Riluzole hydrochloride_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

118 genes differentially expressed following the Riluzole hydrochloride_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.401913
VIM vimentin 0.229878
EFNA5 ephrin-A5 0.165333
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.15551
MEST mesoderm specific transcript 0.130616
DST dystonin 0.121836
TMSB10 thymosin beta 10 0.117391
RPS6 ribosomal protein S6 0.110267
EGFR epidermal growth factor receptor 0.107218
FGFR1 fibroblast growth factor receptor 1 0.104617
TNS3 tensin 3 0.100752
SMAD3 SMAD family member 3 0.0877585
COL6A3 collagen, type VI, alpha 3 0.0834954
MT2A metallothionein 2A 0.0785946
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0767247
PKM pyruvate kinase, muscle 0.0760954
P3H2 prolyl 3-hydroxylase 2 0.072687
FNDC3B fibronectin type III domain containing 3B 0.0717298
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0704235
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0696625
ENO1 enolase 1, (alpha) 0.0685848
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0650414
NKD1 naked cuticle homolog 1 (Drosophila) 0.063391
COL5A2 collagen, type V, alpha 2 0.063049
PM20D1 peptidase M20 domain containing 1 0.0621739
MCL1 myeloid cell leukemia 1 0.0615556
LDHA lactate dehydrogenase A 0.0611448
TMSB4X thymosin beta 4, X-linked 0.0576522
RAD51B RAD51 paralog B 0.057036
MYO1E myosin IE 0.0550925
EXT1 exostosin glycosyltransferase 1 0.0501606
DOCK5 dedicator of cytokinesis 5 0.0474463
NPAS2 neuronal PAS domain protein 2 0.0448896
ZNF292 zinc finger protein 292 0.0396329
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.035597
NRCAM neuronal cell adhesion molecule 0.0327493
HMGA2 high mobility group AT-hook 2 0.0315904
KMT2E lysine (K)-specific methyltransferase 2E 0.0308547
RPS3 ribosomal protein S3 0.0272446
NAMPT nicotinamide phosphoribosyltransferase 0.0254101
RPLP2 ribosomal protein, large, P2 0.02141
RRBP1 ribosome binding protein 1 0.0198289
ACTN4 actinin, alpha 4 0.0187024
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0182754
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0172092
JMJD1C jumonji domain containing 1C 0.0164231
CDH13 cadherin 13 0.0159212
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0154466
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0111899
RPLP1 ribosomal protein, large, P1 0.00837435
ELL2 elongation factor, RNA polymerase II, 2 0.00832346
RTN4 reticulon 4 0.00742237
SND1 staphylococcal nuclease and tudor domain containing 1 0.00578033
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.00397561
ZSWIM6 zinc finger, SWIM-type containing 6 0.00382832

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.201171
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176454
ZBTB20 zinc finger and BTB domain containing 20 -0.160388
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.156588
NAV2 neuron navigator 2 -0.122914
PTMA prothymosin, alpha -0.121543
ANXA2 annexin A2 -0.117752
UBC ubiquitin C -0.109584
VMP1 vacuole membrane protein 1 -0.105586
SNX9 sorting nexin 9 -0.0992609
CEMIP cell migration inducing protein, hyaluronan binding -0.0975525
ZNF608 zinc finger protein 608 -0.0927364
KMT2C lysine (K)-specific methyltransferase 2C -0.0853498
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0845393
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0792999
CADM2 cell adhesion molecule 2 -0.0782427
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0737746
RLF rearranged L-myc fusion -0.07248
STAG2 stromal antigen 2 -0.0717818
CCNI cyclin I -0.0641885
PTK2 protein tyrosine kinase 2 -0.0640787
LMO7 LIM domain 7 -0.0621676
CARD16 caspase recruitment domain family, member 16 -0.0601269
RBM25 RNA binding motif protein 25 -0.0593573
ITGA6 integrin, alpha 6 -0.0574224
PARD3 par-3 family cell polarity regulator -0.0571892
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0567241
NUP58 nucleoporin 58 -0.0547717
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0536813
RPS8 ribosomal protein S8 -0.0527021
FN1 fibronectin 1 -0.0521792
PDE10A phosphodiesterase 10A -0.0473878
RPS27A ribosomal protein S27a -0.0467076
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.043615
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0419387
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0407784
RPS16 ribosomal protein S16 -0.0407643
LIMCH1 LIM and calponin homology domains 1 -0.0388587
WAC WW domain containing adaptor with coiled-coil -0.0379071
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0377123
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0363542
LMAN1 lectin, mannose-binding, 1 -0.035313
PEG10 paternally expressed 10 -0.0299383
ASPH aspartate beta-hydroxylase -0.0284825
BIRC6 baculoviral IAP repeat containing 6 -0.0284591
NDRG1 N-myc downstream regulated 1 -0.0250915
PGK1 phosphoglycerate kinase 1 -0.0228833
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0223426
RPL23 ribosomal protein L23 -0.0209942
PDIA4 protein disulfide isomerase family A, member 4 -0.0203993
IGFBP3 insulin-like growth factor binding protein 3 -0.0146919
TRIO trio Rho guanine nucleotide exchange factor -0.0144172
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0142683
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0112902
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0111514
TTC3 tetratricopeptide repeat domain 3 -0.0110794
EEF2 eukaryotic translation elongation factor 2 -0.0107346
MACF1 microtubule-actin crosslinking factor 1 -0.00960596
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.00889405
MAML2 mastermind-like 2 (Drosophila) -0.00871809
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00838602
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.00500107
PRKCA protein kinase C, alpha -0.00201257