Riluzole hydrochloride_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCG2 secretogranin II 0.129852
CHGB chromogranin B 0.112396
MYH9 myosin, heavy chain 9, non-muscle 0.0953858
TMSB4X thymosin beta 4, X-linked 0.0927243
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0887041
SMOC1 SPARC related modular calcium binding 1 0.0740945
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0651381
LOC112694756 uncharaterized LOC112694756 0.0578535
MPRIP myosin phosphatase Rho interacting protein 0.0530877
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0508631
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0508284
ARGLU1 arginine and glutamate rich 1 0.0506242
STC1 stanniocalcin 1 0.0500679
EEF2 eukaryotic translation elongation factor 2 0.0486567
KIF26B kinesin family member 26B 0.0486278
VGF VGF nerve growth factor inducible 0.046859
NRG1 neuregulin 1 0.0450588
NBEA neurobeachin 0.044376
FNDC3A fibronectin type III domain containing 3A 0.0442216
CALR calreticulin 0.0425012
PRELID3B PRELI domain containing 3B 0.0408281
SMC1A structural maintenance of chromosomes 1A 0.0406867
RPH3AL rabphilin 3A-like (without C2 domains) 0.0406695
ACTG1 actin gamma 1 0.039362
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0390757
COL22A1 collagen, type XXII, alpha 1 0.0378607
TMEM255B transmembrane protein 255B 0.0376187
ZFHX3 zinc finger homeobox 3 0.0374146
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0372228
KLHL29 kelch-like family member 29 0.0368893
SRRM2 serine/arginine repetitive matrix 2 0.0368033
NONO non-POU domain containing, octamer-binding 0.036412
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0360484
DOCK5 dedicator of cytokinesis 5 0.0359218
ASCL1 achaete-scute family bHLH transcription factor 1 0.0348957
KRT18 keratin 18, type I 0.0345482
RNF144A ring finger protein 144A 0.0337471
MT2A metallothionein 2A 0.0331634
NUMA1 nuclear mitotic apparatus protein 1 0.0328797
TPM3 tropomyosin 3 0.0327658
NALF1 NALCN channel auxiliary factor 1 0.0316252
SET SET nuclear proto-oncogene 0.0309386
MSN moesin 0.0309188
INHBA inhibin, beta A 0.0309114
CNKSR3 CNKSR family member 3 0.0302201
PTCHD4 patched domain containing 4 0.0298772
SERGEF secretion regulating guanine nucleotide exchange factor 0.0296157
ST18 suppression of tumorigenicity 18, zinc finger 0.0291183
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0287058
TSHZ2 teashirt zinc finger homeobox 2 0.0277238
RNF213 ring finger protein 213 0.0273251
NCOR2 nuclear receptor corepressor 2 0.0269568
GRB10 growth factor receptor-bound protein 10 0.0267247
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0264806
PLXNA2 plexin A2 0.0263756
DST dystonin 0.0262617
SETX senataxin 0.0262608
MT1X metallothionein 1X 0.0262513
PAEP progestagen-associated endometrial protein 0.0256261
ASPH aspartate beta-hydroxylase 0.0255744
IFI6 interferon, alpha-inducible protein 6 0.0254576
JUN jun proto-oncogene 0.0253528
TSPYL2 TSPY-like 2 0.0251765
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0251698
ASIC2 acid sensing (proton gated) ion channel 2 0.0251102
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0249029
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0242289
SIK2 salt-inducible kinase 2 0.0241514
SNTG1 syntrophin, gamma 1 0.0239573
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.023817
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.0235738
UBAP2L ubiquitin associated protein 2-like 0.0234769
VAV2 vav 2 guanine nucleotide exchange factor 0.02319
GRIK1 glutamate receptor, ionotropic, kainate 1 0.022959
GNL1 guanine nucleotide binding protein-like 1 0.0227015
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.0225863
IPO8 importin 8 0.0224933
ZBTB7C zinc finger and BTB domain containing 7C 0.0224897
STX16 syntaxin 16 0.0221494
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.021955
GPATCH4 G patch domain containing 4 0.0219531
HIPK2 homeodomain interacting protein kinase 2 0.0216138
RPTOR regulatory associated protein of MTOR, complex 1 0.0215823
SON SON DNA binding protein 0.0212187
TRAPPC9 trafficking protein particle complex 9 0.0211702
RPL36A ribosomal protein L36a 0.020998
DIDO1 death inducer-obliterator 1 0.0208774
RPL37 ribosomal protein L37 0.0207337
MSH2 mutS homolog 2 0.0206132
HYOU1 hypoxia up-regulated 1 0.0203972
AOPEP aminopeptidase O (putative) 0.0201852
CDC37 cell division cycle 37 0.0200179
SUB1 SUB1 homolog (S. cerevisiae) 0.0199433
EXT1 exostosin glycosyltransferase 1 0.0197933
BANP BTG3 associated nuclear protein 0.0196483
NAV2 neuron navigator 2 0.0196394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0195745
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0195582
GPC6 glypican 6 0.0195299
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0193389

decreased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 -0.150977
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.145966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142008
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0893981
CENPF centromere protein F, 350/400kDa -0.0835383
PTMA prothymosin, alpha -0.0798834
ZNF292 zinc finger protein 292 -0.0646923
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0623891
CALCA calcitonin-related polypeptide alpha -0.0615523
MIS18BP1 MIS18 binding protein 1 -0.0593383
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0589985
DTNA dystrobrevin, alpha -0.0585322
GPHN gephyrin -0.056103
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0528283
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0521064
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0519064
PDE4B phosphodiesterase 4B, cAMP-specific -0.0495564
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0480138
ADGRL2 adhesion G protein-coupled receptor L2 -0.0457508
SYT1 synaptotagmin I -0.0455021
MKI67 marker of proliferation Ki-67 -0.0441856
MAP1B microtubule-associated protein 1B -0.0429785
ZC3H15 zinc finger CCCH-type containing 15 -0.0429266
SEPTIN7 septin 7 -0.0427307
RPS8 ribosomal protein S8 -0.042712
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0415307
CCDC88A coiled-coil domain containing 88A -0.040769
CKAP5 cytoskeleton associated protein 5 -0.0405155
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0399971
PDS5B PDS5 cohesin associated factor B -0.0394483
TPX2 TPX2, microtubule-associated -0.0391419
NCOR1 nuclear receptor corepressor 1 -0.0382416
ANKRD28 ankyrin repeat domain 28 -0.0378118
PHIP pleckstrin homology domain interacting protein -0.0371277
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0368771
MATR3 matrin 3 -0.0358771
CUL3 cullin 3 -0.0354575
RTN4 reticulon 4 -0.034782
XPO1 exportin 1 -0.0346809
JMJD1C jumonji domain containing 1C -0.0344847
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0342827
PKM pyruvate kinase, muscle -0.0339963
PNISR PNN-interacting serine/arginine-rich protein -0.033713
SMC4 structural maintenance of chromosomes 4 -0.0336274
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0336045
RSRC1 arginine/serine-rich coiled-coil 1 -0.0332484
TTC19 tetratricopeptide repeat domain 19 -0.0331796
PDIA3 protein disulfide isomerase family A, member 3 -0.0329401
NFIA nuclear factor I/A -0.0329277
SINHCAF SIN3-HDAC complex associated factor -0.0327006
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0320076
WDR45B WD repeat domain 45B -0.0313029
PEG10 paternally expressed 10 -0.0309854
RBM39 RNA binding motif protein 39 -0.0308716
GNAS GNAS complex locus -0.030657
RPS11 ribosomal protein S11 -0.0305644
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0303375
TENT5A terminal nucleotidyltransferase 5A -0.03006
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0297646
DSTN destrin (actin depolymerizing factor) -0.0297168
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0292216
PGAP1 post-GPI attachment to proteins 1 -0.0291888
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0288741
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0288013
POTEF POTE ankyrin domain family, member F -0.0286468
BBX bobby sox homolog (Drosophila) -0.028611
ECT2 epithelial cell transforming 2 -0.0285878
RPL8 ribosomal protein L8 -0.0285844
FTL ferritin, light polypeptide -0.0281804
DENND1A DENN/MADD domain containing 1A -0.0279733
FAAH2 fatty acid amide hydrolase 2 -0.0279013
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.027773
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0277007
KMT2E lysine (K)-specific methyltransferase 2E -0.0271922
RB1CC1 RB1-inducible coiled-coil 1 -0.0271164
ENO1 enolase 1, (alpha) -0.0268365
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.02673
NBAS neuroblastoma amplified sequence -0.0265353
TNRC6B trinucleotide repeat containing 6B -0.0263583
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0262863
NIPBL Nipped-B homolog (Drosophila) -0.0262194
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0261791
SETD5 SET domain containing 5 -0.0260896
ATP11B ATPase, class VI, type 11B -0.0260848
COG5 component of oligomeric golgi complex 5 -0.0259573
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.025877
RPL37A ribosomal protein L37a -0.0258752
ZFR zinc finger RNA binding protein -0.0258717
RPLP1 ribosomal protein, large, P1 -0.0258553
RPS23 ribosomal protein S23 -0.0257789
CAMTA1 calmodulin binding transcription activator 1 -0.0257688
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0257137
NPEPPS aminopeptidase puromycin sensitive -0.025687
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0256554
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.025636
TUBB4B tubulin, beta 4B class IVb -0.0255706
GAS2L3 growth arrest-specific 2 like 3 -0.0254703
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0249434
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0246702
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0246546