Riluzole hydrochloride_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.314272
FLNA filamin A, alpha 0.138874
EEF2 eukaryotic translation elongation factor 2 0.130662
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.127055
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.125082
ACTG1 actin gamma 1 0.122782
PLEC plectin 0.112985
APP amyloid beta (A4) precursor protein 0.0850794
PRELID2 PRELI domain containing 2 0.0767927
SMAD3 SMAD family member 3 0.0764025
SRRM2 serine/arginine repetitive matrix 2 0.0730013
TMSB10 thymosin beta 10 0.0699809
LOC112694756 uncharaterized LOC112694756 0.0676443
RPL3 ribosomal protein L3 0.0663758
TNIP1 TNFAIP3 interacting protein 1 0.0644808
B2M beta-2-microglobulin 0.0629671
MACROD2 MACRO domain containing 2 0.0613537
MPRIP myosin phosphatase Rho interacting protein 0.060193
SMC1A structural maintenance of chromosomes 1A 0.0581943
TMSB4X thymosin beta 4, X-linked 0.0580389
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0578988
SET SET nuclear proto-oncogene 0.0574234
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.054589
WWOX WW domain containing oxidoreductase 0.054073
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0516101
YBX1 Y box binding protein 1 0.0492988
EEF1G eukaryotic translation elongation factor 1 gamma 0.049077
NUMA1 nuclear mitotic apparatus protein 1 0.048957
HSPA8 heat shock 70kDa protein 8 0.0489509
CALR calreticulin 0.0483075
ACTN4 actinin, alpha 4 0.0476802
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.045472
ASPH aspartate beta-hydroxylase 0.0446926
MT2A metallothionein 2A 0.044459
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0442546
RPL35A ribosomal protein L35a 0.044147
SON SON DNA binding protein 0.0441368
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0438339
VCL vinculin 0.0434963
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0433086
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0429653
FTH1 ferritin, heavy polypeptide 1 0.0425021
EIF4H eukaryotic translation initiation factor 4H 0.0421646
BCL2L1 BCL2-like 1 0.0420546
NONO non-POU domain containing, octamer-binding 0.0415671
ANXA11 annexin A11 0.0408325
BHLHE40 basic helix-loop-helix family, member e40 0.0408022
OSBPL10 oxysterol binding protein-like 10 0.0407014
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0395612
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0388997
APOL1 apolipoprotein L, 1 0.038882
DIAPH1 diaphanous-related formin 1 0.038282
SEPTIN2 septin 2 0.0380491
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0378247
MACF1 microtubule-actin crosslinking factor 1 0.0373412
RAD51B RAD51 paralog B 0.0372678
FTL ferritin, light polypeptide 0.0370214
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0367571
RPS19 ribosomal protein S19 0.0367571
BBS9 Bardet-Biedl syndrome 9 0.03647
MKI67 marker of proliferation Ki-67 0.0360803
ARID1A AT rich interactive domain 1A (SWI-like) 0.0360103
LDHA lactate dehydrogenase A 0.0357928
RPL11 ribosomal protein L11 0.0356882
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0354193
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0340081
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.033916
RPL35 ribosomal protein L35 0.0336838
FHIT fragile histidine triad 0.0335481
APLP2 amyloid beta (A4) precursor-like protein 2 0.0323358
TPI1 triosephosphate isomerase 1 0.031797
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.031504
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.0312906
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0312881
RPS4X ribosomal protein S4, X-linked 0.0311719
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0310776
TJP1 tight junction protein 1 0.0310221
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0310201
RPL23 ribosomal protein L23 0.0309749
RAD23B RAD23 homolog B (S. cerevisiae) 0.0309564
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0301471
NFE2L1 nuclear factor, erythroid 2-like 1 0.0300973
ARGLU1 arginine and glutamate rich 1 0.0297636
AFDN afadin, adherens junction formation factor 0.029312
MINK1 misshapen-like kinase 1 0.0291268
RRM2 ribonucleotide reductase M2 0.028898
MYEOV myeloma overexpressed 0.0284438
OGA O-GlcNAcase 0.0283623
MED15 mediator complex subunit 15 0.0281556
TPM3 tropomyosin 3 0.0277305
HYOU1 hypoxia up-regulated 1 0.0273709
NCEH1 neutral cholesterol ester hydrolase 1 0.0272698
DSPP dentin sialophosphoprotein 0.0272545
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270645
EZR ezrin 0.0266855
HLA-B major histocompatibility complex, class I, B 0.0264673
CEP250 centrosomal protein 250kDa 0.0262172
SFTPA2 surfactant protein A2 0.0261485
HELLS helicase, lymphoid-specific 0.0260025
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.025925

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170383
CCND1 cyclin D1 -0.0840341
HMGA1 high mobility group AT-hook 1 -0.0589426
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0588237
ALCAM activated leukocyte cell adhesion molecule -0.0559358
DLC1 DLC1 Rho GTPase activating protein -0.0550004
LIMCH1 LIM and calponin homology domains 1 -0.0514032
MAP4 microtubule-associated protein 4 -0.0509599
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0496894
SBF2 SET binding factor 2 -0.0490655
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0475917
FBXL2 F-box and leucine-rich repeat protein 2 -0.0460821
ZBTB20 zinc finger and BTB domain containing 20 -0.0453202
MBD5 methyl-CpG binding domain protein 5 -0.0422551
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0419959
ANXA2 annexin A2 -0.0400232
EGFR epidermal growth factor receptor -0.0383554
NF1 neurofibromin 1 -0.0383402
IGFBP3 insulin-like growth factor binding protein 3 -0.0374587
CD44 CD44 molecule (Indian blood group) -0.0372241
CD2AP CD2-associated protein -0.0349074
ANKRD10 ankyrin repeat domain 10 -0.0342484
CDK13 cyclin-dependent kinase 13 -0.0340319
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.03364
WASF2 WAS protein family, member 2 -0.0335084
JMJD1C jumonji domain containing 1C -0.0315628
NDRG1 N-myc downstream regulated 1 -0.0312397
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0311743
TPT1 tumor protein, translationally-controlled 1 -0.0311482
HMGA2 high mobility group AT-hook 2 -0.0310887
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0307394
GCC2 GRIP and coiled-coil domain containing 2 -0.0305127
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0304703
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0303729
ARHGAP29 Rho GTPase activating protein 29 -0.0302331
FNIP1 folliculin interacting protein 1 -0.0301197
VCAN versican -0.0300865
ANKHD1 ankyrin repeat and KH domain containing 1 -0.029769
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0292066
N4BP2L2 NEDD4 binding protein 2-like 2 -0.029171
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0282477
WSB1 WD repeat and SOCS box containing 1 -0.028036
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0274787
ZNF609 zinc finger protein 609 -0.0271932
BPTF bromodomain PHD finger transcription factor -0.0270622
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0267665
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.026595
THOC2 THO complex 2 -0.0265024
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0260245
CLDN1 claudin 1 -0.0259015
KMT2E lysine (K)-specific methyltransferase 2E -0.0258529
ADAM10 ADAM metallopeptidase domain 10 -0.0252097
RSL1D1 ribosomal L1 domain containing 1 -0.0252039
LITAF lipopolysaccharide-induced TNF factor -0.0249338
TCF12 transcription factor 12 -0.0248916
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0247476
RAB7A RAB7A, member RAS oncogene family -0.0245617
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0242416
RTN3 reticulon 3 -0.0239888
FNBP1L formin binding protein 1-like -0.0239677
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.023719
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0234201
BRWD1 bromodomain and WD repeat domain containing 1 -0.0232227
GNAS GNAS complex locus -0.0230779
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0229337
SLMAP sarcolemma associated protein -0.0228891
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0228529
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0228489
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0226058
AFF1 AF4/FMR2 family, member 1 -0.0225345
BICD1 bicaudal D homolog 1 (Drosophila) -0.0224177
MCTP1 multiple C2 domains, transmembrane 1 -0.0222924
PTK2 protein tyrosine kinase 2 -0.0222665
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0219467
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0218058
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.021696
BIRC6 baculoviral IAP repeat containing 6 -0.0216662
LMAN1 lectin, mannose-binding, 1 -0.021624
USP34 ubiquitin specific peptidase 34 -0.0215452
NBEAL1 neurobeachin-like 1 -0.0213331
GOLGA4 golgin A4 -0.0212799
FLNB filamin B, beta -0.0212399
PARD3 par-3 family cell polarity regulator -0.0211655
ZNF292 zinc finger protein 292 -0.0210072
SH3KBP1 SH3-domain kinase binding protein 1 -0.0210037
PERP PERP, TP53 apoptosis effector -0.0210003
ZMYM2 zinc finger, MYM-type 2 -0.020822
KRT19 keratin 19, type I -0.0206902
MAML2 mastermind-like 2 (Drosophila) -0.0205954
TAS2R14 taste receptor, type 2, member 14 -0.0205881
NOP58 NOP58 ribonucleoprotein -0.0204988
TNIK TRAF2 and NCK interacting kinase -0.0204883
RHEX regulator of hemoglobinization and erythroid cell expansion -0.020397
CLIP2 CAP-GLY domain containing linker protein 2 -0.0203366
KMT2A lysine (K)-specific methyltransferase 2A -0.0202331
SEPTIN7 septin 7 -0.0201298
PRR11 proline rich 11 -0.0201295
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0200336
FMNL2 formin-like 2 -0.0198506
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0197388