Riluzole hydrochloride_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.111336
RPL23 ribosomal protein L23 0.0908136
KRT8 keratin 8, type II 0.078305
EEF2 eukaryotic translation elongation factor 2 0.0746437
VEGFA vascular endothelial growth factor A 0.0742009
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.0681445
MYH9 myosin, heavy chain 9, non-muscle 0.0669632
LOC112694756 uncharaterized LOC112694756 0.0668259
FTH1 ferritin, heavy polypeptide 1 0.0660882
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0644586
SRCIN1 SRC kinase signaling inhibitor 1 0.0624572
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0604774
CEMIP cell migration inducing protein, hyaluronan binding 0.0549517
PLEC plectin 0.0540272
SET SET nuclear proto-oncogene 0.0515791
KRT18 keratin 18, type I 0.0488847
SRRM2 serine/arginine repetitive matrix 2 0.0459249
ASPH aspartate beta-hydroxylase 0.0450997
RPL19 ribosomal protein L19 0.0433779
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0432548
HRNR hornerin 0.0424568
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0397707
MLPH melanophilin 0.0368583
RPL3 ribosomal protein L3 0.0366458
NONO non-POU domain containing, octamer-binding 0.0357067
HSPA8 heat shock 70kDa protein 8 0.0356178
CDK12 cyclin-dependent kinase 12 0.0353624
SMYD3 SET and MYND domain containing 3 0.0350007
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.034829
PNN pinin, desmosome associated protein 0.0343665
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0328133
ACIN1 apoptotic chromatin condensation inducer 1 0.0315454
LIMCH1 LIM and calponin homology domains 1 0.0313786
RPL35A ribosomal protein L35a 0.0306288
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0300647
ADARB1 adenosine deaminase, RNA-specific, B1 0.0292905
MPRIP myosin phosphatase Rho interacting protein 0.0291367
HLA-C major histocompatibility complex, class I, C 0.0290763
TMSB4X thymosin beta 4, X-linked 0.0286174
MMP24OS MMP24 opposite strand 0.0280169
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0277968
NCOR2 nuclear receptor corepressor 2 0.0277748
KMT2D lysine (K)-specific methyltransferase 2D 0.0272048
FGB fibrinogen beta chain 0.0271656
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0269998
DSPP dentin sialophosphoprotein 0.0268861
DUSP16 dual specificity phosphatase 16 0.0267472
LDHA lactate dehydrogenase A 0.0264462
YBX3 Y box binding protein 3 0.0263698
DBN1 drebrin 1 0.0252074
PRRC2A proline-rich coiled-coil 2A 0.0250226
SON SON DNA binding protein 0.024747
DOCK5 dedicator of cytokinesis 5 0.0242525
FAM219A family with sequence similarity 219, member A 0.0241242
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0241212
PLK2 polo-like kinase 2 0.0240828
SMG5 SMG5 nonsense mediated mRNA decay factor 0.0238846
RPL37 ribosomal protein L37 0.0237418
HLA-B major histocompatibility complex, class I, B 0.023731
SEPTIN9 septin 9 0.0229911
SF1 splicing factor 1 0.0227535
RPL35 ribosomal protein L35 0.0227398
B2M beta-2-microglobulin 0.0227024
ADAR adenosine deaminase, RNA-specific 0.0225956
CALCOCO2 calcium binding and coiled-coil domain 2 0.0225361
EPAS1 endothelial PAS domain protein 1 0.0224531
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0224462
IFI6 interferon, alpha-inducible protein 6 0.0222791
ARGLU1 arginine and glutamate rich 1 0.0222467
MINK1 misshapen-like kinase 1 0.0220675
EEF1G eukaryotic translation elongation factor 1 gamma 0.0218888
VAV3 vav 3 guanine nucleotide exchange factor 0.0218634
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0215706
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0214708
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0214108
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0214071
BCL3 B-cell CLL/lymphoma 3 0.021368
GOLGA3 golgin A3 0.0213424
ZHX2 zinc fingers and homeoboxes 2 0.0208356
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207689
NTN4 netrin 4 0.0206949
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0205761
NIBAN2 niban apoptosis regulator 2 0.0205149
BRD2 bromodomain containing 2 0.0203684
NFE2L1 nuclear factor, erythroid 2-like 1 0.0203068
STIP1 stress-induced phosphoprotein 1 0.0201913
LRATD2 LRAT domain containing 2 0.020189
BHLHE40 basic helix-loop-helix family, member e40 0.0199727
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0197946
SERINC3 serine incorporator 3 0.019685
CNOT12 CCR4-NOT transcription complex subunit 12 0.0196823
KRT7 keratin 7, type II 0.0195919
ACTN1 actinin, alpha 1 0.0193857
MIDEAS mitotic deacetylase associated SANT domain protein 0.0193716
EIF4H eukaryotic translation initiation factor 4H 0.019347
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0193457
PRRC2C proline-rich coiled-coil 2C 0.0192953
DUSP4 dual specificity phosphatase 4 0.019261
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0191115
YBX1 Y box binding protein 1 0.0190162

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.149698
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.137862
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126106
VMP1 vacuole membrane protein 1 -0.115736
FBXL20 F-box and leucine-rich repeat protein 20 -0.102409
ACACA acetyl-CoA carboxylase alpha -0.0929966
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0894726
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0834843
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0789844
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0776621
TMEM123 transmembrane protein 123 -0.0770234
PTMA prothymosin, alpha -0.072953
ITCH itchy E3 ubiquitin protein ligase -0.0622386
CATSPERB catsper channel auxiliary subunit beta -0.0597764
IGFBP5 insulin-like growth factor binding protein 5 -0.0562708
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0558618
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0525277
NAMPT nicotinamide phosphoribosyltransferase -0.0498296
DNAH14 dynein, axonemal, heavy chain 14 -0.0495854
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0494119
DTNA dystrobrevin, alpha -0.0481558
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0471142
GRB7 growth factor receptor-bound protein 7 -0.046364
PBX1 pre-B-cell leukemia homeobox 1 -0.0438841
KMT2C lysine (K)-specific methyltransferase 2C -0.0397338
UBC ubiquitin C -0.0395858
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0392519
CCND1 cyclin D1 -0.0389882
VCL vinculin -0.0389061
KMT2E lysine (K)-specific methyltransferase 2E -0.0385771
CCNI cyclin I -0.0382629
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0378372
GNAS GNAS complex locus -0.0373916
KDM5B lysine (K)-specific demethylase 5B -0.0371284
DENND1A DENN/MADD domain containing 1A -0.0370042
STAU1 staufen double-stranded RNA binding protein 1 -0.0355695
NF1 neurofibromin 1 -0.0353247
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0351901
ELOVL5 ELOVL fatty acid elongase 5 -0.0346866
MSMO1 methylsterol monooxygenase 1 -0.0345964
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0344449
SBF2 SET binding factor 2 -0.0338738
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0335161
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0316477
MCL1 myeloid cell leukemia 1 -0.0314739
LDLR low density lipoprotein receptor -0.0311972
PRR11 proline rich 11 -0.0309885
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0306307
WASF2 WAS protein family, member 2 -0.030207
PTPRK protein tyrosine phosphatase, receptor type, K -0.0298539
PDLIM5 PDZ and LIM domain 5 -0.0296088
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0294323
PDIA3 protein disulfide isomerase family A, member 3 -0.0292864
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0292073
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0279951
SHROOM3 shroom family member 3 -0.0279881
JMJD1C jumonji domain containing 1C -0.0278591
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.027495
RTN3 reticulon 3 -0.0273147
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0268334
TRPS1 trichorhinophalangeal syndrome I -0.026322
PARD3 par-3 family cell polarity regulator -0.0263119
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0262943
AHNAK AHNAK nucleoprotein -0.0262022
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.026069
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0257955
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0257548
SEPTIN11 septin 11 -0.0256417
ZFAND3 zinc finger, AN1-type domain 3 -0.0256397
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0255919
MSI2 musashi RNA-binding protein 2 -0.0255727
NEBL nebulette -0.0255219
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255212
BRWD1 bromodomain and WD repeat domain containing 1 -0.0252004
ZNF292 zinc finger protein 292 -0.0251721
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0248565
FDPS farnesyl diphosphate synthase -0.0248391
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0248203
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0247948
GMDS GDP-mannose 4,6-dehydratase -0.0245526
IPO7 importin 7 -0.0245031
ZBTB20 zinc finger and BTB domain containing 20 -0.024406
RAB7A RAB7A, member RAS oncogene family -0.0243267
CANX calnexin -0.024312
GRB10 growth factor receptor-bound protein 10 -0.0242564
ZNF217 zinc finger protein 217 -0.0240889
MDK midkine (neurite growth-promoting factor 2) -0.0237649
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0236594
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0236337
TMEM41B transmembrane protein 41B -0.0235919
S100A9 S100 calcium binding protein A9 -0.023053
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0228015
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0224829
HMGB1 high mobility group box 1 -0.0224563
USP53 ubiquitin specific peptidase 53 -0.0223487
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0222728
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0221109
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0218171
OLA1 Obg-like ATPase 1 -0.0216749
PATJ PATJ crumbs cell polarity complex component -0.0215304