| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Riluzole hydrochloride perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Riluzole hydrochloride_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.408071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.220455 |
| NDRG1 | N-myc downstream regulated 1 | 0.165664 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.127054 |
| CALR | calreticulin | 0.119885 |
| COL5A1 | collagen, type V, alpha 1 | 0.116095 |
| CDH13 | cadherin 13 | 0.107851 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.103888 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.09835 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0948137 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0943235 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.087726 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0780877 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0644313 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0644218 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0568357 |
| ACTG1 | actin gamma 1 | 0.0534265 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0458697 |
| TMSB4X | thymosin beta 4, X-linked | 0.0455863 |
| LDHA | lactate dehydrogenase A | 0.0454564 |
| PDE10A | phosphodiesterase 10A | 0.0454277 |
| ASPH | aspartate beta-hydroxylase | 0.0405219 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.040147 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0383707 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0374025 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0368134 |
| TMSB10 | thymosin beta 10 | 0.0360319 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0358141 |
| CANX | calnexin | 0.0357529 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0354935 |
| ENO1 | enolase 1, (alpha) | 0.0350276 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0345229 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0343708 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0343611 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0342047 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.033987 |
| SDC2 | syndecan 2 | 0.0333744 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0327113 |
| HYOU1 | hypoxia up-regulated 1 | 0.0313367 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.030996 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.030975 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0308126 |
| TNS1 | tensin 1 | 0.0302997 |
| EPHB1 | EPH receptor B1 | 0.029687 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0296122 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.029354 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0284396 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0281211 |
| COL1A1 | collagen, type I, alpha 1 | 0.0275129 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0271718 |
| ATXN1 | ataxin 1 | 0.0268321 |
| NAV1 | neuron navigator 1 | 0.0268268 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0265733 |
| PRKCA | protein kinase C, alpha | 0.0261395 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0254102 |
| APP | amyloid beta (A4) precursor protein | 0.02522 |
| SQSTM1 | sequestosome 1 | 0.0247997 |
| EGFR | epidermal growth factor receptor | 0.0239079 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0238038 |
| CMIP | c-Maf inducing protein | 0.0235109 |
| RUNX1 | runt-related transcription factor 1 | 0.0228968 |
| PRELID2 | PRELI domain containing 2 | 0.0228141 |
| APOL2 | apolipoprotein L, 2 | 0.0227003 |
| FMNL2 | formin-like 2 | 0.0226488 |
| NCOR2 | nuclear receptor corepressor 2 | 0.022516 |
| CAVIN1 | caveolae associated protein 1 | 0.0224378 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0220597 |
| LMNA | lamin A/C | 0.0220097 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0214887 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.021067 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0206466 |
| FBN1 | fibrillin 1 | 0.0205251 |
| HDAC9 | histone deacetylase 9 | 0.0204751 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0203287 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0202366 |
| MED15 | mediator complex subunit 15 | 0.0201329 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.020061 |
| ADM | adrenomedullin | 0.0200356 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0192785 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0192165 |
| HLA-C | major histocompatibility complex, class I, C | 0.0188753 |
| FAM162A | family with sequence similarity 162, member A | 0.0185715 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0184167 |
| FOXP1 | forkhead box P1 | 0.0181497 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0177586 |
| RPL35A | ribosomal protein L35a | 0.0177185 |
| CPNE1 | copine I | 0.0176564 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0176208 |
| HMBOX1 | homeobox containing 1 | 0.017609 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0175977 |
| PTK2 | protein tyrosine kinase 2 | 0.0175708 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0174021 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0173277 |
| PRSS23 | protease, serine, 23 | 0.0170177 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.017009 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0169605 |
| HLA-B | major histocompatibility complex, class I, B | 0.0167794 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0167044 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0166618 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.016652 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.310465 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202438 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0904622 |
| MT2A | metallothionein 2A | -0.0895818 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0685043 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0649856 |
| CD44 | CD44 molecule (Indian blood group) | -0.0626788 |
| POSTN | periostin, osteoblast specific factor | -0.0550396 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0524521 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0458599 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0424336 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0421119 |
| PALLD | palladin, cytoskeletal associated protein | -0.0417758 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0389144 |
| RPS6 | ribosomal protein S6 | -0.0373611 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0348175 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0346891 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0338592 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0338289 |
| VCL | vinculin | -0.0332692 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0332279 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0325775 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0295158 |
| HMGA1 | high mobility group AT-hook 1 | -0.0279057 |
| EGR1 | early growth response 1 | -0.0277334 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0274242 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0271716 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.027 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.02684 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0267612 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0265177 |
| TAPBP | TAP binding protein (tapasin) | -0.0260165 |
| RASA2 | RAS p21 protein activator 2 | -0.0256815 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0253847 |
| VMP1 | vacuole membrane protein 1 | -0.025167 |
| SQLE | squalene epoxidase | -0.0247057 |
| UBC | ubiquitin C | -0.0243908 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0241542 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0240231 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0237901 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0222163 |
| CCND1 | cyclin D1 | -0.0221797 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0221772 |
| PKM | pyruvate kinase, muscle | -0.0217314 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0217107 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0216238 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0214096 |
| DSTN | destrin (actin depolymerizing factor) | -0.0213887 |
| WASF2 | WAS protein family, member 2 | -0.0210129 |
| LIMA1 | LIM domain and actin binding 1 | -0.0208225 |
| LOX | lysyl oxidase | -0.019903 |
| GOLGA4 | golgin A4 | -0.0197862 |
| COL4A1 | collagen, type IV, alpha 1 | -0.019584 |
| NRP1 | neuropilin 1 | -0.0195412 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0191618 |
| S100A10 | S100 calcium binding protein A10 | -0.0189644 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0188611 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0188476 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0186351 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0186277 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0185866 |
| RPL23 | ribosomal protein L23 | -0.018377 |
| ZNF292 | zinc finger protein 292 | -0.0183551 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0183184 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0178664 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.0178648 |
| VIM | vimentin | -0.0178194 |
| COG5 | component of oligomeric golgi complex 5 | -0.0177498 |
| HAS2 | hyaluronan synthase 2 | -0.0175783 |
| SMAD3 | SMAD family member 3 | -0.0174884 |
| CLIC4 | chloride intracellular channel 4 | -0.017488 |
| CCDC88A | coiled-coil domain containing 88A | -0.0174407 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0172 |
| PLSCR1 | phospholipid scramblase 1 | -0.0168354 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0166582 |
| RARS1 | arginyl-tRNA synthetase 1 | -0.0161519 |
| CCNL1 | cyclin L1 | -0.0158753 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0157621 |
| LAMB1 | laminin, beta 1 | -0.0155313 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0153096 |
| IRF1 | interferon regulatory factor 1 | -0.0151932 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0150997 |
| RPL8 | ribosomal protein L8 | -0.0149068 |
| ECE1 | endothelin converting enzyme 1 | -0.0146785 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0146486 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.014551 |
| MAP1B | microtubule-associated protein 1B | -0.0144038 |
| STC1 | stanniocalcin 1 | -0.0143963 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0143287 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0143221 |
| JAK2 | Janus kinase 2 | -0.0141885 |
| MX2 | MX dynamin-like GTPase 2 | -0.014154 |
| MKI67 | marker of proliferation Ki-67 | -0.0140734 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0140483 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0139106 |
| ITGAV | integrin, alpha V | -0.0138556 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.01385 |
| RPS11 | ribosomal protein S11 | -0.0137304 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0135226 |
| TMEM123 | transmembrane protein 123 | -0.0134349 |
