Rifaximin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.108169
SMYD3 SET and MYND domain containing 3 0.0730304
RBM39 RNA binding motif protein 39 0.0634277
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0612727
ERRFI1 ERBB receptor feedback inhibitor 1 0.0608897
IARS1 isoleucyl-tRNA synthetase 1 0.0600575
VIM vimentin 0.0570951
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0548383
DERA deoxyribose-phosphate aldolase (putative) 0.0535669
APOLD1 apolipoprotein L domain containing 1 0.0516149
CEP250 centrosomal protein 250kDa 0.0506165
TRA2A transformer 2 alpha homolog (Drosophila) 0.0476901
OGA O-GlcNAcase 0.0453394
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0443031
RPLP1 ribosomal protein, large, P1 0.0441257
HILPDA hypoxia inducible lipid droplet-associated 0.0436815
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0430211
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0423413
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.0407667
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0406135
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0403462
NAV2 neuron navigator 2 0.0402712
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0396342
SEC62 SEC62 homolog (S. cerevisiae) 0.0395881
CCNT2 cyclin T2 0.0394654
SEPTIN7 septin 7 0.0393214
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0390843
RPS21 ribosomal protein S21 0.0386066
PIBF1 progesterone immunomodulatory binding factor 1 0.0381415
DNAAF9 dynein axonemal assembly factor 9 0.0378034
GIGYF2 GRB10 interacting GYF protein 2 0.0369331
ARL15 ADP-ribosylation factor-like 15 0.0368736
ANKRD12 ankyrin repeat domain 12 0.036625
GPC6 glypican 6 0.0362482
N4BP2L2 NEDD4 binding protein 2-like 2 0.0360937
SNX14 sorting nexin 14 0.0359151
LEPROT leptin receptor overlapping transcript 0.0348068
NCOA6 nuclear receptor coactivator 6 0.0346223
SLC35F5 solute carrier family 35, member F5 0.033966
IFIH1 interferon induced with helicase C domain 1 0.0338263
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0337261
DLG1 discs, large homolog 1 (Drosophila) 0.0332329
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0331903
TPT1 tumor protein, translationally-controlled 1 0.0331318
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330689
CANX calnexin 0.0328441
RAB33B RAB33B, member RAS oncogene family 0.0328364
UBXN4 UBX domain protein 4 0.0325406
USP34 ubiquitin specific peptidase 34 0.0324424
CEP95 centrosomal protein 95kDa 0.0322531
NSD1 nuclear receptor binding SET domain protein 1 0.0322103
RPL35A ribosomal protein L35a 0.0321071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0316884
B2M beta-2-microglobulin 0.0313175
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0312845
HELZ helicase with zinc finger 0.0311754
MMP1 matrix metallopeptidase 1 0.0311404
FNIP1 folliculin interacting protein 1 0.0310596
ZMYND8 zinc finger, MYND-type containing 8 0.030723
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0306441
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0304859
KIF4A kinesin family member 4A 0.0304683
RSRC1 arginine/serine-rich coiled-coil 1 0.030335
CCDC88A coiled-coil domain containing 88A 0.0301547
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0299344
LARS1 leucyl-tRNA synthetase 1 0.0297868
PDGFA platelet-derived growth factor alpha polypeptide 0.0297664
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0297285
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0296275
YLPM1 YLP motif containing 1 0.0295983
TBC1D5 TBC1 domain family, member 5 0.0295905
ITSN2 intersectin 2 0.0293839
XPO6 exportin 6 0.0292035
KIAA1958 KIAA1958 0.0287641
HJURP Holliday junction recognition protein 0.0286707
EIF1 eukaryotic translation initiation factor 1 0.0286272
PTK2 protein tyrosine kinase 2 0.0285896
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0284691
FAM3C family with sequence similarity 3, member C 0.0280055
PNPLA8 patatin-like phospholipase domain containing 8 0.027986
DNM1L dynamin 1-like 0.0278973
YAP1 Yes-associated protein 1 0.0277338
ANKRD17 ankyrin repeat domain 17 0.0277227
RTN4 reticulon 4 0.0277073
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0276225
ZC3H15 zinc finger CCCH-type containing 15 0.027202
ATRN attractin 0.0271851
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.0269545
INSIG2 insulin induced gene 2 0.0269468
ANKRD37 ankyrin repeat domain 37 0.0269225
RARS1 arginyl-tRNA synthetase 1 0.026802
COPB1 coatomer protein complex, subunit beta 1 0.0265674
FAM13A family with sequence similarity 13, member A 0.0263827
FKBP8 FK506 binding protein 8, 38kDa 0.0263085
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.0262166
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0261968
SMC4 structural maintenance of chromosomes 4 0.0261648
SERINC1 serine incorporator 1 0.0261035
MACF1 microtubule-actin crosslinking factor 1 0.0260544
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0258654

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199176
CD44 CD44 molecule (Indian blood group) -0.118769
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0764028
POTEF POTE ankyrin domain family, member F -0.0735049
TMSB10 thymosin beta 10 -0.066407
VMP1 vacuole membrane protein 1 -0.0648299
UBC ubiquitin C -0.0617727
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0605179
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0594594
ENO1 enolase 1, (alpha) -0.0583419
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0532234
PKM pyruvate kinase, muscle -0.0509273
BIRC3 baculoviral IAP repeat containing 3 -0.0490589
ATXN1 ataxin 1 -0.0482478
GLG1 golgi glycoprotein 1 -0.04673
IPO7 importin 7 -0.0437882
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0437644
SPAG9 sperm associated antigen 9 -0.0428731
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0416261
WNK1 WNK lysine deficient protein kinase 1 -0.0414225
MBD5 methyl-CpG binding domain protein 5 -0.0412523
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0411956
CELF1 CUGBP, Elav-like family member 1 -0.0408617
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0402889
CREBRF CREB3 regulatory factor -0.0395282
CSDE1 cold shock domain containing E1, RNA-binding -0.0379871
ABR active BCR-related -0.0375687
EGR1 early growth response 1 -0.0375455
EEF2 eukaryotic translation elongation factor 2 -0.0375226
EFNA5 ephrin-A5 -0.0370921
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0368311
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0364203
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0363804
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0359723
MARCHF6 membrane associated ring-CH-type finger 6 -0.0358292
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0356214
MTMR3 myotubularin related protein 3 -0.0350258
UBE2H ubiquitin-conjugating enzyme E2H -0.0347435
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0347425
ATG7 autophagy related 7 -0.0346397
PDE8A phosphodiesterase 8A -0.0344132
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0342126
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0333471
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0333416
CHD1 chromodomain helicase DNA binding protein 1 -0.0327202
MPRIP myosin phosphatase Rho interacting protein -0.0322224
OSMR oncostatin M receptor -0.0320424
SS18 synovial sarcoma translocation, chromosome 18 -0.0318871
RAB10 RAB10, member RAS oncogene family -0.0318003
FBXL7 F-box and leucine-rich repeat protein 7 -0.0316976
BPTF bromodomain PHD finger transcription factor -0.0315142
PRPF4B pre-mRNA processing factor 4B -0.031142
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0311417
OXSR1 oxidative stress responsive 1 -0.0304292
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0302672
SSH1 slingshot protein phosphatase 1 -0.0299715
GLS2 glutaminase 2 (liver, mitochondrial) -0.0299063
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0297875
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.029563
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0295045
AHNAK AHNAK nucleoprotein -0.029471
FAM193A family with sequence similarity 193, member A -0.0293501
TMCC1 transmembrane and coiled-coil domain family 1 -0.0293341
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0293076
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0292459
NAMPT nicotinamide phosphoribosyltransferase -0.0290653
ATXN2 ataxin 2 -0.0289281
ARHGAP26 Rho GTPase activating protein 26 -0.0288354
CTTN cortactin -0.028754
GNAS GNAS complex locus -0.0285813
ETV1 ets variant 1 -0.0284302
FBXL17 F-box and leucine-rich repeat protein 17 -0.0284099
ASXL1 additional sex combs like transcriptional regulator 1 -0.0279633
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0278282
MBNL2 muscleblind-like splicing regulator 2 -0.0277618
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0276966
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.027671
KHSRP KH-type splicing regulatory protein -0.0276574
ANKRD28 ankyrin repeat domain 28 -0.0276269
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0274708
CAV1 caveolin 1, caveolae protein, 22kDa -0.0274066
CSNK1E casein kinase 1, epsilon -0.0270634
SETD5 SET domain containing 5 -0.0267527
PUM2 pumilio RNA-binding family member 2 -0.0267256
MYO6 myosin VI -0.026603
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0265514
TES testin LIM domain protein -0.0264452
RPS16 ribosomal protein S16 -0.0263845
DIAPH3 diaphanous-related formin 3 -0.0263454
H3-3B H3.3 histone B -0.0262687
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0262265
RPS3 ribosomal protein S3 -0.0262218
RACK1 receptor for activated C kinase 1 -0.0260917
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0260648
NCEH1 neutral cholesterol ester hydrolase 1 -0.0259392
RPS8 ribosomal protein S8 -0.0259015
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0257518
ARB2A ARB2 cotranscriptional regulator A -0.0256694
PRPF8 pre-mRNA processing factor 8 -0.0255651
CUX1 cut-like homeobox 1 -0.0255255