| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Riluzole hydrochloride perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Riluzole hydrochloride_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.262441 |
| GRAMD1B | GRAM domain containing 1B | 0.219104 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.196521 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.123456 |
| ACTG1 | actin gamma 1 | 0.116252 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.108595 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.100416 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0966284 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0901487 |
| HLA-B | major histocompatibility complex, class I, B | 0.0838734 |
| CMIP | c-Maf inducing protein | 0.0786726 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0684059 |
| ACTN1 | actinin, alpha 1 | 0.0660912 |
| RPL3 | ribosomal protein L3 | 0.0633306 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.061581 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0606758 |
| HLA-A | major histocompatibility complex, class I, A | 0.0591229 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0578341 |
| PLEC | plectin | 0.05407 |
| FAM107B | family with sequence similarity 107, member B | 0.0539492 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0528736 |
| LDHA | lactate dehydrogenase A | 0.049263 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0492174 |
| HLA-C | major histocompatibility complex, class I, C | 0.0482545 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0468561 |
| FLNA | filamin A, alpha | 0.0457826 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0427007 |
| TMSB10 | thymosin beta 10 | 0.0425191 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0424686 |
| APP | amyloid beta (A4) precursor protein | 0.040828 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0407816 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0407216 |
| LAMC2 | laminin, gamma 2 | 0.0401552 |
| CALR | calreticulin | 0.040043 |
| ANGPTL4 | angiopoietin-like 4 | 0.0399438 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0398513 |
| MCL1 | myeloid cell leukemia 1 | 0.0386167 |
| PYGL | phosphorylase, glycogen, liver | 0.0384919 |
| MSN | moesin | 0.0384436 |
| FLNB | filamin B, beta | 0.0384382 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0380898 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0373464 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0370324 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0368679 |
| STC1 | stanniocalcin 1 | 0.0360994 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0356985 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0349432 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0345317 |
| S100A6 | S100 calcium binding protein A6 | 0.0344502 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0340961 |
| CAVIN1 | caveolae associated protein 1 | 0.0333021 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0329312 |
| IL6 | interleukin 6 | 0.032887 |
| PFKP | phosphofructokinase, platelet | 0.0322185 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0320644 |
| SFTPA2 | surfactant protein A2 | 0.0315616 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0314958 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0298269 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0296909 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0296536 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0296311 |
| MT1X | metallothionein 1X | 0.0295686 |
| RPL37 | ribosomal protein L37 | 0.0294013 |
| HYOU1 | hypoxia up-regulated 1 | 0.0289756 |
| NDRG1 | N-myc downstream regulated 1 | 0.0287341 |
| CTSL | cathepsin L | 0.0284949 |
| JUN | jun proto-oncogene | 0.0276772 |
| NONO | non-POU domain containing, octamer-binding | 0.0274066 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0271228 |
| TPM3 | tropomyosin 3 | 0.027051 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0267351 |
| BRD2 | bromodomain containing 2 | 0.0266441 |
| HLA-E | major histocompatibility complex, class I, E | 0.0261559 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0259933 |
| SON | SON DNA binding protein | 0.0254096 |
| KRT18 | keratin 18, type I | 0.0253745 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0252372 |
| PRELID3B | PRELI domain containing 3B | 0.0252241 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0251949 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0251864 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0251734 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.025146 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0251388 |
| KLC1 | kinesin light chain 1 | 0.0249965 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0249109 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0247135 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0242215 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0242018 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.024074 |
| DST | dystonin | 0.023936 |
| CEP250 | centrosomal protein 250kDa | 0.0239132 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0239047 |
| FRMD6 | FERM domain containing 6 | 0.0238132 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0237908 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0235402 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0234166 |
| EGR1 | early growth response 1 | 0.0233647 |
| PRDX1 | peroxiredoxin 1 | 0.0231651 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0230313 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.022921 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.285203 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.190904 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0923253 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0785826 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0657756 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0626336 |
| VIM | vimentin | -0.0569367 |
| RTN4 | reticulon 4 | -0.0505307 |
| WDR43 | WD repeat domain 43 | -0.0471537 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0457654 |
| ZNF292 | zinc finger protein 292 | -0.0443552 |
| DENND4A | DENN/MADD domain containing 4A | -0.0430626 |
| USP3 | ubiquitin specific peptidase 3 | -0.0425147 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0423364 |
| RBM39 | RNA binding motif protein 39 | -0.040486 |
| IGF2 | insulin-like growth factor 2 | -0.0376205 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0371601 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0369887 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0368328 |
| SRGN | serglycin | -0.0361072 |
| NOP58 | NOP58 ribonucleoprotein | -0.0354487 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0352075 |
| FTL | ferritin, light polypeptide | -0.0342931 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0340172 |
| RBM25 | RNA binding motif protein 25 | -0.0339047 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0338905 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0338224 |
| HMGA1 | high mobility group AT-hook 1 | -0.0333777 |
| ANKRD28 | ankyrin repeat domain 28 | -0.033357 |
| ZNF207 | zinc finger protein 207 | -0.033281 |
| ECT2 | epithelial cell transforming 2 | -0.0329991 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0322894 |
| CHN1 | chimerin 1 | -0.0316488 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0313687 |
| TMEM123 | transmembrane protein 123 | -0.0313285 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0307129 |
| TFG | TRK-fused gene | -0.0306204 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0302747 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0301569 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0301147 |
| CCNL1 | cyclin L1 | -0.0295919 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0285526 |
| PTK2 | protein tyrosine kinase 2 | -0.0277919 |
| YME1L1 | YME1-like 1 ATPase | -0.0272353 |
| PTMA | prothymosin, alpha | -0.0271892 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0268812 |
| RPS5 | ribosomal protein S5 | -0.0268588 |
| USP34 | ubiquitin specific peptidase 34 | -0.0266703 |
| ERBIN | erbb2 interacting protein | -0.0264585 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0264154 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0263904 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.026326 |
| QKI | QKI, KH domain containing, RNA binding | -0.0256836 |
| GNAS | GNAS complex locus | -0.0252903 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0252621 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0250533 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0247825 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0246189 |
| FGB | fibrinogen beta chain | -0.0245509 |
| PARD3 | par-3 family cell polarity regulator | -0.024522 |
| S100A10 | S100 calcium binding protein A10 | -0.0244415 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0240732 |
| AK1 | adenylate kinase 1 | -0.0239897 |
| RPS23 | ribosomal protein S23 | -0.0238451 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.023812 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0237041 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0236716 |
| RPS15 | ribosomal protein S15 | -0.0236552 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0236068 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0233866 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0232353 |
| RPS2 | ribosomal protein S2 | -0.0232129 |
| NEGR1 | neuronal growth regulator 1 | -0.0231776 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0230651 |
| RNF145 | ring finger protein 145 | -0.023065 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0229168 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.02255 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0224633 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0223101 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0222683 |
| RPL8 | ribosomal protein L8 | -0.0222639 |
| EFNA5 | ephrin-A5 | -0.0221607 |
| HMGB1 | high mobility group box 1 | -0.0221603 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.022133 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0219307 |
| RASAL2 | RAS protein activator like 2 | -0.0219078 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0218756 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0218359 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0217157 |
| PAPOLA | poly(A) polymerase alpha | -0.0215899 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0215287 |
| COG5 | component of oligomeric golgi complex 5 | -0.0214115 |
| RPS12 | ribosomal protein S12 | -0.0213329 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0212788 |
| OLA1 | Obg-like ATPase 1 | -0.0208447 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0207965 |
| EHBP1 | EH domain binding protein 1 | -0.0206899 |
| RPL23A | ribosomal protein L23a | -0.0206012 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0205485 |
| FBXO11 | F-box protein 11 | -0.0204724 |
