Riluzole hydrochloride_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.0805342
EEF2 eukaryotic translation elongation factor 2 0.0754927
CD44 CD44 molecule (Indian blood group) 0.0585496
LOC112694756 uncharaterized LOC112694756 0.054027
SAMD4A sterile alpha motif domain containing 4A 0.0495974
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0472741
SMAD3 SMAD family member 3 0.047147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0467369
MYH9 myosin, heavy chain 9, non-muscle 0.0445766
MARCHF4 membrane associated ring-CH-type finger 4 0.0395164
MPRIP myosin phosphatase Rho interacting protein 0.0395049
RPL37A ribosomal protein L37a 0.0389052
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0384573
HSPA8 heat shock 70kDa protein 8 0.0377847
NONO non-POU domain containing, octamer-binding 0.0374642
EXT1 exostosin glycosyltransferase 1 0.0370807
VIM vimentin 0.0364937
FLNA filamin A, alpha 0.0357863
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0347299
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0332813
PLEC plectin 0.0326024
KMT2D lysine (K)-specific methyltransferase 2D 0.0325421
RPL3 ribosomal protein L3 0.0322363
LDHA lactate dehydrogenase A 0.0320836
ACTN1 actinin, alpha 1 0.0308913
NIBAN2 niban apoptosis regulator 2 0.0306041
MSN moesin 0.0298057
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0295319
HMGA2 high mobility group AT-hook 2 0.0294057
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0290069
ITGA6 integrin, alpha 6 0.0286312
RPLP0 ribosomal protein, large, P0 0.0278575
NDRG1 N-myc downstream regulated 1 0.0278083
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0273862
CD59 CD59 molecule, complement regulatory protein 0.0263313
TPT1 tumor protein, translationally-controlled 1 0.0255259
BCAR3 breast cancer anti-estrogen resistance 3 0.0251508
EFNB2 ephrin-B2 0.0250261
TRIO trio Rho guanine nucleotide exchange factor 0.0248456
FRMD6 FERM domain containing 6 0.024775
CPNE1 copine I 0.0246796
SHB Src homology 2 domain containing adaptor protein B 0.0242005
SRRM2 serine/arginine repetitive matrix 2 0.0237643
TUBA1B tubulin, alpha 1b 0.0235066
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.023433
NCOR2 nuclear receptor corepressor 2 0.0226268
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0224157
RPL7A ribosomal protein L7a 0.022233
MAML2 mastermind-like 2 (Drosophila) 0.0220293
RPL35A ribosomal protein L35a 0.0219225
RPS12 ribosomal protein S12 0.0218072
TPM4 tropomyosin 4 0.0217576
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.02166
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0213174
HEG1 heart development protein with EGF-like domains 1 0.0211942
HLA-B major histocompatibility complex, class I, B 0.0210689
RPS8 ribosomal protein S8 0.0204461
NAV1 neuron navigator 1 0.0202098
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0201626
RPS23 ribosomal protein S23 0.0199547
FOSL1 FOS-like antigen 1 0.0199335
NUMA1 nuclear mitotic apparatus protein 1 0.0198561
DBN1 drebrin 1 0.0196955
RPL15 ribosomal protein L15 0.019476
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0194181
CTBP2 C-terminal binding protein 2 0.019128
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0190684
EEF1G eukaryotic translation elongation factor 1 gamma 0.019059
RPS29 ribosomal protein S29 0.0188526
YBX1 Y box binding protein 1 0.0188182
RACK1 receptor for activated C kinase 1 0.0187109
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0184534
RPS17 ribosomal protein S17 0.0184264
LOC102724023 ES1 protein homolog, mitochondrial 0.0183033
KPNB1 karyopherin (importin) beta 1 0.0182447
RPL28 ribosomal protein L28 0.0182216
TRAPPC9 trafficking protein particle complex 9 0.0180347
RPL11 ribosomal protein L11 0.0178268
MOK MOK protein kinase 0.0177133
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0175405
IGFBP3 insulin-like growth factor binding protein 3 0.0174363
TNIP1 TNFAIP3 interacting protein 1 0.0170437
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0163867
SPTBN2 spectrin, beta, non-erythrocytic 2 0.0163848
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0160986
WNK1 WNK lysine deficient protein kinase 1 0.0160405
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0160327
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0159196
RPL30 ribosomal protein L30 0.015393
MED15 mediator complex subunit 15 0.015383
PCDH11X protocadherin 11 X-linked 0.0152882
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0152734
RPS10 ribosomal protein S10 0.0151443
CALR calreticulin 0.0150628
CALD1 caldesmon 1 0.0150136
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.0150134
RPS13 ribosomal protein S13 0.0149642
RPL7 ribosomal protein L7 0.014956
AGO2 argonaute RISC catalytic component 2 0.0149466
ACTN4 actinin, alpha 4 0.0148886

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223671
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.20095
AKAP12 A kinase (PRKA) anchor protein 12 -0.200313
MMP12 matrix metallopeptidase 12 -0.18694
PRKG1 protein kinase, cGMP-dependent, type I -0.125434
LSAMP limbic system-associated membrane protein -0.121267
EFNA5 ephrin-A5 -0.11981
GPC6 glypican 6 -0.104936
AHNAK AHNAK nucleoprotein -0.103628
PHACTR1 phosphatase and actin regulator 1 -0.10206
DTNA dystrobrevin, alpha -0.0990804
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0809283
PTK2 protein tyrosine kinase 2 -0.0757884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0721049
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0715151
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0695344
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.068086
PTPRD protein tyrosine phosphatase, receptor type, D -0.0674795
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0665179
CD109 CD109 molecule -0.0615994
ZNF292 zinc finger protein 292 -0.0610245
SBF2 SET binding factor 2 -0.05885
ZNF804A zinc finger protein 804A -0.0586767
LIMCH1 LIM and calponin homology domains 1 -0.0580765
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0570747
CDH13 cadherin 13 -0.0569629
MBD5 methyl-CpG binding domain protein 5 -0.0546572
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.054296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0529381
ASPH aspartate beta-hydroxylase -0.0515968
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0508129
FNDC3B fibronectin type III domain containing 3B -0.0506323
RBM39 RNA binding motif protein 39 -0.0501833
FN1 fibronectin 1 -0.0495319
WSB1 WD repeat and SOCS box containing 1 -0.0493839
ZMYM2 zinc finger, MYM-type 2 -0.0491176
H1-0 H1.0 linker histone -0.049097
UBC ubiquitin C -0.0485277
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0469309
PDE4D phosphodiesterase 4D, cAMP-specific -0.0467653
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0458962
PTCHD4 patched domain containing 4 -0.0454654
ZEB1 zinc finger E-box binding homeobox 1 -0.0450176
NF1 neurofibromin 1 -0.043072
TMSB10 thymosin beta 10 -0.0422547
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0422431
JMJD1C jumonji domain containing 1C -0.041887
CDK17 cyclin-dependent kinase 17 -0.041851
TAS2R14 taste receptor, type 2, member 14 -0.041526
ELL2 elongation factor, RNA polymerase II, 2 -0.0404287
PHF3 PHD finger protein 3 -0.0400489
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0398244
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0388883
GLS2 glutaminase 2 (liver, mitochondrial) -0.0388231
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0385363
NAMPT nicotinamide phosphoribosyltransferase -0.0383497
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0381444
ALCAM activated leukocyte cell adhesion molecule -0.0377341
KDM3A lysine (K)-specific demethylase 3A -0.0377223
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0374372
FMNL2 formin-like 2 -0.0371468
RPL23 ribosomal protein L23 -0.0371277
NBAS neuroblastoma amplified sequence -0.0369999
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.036268
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0357516
PNISR PNN-interacting serine/arginine-rich protein -0.0349147
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0349019
RAI14 retinoic acid induced 14 -0.0345298
KIAA1217 KIAA1217 -0.0345075
NUP58 nucleoporin 58 -0.034483
CDK14 cyclin-dependent kinase 14 -0.0343366
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0341789
OSBPL8 oxysterol binding protein-like 8 -0.0341027
SPAG9 sperm associated antigen 9 -0.0340397
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0330756
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0329878
ADAM9 ADAM metallopeptidase domain 9 -0.0327015
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0326841
WAC WW domain containing adaptor with coiled-coil -0.0324739
SEPTIN7 septin 7 -0.0323411
BRWD1 bromodomain and WD repeat domain containing 1 -0.0322501
PBX3 pre-B-cell leukemia homeobox 3 -0.0322224
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0321328
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0320985
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0319402
SAMD3 sterile alpha motif domain containing 3 -0.0317021
PRELID2 PRELI domain containing 2 -0.0309336
PARD3 par-3 family cell polarity regulator -0.030901
GOLGA4 golgin A4 -0.0307823
MYOF myoferlin -0.0307483
MAP4 microtubule-associated protein 4 -0.0302733
BIRC6 baculoviral IAP repeat containing 6 -0.0302091
CFAP20DC CFAP20 domain containing -0.0298795
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0296658
JARID2 jumonji, AT rich interactive domain 2 -0.0296078
CANX calnexin -0.0295952
ANXA2 annexin A2 -0.029331
ARHGAP18 Rho GTPase activating protein 18 -0.0290569
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0281325
LIMS1 LIM and senescent cell antigen-like domains 1 -0.028016