Rimonabant (Hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.133572
FBN1 fibrillin 1 0.0940041
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0869807
OGA O-GlcNAcase 0.0827709
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0715405
FNDC3B fibronectin type III domain containing 3B 0.069073
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0658802
UBC ubiquitin C 0.0622626
PTMA prothymosin, alpha 0.0596532
DLG1 discs, large homolog 1 (Drosophila) 0.057014
ATP13A3 ATPase type 13A3 0.0562517
LOXL2 lysyl oxidase-like 2 0.053966
SQSTM1 sequestosome 1 0.0537852
COL3A1 collagen, type III, alpha 1 0.0536995
MT2A metallothionein 2A 0.0534292
SOD2 superoxide dismutase 2, mitochondrial 0.0524852
TNIP1 TNFAIP3 interacting protein 1 0.0504289
SBF2 SET binding factor 2 0.0503131
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0495805
COL1A2 collagen, type I, alpha 2 0.0494134
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0479031
KDM3A lysine (K)-specific demethylase 3A 0.0464887
NAP1L1 nucleosome assembly protein 1-like 1 0.046378
GPC6 glypican 6 0.0448756
DPYSL3 dihydropyrimidinase-like 3 0.0437349
WDFY1 WD repeat and FYVE domain containing 1 0.0412365
NAV2 neuron navigator 2 0.041057
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0410144
AUTS2 autism susceptibility candidate 2 0.0393499
ELL2 elongation factor, RNA polymerase II, 2 0.039275
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0391713
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0390253
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0389658
NT5C2 5'-nucleotidase, cytosolic II 0.0383998
STC1 stanniocalcin 1 0.038274
GOLGA4 golgin A4 0.0375112
GLS2 glutaminase 2 (liver, mitochondrial) 0.0370501
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0368339
OPTN optineurin 0.0365701
CYLD cylindromatosis (turban tumor syndrome) 0.0365647
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0364539
TRIO trio Rho guanine nucleotide exchange factor 0.03627
APP amyloid beta (A4) precursor protein 0.035879
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0358132
RHOBTB3 Rho-related BTB domain containing 3 0.0354225
MXI1 MAX interactor 1, dimerization protein 0.0353378
FMNL2 formin-like 2 0.0344819
IQGAP1 IQ motif containing GTPase activating protein 1 0.0343979
ANKRD10 ankyrin repeat domain 10 0.0343025
HIP1 huntingtin interacting protein 1 0.0342384
WTAP Wilms tumor 1 associated protein 0.0341697
ESYT2 extended synaptotagmin-like protein 2 0.0340185
FLNB filamin B, beta 0.033565
PSD3 pleckstrin and Sec7 domain containing 3 0.0320971
XPO1 exportin 1 0.032049
NAMPT nicotinamide phosphoribosyltransferase 0.0318398
HELZ helicase with zinc finger 0.0317565
INSIG2 insulin induced gene 2 0.0314877
DENND5A DENN/MADD domain containing 5A 0.0312087
ADAM17 ADAM metallopeptidase domain 17 0.0310003
RNF24 ring finger protein 24 0.0309264
MARCHF6 membrane associated ring-CH-type finger 6 0.030198
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0301089
ARRDC3 arrestin domain containing 3 0.0299163
SLC22A23 solute carrier family 22, member 23 0.0298873
RICTOR RPTOR independent companion of MTOR, complex 2 0.0295681
SEPTIN9 septin 9 0.0295248
WSB1 WD repeat and SOCS box containing 1 0.0293527
SETD5 SET domain containing 5 0.0289486
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0289248
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0285834
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0285201
ZNF292 zinc finger protein 292 0.0282855
CD109 CD109 molecule 0.0281629
MYH9 myosin, heavy chain 9, non-muscle 0.0281167
COL5A2 collagen, type V, alpha 2 0.0278311
RNMT RNA (guanine-7-) methyltransferase 0.0276815
RAB1A RAB1A, member RAS oncogene family 0.0272642
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0271652
NGLY1 N-glycanase 1 0.0270897
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0270432
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269313
ZEB1 zinc finger E-box binding homeobox 1 0.0268762
SSBP2 single-stranded DNA binding protein 2 0.0268652
ARL15 ADP-ribosylation factor-like 15 0.0268385
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.02664
DCAF6 DDB1 and CUL4 associated factor 6 0.026579
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0265269
DDIT4 DNA-damage-inducible transcript 4 0.0259504
RNF145 ring finger protein 145 0.0257027
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0254397
SDC4 syndecan 4 0.0254079
YEATS2 YEATS domain containing 2 0.0252645
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0251651
FNIP1 folliculin interacting protein 1 0.0251284
TMOD1 tropomodulin 1 0.0249855
AHNAK AHNAK nucleoprotein 0.0248131
PICALM phosphatidylinositol binding clathrin assembly protein 0.0247692
WAC WW domain containing adaptor with coiled-coil 0.0245084
NPEPPS aminopeptidase puromycin sensitive 0.0244943

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.245173
PODXL podocalyxin-like -0.176891
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.157435
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.146352
VIM vimentin -0.136858
CDH13 cadherin 13 -0.122747
MAP1B microtubule-associated protein 1B -0.120046
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.106813
FN1 fibronectin 1 -0.10335
TMSB10 thymosin beta 10 -0.0966376
COL5A1 collagen, type V, alpha 1 -0.0962255
ABI3BP ABI family, member 3 (NESH) binding protein -0.0757653
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0735039
NAV1 neuron navigator 1 -0.0709706
SUCNR1 succinate receptor 1 -0.0660285
SLC39A11 solute carrier family 39, member 11 -0.0659603
EGFR epidermal growth factor receptor -0.0611857
SAMD9 sterile alpha motif domain containing 9 -0.0518162
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0479773
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0474463
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0463946
PRSS23 protease, serine, 23 -0.0455188
SORBS2 sorbin and SH3 domain containing 2 -0.0441283
EFNA5 ephrin-A5 -0.0439705
PBX3 pre-B-cell leukemia homeobox 3 -0.0435266
DGKG diacylglycerol kinase, gamma 90kDa -0.0416022
TAGLN2 transgelin 2 -0.0412406
FLT1 fms-related tyrosine kinase 1 -0.0381081
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0379112
LOX lysyl oxidase -0.037807
CYTH3 cytohesin 3 -0.0376491
PLXNA2 plexin A2 -0.036648
POTEF POTE ankyrin domain family, member F -0.0361159
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0349275
ASPH aspartate beta-hydroxylase -0.0343511
TIMP2 TIMP metallopeptidase inhibitor 2 -0.033285
RIGI RNA sensor RIG-I -0.0327878
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0324567
DCLK2 doublecortin-like kinase 2 -0.0320154
PLAT plasminogen activator, tissue -0.0315273
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0313421
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0308127
LRRC17 leucine rich repeat containing 17 -0.0302705
CD59 CD59 molecule, complement regulatory protein -0.0293654
ALCAM activated leukocyte cell adhesion molecule -0.0290312
S100A10 S100 calcium binding protein A10 -0.0290078
COL8A1 collagen, type VIII, alpha 1 -0.0284014
MX2 MX dynamin-like GTPase 2 -0.0278461
CUX1 cut-like homeobox 1 -0.0276136
RASAL2 RAS protein activator like 2 -0.0275394
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0273492
CSTB cystatin B (stefin B) -0.0273107
CCND1 cyclin D1 -0.0269981
TUBB4B tubulin, beta 4B class IVb -0.0269626
PKM pyruvate kinase, muscle -0.0268935
SLC38A1 solute carrier family 38, member 1 -0.0264937
KRT81 keratin 81, type II -0.0263171
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0261235
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0260344
IL7R interleukin 7 receptor -0.0258331
FMN2 formin 2 -0.0256202
SPDL1 spindle apparatus coiled-coil protein 1 -0.0255156
PCDH7 protocadherin 7 -0.0252546
KIAA1549L KIAA1549-like -0.0251799
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0249403
MACF1 microtubule-actin crosslinking factor 1 -0.02454
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0241114
LOC112694756 uncharaterized LOC112694756 -0.023675
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0231069
S100A6 S100 calcium binding protein A6 -0.022908
FSTL1 follistatin-like 1 -0.0228324
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0224181
PFN1 profilin 1 -0.0223629
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0222542
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0219924
RNF213 ring finger protein 213 -0.0219863
FLNA filamin A, alpha -0.0219466
PDIA3 protein disulfide isomerase family A, member 3 -0.0219224
ISG15 ISG15 ubiquitin-like modifier -0.021263
VCL vinculin -0.0212498
SP100 SP100 nuclear antigen -0.0208923
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0207187
OASL 2'-5'-oligoadenylate synthetase-like -0.0200761
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0199991
MBNL1 muscleblind-like splicing regulator 1 -0.0199398
TPM4 tropomyosin 4 -0.0197538
SDCCAG8 serologically defined colon cancer antigen 8 -0.0195506
MYADM myeloid-associated differentiation marker -0.0195205
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0193267
MSN moesin -0.0190597
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0189981
FRMD4A FERM domain containing 4A -0.0188529
TPM1 tropomyosin 1 (alpha) -0.018775
L1CAM L1 cell adhesion molecule -0.0187169
FNDC3A fibronectin type III domain containing 3A -0.018639
S100A11 S100 calcium binding protein A11 -0.0185038
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0184918
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0184084
INTS6 integrator complex subunit 6 -0.0180931
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0178774