Riluzole hydrochloride_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.104839
PM20D1 peptidase M20 domain containing 1 0.0973738
EEF2 eukaryotic translation elongation factor 2 0.0893912
TBXT T-box transcription factor T 0.0801109
NONO non-POU domain containing, octamer-binding 0.075631
GDA guanine deaminase 0.0708705
COL5A2 collagen, type V, alpha 2 0.0697892
DST dystonin 0.0691026
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0672082
TMSB10 thymosin beta 10 0.0651051
RPL35A ribosomal protein L35a 0.0631641
LOC112694756 uncharaterized LOC112694756 0.0621518
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0591491
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0586651
TRIO trio Rho guanine nucleotide exchange factor 0.0585884
CD109 CD109 molecule 0.0576383
P3H2 prolyl 3-hydroxylase 2 0.0554983
TNIP1 TNFAIP3 interacting protein 1 0.054121
FTL ferritin, light polypeptide 0.0532487
RPL37 ribosomal protein L37 0.053134
IGFBP3 insulin-like growth factor binding protein 3 0.0528371
YBX3 Y box binding protein 3 0.0521552
RPL3 ribosomal protein L3 0.0502103
ZEB2 zinc finger E-box binding homeobox 2 0.0495644
TPT1 tumor protein, translationally-controlled 1 0.0494378
PDLIM5 PDZ and LIM domain 5 0.0489679
RAB3B RAB3B, member RAS oncogene family 0.0470539
FTH1 ferritin, heavy polypeptide 1 0.0454932
RPLP1 ribosomal protein, large, P1 0.0435167
CTSL cathepsin L 0.043484
TMSB4X thymosin beta 4, X-linked 0.0431892
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.043006
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0427239
NCOR2 nuclear receptor corepressor 2 0.0426099
CTIF CBP80/20-dependent translation initiation factor 0.0416689
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0414822
HLA-A major histocompatibility complex, class I, A 0.0413894
HLA-B major histocompatibility complex, class I, B 0.0411882
RPL11 ribosomal protein L11 0.0410411
RPLP0 ribosomal protein, large, P0 0.040706
SRRM2 serine/arginine repetitive matrix 2 0.0404198
MSN moesin 0.0403342
RPS27 ribosomal protein S27 0.0401244
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0398489
RPS19 ribosomal protein S19 0.0394997
B2M beta-2-microglobulin 0.0390187
CENPF centromere protein F, 350/400kDa 0.0384977
MT2A metallothionein 2A 0.0384595
MYH9 myosin, heavy chain 9, non-muscle 0.0382255
ESYT2 extended synaptotagmin-like protein 2 0.0374034
RPS6 ribosomal protein S6 0.0371874
RPS4X ribosomal protein S4, X-linked 0.0370502
RPL36A ribosomal protein L36a 0.0367006
PDE10A phosphodiesterase 10A 0.0360557
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0356924
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0356532
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0355857
RPL37A ribosomal protein L37a 0.0351725
BHLHE40 basic helix-loop-helix family, member e40 0.0348734
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0345314
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0345122
BCAR3 breast cancer anti-estrogen resistance 3 0.0321602
HSPA8 heat shock 70kDa protein 8 0.031168
ITPK1 inositol-tetrakisphosphate 1-kinase 0.030975
NPAS2 neuronal PAS domain protein 2 0.0306513
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0302136
CEP72 centrosomal protein 72kDa 0.0298884
EGR1 early growth response 1 0.0292922
RPL31 ribosomal protein L31 0.0291198
EEF1G eukaryotic translation elongation factor 1 gamma 0.0283156
OASL 2'-5'-oligoadenylate synthetase-like 0.0281411
ALPK2 alpha-kinase 2 0.0275879
RPL36 ribosomal protein L36 0.0275594
ANTXR1 anthrax toxin receptor 1 0.0273981
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0273509
KPNB1 karyopherin (importin) beta 1 0.0272092
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0268521
RPL35 ribosomal protein L35 0.0267376
RPS17 ribosomal protein S17 0.0265368
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.026157
RPL19 ribosomal protein L19 0.0261282
DOCK5 dedicator of cytokinesis 5 0.0259273
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0256982
MAP7 microtubule-associated protein 7 0.025483
CEP250 centrosomal protein 250kDa 0.0245895
RPH3AL rabphilin 3A-like (without C2 domains) 0.0245315
RPL9 ribosomal protein L9 0.0244671
KMT2D lysine (K)-specific methyltransferase 2D 0.0240571
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0240252
RPS21 ribosomal protein S21 0.0237639
MKI67 marker of proliferation Ki-67 0.0235574
DUSP4 dual specificity phosphatase 4 0.0234177
OLFML2A olfactomedin-like 2A 0.023361
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0230919
SCARA5 scavenger receptor class A, member 5 0.0228986
NUMA1 nuclear mitotic apparatus protein 1 0.0228375
EIF4H eukaryotic translation initiation factor 4H 0.0226666
SFTPA2 surfactant protein A2 0.022639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0226187
IGF1R insulin-like growth factor 1 receptor 0.0226131

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.263406
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.179016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.158364
FN1 fibronectin 1 -0.12472
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.122491
EFNA5 ephrin-A5 -0.110645
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0807982
CANX calnexin -0.0775715
TM4SF1 transmembrane 4 L six family member 1 -0.0754161
NAMPT nicotinamide phosphoribosyltransferase -0.0720064
UBC ubiquitin C -0.0700969
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0651898
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0643308
VCL vinculin -0.0618757
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0616766
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0556315
PSD3 pleckstrin and Sec7 domain containing 3 -0.055063
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0523286
MCL1 myeloid cell leukemia 1 -0.0513614
PDIA3 protein disulfide isomerase family A, member 3 -0.0492528
TFPI2 tissue factor pathway inhibitor 2 -0.0479385
VIM vimentin -0.047054
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0429855
INTS6 integrator complex subunit 6 -0.0419491
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.041745
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0416896
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0401908
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0397742
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0394876
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0393967
SLC38A2 solute carrier family 38, member 2 -0.0373817
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0373595
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0372125
MBD5 methyl-CpG binding domain protein 5 -0.0368483
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0367632
AUTS2 autism susceptibility candidate 2 -0.036545
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0360262
RPS27A ribosomal protein S27a -0.0353421
SRGN serglycin -0.0352347
BIRC6 baculoviral IAP repeat containing 6 -0.0343737
USP34 ubiquitin specific peptidase 34 -0.0343057
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.033417
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0327483
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0324357
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0322171
SEC31A SEC31 homolog A (S. cerevisiae) -0.0313874
NBEAL1 neurobeachin-like 1 -0.0312551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.031163
MAP4 microtubule-associated protein 4 -0.0306401
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0305697
RTN4 reticulon 4 -0.0299455
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.02984
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0296021
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0295841
NF1 neurofibromin 1 -0.0293124
PDIA6 protein disulfide isomerase family A, member 6 -0.0292365
AHNAK AHNAK nucleoprotein -0.0290947
KMT2E lysine (K)-specific methyltransferase 2E -0.028698
JMJD1C jumonji domain containing 1C -0.0285975
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0284367
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0284117
GOLGA4 golgin A4 -0.027953
ASPH aspartate beta-hydroxylase -0.0277614
RAB1A RAB1A, member RAS oncogene family -0.02771
CDK13 cyclin-dependent kinase 13 -0.0276077
NAP1L1 nucleosome assembly protein 1-like 1 -0.027493
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0274601
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0269681
CUX1 cut-like homeobox 1 -0.0267947
FNDC3A fibronectin type III domain containing 3A -0.0267769
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0266281
FNIP1 folliculin interacting protein 1 -0.0261967
PDIA4 protein disulfide isomerase family A, member 4 -0.0257465
DIAPH2 diaphanous-related formin 2 -0.025144
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0248431
RAP1B RAP1B, member of RAS oncogene family -0.0247848
DENND1A DENN/MADD domain containing 1A -0.0247842
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0246781
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0244853
FNDC3B fibronectin type III domain containing 3B -0.0243683
SPDYA speedy/RINGO cell cycle regulator family member A -0.0243475
PUM2 pumilio RNA-binding family member 2 -0.0241956
LMAN1 lectin, mannose-binding, 1 -0.0240682
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0238941
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0238861
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0238477
USP15 ubiquitin specific peptidase 15 -0.023626
MCTP1 multiple C2 domains, transmembrane 1 -0.0235819
ADGRD1 adhesion G protein-coupled receptor D1 -0.0235499
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0234306
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0233684
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0231847
VMP1 vacuole membrane protein 1 -0.0230861
CCDC88A coiled-coil domain containing 88A -0.0230384
SOD2 superoxide dismutase 2, mitochondrial -0.0229862
USP53 ubiquitin specific peptidase 53 -0.0227768
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0227085
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0226764
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0224398
MBNL1 muscleblind-like splicing regulator 1 -0.0222995