Rimonabant (Hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.106199
PTMA prothymosin, alpha 0.0816988
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646469
UBC ubiquitin C 0.0643858
RPL4 ribosomal protein L4 0.0596466
BHLHE40 basic helix-loop-helix family, member e40 0.0537998
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0533442
AKAP12 A kinase (PRKA) anchor protein 12 0.0510601
TNIP1 TNFAIP3 interacting protein 1 0.0505805
KDM3A lysine (K)-specific demethylase 3A 0.0477959
RPS27A ribosomal protein S27a 0.0470421
RPL7A ribosomal protein L7a 0.0446676
NAP1L1 nucleosome assembly protein 1-like 1 0.0435254
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0421965
TPT1 tumor protein, translationally-controlled 1 0.0419809
RPL23 ribosomal protein L23 0.0415352
TMSB4X thymosin beta 4, X-linked 0.0409625
S100A10 S100 calcium binding protein A10 0.04044
KRT18 keratin 18, type I 0.0387003
RPS17 ribosomal protein S17 0.0382174
EIF1 eukaryotic translation initiation factor 1 0.0367481
RPS3 ribosomal protein S3 0.0357266
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0331098
UPP1 uridine phosphorylase 1 0.0331097
RPLP1 ribosomal protein, large, P1 0.0329481
RPS8 ribosomal protein S8 0.0328134
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0315977
MT2A metallothionein 2A 0.0315598
RPL19 ribosomal protein L19 0.0313931
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.031391
RPS19 ribosomal protein S19 0.0313798
UBA2 ubiquitin-like modifier activating enzyme 2 0.0309942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0306053
TKT transketolase 0.0304685
RPL7 ribosomal protein L7 0.0297865
OGA O-GlcNAcase 0.0285329
CANX calnexin 0.028239
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0282232
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0281591
SRRM2 serine/arginine repetitive matrix 2 0.0277681
HSPA8 heat shock 70kDa protein 8 0.0267957
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0256671
EEF2 eukaryotic translation elongation factor 2 0.0255274
RPL12 ribosomal protein L12 0.0250934
RPL32 ribosomal protein L32 0.0250291
RPL37 ribosomal protein L37 0.0249894
DDIT4 DNA-damage-inducible transcript 4 0.0248704
TMSB10 thymosin beta 10 0.0247026
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0246603
RPL27 ribosomal protein L27 0.0244258
C15ORF48 chromosome 15 open reading frame 48 0.0242663
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.023658
RPS5 ribosomal protein S5 0.023408
RPL11 ribosomal protein L11 0.0230736
RPL3 ribosomal protein L3 0.022948
RPS13 ribosomal protein S13 0.0229395
RPS23 ribosomal protein S23 0.0228149
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.022694
PGK1 phosphoglycerate kinase 1 0.0225104
NAV2 neuron navigator 2 0.0224048
RPL8 ribosomal protein L8 0.022312
HELZ helicase with zinc finger 0.0223039
RPLP2 ribosomal protein, large, P2 0.0223003
VIM vimentin 0.0222679
RPLP0 ribosomal protein, large, P0 0.0222452
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0221665
RPL14 ribosomal protein L14 0.0218457
RPS12 ribosomal protein S12 0.0216355
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0216224
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0214279
RPS4X ribosomal protein S4, X-linked 0.021317
RPL37A ribosomal protein L37a 0.0212694
NACA nascent polypeptide-associated complex alpha subunit 0.0210293
EIF4A1 eukaryotic translation initiation factor 4A1 0.0208208
RPL18 ribosomal protein L18 0.0206869
RPL13A ribosomal protein L13a 0.0206052
RPL28 ribosomal protein L28 0.0203635
RPL31 ribosomal protein L31 0.0201914
TOP2B topoisomerase (DNA) II beta 180kDa 0.0200829
TPI1 triosephosphate isomerase 1 0.0198027
RPS24 ribosomal protein S24 0.0194149
IPO7 importin 7 0.0191611
RPL5 ribosomal protein L5 0.0191201
TRIO trio Rho guanine nucleotide exchange factor 0.0190121
CTNND1 catenin (cadherin-associated protein), delta 1 0.018859
RPS16 ribosomal protein S16 0.018802
KRT81 keratin 81, type II 0.0187913
CKAP5 cytoskeleton associated protein 5 0.0185286
RPS27 ribosomal protein S27 0.0182733
HDGF hepatoma-derived growth factor 0.0182678
MXI1 MAX interactor 1, dimerization protein 0.0179776
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0177757
MATR3 matrin 3 0.0176472
MYH9 myosin, heavy chain 9, non-muscle 0.0175805
RPL36 ribosomal protein L36 0.01747
MT1X metallothionein 1X 0.0172615
MKI67 marker of proliferation Ki-67 0.0172004
RACK1 receptor for activated C kinase 1 0.0170838
RPS11 ribosomal protein S11 0.0170332
ZMYM2 zinc finger, MYM-type 2 0.0169079

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.331851
ACTG1 actin gamma 1 -0.162309
IGFBP3 insulin-like growth factor binding protein 3 -0.161735
NDRG1 N-myc downstream regulated 1 -0.12965
EFNA5 ephrin-A5 -0.119176
FNDC3B fibronectin type III domain containing 3B -0.111108
PDE10A phosphodiesterase 10A -0.108297
VCL vinculin -0.0921965
FTH1 ferritin, heavy polypeptide 1 -0.0855357
GRB10 growth factor receptor-bound protein 10 -0.0835109
EGFR epidermal growth factor receptor -0.0818771
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0815285
KYNU kynureninase -0.0749675
THSD4 thrombospondin, type I, domain containing 4 -0.0622271
EXT1 exostosin glycosyltransferase 1 -0.0619628
RNF213 ring finger protein 213 -0.0608999
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0597142
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0593207
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0592232
AUTS2 autism susceptibility candidate 2 -0.0581965
ARHGAP26 Rho GTPase activating protein 26 -0.0564772
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0562075
MYO1E myosin IE -0.0561489
ZBTB20 zinc finger and BTB domain containing 20 -0.0559294
RIGI RNA sensor RIG-I -0.0543051
SLC35F3 solute carrier family 35, member F3 -0.0538656
IGFBP4 insulin-like growth factor binding protein 4 -0.0535886
MAML3 mastermind-like 3 (Drosophila) -0.0522905
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0486394
FBXO11 F-box protein 11 -0.0485638
OSMR oncostatin M receptor -0.0473814
PDLIM5 PDZ and LIM domain 5 -0.0470313
EHBP1 EH domain binding protein 1 -0.0464284
SP100 SP100 nuclear antigen -0.0463974
EGR1 early growth response 1 -0.0458099
DOCK5 dedicator of cytokinesis 5 -0.0439791
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.04373
NCOA7 nuclear receptor coactivator 7 -0.043711
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0435446
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0431854
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0422662
CMIP c-Maf inducing protein -0.0416895
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0408316
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.039998
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0380282
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0378933
CCDC88A coiled-coil domain containing 88A -0.0378805
PTPRM protein tyrosine phosphatase, receptor type, M -0.0375144
LOC112694756 uncharaterized LOC112694756 -0.0368059
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0362537
EPAS1 endothelial PAS domain protein 1 -0.0359641
ALCAM activated leukocyte cell adhesion molecule -0.0356572
NRIP1 nuclear receptor interacting protein 1 -0.0354771
RIN2 Ras and Rab interactor 2 -0.0350025
LAMA5 laminin, alpha 5 -0.0349245
IGF1R insulin-like growth factor 1 receptor -0.0339717
PSD3 pleckstrin and Sec7 domain containing 3 -0.033437
PRKCA protein kinase C, alpha -0.0330747
GOLGB1 golgin B1 -0.032876
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0327971
CD44 CD44 molecule (Indian blood group) -0.0320894
TJP1 tight junction protein 1 -0.0319436
JMJD1C jumonji domain containing 1C -0.0317644
RAD51B RAD51 paralog B -0.0314762
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0314691
STC1 stanniocalcin 1 -0.0311485
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0310894
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0309863
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0308969
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.030641
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0305451
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0302311
GPC6 glypican 6 -0.0301882
LPP LIM domain containing preferred translocation partner in lipoma -0.0295858
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0294832
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0293752
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0290516
FLNB filamin B, beta -0.0288042
AKAP13 A kinase (PRKA) anchor protein 13 -0.0283725
LIMCH1 LIM and calponin homology domains 1 -0.0281219
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.02767
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0275128
NPAS2 neuronal PAS domain protein 2 -0.0273895
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0270111
PTBP3 polypyrimidine tract binding protein 3 -0.0268988
BPTF bromodomain PHD finger transcription factor -0.0266081
PMP22 peripheral myelin protein 22 -0.0264495
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0264411
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0263283
NT5C2 5'-nucleotidase, cytosolic II -0.0262397
TAS2R14 taste receptor, type 2, member 14 -0.0261917
RAB10 RAB10, member RAS oncogene family -0.0259958
PLSCR1 phospholipid scramblase 1 -0.0258718
ACTN4 actinin, alpha 4 -0.0258663
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0258506
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0256631
LOXL2 lysyl oxidase-like 2 -0.0256454
TBC1D5 TBC1 domain family, member 5 -0.0255121
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0252911
FNDC3A fibronectin type III domain containing 3A -0.0252858