Riluzole hydrochloride_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.158251
TMSB4X thymosin beta 4, X-linked 0.145395
LOC112694756 uncharaterized LOC112694756 0.113176
EGFR epidermal growth factor receptor 0.0994086
PDE4D phosphodiesterase 4D, cAMP-specific 0.0950964
PKM pyruvate kinase, muscle 0.0927105
PDGFC platelet derived growth factor C 0.0822867
SRRM2 serine/arginine repetitive matrix 2 0.0646398
RPL3 ribosomal protein L3 0.064178
LDHA lactate dehydrogenase A 0.0612028
ATP9B ATPase, class II, type 9B 0.0557571
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0528566
TXNRD1 thioredoxin reductase 1 0.0518541
S100A6 S100 calcium binding protein A6 0.051645
NONO non-POU domain containing, octamer-binding 0.0512143
EZR ezrin 0.0488995
ACTG1 actin gamma 1 0.048732
HSPA8 heat shock 70kDa protein 8 0.0484054
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0468004
CAMTA1 calmodulin binding transcription activator 1 0.044328
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0442435
PFN1 profilin 1 0.04346
NCEH1 neutral cholesterol ester hydrolase 1 0.0410808
ZEB1 zinc finger E-box binding homeobox 1 0.0410776
DUSP4 dual specificity phosphatase 4 0.0406985
PYGB phosphorylase, glycogen; brain 0.0402265
CPNE1 copine I 0.0402117
PRELID2 PRELI domain containing 2 0.0381241
SON SON DNA binding protein 0.0377403
PRPF38B pre-mRNA processing factor 38B 0.0363516
EEF1G eukaryotic translation elongation factor 1 gamma 0.0362358
BRD2 bromodomain containing 2 0.0360009
APLP2 amyloid beta (A4) precursor-like protein 2 0.0359951
SOX6 SRY (sex determining region Y)-box 6 0.03534
PRELID3B PRELI domain containing 3B 0.0344243
ZFAND3 zinc finger, AN1-type domain 3 0.0339413
ZNF608 zinc finger protein 608 0.0333255
HDAC9 histone deacetylase 9 0.0331517
TJP1 tight junction protein 1 0.0329916
JUN jun proto-oncogene 0.0329622
ARGLU1 arginine and glutamate rich 1 0.0323868
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0322806
EIF4A2 eukaryotic translation initiation factor 4A2 0.0312873
RPS13 ribosomal protein S13 0.0312509
PRDX2 peroxiredoxin 2 0.0308184
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0291142
RTN4 reticulon 4 0.0289115
RNF145 ring finger protein 145 0.0288327
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0287567
TNIP1 TNFAIP3 interacting protein 1 0.0286438
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0284127
AMOTL2 angiomotin like 2 0.0281223
NFE2L1 nuclear factor, erythroid 2-like 1 0.0268876
SQSTM1 sequestosome 1 0.0268649
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0266137
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0264599
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0260487
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0260296
AHCYL2 adenosylhomocysteinase-like 2 0.0254948
TMSB10 thymosin beta 10 0.0254878
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0254105
SFTPA2 surfactant protein A2 0.0253711
KMT2D lysine (K)-specific methyltransferase 2D 0.0253085
PHF21A PHD finger protein 21A 0.0250182
RPL15 ribosomal protein L15 0.0247041
RPL23 ribosomal protein L23 0.0243007
KLF3 Kruppel-like factor 3 (basic) 0.0242102
RPL37 ribosomal protein L37 0.0241232
SETD5 SET domain containing 5 0.0240027
LOXL3 lysyl oxidase-like 3 0.0238203
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0238055
RPS20 ribosomal protein S20 0.0236742
TMEM65 transmembrane protein 65 0.0235988
TNRC18 trinucleotide repeat containing 18 0.0235413
CEP250 centrosomal protein 250kDa 0.0235305
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0232387
GLI3 GLI family zinc finger 3 0.0231168
PDE8A phosphodiesterase 8A 0.0231004
MINK1 misshapen-like kinase 1 0.0230682
TRAF3 TNF receptor-associated factor 3 0.0230665
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0228509
SMC1A structural maintenance of chromosomes 1A 0.0228344
ECPAS Ecm29 proteasome adaptor and scaffold 0.0227593
HIPK3 homeodomain interacting protein kinase 3 0.0222349
B2M beta-2-microglobulin 0.0222294
TPM4 tropomyosin 4 0.022163
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0221325
IRS1 insulin receptor substrate 1 0.022074
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0219959
NUMA1 nuclear mitotic apparatus protein 1 0.0219837
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.021773
SAMD4A sterile alpha motif domain containing 4A 0.0217408
AKAP13 A kinase (PRKA) anchor protein 13 0.021691
FMN1 formin 1 0.0216284
DSTN destrin (actin depolymerizing factor) 0.0214409
EWSR1 EWS RNA-binding protein 1 0.0214271
YARS1 tyrosyl-tRNA synthetase 1 0.0214246
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.0213918
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.0211303
SNX3 sorting nexin 3 0.0211126

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.181656
CPED1 cadherin-like and PC-esterase domain containing 1 -0.16272
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.148391
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10695
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.100532
BMP10 bone morphogenetic protein 10 -0.0968357
PTMA prothymosin, alpha -0.0902613
CCND1 cyclin D1 -0.081614
WSB1 WD repeat and SOCS box containing 1 -0.076479
ADAM10 ADAM metallopeptidase domain 10 -0.0706823
NBEA neurobeachin -0.0681629
AHNAK AHNAK nucleoprotein -0.0672607
DLG1 discs, large homolog 1 (Drosophila) -0.0608645
CAMKMT calmodulin-lysine N-methyltransferase -0.0603415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0602004
NAV2 neuron navigator 2 -0.0596744
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0584434
BMP2K BMP2 inducible kinase -0.0566224
MKI67 marker of proliferation Ki-67 -0.0563611
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0534539
EVI5 ecotropic viral integration site 5 -0.0533362
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0519864
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0511265
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0486971
GNAS GNAS complex locus -0.0478028
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0459516
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.045815
CENPF centromere protein F, 350/400kDa -0.0457553
NEBL nebulette -0.0452968
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0447634
TPT1 tumor protein, translationally-controlled 1 -0.0438483
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0432306
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0425388
MBNL1 muscleblind-like splicing regulator 1 -0.0415127
XPO1 exportin 1 -0.0412633
DIAPH3 diaphanous-related formin 3 -0.0408461
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.039313
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0380886
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0379581
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0374496
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0370937
SMC4 structural maintenance of chromosomes 4 -0.0370666
GPHN gephyrin -0.0370346
DGKH diacylglycerol kinase, eta -0.0364138
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0355912
NFIA nuclear factor I/A -0.0355422
ARID4B AT rich interactive domain 4B (RBP1-like) -0.035405
MON2 MON2 homolog (S. cerevisiae) -0.0352183
RAB7A RAB7A, member RAS oncogene family -0.0350138
FOXP1 forkhead box P1 -0.0349151
ZMYND8 zinc finger, MYND-type containing 8 -0.0348836
ZNF292 zinc finger protein 292 -0.0344315
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0344134
EHBP1 EH domain binding protein 1 -0.0340816
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0338526
BCOR BCL6 corepressor -0.0327828
RPL5 ribosomal protein L5 -0.0327055
NIPBL Nipped-B homolog (Drosophila) -0.0320971
CUX1 cut-like homeobox 1 -0.0317999
RPS8 ribosomal protein S8 -0.031293
NAP1L1 nucleosome assembly protein 1-like 1 -0.0312871
SSBP2 single-stranded DNA binding protein 2 -0.0311901
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0308861
ZNF638 zinc finger protein 638 -0.0307597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0307171
VCL vinculin -0.0305903
LARS1 leucyl-tRNA synthetase 1 -0.0304807
KPNB1 karyopherin (importin) beta 1 -0.0304709
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0301287
PGK1 phosphoglycerate kinase 1 -0.0296882
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0296106
PHIP pleckstrin homology domain interacting protein -0.0291866
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.029174
TAS2R14 taste receptor, type 2, member 14 -0.028842
KMT2E lysine (K)-specific methyltransferase 2E -0.0288097
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0284715
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0282359
RSL1D1 ribosomal L1 domain containing 1 -0.0280134
CD2AP CD2-associated protein -0.0277857
MYOF myoferlin -0.027717
LIMD1 LIM domains containing 1 -0.0275892
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0275188
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0273176
ZMYM2 zinc finger, MYM-type 2 -0.0272928
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0271507
PDE4B phosphodiesterase 4B, cAMP-specific -0.0271117
HJURP Holliday junction recognition protein -0.0270834
ANKRD12 ankyrin repeat domain 12 -0.0268917
SEPTIN7 septin 7 -0.0267532
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0267372
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0264393
PIAS1 protein inhibitor of activated STAT, 1 -0.0264337
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0263672
FAF1 Fas (TNFRSF6) associated factor 1 -0.0258863
DIAPH2 diaphanous-related formin 2 -0.025489
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0254673
JMJD1C jumonji domain containing 1C -0.0254387
SMYD3 SET and MYND domain containing 3 -0.025386
KDM4B lysine (K)-specific demethylase 4B -0.0251813
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.025181