Rifaximin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rifaximin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rifaximin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.182822
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.134557
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.132508
NRG1 neuregulin 1 0.123197
CANX calnexin 0.113541
ITGA1 integrin, alpha 1 0.107674
ASPH aspartate beta-hydroxylase 0.106257
SQSTM1 sequestosome 1 0.105895
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0997113
FN1 fibronectin 1 0.0946195
TRIO trio Rho guanine nucleotide exchange factor 0.0945558
PTMA prothymosin, alpha 0.0851695
GLIS3 GLIS family zinc finger 3 0.0829869
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0698281
PRRC2C proline-rich coiled-coil 2C 0.0679043
CALR calreticulin 0.0664646
RBM39 RNA binding motif protein 39 0.0662788
SFTPA2 surfactant protein A2 0.064537
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0631813
OGA O-GlcNAcase 0.0630399
TMEM165 transmembrane protein 165 0.0608764
APLP2 amyloid beta (A4) precursor-like protein 2 0.0589283
HMGA2 high mobility group AT-hook 2 0.0571562
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.05574
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0550265
IFI27 interferon, alpha-inducible protein 27 0.0542445
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0541805
B2M beta-2-microglobulin 0.0491805
TMSB4X thymosin beta 4, X-linked 0.0488895
AHR aryl hydrocarbon receptor 0.0487295
TPR translocated promoter region, nuclear basket protein 0.0473724
RPL26 ribosomal protein L26 0.0469451
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0464304
NAMPT nicotinamide phosphoribosyltransferase 0.046423
FNDC3B fibronectin type III domain containing 3B 0.0441465
RPL7 ribosomal protein L7 0.0439479
ETNK1 ethanolamine kinase 1 0.043286
FAT1 FAT atypical cadherin 1 0.042602
STC2 stanniocalcin 2 0.0424471
GOLGA4 golgin A4 0.0418934
MYH9 myosin, heavy chain 9, non-muscle 0.0408405
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.040682
TBC1D22A TBC1 domain family, member 22A 0.0399295
RNF145 ring finger protein 145 0.0395049
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0392445
HMGB3 high mobility group box 3 0.0377372
PTK2 protein tyrosine kinase 2 0.0377225
EREG epiregulin 0.0374004
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0372611
LMNA lamin A/C 0.0369079
FAM13A family with sequence similarity 13, member A 0.0363398
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0354604
CTBP2 C-terminal binding protein 2 0.0354344
RAI14 retinoic acid induced 14 0.0351749
DST dystonin 0.035075
PKM pyruvate kinase, muscle 0.0348609
PCBP2 poly(rC) binding protein 2 0.034759
AFDN afadin, adherens junction formation factor 0.0342601
CALU calumenin 0.0341546
IGFBP3 insulin-like growth factor binding protein 3 0.033994
RICTOR RPTOR independent companion of MTOR, complex 2 0.0339085
BIRC6 baculoviral IAP repeat containing 6 0.0337642
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0330846
COPA coatomer protein complex, subunit alpha 0.0329455
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0328002
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0325664
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0324246
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0320327
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0320299
ACBD3 acyl-CoA binding domain containing 3 0.0317648
FLNA filamin A, alpha 0.0317592
ZCCHC7 zinc finger, CCHC domain containing 7 0.0317093
NPEPPS aminopeptidase puromycin sensitive 0.0311593
HIPK2 homeodomain interacting protein kinase 2 0.030826
PDIA3 protein disulfide isomerase family A, member 3 0.0306992
NAP1L1 nucleosome assembly protein 1-like 1 0.0305211
PICALM phosphatidylinositol binding clathrin assembly protein 0.030421
TMEM156 transmembrane protein 156 0.0304183
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0304055
RPL35A ribosomal protein L35a 0.0302392
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0301096
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0298587
RSRC2 arginine/serine-rich coiled-coil 2 0.0297335
RPS21 ribosomal protein S21 0.0293294
KDM5B lysine (K)-specific demethylase 5B 0.0292924
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0292803
S100A6 S100 calcium binding protein A6 0.0292199
HLA-B major histocompatibility complex, class I, B 0.0290899
LIMCH1 LIM and calponin homology domains 1 0.0289165
SFXN1 sideroflexin 1 0.0287987
KMT2C lysine (K)-specific methyltransferase 2C 0.0285771
GOLT1B golgi transport 1B 0.0285677
EXT1 exostosin glycosyltransferase 1 0.0283532
SEC23A Sec23 homolog A (S. cerevisiae) 0.028029
AOPEP aminopeptidase O (putative) 0.0279656
ETV6 ets variant 6 0.0279407
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0277607
TFG TRK-fused gene 0.02771
SEC31A SEC31 homolog A (S. cerevisiae) 0.0275293
SYT1 synaptotagmin I 0.0273046

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.334143
MT2A metallothionein 2A -0.104466
FTL ferritin, light polypeptide -0.0714857
NDRG1 N-myc downstream regulated 1 -0.0466365
POTEF POTE ankyrin domain family, member F -0.0368829
RPLP1 ribosomal protein, large, P1 -0.0349487
ANKRD28 ankyrin repeat domain 28 -0.0302385
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0294718
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0278953
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0276073
IER3 immediate early response 3 -0.0274098
NPAS2 neuronal PAS domain protein 2 -0.0273214
SMYD3 SET and MYND domain containing 3 -0.0240671
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0236767
TMSB10 thymosin beta 10 -0.0235661
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0235274
IFIH1 interferon induced with helicase C domain 1 -0.0228234
GNAS GNAS complex locus -0.0224733
RPS15 ribosomal protein S15 -0.0210231
MAP1B microtubule-associated protein 1B -0.0210138
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0208696
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0207589
SRRM2 serine/arginine repetitive matrix 2 -0.0199512
EGR1 early growth response 1 -0.0196066
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0195879
CENPF centromere protein F, 350/400kDa -0.0195106
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0193054
AREG amphiregulin -0.0188931
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0188694
CLIP2 CAP-GLY domain containing linker protein 2 -0.0181542
SCLT1 sodium channel and clathrin linker 1 -0.0179612
RPL28 ribosomal protein L28 -0.017857
SCFD2 sec1 family domain containing 2 -0.0174773
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0174048
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0171505
TXNIP thioredoxin interacting protein -0.017093
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0167669
MSN moesin -0.0167106
PLAUR plasminogen activator, urokinase receptor -0.0166843
ZNF217 zinc finger protein 217 -0.0166141
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0166132
TUBB4B tubulin, beta 4B class IVb -0.0165344
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0164772
GAS2L3 growth arrest-specific 2 like 3 -0.0164696
RPLP2 ribosomal protein, large, P2 -0.0164091
DNM1L dynamin 1-like -0.0162295
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0159795
RNASEH2A ribonuclease H2, subunit A -0.015886
LTBP1 latent transforming growth factor beta binding protein 1 -0.0156543
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0155585
RUNX1 runt-related transcription factor 1 -0.0154599
BBX bobby sox homolog (Drosophila) -0.0153655
RHEB Ras homolog enriched in brain -0.0153147
BCAS3 breast carcinoma amplified sequence 3 -0.0152699
CKAP2 cytoskeleton associated protein 2 -0.0151944
PLPP3 phospholipid phosphatase 3 -0.0151114
RPS11 ribosomal protein S11 -0.0151097
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0148352
NPC1 Niemann-Pick disease, type C1 -0.0146341
JMY junction mediating and regulatory protein, p53 cofactor -0.0145078
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.014405
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0144049
RPS2 ribosomal protein S2 -0.0143899
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0141839
NAV2 neuron navigator 2 -0.0140988
CTSD cathepsin D -0.013704
SAMD8 sterile alpha motif domain containing 8 -0.0136632
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0135819
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.0135246
OSMR oncostatin M receptor -0.0134456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0133662
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0133378
QKI QKI, KH domain containing, RNA binding -0.0132862
LOXL2 lysyl oxidase-like 2 -0.0132567
WARS1 tryptophanyl-tRNA synthetase 1 -0.0131051
CAPRIN2 caprin family member 2 -0.0130373
SSH1 slingshot protein phosphatase 1 -0.0130083
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.012982
PHF21A PHD finger protein 21A -0.0129703
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0129493
RAB7A RAB7A, member RAS oncogene family -0.0129422
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0128242
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0126136
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0123143
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0122576
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.012117
BLZF1 basic leucine zipper nuclear factor 1 -0.0120818
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.011982
TPST1 tyrosylprotein sulfotransferase 1 -0.0119273
BRCA2 breast cancer 2, early onset -0.0119196
UBE2W ubiquitin-conjugating enzyme E2W (putative) -0.0119175
CBFB core-binding factor, beta subunit -0.0119107
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0118826
KIF14 kinesin family member 14 -0.011875
RPS5 ribosomal protein S5 -0.0118677
RAB22A RAB22A, member RAS oncogene family -0.0118584
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0118426
CAMKMT calmodulin-lysine N-methyltransferase -0.0118424
LMAN2 lectin, mannose-binding 2 -0.0116702
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0116271