Riluzole hydrochloride_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.251183
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.123702
MYH9 myosin, heavy chain 9, non-muscle 0.103179
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0920885
BHLHE40 basic helix-loop-helix family, member e40 0.0889943
HLA-B major histocompatibility complex, class I, B 0.0885431
TNIP1 TNFAIP3 interacting protein 1 0.0794665
MT2A metallothionein 2A 0.0786183
CALR calreticulin 0.0774137
B2M beta-2-microglobulin 0.0762203
LOC112694756 uncharaterized LOC112694756 0.0762123
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0744845
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0649919
TRIO trio Rho guanine nucleotide exchange factor 0.0648541
MPRIP myosin phosphatase Rho interacting protein 0.0632897
ANKRD11 ankyrin repeat domain 11 0.0631875
APP amyloid beta (A4) precursor protein 0.060207
PLEC plectin 0.0578577
HLA-C major histocompatibility complex, class I, C 0.0530898
HDAC9 histone deacetylase 9 0.0517955
NFE2L1 nuclear factor, erythroid 2-like 1 0.0502488
TMSB4X thymosin beta 4, X-linked 0.0475441
FLNA filamin A, alpha 0.0471879
RRM2 ribonucleotide reductase M2 0.0465455
MACF1 microtubule-actin crosslinking factor 1 0.046224
MT1X metallothionein 1X 0.0459398
MSN moesin 0.0449852
EEF2 eukaryotic translation elongation factor 2 0.0434941
PLXNA2 plexin A2 0.0431243
AHNAK2 AHNAK nucleoprotein 2 0.0428362
CD44 CD44 molecule (Indian blood group) 0.0426488
IGFBP3 insulin-like growth factor binding protein 3 0.0417547
DBN1 drebrin 1 0.0417426
TPM3 tropomyosin 3 0.0410501
CENPF centromere protein F, 350/400kDa 0.0404968
SLC39A11 solute carrier family 39, member 11 0.0403116
FN1 fibronectin 1 0.0393061
NONO non-POU domain containing, octamer-binding 0.0384403
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0383468
SRRM2 serine/arginine repetitive matrix 2 0.0383316
BCL2L1 BCL2-like 1 0.0383114
COL5A1 collagen, type V, alpha 1 0.0377738
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0376571
CD59 CD59 molecule, complement regulatory protein 0.0367813
NUMA1 nuclear mitotic apparatus protein 1 0.0367736
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0367109
HRNR hornerin 0.0364326
IQGAP3 IQ motif containing GTPase activating protein 3 0.0363807
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0362486
LDHA lactate dehydrogenase A 0.0357622
DOCK5 dedicator of cytokinesis 5 0.0355872
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.034478
IFITM3 interferon induced transmembrane protein 3 0.0342347
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0338506
SFXN3 sideroflexin 3 0.0334351
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.032634
CDH13 cadherin 13 0.0322771
ASPH aspartate beta-hydroxylase 0.0322232
MKI67 marker of proliferation Ki-67 0.0311616
SMAD3 SMAD family member 3 0.0310675
NAV2 neuron navigator 2 0.030721
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0306264
CEP250 centrosomal protein 250kDa 0.029428
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0294238
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0286525
SEPTIN2 septin 2 0.0284854
SON SON DNA binding protein 0.0282857
PRELID2 PRELI domain containing 2 0.0280043
NCOR2 nuclear receptor corepressor 2 0.0279145
NIBAN2 niban apoptosis regulator 2 0.0276864
FAM162A family with sequence similarity 162, member A 0.0275397
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.027462
SET SET nuclear proto-oncogene 0.0274049
EIF4H eukaryotic translation initiation factor 4H 0.027398
PLAT plasminogen activator, tissue 0.0261174
ANLN anillin, actin binding protein 0.0257547
GUK1 guanylate kinase 1 0.0256533
MINK1 misshapen-like kinase 1 0.0252583
KRT8 keratin 8, type II 0.0246085
LIMCH1 LIM and calponin homology domains 1 0.0239972
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0239222
DIAPH3 diaphanous-related formin 3 0.023709
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0234306
RNF213 ring finger protein 213 0.023005
CNOT12 CCR4-NOT transcription complex subunit 12 0.0228613
E2F7 E2F transcription factor 7 0.0228107
PFKP phosphofructokinase, platelet 0.0227772
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0227301
ISG15 ISG15 ubiquitin-like modifier 0.0226205
FOSL1 FOS-like antigen 1 0.022412
DCLK2 doublecortin-like kinase 2 0.0223344
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0222485
PLXNA3 plexin A3 0.0222038
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0221807
ZMIZ1 zinc finger, MIZ-type containing 1 0.0210563
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0209103
SPDL1 spindle apparatus coiled-coil protein 1 0.0208474
MCFD2 multiple coagulation factor deficiency 2 0.0206404
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0204713
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0204487

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.179222
LOX lysyl oxidase -0.179087
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159951
FBN1 fibrillin 1 -0.144229
COL8A1 collagen, type VIII, alpha 1 -0.127276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113549
COL1A2 collagen, type I, alpha 2 -0.098901
COL3A1 collagen, type III, alpha 1 -0.081502
ZBTB20 zinc finger and BTB domain containing 20 -0.081007
COL5A2 collagen, type V, alpha 2 -0.0804315
ZFP36L1 ZFP36 ring finger protein-like 1 -0.079372
SOD2 superoxide dismutase 2, mitochondrial -0.0785418
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0782823
DLG1 discs, large homolog 1 (Drosophila) -0.0753735
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0744201
CCND1 cyclin D1 -0.0710404
AHNAK AHNAK nucleoprotein -0.0673531
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0654983
MAP4 microtubule-associated protein 4 -0.0627444
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0623858
AKAP12 A kinase (PRKA) anchor protein 12 -0.0613261
MYADM myeloid-associated differentiation marker -0.0588738
LOXL2 lysyl oxidase-like 2 -0.0568961
CD99 CD99 molecule -0.0555534
UBC ubiquitin C -0.054768
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0484678
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.047948
NDRG1 N-myc downstream regulated 1 -0.0470916
AUTS2 autism susceptibility candidate 2 -0.0469543
SEC31A SEC31 homolog A (S. cerevisiae) -0.0446079
ARL15 ADP-ribosylation factor-like 15 -0.0439231
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0402726
NAP1L1 nucleosome assembly protein 1-like 1 -0.0401216
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0389787
TTC3 tetratricopeptide repeat domain 3 -0.0387194
ABI3BP ABI family, member 3 (NESH) binding protein -0.0379208
ZEB1 zinc finger E-box binding homeobox 1 -0.036276
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0359715
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0353925
CUX1 cut-like homeobox 1 -0.0352806
MRPS6 mitochondrial ribosomal protein S6 -0.0346288
PSD3 pleckstrin and Sec7 domain containing 3 -0.0339572
SBF2 SET binding factor 2 -0.0338793
IFI16 interferon, gamma-inducible protein 16 -0.0331941
INSIG1 insulin induced gene 1 -0.0327319
SUCNR1 succinate receptor 1 -0.0326523
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0324063
GPC6 glypican 6 -0.0323619
CANX calnexin -0.0322127
PTMA prothymosin, alpha -0.0318358
MMP12 matrix metallopeptidase 12 -0.0312279
THBS2 thrombospondin 2 -0.0312119
FRMD4A FERM domain containing 4A -0.0309202
FRMD5 FERM domain containing 5 -0.0305451
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.030496
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304708
EHBP1 EH domain binding protein 1 -0.0303789
DPYSL3 dihydropyrimidinase-like 3 -0.0301343
PDIA3 protein disulfide isomerase family A, member 3 -0.029959
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.029836
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0297121
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0294153
EGFR epidermal growth factor receptor -0.0292441
KDM5B lysine (K)-specific demethylase 5B -0.0290604
KIFAP3 kinesin-associated protein 3 -0.0289343
MEIS2 Meis homeobox 2 -0.0288446
STC1 stanniocalcin 1 -0.0287217
GOLGA4 golgin A4 -0.0286787
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0278765
MBD5 methyl-CpG binding domain protein 5 -0.0273589
LMAN1 lectin, mannose-binding, 1 -0.0273498
PDE4D phosphodiesterase 4D, cAMP-specific -0.0272516
TM4SF1 transmembrane 4 L six family member 1 -0.0271355
NBEAL1 neurobeachin-like 1 -0.0270876
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0268234
ARL4C ADP-ribosylation factor-like 4C -0.0267469
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0267188
RAB1A RAB1A, member RAS oncogene family -0.0267049
FBXO11 F-box protein 11 -0.0265395
IARS1 isoleucyl-tRNA synthetase 1 -0.0260098
FNIP1 folliculin interacting protein 1 -0.0258039
FAM114A1 family with sequence similarity 114, member A1 -0.0256908
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0256447
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0255072
JAZF1 JAZF zinc finger 1 -0.0253588
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0253459
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0252987
ZNF207 zinc finger protein 207 -0.0247572
USP34 ubiquitin specific peptidase 34 -0.0245957
GNAS GNAS complex locus -0.0244671
POTEF POTE ankyrin domain family, member F -0.0243456
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0242038
TAPBP TAP binding protein (tapasin) -0.0241229
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240599
MAML2 mastermind-like 2 (Drosophila) -0.023942
HDLBP high density lipoprotein binding protein -0.0238886
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0238712
WASF2 WAS protein family, member 2 -0.0237499
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0235347
KMT2E lysine (K)-specific methyltransferase 2E -0.0234999