Riluzole hydrochloride_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.213327
CEMIP cell migration inducing protein, hyaluronan binding 0.188801
KRT18 keratin 18, type I 0.14263
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.139987
EEF2 eukaryotic translation elongation factor 2 0.129134
FAT1 FAT atypical cadherin 1 0.105803
CALR calreticulin 0.102858
TMSB10 thymosin beta 10 0.0933003
PTMA prothymosin, alpha 0.085564
LOC112694756 uncharaterized LOC112694756 0.08327
SRRM2 serine/arginine repetitive matrix 2 0.0815203
TPT1 tumor protein, translationally-controlled 1 0.0808201
MYH9 myosin, heavy chain 9, non-muscle 0.0787972
MT2A metallothionein 2A 0.0716773
LDHA lactate dehydrogenase A 0.0694362
ACTG1 actin gamma 1 0.0676642
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0627397
RPL3 ribosomal protein L3 0.0565856
TNS4 tensin 4 0.0540403
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0537586
PDIA4 protein disulfide isomerase family A, member 4 0.0520799
MT1E metallothionein 1E 0.0504881
NUMA1 nuclear mitotic apparatus protein 1 0.0486916
MPRIP myosin phosphatase Rho interacting protein 0.0452846
EEF1G eukaryotic translation elongation factor 1 gamma 0.0438112
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0415092
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.041114
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0405445
MACF1 microtubule-actin crosslinking factor 1 0.0403191
RPS27A ribosomal protein S27a 0.0397037
TMSB4X thymosin beta 4, X-linked 0.039231
SAMD5 sterile alpha motif domain containing 5 0.0390431
ASPH aspartate beta-hydroxylase 0.0383404
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.037623
TNIP1 TNFAIP3 interacting protein 1 0.0375908
HSPA8 heat shock 70kDa protein 8 0.0374858
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0373726
ABHD2 abhydrolase domain containing 2 0.0372139
ENO1 enolase 1, (alpha) 0.0370027
TMEM45B transmembrane protein 45B 0.0364197
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0363749
RPL37 ribosomal protein L37 0.035794
VEGFA vascular endothelial growth factor A 0.0354796
TUBA1B tubulin, alpha 1b 0.0351429
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0350957
GMDS GDP-mannose 4,6-dehydratase 0.034571
NONO non-POU domain containing, octamer-binding 0.0345056
KLF3 Kruppel-like factor 3 (basic) 0.0342599
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031958
MYO1E myosin IE 0.0315764
S100A6 S100 calcium binding protein A6 0.0307447
RPL15 ribosomal protein L15 0.0304743
FTL ferritin, light polypeptide 0.0299412
MINK1 misshapen-like kinase 1 0.0296049
RPL35A ribosomal protein L35a 0.0295812
CD9 CD9 molecule 0.0294409
RAD51B RAD51 paralog B 0.028941
CMIP c-Maf inducing protein 0.0286394
EPHB2 EPH receptor B2 0.0281643
NCOR2 nuclear receptor corepressor 2 0.0280864
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.028084
MYH14 myosin, heavy chain 14, non-muscle 0.027855
SH3D19 SH3 domain containing 19 0.02772
RPL9 ribosomal protein L9 0.0277054
MT1X metallothionein 1X 0.0275767
GUK1 guanylate kinase 1 0.0274601
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0270608
MLEC malectin 0.0259515
GIGYF2 GRB10 interacting GYF protein 2 0.0258771
RPL23 ribosomal protein L23 0.0257689
KMT2D lysine (K)-specific methyltransferase 2D 0.0254213
MYO5B myosin VB 0.0252209
TRIO trio Rho guanine nucleotide exchange factor 0.0243083
RPS12 ribosomal protein S12 0.0242624
OCIAD2 OCIA domain containing 2 0.0242189
HYOU1 hypoxia up-regulated 1 0.0241229
PDZD8 PDZ domain containing 8 0.0237496
TPM3 tropomyosin 3 0.0237345
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0236499
NEBL nebulette 0.0232801
SPON1 spondin 1, extracellular matrix protein 0.0232698
ZFP36L2 ZFP36 ring finger protein-like 2 0.0232692
SOX9 SRY (sex determining region Y)-box 9 0.0230161
RPS3 ribosomal protein S3 0.0228104
RRM2 ribonucleotide reductase M2 0.0226474
PRELID3B PRELI domain containing 3B 0.022643
RPS17 ribosomal protein S17 0.022641
CPNE1 copine I 0.0226138
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.022398
PDE4D phosphodiesterase 4D, cAMP-specific 0.0223219
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0220461
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0218166
GPR39 G protein-coupled receptor 39 0.0216874
SRSF4 serine/arginine-rich splicing factor 4 0.0216285
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.021473
RPL7 ribosomal protein L7 0.0213255
BMP4 bone morphogenetic protein 4 0.0212846
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0212619
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0212082
RPL27 ribosomal protein L27 0.0211833

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.231248
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.101415
TXNIP thioredoxin interacting protein -0.0897609
NDRG1 N-myc downstream regulated 1 -0.0839629
GOLGA4 golgin A4 -0.0837876
MUC6 mucin 6, oligomeric mucus/gel-forming -0.075511
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0745484
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0707169
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0673425
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0659663
FAM13A family with sequence similarity 13, member A -0.0642577
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0631407
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.062908
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0625334
RPS6 ribosomal protein S6 -0.0598688
EREG epiregulin -0.0592837
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0557947
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0544762
RBM39 RNA binding motif protein 39 -0.0530233
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0514338
MED13L mediator complex subunit 13-like -0.0504441
BIRC6 baculoviral IAP repeat containing 6 -0.0496529
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0481906
GPHN gephyrin -0.0480777
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0472992
UBA6 ubiquitin-like modifier activating enzyme 6 -0.046254
IARS1 isoleucyl-tRNA synthetase 1 -0.0461314
NCOR1 nuclear receptor corepressor 1 -0.0455984
WDR45B WD repeat domain 45B -0.045304
H1-0 H1.0 linker histone -0.0452787
HMGA1 high mobility group AT-hook 1 -0.0452154
ZNF292 zinc finger protein 292 -0.0447757
RAB1A RAB1A, member RAS oncogene family -0.0440715
EZR ezrin -0.0439604
PNISR PNN-interacting serine/arginine-rich protein -0.0416421
RAP1B RAP1B, member of RAS oncogene family -0.0416381
NPSR1 neuropeptide S receptor 1 -0.0411419
SEC31A SEC31 homolog A (S. cerevisiae) -0.0408213
GDF15 growth differentiation factor 15 -0.0396823
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0393759
PUM2 pumilio RNA-binding family member 2 -0.0392497
ZMYM2 zinc finger, MYM-type 2 -0.0389422
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0384989
KMT2E lysine (K)-specific methyltransferase 2E -0.0377147
NF1 neurofibromin 1 -0.0377032
KDM3A lysine (K)-specific demethylase 3A -0.037326
NAMPT nicotinamide phosphoribosyltransferase -0.0372832
COG5 component of oligomeric golgi complex 5 -0.0370376
ESYT2 extended synaptotagmin-like protein 2 -0.0370237
PIGR polymeric immunoglobulin receptor -0.0366393
GCC2 GRIP and coiled-coil domain containing 2 -0.0360114
USP3 ubiquitin specific peptidase 3 -0.0353852
MXI1 MAX interactor 1, dimerization protein -0.0351275
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0348698
VMP1 vacuole membrane protein 1 -0.034764
RPL5 ribosomal protein L5 -0.0345652
RNF145 ring finger protein 145 -0.0341728
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0340233
WAC WW domain containing adaptor with coiled-coil -0.03402
TMEM123 transmembrane protein 123 -0.034009
MATR3 matrin 3 -0.033795
ARF4 ADP-ribosylation factor 4 -0.0336588
DDIT4 DNA-damage-inducible transcript 4 -0.0334986
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0332693
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0332218
ANXA2 annexin A2 -0.0327758
SLC38A2 solute carrier family 38, member 2 -0.0327748
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0326232
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0324784
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0324346
TM9SF3 transmembrane 9 superfamily member 3 -0.0319441
SETD5 SET domain containing 5 -0.0316844
JMJD1C jumonji domain containing 1C -0.0316786
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0316748
TFRC transferrin receptor -0.0313428
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0313017
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0312297
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0311423
GARS1 glycyl-tRNA synthetase 1 -0.0310666
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0307142
SBF2 SET binding factor 2 -0.0305017
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0301607
KITLG KIT ligand -0.0300856
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.029944
TSC22D2 TSC22 domain family, member 2 -0.0292503
DERA deoxyribose-phosphate aldolase (putative) -0.0290765
ATF4 activating transcription factor 4 -0.029028
ANXA1 annexin A1 -0.0290014
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0288809
NFIA nuclear factor I/A -0.0287184
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0287164
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.028677
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0281649
MON2 MON2 homolog (S. cerevisiae) -0.0279675
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0276838
MBNL1 muscleblind-like splicing regulator 1 -0.0276807
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0275117
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0268158
FNBP1L formin binding protein 1-like -0.0265481
SPAG9 sperm associated antigen 9 -0.0265016