Riluzole hydrochloride_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Riluzole hydrochloride_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.121435
AKAP12 A kinase (PRKA) anchor protein 12 0.116673
PLEC plectin 0.109239
MYH9 myosin, heavy chain 9, non-muscle 0.0955925
DST dystonin 0.0903618
ANGPTL4 angiopoietin-like 4 0.0891854
EEF2 eukaryotic translation elongation factor 2 0.0861773
LOC112694756 uncharaterized LOC112694756 0.082562
FLNA filamin A, alpha 0.079335
SFTPA2 surfactant protein A2 0.0676669
RNF213 ring finger protein 213 0.0669218
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0652327
NONO non-POU domain containing, octamer-binding 0.0633821
TMSB10 thymosin beta 10 0.0631807
SOX10 SRY (sex determining region Y)-box 10 0.0594306
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.057091
CD59 CD59 molecule, complement regulatory protein 0.0563222
NFE2L1 nuclear factor, erythroid 2-like 1 0.0538394
SRRM2 serine/arginine repetitive matrix 2 0.0536086
ACTN1 actinin, alpha 1 0.0526796
HLA-B major histocompatibility complex, class I, B 0.0523403
MSN moesin 0.0515278
B2M beta-2-microglobulin 0.051476
AMOTL1 angiomotin like 1 0.051035
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0487375
CEP250 centrosomal protein 250kDa 0.0484481
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0472247
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0463315
WWTR1 WW domain containing transcription regulator 1 0.0461026
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0452031
HDAC9 histone deacetylase 9 0.0434563
TNIP1 TNFAIP3 interacting protein 1 0.0433932
HDAC4 histone deacetylase 4 0.0422482
RPL35A ribosomal protein L35a 0.0421396
BHLHE40 basic helix-loop-helix family, member e40 0.041926
HLA-C major histocompatibility complex, class I, C 0.0416474
ACTN4 actinin, alpha 4 0.0411888
OSBPL10 oxysterol binding protein-like 10 0.0408378
LDHA lactate dehydrogenase A 0.0401882
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0397819
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0391243
HMG20B high mobility group 20B 0.0388424
RPL3 ribosomal protein L3 0.038777
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.038362
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0382046
RAD51B RAD51 paralog B 0.0373323
PFKP phosphofructokinase, platelet 0.0359004
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0358866
HLA-A major histocompatibility complex, class I, A 0.0356992
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0347519
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0345751
UBASH3B ubiquitin associated and SH3 domain containing B 0.0344243
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0341435
MELTF melanotransferrin 0.0340154
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0335668
LPP LIM domain containing preferred translocation partner in lipoma 0.033457
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.032816
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0327975
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0327017
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0323441
DBN1 drebrin 1 0.0322567
MAML3 mastermind-like 3 (Drosophila) 0.0319924
SMAD3 SMAD family member 3 0.0318437
VEGFA vascular endothelial growth factor A 0.0318234
SOX6 SRY (sex determining region Y)-box 6 0.0313068
FN1 fibronectin 1 0.0311812
IFI6 interferon, alpha-inducible protein 6 0.0311288
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0307639
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0301809
NAV1 neuron navigator 1 0.0299414
SON SON DNA binding protein 0.0298195
IQGAP3 IQ motif containing GTPase activating protein 3 0.0297922
IGF1R insulin-like growth factor 1 receptor 0.0296826
NCOR2 nuclear receptor corepressor 2 0.029638
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.029519
CYB5R3 cytochrome b5 reductase 3 0.0293221
PDE4D phosphodiesterase 4D, cAMP-specific 0.0288286
ACTG1 actin gamma 1 0.0288276
AFDN afadin, adherens junction formation factor 0.0282556
ENO1 enolase 1, (alpha) 0.0280655
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.027793
FUS FUS RNA binding protein 0.0275252
NUMA1 nuclear mitotic apparatus protein 1 0.027519
GUK1 guanylate kinase 1 0.0271875
RRBP1 ribosome binding protein 1 0.026811
SEPTIN9 septin 9 0.0266179
ARHGAP5 Rho GTPase activating protein 5 0.0264711
KMT2D lysine (K)-specific methyltransferase 2D 0.0262234
MACF1 microtubule-actin crosslinking factor 1 0.0256272
LRMDA leucine rich melanocyte differentiation associated 0.0254083
NIBAN2 niban apoptosis regulator 2 0.0253461
CTSL cathepsin L 0.0253338
EIF4H eukaryotic translation initiation factor 4H 0.0252303
KPNB1 karyopherin (importin) beta 1 0.0249922
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0249512
HRNR hornerin 0.0247118
TPI1 triosephosphate isomerase 1 0.0246613
MT1X metallothionein 1X 0.0244011
TCF20 transcription factor 20 (AR1) 0.0241265
ARID1A AT rich interactive domain 1A (SWI-like) 0.0239554

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206868
LSAMP limbic system-associated membrane protein -0.130789
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.089229
GOLGA4 golgin A4 -0.0865498
FMN1 formin 1 -0.0621647
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0607519
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0594203
SPAG9 sperm associated antigen 9 -0.0552601
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0552378
NAMPT nicotinamide phosphoribosyltransferase -0.0545657
RAB7A RAB7A, member RAS oncogene family -0.0534143
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0482005
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0455886
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0454107
MAP4 microtubule-associated protein 4 -0.0416723
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0396756
TENM1 teneurin transmembrane protein 1 -0.0391472
TSC22D2 TSC22 domain family, member 2 -0.0386005
SQSTM1 sequestosome 1 -0.0383828
KMT2E lysine (K)-specific methyltransferase 2E -0.0383067
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.037938
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0366209
ZNF292 zinc finger protein 292 -0.0364421
SBF2 SET binding factor 2 -0.0363073
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0359419
ELL2 elongation factor, RNA polymerase II, 2 -0.0337212
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0332616
MMP12 matrix metallopeptidase 12 -0.0321794
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0319758
ZFAND3 zinc finger, AN1-type domain 3 -0.0310574
KMT2C lysine (K)-specific methyltransferase 2C -0.0310491
GPHN gephyrin -0.0301041
GARS1 glycyl-tRNA synthetase 1 -0.0299174
HELZ helicase with zinc finger -0.029899
ATP13A3 ATPase type 13A3 -0.0298476
PNPLA8 patatin-like phospholipase domain containing 8 -0.0293576
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0291818
TASOR2 transcription activation suppressor family member 2 -0.0288439
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0288115
SEC24A SEC24 family member A -0.0287902
TFRC transferrin receptor -0.0287898
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0285463
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0285314
LAMP2 lysosomal-associated membrane protein 2 -0.0279838
CLINT1 clathrin interactor 1 -0.0279564
NAP1L1 nucleosome assembly protein 1-like 1 -0.0276455
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0276299
TFG TRK-fused gene -0.0276064
JMJD1C jumonji domain containing 1C -0.0270897
UBA6 ubiquitin-like modifier activating enzyme 6 -0.02672
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.026409
RYBP RING1 and YY1 binding protein -0.0264026
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0263542
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0263241
USP3 ubiquitin specific peptidase 3 -0.0262224
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0261716
HMGA2 high mobility group AT-hook 2 -0.025961
ICAM1 intercellular adhesion molecule 1 -0.0256623
BCAS3 breast carcinoma amplified sequence 3 -0.0254082
KDM5B lysine (K)-specific demethylase 5B -0.0253864
RBM39 RNA binding motif protein 39 -0.0252331
DLG1 discs, large homolog 1 (Drosophila) -0.0251394
RPS2 ribosomal protein S2 -0.0250632
NRG3 neuregulin 3 -0.0248233
PUM2 pumilio RNA-binding family member 2 -0.0248034
MARCHF1 membrane associated ring-CH-type finger 1 -0.0246883
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0246059
NOP58 NOP58 ribonucleoprotein -0.024602
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0244073
PEX5L peroxisomal biogenesis factor 5-like -0.0243703
OXSR1 oxidative stress responsive 1 -0.0243478
TFPI2 tissue factor pathway inhibitor 2 -0.024129
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0240764
COG5 component of oligomeric golgi complex 5 -0.0236174
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.023529
TRIQK triple QxxK/R motif containing -0.0234696
SLC39A11 solute carrier family 39, member 11 -0.0234136
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0233002
LCORL ligand dependent nuclear receptor corepressor-like -0.0231462
SEC31A SEC31 homolog A (S. cerevisiae) -0.0229018
CHD1 chromodomain helicase DNA binding protein 1 -0.022894
CDK13 cyclin-dependent kinase 13 -0.022802
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0227935
CSDE1 cold shock domain containing E1, RNA-binding -0.022453
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0224317
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0222617
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0221891
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0220609
PAPOLA poly(A) polymerase alpha -0.0220358
WAC WW domain containing adaptor with coiled-coil -0.0217867
FILIP1 filamin A interacting protein 1 -0.0217478
BRWD3 bromodomain and WD repeat domain containing 3 -0.0216229
GLS2 glutaminase 2 (liver, mitochondrial) -0.0215887
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.021505
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0214448
PNISR PNN-interacting serine/arginine-rich protein -0.0213582
TUSC3 tumor suppressor candidate 3 -0.0212347
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0212289
MAPK8 mitogen-activated protein kinase 8 -0.0212125
PMEL premelanosome protein -0.0211483