Rimonabant (Hydrochloride)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.216342
PTMA prothymosin, alpha 0.119585
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0939284
TMSB10 thymosin beta 10 0.0789593
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0685591
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0585769
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0541067
NAP1L1 nucleosome assembly protein 1-like 1 0.0463387
RPL23 ribosomal protein L23 0.0453945
AHNAK AHNAK nucleoprotein 0.0453362
CALR calreticulin 0.0432954
RPS27A ribosomal protein S27a 0.0425938
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.042199
EEF2 eukaryotic translation elongation factor 2 0.0399998
ECT2 epithelial cell transforming 2 0.036997
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0364405
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0361752
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0345541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0343368
RPL37 ribosomal protein L37 0.0343195
CLDN1 claudin 1 0.0337317
KPNB1 karyopherin (importin) beta 1 0.0331164
ANXA1 annexin A1 0.032958
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0328887
ACTG1 actin gamma 1 0.0327536
BIRC3 baculoviral IAP repeat containing 3 0.0324989
RPS3 ribosomal protein S3 0.032458
MYL12B myosin, light chain 12B, regulatory 0.0319467
TPT1 tumor protein, translationally-controlled 1 0.0310964
RPS12 ribosomal protein S12 0.0309735
RPL37A ribosomal protein L37a 0.0307134
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0302889
HDGF hepatoma-derived growth factor 0.0301977
AKAP12 A kinase (PRKA) anchor protein 12 0.0297437
RPL4 ribosomal protein L4 0.0291662
HLA-A major histocompatibility complex, class I, A 0.0289732
IFIH1 interferon induced with helicase C domain 1 0.028618
PA2G4 proliferation-associated 2G4, 38kDa 0.0285188
CENPF centromere protein F, 350/400kDa 0.0282979
SMC4 structural maintenance of chromosomes 4 0.0280524
LDHA lactate dehydrogenase A 0.0278921
EIF4A1 eukaryotic translation initiation factor 4A1 0.0275076
PCBP2 poly(rC) binding protein 2 0.0267522
ENO1 enolase 1, (alpha) 0.0264773
LDHB lactate dehydrogenase B 0.0262797
MKI67 marker of proliferation Ki-67 0.0256329
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0255293
AREG amphiregulin 0.0252316
TPI1 triosephosphate isomerase 1 0.0248463
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0239087
TPX2 TPX2, microtubule-associated 0.0238912
FUS FUS RNA binding protein 0.0233707
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0230494
TM4SF1 transmembrane 4 L six family member 1 0.0229968
RPL35A ribosomal protein L35a 0.0226271
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0225524
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224567
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0224323
RPS4X ribosomal protein S4, X-linked 0.0217118
RPL19 ribosomal protein L19 0.0208605
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0208269
PGK1 phosphoglycerate kinase 1 0.0207982
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0204856
HMGB1 high mobility group box 1 0.020443
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.020368
RPLP1 ribosomal protein, large, P1 0.0202724
RBM25 RNA binding motif protein 25 0.0202658
GASK1B golgi associated kinase 1B 0.0201549
NLGN1 neuroligin 1 0.0201504
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0200704
S100A6 S100 calcium binding protein A6 0.0194522
RPL7A ribosomal protein L7a 0.0194031
RPS24 ribosomal protein S24 0.0192601
NAMPT nicotinamide phosphoribosyltransferase 0.0191047
EEF1G eukaryotic translation elongation factor 1 gamma 0.0188817
YBX1 Y box binding protein 1 0.0185285
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0183793
CSDE1 cold shock domain containing E1, RNA-binding 0.018342
MARCHF6 membrane associated ring-CH-type finger 6 0.0182155
SERBP1 SERPINE1 mRNA binding protein 1 0.0181939
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0179931
HMGB2 high mobility group box 2 0.0179313
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0176294
TMPO thymopoietin 0.0176165
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0174459
CELF2 CUGBP, Elav-like family member 2 0.0174393
EDARADD EDAR-associated death domain 0.0174168
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0172494
SLC38A1 solute carrier family 38, member 1 0.0170524
RPL12 ribosomal protein L12 0.0169553
RACK1 receptor for activated C kinase 1 0.0168674
RPS17 ribosomal protein S17 0.0168665
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0168511
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0167409
CNRIP1 cannabinoid receptor interacting protein 1 0.0166782
NACA nascent polypeptide-associated complex alpha subunit 0.0165412
RPS8 ribosomal protein S8 0.0165061
RAD21 RAD21 homolog (S. pombe) 0.0164428
KHSRP KH-type splicing regulatory protein 0.0162949
H1-0 H1.0 linker histone 0.0162837

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.196294
MMP12 matrix metallopeptidase 12 -0.0901299
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0848852
RPS2 ribosomal protein S2 -0.0821493
JMJD1C jumonji domain containing 1C -0.0737783
ZBTB20 zinc finger and BTB domain containing 20 -0.0722749
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0631436
HMGA2 high mobility group AT-hook 2 -0.0612991
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0599729
PDE4D phosphodiesterase 4D, cAMP-specific -0.0584924
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0558073
ANKRD17 ankyrin repeat domain 17 -0.0528714
WNK1 WNK lysine deficient protein kinase 1 -0.0526451
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0523363
USP34 ubiquitin specific peptidase 34 -0.0484633
ZNF804A zinc finger protein 804A -0.0456517
ANKRD12 ankyrin repeat domain 12 -0.0450799
RABGAP1L RAB GTPase activating protein 1-like -0.044881
CLTC clathrin, heavy chain (Hc) -0.0424881
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0424513
EHBP1 EH domain binding protein 1 -0.0423228
TAS2R14 taste receptor, type 2, member 14 -0.041441
PCDH7 protocadherin 7 -0.0412206
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0397844
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0388944
CCSER1 coiled-coil serine-rich protein 1 -0.0385569
DPYD dihydropyrimidine dehydrogenase -0.0380837
EXOC6B exocyst complex component 6B -0.0375059
NABP1 nucleic acid binding protein 1 -0.0374663
MBD5 methyl-CpG binding domain protein 5 -0.0348197
NIPBL Nipped-B homolog (Drosophila) -0.0346962
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0336784
TRIO trio Rho guanine nucleotide exchange factor -0.0335655
INTS6 integrator complex subunit 6 -0.0328874
ZNF638 zinc finger protein 638 -0.0328461
EXOC4 exocyst complex component 4 -0.030709
FBXO11 F-box protein 11 -0.0302128
TENM3 teneurin transmembrane protein 3 -0.0300751
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0300632
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0300552
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0286757
GOLGB1 golgin B1 -0.0279908
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0278907
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0274296
IL6ST interleukin 6 signal transducer -0.0272729
ASPH aspartate beta-hydroxylase -0.0272555
ARL15 ADP-ribosylation factor-like 15 -0.0271984
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0270938
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.026707
RTN4 reticulon 4 -0.0266621
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.026646
ANK2 ankyrin 2, neuronal -0.0266309
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0266027
TNRC6B trinucleotide repeat containing 6B -0.0265763
YAP1 Yes-associated protein 1 -0.0260859
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0260296
GOLGA4 golgin A4 -0.0256134
PRKCE protein kinase C, epsilon -0.0256082
EPHA5 EPH receptor A5 -0.0255581
CAMKMT calmodulin-lysine N-methyltransferase -0.0255326
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0254127
NKTR natural killer cell triggering receptor -0.0251123
BCAS3 breast carcinoma amplified sequence 3 -0.0250355
RAB10 RAB10, member RAS oncogene family -0.025
PCDH9 protocadherin 9 -0.0249357
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0246212
SBF2 SET binding factor 2 -0.0245021
RNF13 ring finger protein 13 -0.0244399
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0242382
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0241169
KDM5A lysine (K)-specific demethylase 5A -0.0240827
FNIP1 folliculin interacting protein 1 -0.0237423
ZFAND3 zinc finger, AN1-type domain 3 -0.0236983
NEBL nebulette -0.0236788
PATJ PATJ crumbs cell polarity complex component -0.0234553
NEGR1 neuronal growth regulator 1 -0.02317
AUTS2 autism susceptibility candidate 2 -0.0231176
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0230636
PRKN parkin RBR E3 ubiquitin protein ligase -0.0223151
NF1 neurofibromin 1 -0.0222105
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0221181
AFF4 AF4/FMR2 family, member 4 -0.0218602
AGO3 argonaute RISC catalytic component 3 -0.021856
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0217958
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0217353
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0215764
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0215688
SLC38A2 solute carrier family 38, member 2 -0.0215433
BIRC6 baculoviral IAP repeat containing 6 -0.0213202
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0211192
LPP LIM domain containing preferred translocation partner in lipoma -0.021072
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0209826
PHF3 PHD finger protein 3 -0.0208599
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0205322
RAB7A RAB7A, member RAS oncogene family -0.020305
ITSN2 intersectin 2 -0.0202972
TXNRD1 thioredoxin reductase 1 -0.0201855
GSK3B glycogen synthase kinase 3 beta -0.0200563
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0200092
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0199955