Riluzole hydrochloride_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Riluzole hydrochloride_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 0.177069
GRAMD1B GRAM domain containing 1B 0.16092
MT2A metallothionein 2A 0.143359
TMSB10 thymosin beta 10 0.12241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0997186
MYH9 myosin, heavy chain 9, non-muscle 0.0847228
SRRM2 serine/arginine repetitive matrix 2 0.08395
SEC61G Sec61 gamma subunit 0.0819227
FTH1 ferritin, heavy polypeptide 1 0.0799542
KRT18 keratin 18, type I 0.0780025
EGR1 early growth response 1 0.0778808
LDHA lactate dehydrogenase A 0.0721004
RPL35A ribosomal protein L35a 0.0667577
TNIP1 TNFAIP3 interacting protein 1 0.0654671
BCAR3 breast cancer anti-estrogen resistance 3 0.0609667
PLEC plectin 0.0594349
PM20D1 peptidase M20 domain containing 1 0.058949
FTL ferritin, light polypeptide 0.0578923
AREG amphiregulin 0.0570624
ELL2 elongation factor, RNA polymerase II, 2 0.0559007
YBX3 Y box binding protein 3 0.0541095
RPS3 ribosomal protein S3 0.0516047
ANKRD11 ankyrin repeat domain 11 0.0512784
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0512755
STC1 stanniocalcin 1 0.0511005
ARGLU1 arginine and glutamate rich 1 0.0501731
ENO1 enolase 1, (alpha) 0.0479813
HYOU1 hypoxia up-regulated 1 0.0477589
KRT8 keratin 8, type II 0.0469874
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0467797
HSPA8 heat shock 70kDa protein 8 0.0467243
SON SON DNA binding protein 0.0464559
ACTG1 actin gamma 1 0.046381
RPLP1 ribosomal protein, large, P1 0.0462652
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0447735
EEF2 eukaryotic translation elongation factor 2 0.0427616
TES testin LIM domain protein 0.0420925
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0418459
RPL3 ribosomal protein L3 0.0417765
AKAP12 A kinase (PRKA) anchor protein 12 0.0413259
S100P S100 calcium binding protein P 0.0408188
LAMA4 laminin, alpha 4 0.040617
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0394266
RPL11 ribosomal protein L11 0.03942
CALR calreticulin 0.0393168
RPL37 ribosomal protein L37 0.0392693
B2M beta-2-microglobulin 0.0392085
MSN moesin 0.0387804
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0381417
PTMA prothymosin, alpha 0.0381126
HLA-B major histocompatibility complex, class I, B 0.0376512
MT1X metallothionein 1X 0.0368552
LMO7 LIM domain 7 0.0367162
KMT2D lysine (K)-specific methyltransferase 2D 0.036211
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0358431
CIB1 calcium and integrin binding 1 (calmyrin) 0.0355566
TPT1 tumor protein, translationally-controlled 1 0.0352788
CEMIP cell migration inducing protein, hyaluronan binding 0.0348547
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0344264
RPL37A ribosomal protein L37a 0.0330433
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0323908
MAGEA4 melanoma antigen family A4 0.0323302
RHOV ras homolog family member V 0.0320928
BMP6 bone morphogenetic protein 6 0.0319978
EPAS1 endothelial PAS domain protein 1 0.031433
TRAPPC9 trafficking protein particle complex 9 0.0313978
DOCK5 dedicator of cytokinesis 5 0.0307786
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0304379
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0304368
IGFBP3 insulin-like growth factor binding protein 3 0.0301699
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0299002
SLTM SAFB-like, transcription modulator 0.0298678
RPS27 ribosomal protein S27 0.0296066
GUK1 guanylate kinase 1 0.0294616
MPRIP myosin phosphatase Rho interacting protein 0.0294211
STEAP3 STEAP family member 3, metalloreductase 0.0289302
SDC1 syndecan 1 0.0289019
EXT1 exostosin glycosyltransferase 1 0.0283757
EZR ezrin 0.028256
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0280952
ZNF185 zinc finger protein 185 (LIM domain) 0.0280758
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0280223
SEPTIN2 septin 2 0.0277737
RNF213 ring finger protein 213 0.0276801
MORF4L2 mortality factor 4 like 2 0.0275114
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0270225
TPI1 triosephosphate isomerase 1 0.0270008
MCL1 myeloid cell leukemia 1 0.0269652
RPLP0 ribosomal protein, large, P0 0.0268988
RPS17 ribosomal protein S17 0.026884
ACTN1 actinin, alpha 1 0.0263786
RPL23 ribosomal protein L23 0.0262699
RPS25 ribosomal protein S25 0.0262661
PGK1 phosphoglycerate kinase 1 0.0262566
RPL12 ribosomal protein L12 0.026243
SAMD4A sterile alpha motif domain containing 4A 0.0260276
NTSR1 neurotensin receptor 1 (high affinity) 0.0259235
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.0258706
RPS19 ribosomal protein S19 0.0258192
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0256617

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.320025
EGFR epidermal growth factor receptor -0.217282
LRP1B low density lipoprotein receptor-related protein 1B -0.0936932
PTPRM protein tyrosine phosphatase, receptor type, M -0.0920949
AKR1C1 aldo-keto reductase family 1, member C1 -0.0847541
CAV1 caveolin 1, caveolae protein, 22kDa -0.0700448
NAMPT nicotinamide phosphoribosyltransferase -0.0661968
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0568845
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0553666
SOD2 superoxide dismutase 2, mitochondrial -0.0425035
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0417789
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.041447
TMEM165 transmembrane protein 165 -0.0393189
CCND1 cyclin D1 -0.0393139
USP34 ubiquitin specific peptidase 34 -0.0387852
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.038475
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0384534
MCTP1 multiple C2 domains, transmembrane 1 -0.037826
ANKRD12 ankyrin repeat domain 12 -0.0366671
FNDC3B fibronectin type III domain containing 3B -0.0357617
PATJ PATJ crumbs cell polarity complex component -0.0350921
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0341629
NRIP1 nuclear receptor interacting protein 1 -0.0341007
KMT2E lysine (K)-specific methyltransferase 2E -0.0339536
SPAG9 sperm associated antigen 9 -0.0338785
H1-0 H1.0 linker histone -0.0335978
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335014
ARHGAP32 Rho GTPase activating protein 32 -0.0331562
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0331209
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0330755
WASF2 WAS protein family, member 2 -0.0325412
ABLIM1 actin binding LIM protein 1 -0.0308098
USP53 ubiquitin specific peptidase 53 -0.030223
EFNA5 ephrin-A5 -0.0298635
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0298262
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0291285
MKI67 marker of proliferation Ki-67 -0.0290388
GSK3B glycogen synthase kinase 3 beta -0.0280334
BIRC6 baculoviral IAP repeat containing 6 -0.0277402
SLMAP sarcolemma associated protein -0.0269886
OSMR oncostatin M receptor -0.0262993
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0262856
SBF2 SET binding factor 2 -0.0261843
EHBP1 EH domain binding protein 1 -0.0259675
BRWD1 bromodomain and WD repeat domain containing 1 -0.0257562
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0253998
ZNF638 zinc finger protein 638 -0.0252916
KDM2A lysine (K)-specific demethylase 2A -0.0252063
BIRC3 baculoviral IAP repeat containing 3 -0.0250821
TAS2R14 taste receptor, type 2, member 14 -0.02505
PAPOLA poly(A) polymerase alpha -0.024973
JMJD1C jumonji domain containing 1C -0.0248357
ANXA2 annexin A2 -0.0246394
ANKRD10 ankyrin repeat domain 10 -0.024389
AHNAK AHNAK nucleoprotein -0.0239954
RIN2 Ras and Rab interactor 2 -0.0239317
RNF145 ring finger protein 145 -0.0236722
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0236454
GCLC glutamate-cysteine ligase, catalytic subunit -0.0231707
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0226868
WDR45B WD repeat domain 45B -0.0225666
RAB10 RAB10, member RAS oncogene family -0.0224005
RAP1B RAP1B, member of RAS oncogene family -0.0219809
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0215947
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0214684
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0214414
ZMYM2 zinc finger, MYM-type 2 -0.021302
FNIP1 folliculin interacting protein 1 -0.0211852
ECT2 epithelial cell transforming 2 -0.0210093
TRAF3 TNF receptor-associated factor 3 -0.0207361
ARHGAP26 Rho GTPase activating protein 26 -0.0206091
ZC3H11A zinc finger CCCH-type containing 11A -0.0203193
NF1 neurofibromin 1 -0.0202602
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0201667
RUNX1 runt-related transcription factor 1 -0.020125
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0200747
RASA2 RAS p21 protein activator 2 -0.0196859
NABP1 nucleic acid binding protein 1 -0.019655
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0196496
MBD5 methyl-CpG binding domain protein 5 -0.0194181
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0193513
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0193269
SEC31A SEC31 homolog A (S. cerevisiae) -0.0192863
LAMC2 laminin, gamma 2 -0.0191314
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0188252
TPD52 tumor protein D52 -0.0187655
TNS3 tensin 3 -0.0186786
GPATCH2L G patch domain containing 2-like -0.0185904
STRN3 striatin, calmodulin binding protein 3 -0.0183499
MCU mitochondrial calcium uniporter -0.0183494
IGFBP5 insulin-like growth factor binding protein 5 -0.0183192
TLK1 tousled-like kinase 1 -0.01825
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0182281
NGLY1 N-glycanase 1 -0.0181959
CDC73 cell division cycle 73 -0.0180221
MAML2 mastermind-like 2 (Drosophila) -0.0178831
UVRAG UV radiation resistance associated -0.0178085
CDCP1 CUB domain containing protein 1 -0.0176031
MARF1 meiosis regulator and mRNA stability factor 1 -0.0174982
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0172372