Riluzole hydrochloride_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.162017
PODXL podocalyxin-like 0.126789
MYH9 myosin, heavy chain 9, non-muscle 0.123193
PLEC plectin 0.122245
MT2A metallothionein 2A 0.117811
HLA-B major histocompatibility complex, class I, B 0.109209
PALM2AKAP2 PALM2 and AKAP2 fusion 0.10543
LOC112694756 uncharaterized LOC112694756 0.103753
MSN moesin 0.0943241
TMSB4X thymosin beta 4, X-linked 0.080833
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.074572
LDHA lactate dehydrogenase A 0.0716003
IFITM3 interferon induced transmembrane protein 3 0.0681337
BCAR3 breast cancer anti-estrogen resistance 3 0.0649832
LAMC2 laminin, gamma 2 0.0613378
TGM2 transglutaminase 2 0.0592276
SRRM2 serine/arginine repetitive matrix 2 0.0584045
HLA-A major histocompatibility complex, class I, A 0.058162
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0569861
CPNE1 copine I 0.0555689
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0543471
NCOR2 nuclear receptor corepressor 2 0.0517203
TMSB10 thymosin beta 10 0.0508777
PLS3 plastin 3 0.0503193
TNIP1 TNFAIP3 interacting protein 1 0.0498589
RPL37 ribosomal protein L37 0.0494903
IFI6 interferon, alpha-inducible protein 6 0.0485766
CEMIP cell migration inducing protein, hyaluronan binding 0.0475513
NONO non-POU domain containing, octamer-binding 0.0467835
HLA-C major histocompatibility complex, class I, C 0.0459999
NUMA1 nuclear mitotic apparatus protein 1 0.0452262
LMO7 LIM domain 7 0.0448879
ENO1 enolase 1, (alpha) 0.0446678
AOPEP aminopeptidase O (putative) 0.0445916
APLP2 amyloid beta (A4) precursor-like protein 2 0.0427711
BCL2L1 BCL2-like 1 0.0415336
CD59 CD59 molecule, complement regulatory protein 0.0411406
FTH1 ferritin, heavy polypeptide 1 0.0400797
FTL ferritin, light polypeptide 0.0394963
TPM3 tropomyosin 3 0.0394765
ITGB4 integrin, beta 4 0.0394035
RPL35A ribosomal protein L35a 0.0393841
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0388519
AMOTL1 angiomotin like 1 0.0374791
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0374226
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0367859
EEF2 eukaryotic translation elongation factor 2 0.0361873
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0360534
ARGLU1 arginine and glutamate rich 1 0.0357722
ACTN1 actinin, alpha 1 0.0355141
IFITM1 interferon induced transmembrane protein 1 0.0354741
YBX3 Y box binding protein 3 0.0351133
MPRIP myosin phosphatase Rho interacting protein 0.0350969
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.03469
TXNIP thioredoxin interacting protein 0.0346605
RPL3 ribosomal protein L3 0.034582
PCDH1 protocadherin 1 0.0342889
SH3PXD2A SH3 and PX domains 2A 0.0341904
GUK1 guanylate kinase 1 0.0341523
CEP250 centrosomal protein 250kDa 0.0341436
IFI44L interferon-induced protein 44-like 0.0335441
MACF1 microtubule-actin crosslinking factor 1 0.032894
BLCAP bladder cancer associated protein 0.0324247
AHNAK2 AHNAK nucleoprotein 2 0.0320755
PRSS23 protease, serine, 23 0.0317768
IFI27 interferon, alpha-inducible protein 27 0.0308671
HLA-E major histocompatibility complex, class I, E 0.0303894
CD9 CD9 molecule 0.030289
WARS1 tryptophanyl-tRNA synthetase 1 0.0302416
PLAT plasminogen activator, tissue 0.0301418
BHLHE40 basic helix-loop-helix family, member e40 0.0299914
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0299475
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0296453
PRELID3B PRELI domain containing 3B 0.0294143
PRRC2C proline-rich coiled-coil 2C 0.0293089
JAG1 jagged 1 0.0292979
MT1X metallothionein 1X 0.0291371
RPS19 ribosomal protein S19 0.029132
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0290349
MT1E metallothionein 1E 0.0288694
CALR calreticulin 0.0288512
FOSL1 FOS-like antigen 1 0.028632
SFTPA2 surfactant protein A2 0.0281615
S100A9 S100 calcium binding protein A9 0.0274306
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0274246
ANGPTL4 angiopoietin-like 4 0.0271645
MYOF myoferlin 0.0269453
APP amyloid beta (A4) precursor protein 0.0268066
FRMD6 FERM domain containing 6 0.026205
SET SET nuclear proto-oncogene 0.0260458
ZNF185 zinc finger protein 185 (LIM domain) 0.0259108
LAMA5 laminin, alpha 5 0.0257273
RPL31 ribosomal protein L31 0.0255876
SLK STE20-like kinase 0.0254823
NIBAN2 niban apoptosis regulator 2 0.0252917
EFHD2 EF-hand domain family, member D2 0.0251471
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0249121
LRRC8A leucine rich repeat containing 8 family, member A 0.0246367
PDE4D phosphodiesterase 4D, cAMP-specific 0.0241447
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0240673

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0999267
MTSS1 metastasis suppressor 1 -0.074825
TRIO trio Rho guanine nucleotide exchange factor -0.0734517
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0710928
MEF2A myocyte enhancer factor 2A -0.0642933
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0630756
NAMPT nicotinamide phosphoribosyltransferase -0.0627245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0600186
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0567936
DPYD dihydropyrimidine dehydrogenase -0.0540454
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0510382
RBM39 RNA binding motif protein 39 -0.0507988
KIAA1217 KIAA1217 -0.0498575
NRIP1 nuclear receptor interacting protein 1 -0.048309
SEC31A SEC31 homolog A (S. cerevisiae) -0.0482181
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0477536
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0461804
SULF1 sulfatase 1 -0.0431617
EMP1 epithelial membrane protein 1 -0.0430685
GOLGA4 golgin A4 -0.0418393
WASF2 WAS protein family, member 2 -0.0416238
ALCAM activated leukocyte cell adhesion molecule -0.0414104
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0407566
ITCH itchy E3 ubiquitin protein ligase -0.0398262
DLG1 discs, large homolog 1 (Drosophila) -0.0384019
FNIP1 folliculin interacting protein 1 -0.0378422
S100A10 S100 calcium binding protein A10 -0.0375441
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0366893
RAI14 retinoic acid induced 14 -0.034985
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0348412
GNAS GNAS complex locus -0.0336001
INTS6 integrator complex subunit 6 -0.0335423
SBF2 SET binding factor 2 -0.0325539
CANX calnexin -0.0322208
SQLE squalene epoxidase -0.0320517
PALLD palladin, cytoskeletal associated protein -0.0319185
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.031778
SQSTM1 sequestosome 1 -0.0317569
ANKRD33B ankyrin repeat domain 33B -0.0316838
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0304957
COG5 component of oligomeric golgi complex 5 -0.0304208
ANXA2 annexin A2 -0.029926
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0295704
FSCN1 fascin actin-bundling protein 1 -0.0285535
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0282217
PIBF1 progesterone immunomodulatory binding factor 1 -0.0281821
LDLR low density lipoprotein receptor -0.0276412
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0272967
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0272875
PDGFB platelet-derived growth factor beta polypeptide -0.026555
ABI3BP ABI family, member 3 (NESH) binding protein -0.0263811
SCFD1 sec1 family domain containing 1 -0.0256788
SUCO SUN domain containing ossification factor -0.0255076
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0254824
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0251349
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0249887
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0248827
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0248797
HM13 histocompatibility (minor) 13 -0.0247414
CSDE1 cold shock domain containing E1, RNA-binding -0.0247245
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0245444
STC1 stanniocalcin 1 -0.0244077
BZW1 basic leucine zipper and W2 domains 1 -0.0241961
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.0240134
COPB1 coatomer protein complex, subunit beta 1 -0.023968
GLG1 golgi glycoprotein 1 -0.0239189
NAP1L1 nucleosome assembly protein 1-like 1 -0.0238168
LMAN1 lectin, mannose-binding, 1 -0.0234096
ANLN anillin, actin binding protein -0.0233287
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0232845
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0232665
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0229983
ZFR zinc finger RNA binding protein -0.0229772
GARS1 glycyl-tRNA synthetase 1 -0.0227613
SRP54 signal recognition particle 54kDa -0.022546
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0223891
STAU1 staufen double-stranded RNA binding protein 1 -0.0223671
KMT2E lysine (K)-specific methyltransferase 2E -0.0220763
TMEM263 transmembrane protein 263 -0.0220282
DSTN destrin (actin depolymerizing factor) -0.0218315
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0217879
RIN2 Ras and Rab interactor 2 -0.0216568
AHNAK AHNAK nucleoprotein -0.021626
OGA O-GlcNAcase -0.0215433
MTDH metadherin -0.0213889
TMEM123 transmembrane protein 123 -0.0213087
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0212717
TKT transketolase -0.0209877
UFM1 ubiquitin-fold modifier 1 -0.0209414
GLS2 glutaminase 2 (liver, mitochondrial) -0.0208983
YME1L1 YME1-like 1 ATPase -0.0208443
HMGA2 high mobility group AT-hook 2 -0.0208113
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.020794
WSB1 WD repeat and SOCS box containing 1 -0.0206647
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0206038
BZW2 basic leucine zipper and W2 domains 2 -0.0205824
CD99 CD99 molecule -0.0202006
RAB1A RAB1A, member RAS oncogene family -0.0201491
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0200439
FNDC3A fibronectin type III domain containing 3A -0.0200389