Riluzole hydrochloride_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.137113
KRT8 keratin 8, type II 0.119349
KRT18 keratin 18, type I 0.110845
LOC112694756 uncharaterized LOC112694756 0.0911193
MYH9 myosin, heavy chain 9, non-muscle 0.0737196
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0670473
MPRIP myosin phosphatase Rho interacting protein 0.0653382
HLA-B major histocompatibility complex, class I, B 0.0616496
RPL3 ribosomal protein L3 0.0603064
SRRM2 serine/arginine repetitive matrix 2 0.0584905
TNIP1 TNFAIP3 interacting protein 1 0.0517849
ANXA11 annexin A11 0.0487949
EEF1G eukaryotic translation elongation factor 1 gamma 0.0487628
KMT2D lysine (K)-specific methyltransferase 2D 0.0442399
FAT1 FAT atypical cadherin 1 0.043542
TMSB10 thymosin beta 10 0.0423085
ITGB4 integrin, beta 4 0.0407
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0403891
MT2A metallothionein 2A 0.0389177
ARGLU1 arginine and glutamate rich 1 0.0386985
RPS19 ribosomal protein S19 0.0386335
POTEF POTE ankyrin domain family, member F 0.0385845
PCBP2 poly(rC) binding protein 2 0.0385511
ACTG1 actin gamma 1 0.0385141
NONO non-POU domain containing, octamer-binding 0.0369982
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.03586
RPL37 ribosomal protein L37 0.0327761
TNRC18 trinucleotide repeat containing 18 0.032258
RNF145 ring finger protein 145 0.0313933
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0313513
KTN1 kinectin 1 (kinesin receptor) 0.0307811
PRRC2C proline-rich coiled-coil 2C 0.0303407
NCOR2 nuclear receptor corepressor 2 0.0302443
BCL2L1 BCL2-like 1 0.0302374
LDHA lactate dehydrogenase A 0.0300426
YBX1 Y box binding protein 1 0.029677
ESYT2 extended synaptotagmin-like protein 2 0.0288945
EPHA2 EPH receptor A2 0.0285627
PKM pyruvate kinase, muscle 0.0277799
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0276087
RPL36 ribosomal protein L36 0.027265
SET SET nuclear proto-oncogene 0.0272322
S100P S100 calcium binding protein P 0.0271896
MUC13 mucin 13, cell surface associated 0.0270667
HLA-C major histocompatibility complex, class I, C 0.0267505
TPM3 tropomyosin 3 0.0265971
HLA-A major histocompatibility complex, class I, A 0.0263869
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0252708
BHLHE40 basic helix-loop-helix family, member e40 0.0251757
SON SON DNA binding protein 0.0245787
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0243277
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0242698
PLEC plectin 0.0240364
SFPQ splicing factor proline/glutamine-rich 0.0239648
WWOX WW domain containing oxidoreductase 0.0237024
FTH1 ferritin, heavy polypeptide 1 0.0236871
PRELID3B PRELI domain containing 3B 0.023646
SEPTIN2 septin 2 0.022699
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0226491
RNF43 ring finger protein 43 0.0221491
MINK1 misshapen-like kinase 1 0.0220217
VEGFA vascular endothelial growth factor A 0.0219595
RREB1 ras responsive element binding protein 1 0.0218136
RPS14 ribosomal protein S14 0.0218134
IFITM3 interferon induced transmembrane protein 3 0.0217434
NUMA1 nuclear mitotic apparatus protein 1 0.0213669
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0212671
NDRG1 N-myc downstream regulated 1 0.0209958
B2M beta-2-microglobulin 0.020907
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0208437
RIMKLB ribosomal modification protein rimK-like family member B 0.020787
YBX3 Y box binding protein 3 0.0205473
HRNR hornerin 0.0205229
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0203476
WWC1 WW and C2 domain containing 1 0.020322
PFN1 profilin 1 0.0202887
CD9 CD9 molecule 0.0202295
CD46 CD46 molecule, complement regulatory protein 0.0198665
DOCK5 dedicator of cytokinesis 5 0.0197953
MACROH2A1 macroH2A.1 histone 0.0197934
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0193855
CHD1 chromodomain helicase DNA binding protein 1 0.0190662
ASPH aspartate beta-hydroxylase 0.0190472
IFI27 interferon, alpha-inducible protein 27 0.0185843
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0184917
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0184703
FTL ferritin, light polypeptide 0.0182472
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0182465
APOL2 apolipoprotein L, 2 0.0181667
TPI1 triosephosphate isomerase 1 0.0179801
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0179365
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0178946
RPS27 ribosomal protein S27 0.0178548
MT1X metallothionein 1X 0.0178296
GIGYF2 GRB10 interacting GYF protein 2 0.0178059
SLK STE20-like kinase 0.017761
DIAPH1 diaphanous-related formin 1 0.0176594
DBN1 drebrin 1 0.0175738
ARID1A AT rich interactive domain 1A (SWI-like) 0.0174723
TUBA1B tubulin, alpha 1b 0.0174657

decreased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 -0.145673
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.144298
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140966
TPT1 tumor protein, translationally-controlled 1 -0.116116
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115141
GMDS GDP-mannose 4,6-dehydratase -0.112708
LMO7 LIM domain 7 -0.106687
ZSWIM6 zinc finger, SWIM-type containing 6 -0.105479
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.101934
MYO1E myosin IE -0.0904703
VCL vinculin -0.0878778
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.08606
ANXA2 annexin A2 -0.0845769
PTPRK protein tyrosine phosphatase, receptor type, K -0.0842549
PTPRB protein tyrosine phosphatase, receptor type, B -0.0833249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0808261
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0757354
INTS6 integrator complex subunit 6 -0.0740669
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.069482
PTPRR protein tyrosine phosphatase, receptor type, R -0.0684728
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0662688
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0654478
CATSPERB catsper channel auxiliary subunit beta -0.064892
TAS2R14 taste receptor, type 2, member 14 -0.0613983
RPL34 ribosomal protein L34 -0.059207
FRMD5 FERM domain containing 5 -0.0579036
EXT1 exostosin glycosyltransferase 1 -0.0563267
RIGI RNA sensor RIG-I -0.0559597
SEC31A SEC31 homolog A (S. cerevisiae) -0.0559289
CCSER1 coiled-coil serine-rich protein 1 -0.0547158
CANX calnexin -0.0543013
PDLIM5 PDZ and LIM domain 5 -0.0531136
RPS8 ribosomal protein S8 -0.0510731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0509078
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0500406
SP100 SP100 nuclear antigen -0.0491061
THSD4 thrombospondin, type I, domain containing 4 -0.048121
CDK13 cyclin-dependent kinase 13 -0.0478522
KLF5 Kruppel-like factor 5 (intestinal) -0.0467662
NT5C2 5'-nucleotidase, cytosolic II -0.0460842
MCU mitochondrial calcium uniporter -0.0458098
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0451519
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0448882
RAP1B RAP1B, member of RAS oncogene family -0.0447183
PATJ PATJ crumbs cell polarity complex component -0.0445282
PDE4D phosphodiesterase 4D, cAMP-specific -0.0443632
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0436016
JMJD1C jumonji domain containing 1C -0.043593
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0434125
RAB1A RAB1A, member RAS oncogene family -0.042991
LPP LIM domain containing preferred translocation partner in lipoma -0.0427688
LAMB3 laminin, beta 3 -0.0425586
TRIM2 tripartite motif containing 2 -0.0412489
PDIA3 protein disulfide isomerase family A, member 3 -0.0411135
USP53 ubiquitin specific peptidase 53 -0.040647
IFRD1 interferon-related developmental regulator 1 -0.0404197
PRELID2 PRELI domain containing 2 -0.0403962
CUX1 cut-like homeobox 1 -0.039734
IRF1 interferon regulatory factor 1 -0.0396124
MON2 MON2 homolog (S. cerevisiae) -0.0395288
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0395211
LRRC23 leucine rich repeat containing 23 -0.0391539
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0386581
RPL4 ribosomal protein L4 -0.037758
GOLGA4 golgin A4 -0.0375989
SHROOM3 shroom family member 3 -0.0375429
MYO6 myosin VI -0.0370356
DSG3 desmoglein 3 -0.0368412
RPS6 ribosomal protein S6 -0.036511
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0359686
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0358628
CALB1 calbindin 1, 28kDa -0.0357413
DENND1A DENN/MADD domain containing 1A -0.035663
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0349254
TCF12 transcription factor 12 -0.0348553
FNDC3B fibronectin type III domain containing 3B -0.0346126
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0345076
TTC3 tetratricopeptide repeat domain 3 -0.0337927
USP15 ubiquitin specific peptidase 15 -0.0337583
PLSCR1 phospholipid scramblase 1 -0.0336511
PALLD palladin, cytoskeletal associated protein -0.0336198
LARP1B La ribonucleoprotein domain family, member 1B -0.0328202
STK17A serine/threonine kinase 17a -0.0326079
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0325777
PLAC8 placenta-specific 8 -0.0321132
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0315281
AHNAK AHNAK nucleoprotein -0.0313844
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0312952
COG5 component of oligomeric golgi complex 5 -0.0311727
SLC38A2 solute carrier family 38, member 2 -0.0310876
RPS24 ribosomal protein S24 -0.0310086
TJP1 tight junction protein 1 -0.0309668
PHF3 PHD finger protein 3 -0.0308179
NABP1 nucleic acid binding protein 1 -0.0308097
FNIP1 folliculin interacting protein 1 -0.030797
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0307182
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0307098
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.03045
NPSR1 neuropeptide S receptor 1 -0.0303463
IARS1 isoleucyl-tRNA synthetase 1 -0.0302433