Riluzole hydrochloride_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.15778
IGFBP3 insulin-like growth factor binding protein 3 0.0965609
EEF2 eukaryotic translation elongation factor 2 0.0955846
CEMIP cell migration inducing protein, hyaluronan binding 0.0902489
TNIP1 TNFAIP3 interacting protein 1 0.0855605
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0826743
MYH9 myosin, heavy chain 9, non-muscle 0.0817226
SMAD3 SMAD family member 3 0.0759838
PLEC plectin 0.0711363
MT1X metallothionein 1X 0.0709056
FTH1 ferritin, heavy polypeptide 1 0.0661292
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0608863
MT2A metallothionein 2A 0.0600325
STC1 stanniocalcin 1 0.05819
MSN moesin 0.0577185
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0561583
NONO non-POU domain containing, octamer-binding 0.0546792
LOC112694756 uncharaterized LOC112694756 0.0536846
ACTG1 actin gamma 1 0.0536008
TMSB10 thymosin beta 10 0.0515805
GRB10 growth factor receptor-bound protein 10 0.0510663
TNS1 tensin 1 0.0483023
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0441205
RPL3 ribosomal protein L3 0.0418848
EEF1G eukaryotic translation elongation factor 1 gamma 0.0413024
TGM2 transglutaminase 2 0.0411211
RHCG Rh family, C glycoprotein 0.0404973
SRRM2 serine/arginine repetitive matrix 2 0.0404173
BCL3 B-cell CLL/lymphoma 3 0.0400457
STEAP3 STEAP family member 3, metalloreductase 0.0397194
MCL1 myeloid cell leukemia 1 0.0395817
MPRIP myosin phosphatase Rho interacting protein 0.0383469
FLNA filamin A, alpha 0.0360806
HSPA8 heat shock 70kDa protein 8 0.0359424
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0354512
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0337224
SHB Src homology 2 domain containing adaptor protein B 0.0334923
EPAS1 endothelial PAS domain protein 1 0.0334207
NPAS2 neuronal PAS domain protein 2 0.0329058
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0312392
CMIP c-Maf inducing protein 0.0310205
AXL AXL receptor tyrosine kinase 0.0304333
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300569
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0294933
THSD4 thrombospondin, type I, domain containing 4 0.029485
YBX3 Y box binding protein 3 0.0294599
BMP6 bone morphogenetic protein 6 0.0292608
AHNAK2 AHNAK nucleoprotein 2 0.0281263
KRT8 keratin 8, type II 0.0274323
GRAMD1B GRAM domain containing 1B 0.0270374
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0263482
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0258572
RPS19 ribosomal protein S19 0.0258182
MINK1 misshapen-like kinase 1 0.0257885
EGR1 early growth response 1 0.0256608
VEGFA vascular endothelial growth factor A 0.0256099
NUMA1 nuclear mitotic apparatus protein 1 0.0255024
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0250583
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.024922
DOCK5 dedicator of cytokinesis 5 0.0248565
SON SON DNA binding protein 0.0245799
BCL2L1 BCL2-like 1 0.024217
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0241694
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0241295
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0236136
FRMD6 FERM domain containing 6 0.0235033
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0234221
RPL11 ribosomal protein L11 0.0233072
NCEH1 neutral cholesterol ester hydrolase 1 0.0232534
ACTN1 actinin, alpha 1 0.0230326
LDHA lactate dehydrogenase A 0.0229333
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.022802
MLPH melanophilin 0.0225624
RPS4X ribosomal protein S4, X-linked 0.0221425
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0221209
DOCK4 dedicator of cytokinesis 4 0.0220224
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0220001
NCOR2 nuclear receptor corepressor 2 0.0216935
KRT18 keratin 18, type I 0.0215582
KDM6B lysine (K)-specific demethylase 6B 0.0215373
BRD2 bromodomain containing 2 0.021529
AKAP13 A kinase (PRKA) anchor protein 13 0.0215058
SEPTIN9 septin 9 0.021395
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0208477
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0206807
RPS17 ribosomal protein S17 0.0205629
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0205564
C1D C1D nuclear receptor corepressor 0.0203669
LAMA5 laminin, alpha 5 0.0201942
HLA-C major histocompatibility complex, class I, C 0.0199006
HRNR hornerin 0.0198029
BACE2 beta-site APP-cleaving enzyme 2 0.0197306
CNOT12 CCR4-NOT transcription complex subunit 12 0.0195521
KMT2D lysine (K)-specific methyltransferase 2D 0.0195249
PMEPA1 prostate transmembrane protein, androgen induced 1 0.019444
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.019129
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0189422
UBA1 ubiquitin-like modifier activating enzyme 1 0.0186846
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0186713
UBASH3B ubiquitin associated and SH3 domain containing B 0.0186274

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.260117
IGFBP4 insulin-like growth factor binding protein 4 -0.108725
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0866815
USP3 ubiquitin specific peptidase 3 -0.0824246
FTL ferritin, light polypeptide -0.0822012
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0727032
SPAG9 sperm associated antigen 9 -0.0726575
EHBP1 EH domain binding protein 1 -0.0715685
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0705027
AKR1C2 aldo-keto reductase family 1, member C2 -0.0701824
KCTD9 potassium channel tetramerization domain containing 9 -0.0661727
PDE4D phosphodiesterase 4D, cAMP-specific -0.0652776
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.063927
PTMA prothymosin, alpha -0.0625724
AHNAK AHNAK nucleoprotein -0.0615003
PARD3 par-3 family cell polarity regulator -0.0595773
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0553194
CANX calnexin -0.0548143
SBF2 SET binding factor 2 -0.0543414
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0541634
ANXA2 annexin A2 -0.0538475
RAI14 retinoic acid induced 14 -0.0533678
PTPRJ protein tyrosine phosphatase, receptor type, J -0.052199
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.052052
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0504589
BIRC6 baculoviral IAP repeat containing 6 -0.049896
KRT81 keratin 81, type II -0.049525
GOLGA4 golgin A4 -0.0491555
TKT transketolase -0.0486305
NAMPT nicotinamide phosphoribosyltransferase -0.0484613
NCOA7 nuclear receptor coactivator 7 -0.0479919
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0475717
FNDC3B fibronectin type III domain containing 3B -0.0474706
KDM3A lysine (K)-specific demethylase 3A -0.0469861
ZBTB20 zinc finger and BTB domain containing 20 -0.0465654
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0454828
HELZ helicase with zinc finger -0.0452713
UBC ubiquitin C -0.0444988
RAB1A RAB1A, member RAS oncogene family -0.0444518
S100A10 S100 calcium binding protein A10 -0.0442155
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.044155
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0441498
TM4SF1 transmembrane 4 L six family member 1 -0.0405367
NF1 neurofibromin 1 -0.0400895
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0399098
CA12 carbonic anhydrase XII -0.0398527
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0392409
FMNL2 formin-like 2 -0.0384074
DENND4C DENN/MADD domain containing 4C -0.0381285
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0371874
VIM vimentin -0.0371169
ECT2 epithelial cell transforming 2 -0.0369047
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0368319
PTBP3 polypyrimidine tract binding protein 3 -0.0367271
USP34 ubiquitin specific peptidase 34 -0.0361257
SLC38A1 solute carrier family 38, member 1 -0.035551
SP100 SP100 nuclear antigen -0.0354443
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0353956
NPEPPS aminopeptidase puromycin sensitive -0.0352945
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0351725
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0349966
MAP4 microtubule-associated protein 4 -0.0349789
ZNF292 zinc finger protein 292 -0.0349021
BZW1 basic leucine zipper and W2 domains 1 -0.034734
DENND4A DENN/MADD domain containing 4A -0.0346756
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0346607
RAP1B RAP1B, member of RAS oncogene family -0.034195
KLF6 Kruppel-like factor 6 -0.0336905
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0336127
WAC WW domain containing adaptor with coiled-coil -0.0333031
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0330668
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0328937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0328285
H1-0 H1.0 linker histone -0.0327711
PGK1 phosphoglycerate kinase 1 -0.0324656
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0323808
MAP1B microtubule-associated protein 1B -0.0320866
RIN2 Ras and Rab interactor 2 -0.0317836
FBXL2 F-box and leucine-rich repeat protein 2 -0.0315689
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.031308
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0312764
JMJD1C jumonji domain containing 1C -0.0310969
PUM2 pumilio RNA-binding family member 2 -0.0310401
SEC31A SEC31 homolog A (S. cerevisiae) -0.0308404
WASF2 WAS protein family, member 2 -0.0307258
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0303531
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0302111
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0301889
SRP54 signal recognition particle 54kDa -0.030158
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0301042
EREG epiregulin -0.0300499
VEZT vezatin, adherens junctions transmembrane protein -0.029891
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0297787
PTK2 protein tyrosine kinase 2 -0.029768
WSB1 WD repeat and SOCS box containing 1 -0.0296325
WDR45B WD repeat domain 45B -0.0296307
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.029606
TCF12 transcription factor 12 -0.029428
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0293882
HIP1 huntingtin interacting protein 1 -0.0292356