0077186
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00329968
RPS3 ribosomal protein S3 -0.00243282
PDE4D phosphodiesterase 4D, cAMP-specific -0.00213942
DST dystonin -3.00006E-4