Riluzole hydrochloride_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Riluzole hydrochloride perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Riluzole hydrochloride_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.27325
MYH9 myosin, heavy chain 9, non-muscle 0.122851
EEF2 eukaryotic translation elongation factor 2 0.119378
KRT8 keratin 8, type II 0.111997
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.107966
NONO non-POU domain containing, octamer-binding 0.100231
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0998997
KRT18 keratin 18, type I 0.0895305
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0791737
ENO1 enolase 1, (alpha) 0.0790631
PLEC plectin 0.074133
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0662642
RPL3 ribosomal protein L3 0.0600101
HDAC4 histone deacetylase 4 0.0558547
PGK1 phosphoglycerate kinase 1 0.0550982
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0543739
NUMA1 nuclear mitotic apparatus protein 1 0.0535852
ARGLU1 arginine and glutamate rich 1 0.0530257
KIZ kizuna centrosomal protein 0.0528137
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0516394
LOC112694756 uncharaterized LOC112694756 0.0509089
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.050692
MSN moesin 0.0504483
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0493635
LDHA lactate dehydrogenase A 0.0493038
EEF1G eukaryotic translation elongation factor 1 gamma 0.0479192
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0475217
SMAD3 SMAD family member 3 0.0473387
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0469734
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0465212
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.046318
RPL37A ribosomal protein L37a 0.0460474
ACTN1 actinin, alpha 1 0.0444521
YAP1 Yes-associated protein 1 0.0433646
TMSB10 thymosin beta 10 0.0431859
RPL35A ribosomal protein L35a 0.0430168
HSPA8 heat shock 70kDa protein 8 0.038432
TNS3 tensin 3 0.0382482
RPL31 ribosomal protein L31 0.0381743
SRRM2 serine/arginine repetitive matrix 2 0.0380416
DSPP dentin sialophosphoprotein 0.0376419
ATXN1 ataxin 1 0.0376273
NTSR1 neurotensin receptor 1 (high affinity) 0.0372693
RPS19 ribosomal protein S19 0.0372229
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0371453
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0371289
PROX1 prospero homeobox 1 0.0367566
SEPTIN9 septin 9 0.0353717
ASPH aspartate beta-hydroxylase 0.035268
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.033859
YBX1 Y box binding protein 1 0.0333632
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0333351
NAV2 neuron navigator 2 0.0333288
MT2A metallothionein 2A 0.032453
MINK1 misshapen-like kinase 1 0.0323286
TUBA1B tubulin, alpha 1b 0.032036
RPS17 ribosomal protein S17 0.0316276
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0315117
CPNE1 copine I 0.031423
FAT1 FAT atypical cadherin 1 0.0307688
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0303972
PCBP2 poly(rC) binding protein 2 0.0301902
FTL ferritin, light polypeptide 0.0301744
AOPEP aminopeptidase O (putative) 0.0299525
CD46 CD46 molecule, complement regulatory protein 0.0298237
KMT2D lysine (K)-specific methyltransferase 2D 0.0298221
CEMIP cell migration inducing protein, hyaluronan binding 0.0296466
RNF43 ring finger protein 43 0.029599
RAD51B RAD51 paralog B 0.0295838
RPS3 ribosomal protein S3 0.0290939
TNIP1 TNFAIP3 interacting protein 1 0.0287607
RPL15 ribosomal protein L15 0.0286872
PKM pyruvate kinase, muscle 0.0285467
PRELID2 PRELI domain containing 2 0.028416
RPL37 ribosomal protein L37 0.0283831
MACF1 microtubule-actin crosslinking factor 1 0.0281364
BCL2L1 BCL2-like 1 0.0280157
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0279573
MCC mutated in colorectal cancers 0.0275786
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0274825
RPS12 ribosomal protein S12 0.0271847
RLIM ring finger protein, LIM domain interacting 0.0263594
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0262773
CALR calreticulin 0.0262235
TNS4 tensin 4 0.0259271
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0256091
FLNA filamin A, alpha 0.025247
B2M beta-2-microglobulin 0.0252387
MPRIP myosin phosphatase Rho interacting protein 0.0252032
AXIN2 axin 2 0.025099
ABHD2 abhydrolase domain containing 2 0.0250822
CD9 CD9 molecule 0.0245042
RPS13 ribosomal protein S13 0.0244821
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0243802
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 0.0242537
TRAF5 TNF receptor-associated factor 5 0.0240105
SMC1A structural maintenance of chromosomes 1A 0.0235892
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0234889
CEP250 centrosomal protein 250kDa 0.0234452
PRELID3B PRELI domain containing 3B 0.0232989

decreased expression

Symbol Name Standardized Value
CCND1 cyclin D1 -0.102264
CDH13 cadherin 13 -0.090822
AKAP12 A kinase (PRKA) anchor protein 12 -0.0831683
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0705521
SLC38A2 solute carrier family 38, member 2 -0.0669312
ANXA2 annexin A2 -0.0669056
CDK6 cyclin-dependent kinase 6 -0.0632349
VCL vinculin -0.0631542
LOC102724023 ES1 protein homolog, mitochondrial -0.062193
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0590491
IARS1 isoleucyl-tRNA synthetase 1 -0.0569151
HMGA1 high mobility group AT-hook 1 -0.0515847
TMEM123 transmembrane protein 123 -0.0509777
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0509737
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0504359
EZR ezrin -0.0493122
THOC2 THO complex 2 -0.0477154
TAS2R14 taste receptor, type 2, member 14 -0.047382
JMJD1C jumonji domain containing 1C -0.0453865
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0451644
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0446909
RBM39 RNA binding motif protein 39 -0.0438335
GARS1 glycyl-tRNA synthetase 1 -0.0437109
NF1 neurofibromin 1 -0.0431689
RBM25 RNA binding motif protein 25 -0.042864
PDE4D phosphodiesterase 4D, cAMP-specific -0.0427734
SLC38A1 solute carrier family 38, member 1 -0.0421528
ITGA6 integrin, alpha 6 -0.0421502
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0412123
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0409492
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0403611
HMGB1 high mobility group box 1 -0.0402704
NAP1L1 nucleosome assembly protein 1-like 1 -0.0396884
LRPPRC leucine-rich pentatricopeptide repeat containing -0.039386
GCLC glutamate-cysteine ligase, catalytic subunit -0.0382247
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0381267
PERP PERP, TP53 apoptosis effector -0.0379992
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0379512
NIPBL Nipped-B homolog (Drosophila) -0.0374771
IPO7 importin 7 -0.0367647
GNAS GNAS complex locus -0.036707
IER3 immediate early response 3 -0.0363458
BIRC6 baculoviral IAP repeat containing 6 -0.0360126
H1-0 H1.0 linker histone -0.0358569
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0356731
ANKRD28 ankyrin repeat domain 28 -0.0355812
MAP4 microtubule-associated protein 4 -0.0354578
TARS1 threonyl-tRNA synthetase 1 -0.0349611
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0343636
PHF14 PHD finger protein 14 -0.0342109
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0336615
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0331462
GCC2 GRIP and coiled-coil domain containing 2 -0.033054
USP34 ubiquitin specific peptidase 34 -0.0328224
SKAP1 src kinase associated phosphoprotein 1 -0.0327976
FRMD5 FERM domain containing 5 -0.0327553
RPS6 ribosomal protein S6 -0.0326562
CDK13 cyclin-dependent kinase 13 -0.0316431
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0311999
RTN3 reticulon 3 -0.0308261
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0308222
DLG1 discs, large homolog 1 (Drosophila) -0.0307528
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0307059
CBX3 chromobox homolog 3 -0.0304791
TM4SF1 transmembrane 4 L six family member 1 -0.0302789
MON2 MON2 homolog (S. cerevisiae) -0.0300695
SEC31A SEC31 homolog A (S. cerevisiae) -0.0300634
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0300461
MORF4L2 mortality factor 4 like 2 -0.0299207
GOLGA4 golgin A4 -0.0295551
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0295224
ZBTB20 zinc finger and BTB domain containing 20 -0.0294317
FNDC3A fibronectin type III domain containing 3A -0.0293575
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0291278
PIBF1 progesterone immunomodulatory binding factor 1 -0.0291145
ZFR zinc finger RNA binding protein -0.0287419
NOP58 NOP58 ribonucleoprotein -0.0284277
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0282164
SYT1 synaptotagmin I -0.0280903
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0280458
AHNAK AHNAK nucleoprotein -0.0274655
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.027304
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0272956
ADGRL2 adhesion G protein-coupled receptor L2 -0.0271591
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0269615
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0267649
RSL1D1 ribosomal L1 domain containing 1 -0.0266506
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0265915
ECT2 epithelial cell transforming 2 -0.0265887
BCLAF1 BCL2-associated transcription factor 1 -0.026547
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0264299
U2SURP U2 snRNP-associated SURP domain containing -0.0264129
KLF6 Kruppel-like factor 6 -0.0261902
SRSF10 serine/arginine-rich splicing factor 10 -0.0259073
TRA2A transformer 2 alpha homolog (Drosophila) -0.025881
LMO7 LIM domain 7 -0.0257894
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0256422
SPATA13 spermatogenesis associated 13 -0.0254456
AK1 adenylate kinase 1 -0.0253193
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0253159