Rimonabant (Hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.201044
GPC6 glypican 6 0.172594
MYH9 myosin, heavy chain 9, non-muscle 0.100416
FRMD4A FERM domain containing 4A 0.0958043
TRIO trio Rho guanine nucleotide exchange factor 0.094108
GLS2 glutaminase 2 (liver, mitochondrial) 0.093325
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0811298
EXT1 exostosin glycosyltransferase 1 0.0774721
FNDC3B fibronectin type III domain containing 3B 0.0752187
SMAD3 SMAD family member 3 0.0640106
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0612937
RAI14 retinoic acid induced 14 0.0609532
NRIP1 nuclear receptor interacting protein 1 0.0587108
NAV2 neuron navigator 2 0.0578488
ATP13A3 ATPase type 13A3 0.0543721
TPM3 tropomyosin 3 0.0524304
GLIS3 GLIS family zinc finger 3 0.0509855
VCL vinculin 0.0508527
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.045497
ITGAV integrin, alpha V 0.0423787
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0421558
PBX1 pre-B-cell leukemia homeobox 1 0.0414557
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0405075
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0402775
AHNAK AHNAK nucleoprotein 0.0398107
P3H2 prolyl 3-hydroxylase 2 0.03981
APP amyloid beta (A4) precursor protein 0.039781
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0393002
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.038598
CALU calumenin 0.0384891
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0377571
TSHZ2 teashirt zinc finger homeobox 2 0.0363192
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0359208
TNS3 tensin 3 0.0358192
LPP LIM domain containing preferred translocation partner in lipoma 0.0353504
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0351488
ANKRD10 ankyrin repeat domain 10 0.0351254
SEPTIN9 septin 9 0.0347118
MACF1 microtubule-actin crosslinking factor 1 0.0342909
PDE4D phosphodiesterase 4D, cAMP-specific 0.0336698
ANKRD11 ankyrin repeat domain 11 0.0330651
PTK2 protein tyrosine kinase 2 0.0328657
PAX8 paired box 8 0.0328138
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0325569
FAT1 FAT atypical cadherin 1 0.0325259
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0324395
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0319992
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0317709
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0315599
RRM2 ribonucleotide reductase M2 0.0312808
PTBP3 polypyrimidine tract binding protein 3 0.0312532
SDC4 syndecan 4 0.0311556
ETV6 ets variant 6 0.0311469
SP3 Sp3 transcription factor 0.0307342
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0304271
DOCK5 dedicator of cytokinesis 5 0.0302776
EXOC4 exocyst complex component 4 0.0299671
ADAM10 ADAM metallopeptidase domain 10 0.0297199
DST dystonin 0.0296467
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0296233
RUNX1 runt-related transcription factor 1 0.0295444
ARRDC3 arrestin domain containing 3 0.0295323
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.029198
EHBP1 EH domain binding protein 1 0.0291222
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0289377
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0288986
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0287668
SET SET nuclear proto-oncogene 0.0285314
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0282521
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0275904
PDLIM5 PDZ and LIM domain 5 0.027586
SBF2 SET binding factor 2 0.0274707
SPIDR scaffolding protein involved in DNA repair 0.0273066
FNIP1 folliculin interacting protein 1 0.0268285
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0266492
BIRC6 baculoviral IAP repeat containing 6 0.0264239
NRP1 neuropilin 1 0.0262738
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0261186
VEGFA vascular endothelial growth factor A 0.0255115
CMIP c-Maf inducing protein 0.0253776
SAMD4A sterile alpha motif domain containing 4A 0.0248955
RAD51B RAD51 paralog B 0.0247759
ZCCHC7 zinc finger, CCHC domain containing 7 0.0247357
COL4A1 collagen, type IV, alpha 1 0.0245932
FAM20C family with sequence similarity 20, member C 0.0244591
DENND5A DENN/MADD domain containing 5A 0.0239011
KYNU kynureninase 0.0238211
USP34 ubiquitin specific peptidase 34 0.0237573
GIGYF2 GRB10 interacting GYF protein 2 0.0236144
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0234039
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0233032
SEC24D SEC24 family member D 0.0232018
AKAP13 A kinase (PRKA) anchor protein 13 0.0231148
EFNA5 ephrin-A5 0.022758
MSN moesin 0.0227486
AGFG1 ArfGAP with FG repeats 1 0.0227115
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0223783
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0222784
SMYD3 SET and MYND domain containing 3 0.0220512
DENND2B DENN domain containing 2B 0.0219768

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.300091
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191608
TMSB10 thymosin beta 10 -0.177076
IGFBP3 insulin-like growth factor binding protein 3 -0.162295
VIM vimentin -0.155244
FTH1 ferritin, heavy polypeptide 1 -0.135532
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0929137
HSPB1 heat shock 27kDa protein 1 -0.0886164
RPS6 ribosomal protein S6 -0.0804701
B2M beta-2-microglobulin -0.0752127
ICAM1 intercellular adhesion molecule 1 -0.0719885
RPL35A ribosomal protein L35a -0.0696388
PFN1 profilin 1 -0.0640997
EIF1 eukaryotic translation initiation factor 1 -0.0639576
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0633605
RPLP1 ribosomal protein, large, P1 -0.0615801
POTEF POTE ankyrin domain family, member F -0.0553456
GDF15 growth differentiation factor 15 -0.0552853
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0549739
ZFP36L1 ZFP36 ring finger protein-like 1 -0.054235
NDRG1 N-myc downstream regulated 1 -0.0539351
UBC ubiquitin C -0.0521478
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0509538
CSF1 colony stimulating factor 1 (macrophage) -0.0508407
LOC112694756 uncharaterized LOC112694756 -0.0502178
RPS19 ribosomal protein S19 -0.0492644
PDIA3 protein disulfide isomerase family A, member 3 -0.0483787
RPS5 ribosomal protein S5 -0.0477293
HLA-B major histocompatibility complex, class I, B -0.0477103
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0472607
PKM pyruvate kinase, muscle -0.0458995
CTSD cathepsin D -0.0452561
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.044774
MT2A metallothionein 2A -0.0441384
RPL28 ribosomal protein L28 -0.0435631
RPL34 ribosomal protein L34 -0.0433546
RPS8 ribosomal protein S8 -0.0410744
RPL31 ribosomal protein L31 -0.04093
RPL12 ribosomal protein L12 -0.0401593
RPS20 ribosomal protein S20 -0.0378127
S100A10 S100 calcium binding protein A10 -0.0376492
RPLP0 ribosomal protein, large, P0 -0.037326
TPT1 tumor protein, translationally-controlled 1 -0.0361099
RPL8 ribosomal protein L8 -0.0350798
RPLP2 ribosomal protein, large, P2 -0.0344574
IFITM3 interferon induced transmembrane protein 3 -0.0340983
RPL23 ribosomal protein L23 -0.0340274
RPS14 ribosomal protein S14 -0.0338258
GNAS GNAS complex locus -0.0327443
CD44 CD44 molecule (Indian blood group) -0.0326449
RPS24 ribosomal protein S24 -0.032312
TKT transketolase -0.0313239
ARF1 ADP-ribosylation factor 1 -0.0311204
MTDH metadherin -0.0309348
ADM adrenomedullin -0.0308368
LMNA lamin A/C -0.0305141
RAB7A RAB7A, member RAS oncogene family -0.0301486
RAB2A RAB2A, member RAS oncogene family -0.0299668
HMGA1 high mobility group AT-hook 1 -0.0299656
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0296764
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0296658
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0293808
TAGLN2 transgelin 2 -0.0293321
RACK1 receptor for activated C kinase 1 -0.029186
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0291497
CXXC1 CXXC finger protein 1 -0.0286836
MYADM myeloid-associated differentiation marker -0.0286173
RPS2 ribosomal protein S2 -0.0283376
SDCBP syndecan binding protein (syntenin) -0.0280819
HLA-A major histocompatibility complex, class I, A -0.0280296
S100A6 S100 calcium binding protein A6 -0.0274622
RPL19 ribosomal protein L19 -0.0273533
TFPI2 tissue factor pathway inhibitor 2 -0.0272929
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0272648
ATP5F1B ATP synthase F1 subunit beta -0.0271526
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0271364
RPS13 ribosomal protein S13 -0.0267298
RPS23 ribosomal protein S23 -0.0266613
RPL30 ribosomal protein L30 -0.0263742
EEF2 eukaryotic translation elongation factor 2 -0.0259451
MORF4L2 mortality factor 4 like 2 -0.025478
S100A11 S100 calcium binding protein A11 -0.025006
HLA-C major histocompatibility complex, class I, C -0.0244505
TUBA1B tubulin, alpha 1b -0.0244446
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.0242929
RPL35 ribosomal protein L35 -0.0242595
RPL11 ribosomal protein L11 -0.0241924
HMGB1 high mobility group box 1 -0.02413
UBB ubiquitin B -0.0239527
S100A9 S100 calcium binding protein A9 -0.023822
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0236324
RPS27 ribosomal protein S27 -0.0235879
RPS16 ribosomal protein S16 -0.0229545
LITAF lipopolysaccharide-induced TNF factor -0.0229388
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0229234
RPS27A ribosomal protein S27a -0.0228757
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0228309
CYB5R3 cytochrome b5 reductase 3 -0.0228264
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0227001
TPI1 triosephosphate isomerase 1 -0.0226651